Aloin (BioDeep_00000000537)

 

Secondary id: BioDeep_00000003341

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one;Aloin

化学式: C21H22O9 (418.1264)
中文名称: 芦荟苷 B, 芦荟素 B, 芦荟苷B, 芦荟提取液, 芦荟苷A, 芦荟甙 B, 芦荟甙
谱图信息: 最多检出来源 Viridiplantae(plant) 26.26%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2C4C(C(C(C(O4)CO)O)O)O)C=C(C=C3O)CO
InChI: InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29697 - Laxative
D005765 - Gastrointestinal Agents > D002400 - Cathartics
Aloin A is a C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S diastereoisomer). It has a role as a metabolite and a laxative. It is a C-glycosyl compound, a member of anthracenes, a cyclic ketone and a member of phenols.
Barbaloin is a natural product found in Aloe africana, Aloe castanea, and other organisms with data available.
See also: Aloe Vera Leaf (part of); Frangula purshiana Bark (part of).
A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S diastereoisomer).
Aloin B is a C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9R diastereoisomer). It has a role as a metabolite and a laxative. It is a C-glycosyl compound, a member of anthracenes, a cyclic ketone and a member of phenols.
Aloin is a natural product found in Aloe africana, Aloe castanea, and other organisms with data available.
See also: Aloe Vera Leaf (part of); Frangula purshiana Bark (part of).
A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9R diastereoisomer).
IPB_RECORD: 1881; CONFIDENCE confident structure
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity.
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity.
Aloin B is an isomer of aloin, a physiologically active anthraquinone compound in aloe.
Aloin B is an isomer of aloin, a physiologically active anthraquinone compound in aloe.
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs)[1][2].

同义名列表

77 个代谢物同义名

aloin B; Aloin; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one;Aloin; (S)-1,8-dihydroxy-3-(hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)anthracen-9(10H)-one; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one; (1S)-1,5-anhydro-1-[(9S)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]-D-glucitol; (1S)-1,5-anhydro-1-((9S)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl)-D-glucitol; 9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-; 10-.BETA.-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone-, 10(S)-; 9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (S)-; 9(10H)-Anthracenone, 10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-; 1,8-Dihydroxy-3-hydroxymethyl-10-(6-hydroxymