Desipramine (BioDeep_00000001456)
Secondary id: BioDeep_00000408812
human metabolite Endogenous blood metabolite
代谢物信息卡片
(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine
化学式: C18H22N2 (266.1783)
中文名称: 地昔帕明
谱图信息:
最多检出来源 Homo sapiens(blood) 58.1%
分子结构信息
SMILES: CNCCCN1C2=CC=CC=C2CCC2=CC=CC=C12
InChI: InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
描述信息
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
D004791 - Enzyme Inhibitors
同义名列表
51 个代谢物同义名
(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine; 3-(10,11-DIHYDRO-5H-dibenzo[b,F]azepin-5-yl)-N-methylpropan-1-amine; Rhône-poulenc rorer brand OF desipramine hydrochloride; Rhône poulenc rorer brand OF desipramine hydrochloride; Aventis behring brand OF desipramine hydrochloride; Pharmascience brand OF desipramine hydrochloride; Ratiopharm brand OF desipramine hydrochloride; Novopharm brand OF desipramine hydrochloride; Nu pharm brand OF desipramine hydrochloride; Novartis brand OF desipramine hydrochloride; Nu-pharm brand OF desipramine hydrochloride; Temmler brand OF desipramine hydrochloride; Aventis brand OF desipramine hydrochloride; Apotex brand OF desipramine hydrochloride; 5-(gamma-Methylaminopropyl)iminodibenzyl; N-(3-Methylaminopropyl)iminobibenzyl; 5-(g-Methylaminopropyl)iminodibenzyl; 5-(Γ-methylaminopropyl)iminodibenzyl; Methylaminopropyliminodibenzyl; Hydrochloride, desipramine; Desipramine hydrochloride; Monodemethylimipramine; Desmethylimipramine; Demethylimipramine; Dimethylimipramine; Ratio-desipramine; Ratio desipramine; Novo-desipramine; Novo desipramine; PMS-Desipramine; PMS Desipramine; Apo-desipramine; Apo desipramine; Nu-desipramine; Nu desipramine; Desimipramine; Norimipramine; Desimpramine; Desipraminum; Desipramina; desipramine; Dezipramine; Desipramin; Pertofrane; Pertrofran; Norpramine; Pertofran; Norpramin; Petylyl; DMI; Desipramine
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:47781
- KEGG: C06943
- KEGGdrug: D07791
- PubChem: 2995
- HMDB: HMDB0015282
- Metlin: METLIN501
- DrugBank: DB01151
- ChEMBL: CHEMBL72
- Wikipedia: Desipramine
- MeSH: Desipramine
- chemspider: 2888
- CAS: 50-47-5
- PMhub: MS000000563
- PubChem: 9158
- PDB-CCD: DSM
- NIKKAJI: J8.596K
- RefMet: Desipramine
- KNApSAcK: 47781
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
4 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(4)
- Imipramine Action Pathway:
Imipramine + NADH + Oxygen ⟶ Desipramine + Formaldehyde + NAD + Water - Imipramine Metabolism Pathway:
Imipramine + NADH + Oxygen ⟶ Desipramine + Formaldehyde + NAD + Water - Desipramine Action Pathway:
Desipramine + Hydrogen Ion + NADPH + Oxygen ⟶ 2-hydroxydesipramine + NADP + Water - Desipramine Metabolism Pathway:
Desipramine + Hydrogen Ion + NADPH + Oxygen ⟶ 2-hydroxydesipramine + NADP + Water
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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10.1002/bdd.1922. [PMID: 25296725] - Toru Kawada, Tsuyoshi Akiyama, Shuji Shimizu, Yusuke Sata, Michael J Turner, Mikiyasu Shirai, Masaru Sugimachi. Acute effects of arterial baroreflex on sympathetic nerve activity and plasma norepinephrine concentration.
Autonomic neuroscience : basic & clinical.
2014 Dec; 186(?):62-8. doi:
10.1016/j.autneu.2014.10.016. [PMID: 25458434] - Tanya Chotibut, Victoria Fields, Michael F Salvatore. Norepinephrine transporter inhibition with desipramine exacerbates L-DOPA-induced dyskinesia: role for synaptic dopamine regulation in denervated nigrostriatal terminals.
Molecular pharmacology.
2014 Dec; 86(6):675-85. doi:
10.1124/mol.114.093302. [PMID: 25208966] - Joseph C O'Sullivan, Arthur D Johnson, Melissa A Waterman. Comparative resuscitation measures for the treatment of desipramine overdose.
Military medicine.
2014 Nov; 179(11):1266-72. doi:
10.7205/milmed-d-14-00050. [PMID: 25373053] - Irundika H K Dias, Jayna Mistry, Shaun Fell, Ana Reis, Corinne M Spickett, Maria C Polidori, Gregory Y H Lip, Helen R Griffiths. Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.
Free radical biology & medicine.
2014 Oct; 75(?):48-59. doi:
10.1016/j.freeradbiomed.2014.07.012. [PMID: 25048970] - Aparna Shah, Alan Frazer. Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats.
Psychopharmacology.
2014 Sep; 231(18):3685-94. doi:
10.1007/s00213-014-3510-9. [PMID: 24590054] - Danielle Gulick, David T Chau, Jibran Y Khokhar, Ree Dawson, Alan I Green. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster.
Psychiatry research.
2014 Aug; 218(3):329-34. doi:
10.1016/j.psychres.2014.04.038. [PMID: 24836200] - Kelley Ramey, Joseph D Ma, Brookie M Best, Rabia S Atayee, Candis M Morello. Variability in metabolism of imipramine and desipramine using urinary excretion data.
Journal of analytical toxicology.
2014 Jul; 38(6):368-74. doi:
10.1093/jat/bku034. [PMID: 24782142] - Silvia Di Prisco, Elisa Merega, Massimiliano Lanfranco, Simona Casazza, Antonio Uccelli, Anna Pittaluga. Acute desipramine restores presynaptic cortical defects in murine experimental autoimmune encephalomyelitis by suppressing central CCL5 overproduction.
British journal of pharmacology.
2014 May; 171(9):2457-67. doi:
10.1111/bph.12631. [PMID: 24528439] - Danuta Wrona, Magdalena Listowska, Marta Kubera, Wojciech Glac, Beata Grembecka, Karolina Plucińska, Irena Majkutewicz, Magdalena Podlacha. Effects of chronic desipramine pretreatment on open field-induced suppression of blood natural killer cell activity and cytokine response depend on the rat's behavioral characteristics.
Journal of neuroimmunology.
2014 Mar; 268(1-2):13-24. doi:
10.1016/j.jneuroim.2013.10.001. [PMID: 24461377] - Walter Krauwinkel, James Dickinson, Marloes Schaddelee, John Meijer, Reiner Tretter, Jeroen van de Wetering, Gregory Strabach, Marcel van Gelderen. The effect of mirabegron, a potent and selective β3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol.
European journal of drug metabolism and pharmacokinetics.
2014 Mar; 39(1):43-52. doi:
10.1007/s13318-013-0133-1. [PMID: 23728524] - Hanna S Lindgren, Merve Demirbugen, Filip Bergqvist, Emma L Lane, Stephen B Dunnett. The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions.
Experimental neurology.
2014 Mar; 253(?):52-62. doi:
10.1016/j.expneurol.2013.11.015. [PMID: 24333808] - Ornella Di Pietro, Elisabet Viayna, Esther Vicente-García, Manuela Bartolini, Rosario Ramón, Jordi Juárez-Jiménez, M Victòria Clos, Belén Pérez, Vincenza Andrisano, F Javier Luque, Rodolfo Lavilla, Diego Muñoz-Torrero. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
European journal of medicinal chemistry.
2014 Feb; 73(?):141-52. doi:
10.1016/j.ejmech.2013.12.008. [PMID: 24389509] - Wenjing Li, Xiaoyan Yang, Shasha Xing, Fang Bian, Wanjing Yao, Xiangli Bai, Tao Zheng, Guangjie Wu, Si Jin. Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall.
Oxidative medicine and cellular longevity.
2014; 2014(?):823071. doi:
10.1155/2014/823071. [PMID: 24817993] - Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
10.1093/toxsci/kft205. [PMID: 24052561] - Jung-eun Park, Chiman Song, Keehyun Choi, Taebo Sim, Bongjin Moon, Eun Joo Roh. Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.
Bioorganic & medicinal chemistry letters.
2013 Oct; 23(20):5515-8. doi:
10.1016/j.bmcl.2013.08.062. [PMID: 24012181] - Danuta Wrona, Magdalena Listowska, Marta Kubera, Irena Majkutewicz, Wojciech Glac, Bogumiła Wojtyła-Kuchta, Karolina Plucińska, Beata Grembecka, Magdalena Podlacha. Chronic antidepressant desipramine treatment increases open field-induced brain expression and spleen production of interleukin 10 in rats.
Brain research bulletin.
2013 Oct; 99(?):117-31. doi:
10.1016/j.brainresbull.2013.10.002. [PMID: 24161357] - Melissa M Kaczmarczyk, Agnieszka S Machaj, Gabriel S Chiu, Marcus A Lawson, Stephen J Gainey, Jason M York, Daryl D Meling, Stephen A Martin, Kristin A Kwakwa, Andrew F Newman, Jeffrey A Woods, Keith W Kelley, Yanyan Wang, Michael J Miller, Gregory G Freund. Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice.
Psychoneuroendocrinology.
2013 Sep; 38(9):1553-64. doi:
10.1016/j.psyneuen.2013.01.004. [PMID: 23411461] - Ming Yu, Jody Bozek, Mikhail Kagan, Mary Guaraldi, Paula Silva, Michael Azure, David Onthank, Simon P Robinson. Cardiac retention of PET neuronal imaging agent LMI1195 in different species: impact of norepinephrine uptake-1 and -2 transporters.
Nuclear medicine and biology.
2013 Jul; 40(5):682-8. doi:
10.1016/j.nucmedbio.2013.03.003. [PMID: 23601914] - James T Thackeray, Jennifer M Renaud, Myra Kordos, Ran Klein, Robert A Dekemp, Rob S B Beanlands, Jean N DaSilva. Test-retest repeatability of quantitative cardiac 11C-meta-hydroxyephedrine measurements in rats by small animal positron emission tomography.
Nuclear medicine and biology.
2013 Jul; 40(5):676-81. doi:
10.1016/j.nucmedbio.2013.03.007. [PMID: 23664690] - Caroline Nothdurfter, Sascha Tanasic, Barbara Di Benedetto, Manfred Uhr, Eva-Maria Wagner, Kate E Gilling, Chris G Parsons, Theo Rein, Florian Holsboer, Rainer Rupprecht, Gerhard Rammes. Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds.
The international journal of neuropsychopharmacology.
2013 Jul; 16(6):1361-71. doi:
10.1017/s146114571200140x. [PMID: 23217923] - Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - Brian Platt, Janet Schulenberg, Nicole Klee, Maryam Nizami, Janet A Clark. A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Psychopharmacology.
2013 Apr; 226(3):501-13. doi:
10.1007/s00213-012-2923-6. [PMID: 23179968] - Bankim J Sanghavi, Ashwini K Srivastava. Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode.
The Analyst.
2013 Mar; 138(5):1395-404. doi:
10.1039/c2an36330e. [PMID: 23324861] - Sandra A Bright, Anne Brinkø, Maja Thim Larsen, Steffen Sinning, D Clive Williams, Henrik H Jensen. Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.
Bioorganic & medicinal chemistry letters.
2013 Mar; 23(5):1220-4. doi:
10.1016/j.bmcl.2013.01.020. [PMID: 23385211] - Alice I Nichols, Madelyn Abell, Abell Madelyn, Yang Chen, Jessica A Behrle, Glen Frick, Jeffrey Paul. Effects of desvenlafaxine on the pharmacokinetics of desipramine in healthy adults.
International clinical psychopharmacology.
2013 Mar; 28(2):99-105. doi:
10.1097/yic.0b013e32835c1f49. [PMID: 23221858] - Y Zhang, H Zhen, W Yao, F Bian, X Mao, X Yang, S Jin. Antidepressant drug, desipramine, alleviates allergic rhinitis by regulating Treg and Th17 cells.
International journal of immunopathology and pharmacology.
2013 Jan; 26(1):107-15. doi:
10.1177/039463201302600110. [PMID: 23527713] - Julia Shanks, Saras Mane, Rebecca Ryan, David J Paterson. Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat.
Hypertension (Dallas, Tex. : 1979).
2013 Jan; 61(1):187-93. doi:
10.1161/hypertensionaha.112.202184. [PMID: 23172922] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Mohammad Saraji, Narges Mehrafza, Ali Akbar Hajialiakbari Bidgoli, Mohammad Taghi Jafari. Determination of desipramine in biological samples using liquid-liquid-liquid microextraction combined with in-syringe derivatization, gas chromatography, and nitrogen/phosphorus detection.
Journal of separation science.
2012 Oct; 35(19):2637-44. doi:
10.1002/jssc.201200334. [PMID: 22887899] - Theodore J Zwang, Reena Patel, Malkiat S Johal, Cynthia R Selassie. Desolvation of BSA-ligand complexes measured using the quartz crystal microbalance and dual polarization interferometer.
Langmuir : the ACS journal of surfaces and colloids.
2012 Jun; 28(25):9616-20. doi:
10.1021/la301718m. [PMID: 22621286] - Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź. Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice.
Journal of neural transmission (Vienna, Austria : 1996).
2012 Jun; 119(6):645-52. doi:
10.1007/s00702-011-0756-9. [PMID: 22215207] - F E O'Brien, G Clarke, P Fitzgerald, T G Dinan, B T Griffin, J F Cryan. Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats.
British journal of pharmacology.
2012 Jun; 166(4):1333-43. doi:
10.1111/j.1476-5381.2012.01858.x. [PMID: 22250926] - Michael Liebrenz, Danielle Hof, Anna Buadze, Rudolf Stohler, Dominique Eich. High dose methylphenidate treatment in adult attention deficit hyperactivity disorder: a case report.
Journal of medical case reports.
2012 May; 6(?):125. doi:
10.1186/1752-1947-6-125. [PMID: 22583957] - Wadad Saba, Marie-Anne Peyronneau, Frédéric Dollé, Sébastien Goutal, Michel Bottlaender, Héric Valette. Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling Part I: PET studies.
Nuclear medicine and biology.
2012 Feb; 39(2):227-33. doi:
10.1016/j.nucmedbio.2011.08.003. [PMID: 22033025] - S B Sartori, N Whittle, A Hetzenauer, N Singewald. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
Neuropharmacology.
2012 Jan; 62(1):304-12. doi:
10.1016/j.neuropharm.2011.07.027. [PMID: 21835188] - Paul W Andrews, J Anderson Thomson, Ananda Amstadter, Michael C Neale. Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.
Frontiers in psychology.
2012; 3(?):117. doi:
10.3389/fpsyg.2012.00117. [PMID: 22536191] - Jingqiu Chen, Daniel Korostyshevsky, Sean Lee, Ethan O Perlstein. Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy.
PloS one.
2012; 7(4):e34024. doi:
10.1371/journal.pone.0034024. [PMID: 22529904] - Marco Antonioli, Joanna Rybka, Livia A Carvalho. Neuroimmune endocrine effects of antidepressants.
Neuropsychiatric disease and treatment.
2012; 8(?):65-83. doi:
10.2147/ndt.s16409. [PMID: 22347798] - Peyman Kabolizadeh, Brigitte J Engelmann, Nicholas Pullen, Jennifer K Stewart, John J Ryan, Nicholas P Farrell. Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2012 Jan; 17(1):123-32. doi:
10.1007/s00775-011-0836-1. [PMID: 21918844] - Aleksandra Jaworska, Renata Wietecha-Posłuszny, Michał Woźniakiewicz, Paweł Kościelniak, Kamilla Malek. Evaluation of the potential of surface enhancement Raman spectroscopy for detection of tricyclic psychotropic drugs. Case studies on imipramine and its metabolite.
The Analyst.
2011 Nov; 136(22):4704-9. doi:
10.1039/c1an15598a. [PMID: 21961110] - David J O'Neill, Adedayo Adedoyin, Jenifer A Bray, Darlene C Deecher, Andrew Fensome, Joel A Goldberg, Jim Harrison, Liza Leventhal, Charles Mann, Lilly Mark, Lisa Nogle, Nicole R Sullivan, Taylor B Spangler, Eugene A Terefenko, Eugene J Trybulski, Albert J Uveges, An Vu, Garth T Whiteside, Puwen Zhang. Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
Journal of medicinal chemistry.
2011 Oct; 54(19):6824-31. doi:
10.1021/jm200733r. [PMID: 21916421] - Susan L Erickson, Anjalika R Gandhi, Josephine K Asafu-Adjei, Allan R Sampson, LeeAnn Miner, Randy D Blakely, Susan R Sesack. Chronic desipramine treatment alters tyrosine hydroxylase but not norepinephrine transporter immunoreactivity in norepinephrine axons in the rat prefrontal cortex.
The international journal of neuropsychopharmacology.
2011 Oct; 14(9):1219-32. doi:
10.1017/s1461145710001525. [PMID: 21208501] - David S Goldstein, Courtney Holmes, Irwin J Kopin, Yehonatan Sharabi. Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases.
The Journal of clinical investigation.
2011 Aug; 121(8):3320-30. doi:
10.1172/jci45803. [PMID: 21785221] - Luciana S Branco-de-Almeida, Mikihito Kajiya, Cristina R Cardoso, Marcelo J B Silva, Kouji Ohta, Pedro L Rosalen, Gilson C N Franco, Xiaozhe Han, Martin A Taubman, Toshihisa Kawai. Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes.
FEMS immunology and medical microbiology.
2011 Aug; 62(3):283-94. doi:
10.1111/j.1574-695x.2011.00816.x. [PMID: 21569123] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Shilan Mozaffari, Hadi Esmaily, Roja Rahimi, Maryam Baeeri, Yara Sanei, Azar Asadi-Shahmirzadi, Mohammad-Hossein Salehi-Surmaghi, Mohammad Abdollahi. Effects of Hypericum perforatum extract on rat irritable bowel syndrome.
Pharmacognosy magazine.
2011 Jul; 7(27):213-23. doi:
10.4103/0973-1296.84235. [PMID: 21969792] - Lifen Wang, Hongtao Zhen, Wanjing Yao, Fang Bian, Fan Zhou, Xiaofang Mao, Ping Yao, Si Jin. Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-κB pathway in bronchial epithelial cells.
American journal of physiology. Cell physiology.
2011 Jul; 301(1):C171-80. doi:
10.1152/ajpcell.00363.2010. [PMID: 21389273] - M T Jafari, M Saraji, H Sherafatmand. Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples.
Analytical and bioanalytical chemistry.
2011 Apr; 399(10):3555-64. doi:
10.1007/s00216-011-4730-z. [PMID: 21298415] - Ingo Staudacher, Lu Wang, Xiaoping Wan, Sabrina Obers, Wolfgang Wenzel, Frank Tristram, Ronald Koschny, Kathrin Staudacher, Jana Kisselbach, Patrick Koelsch, Patrick A Schweizer, Hugo A Katus, Eckhard Ficker, Dierk Thomas. hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Feb; 383(2):119-39. doi:
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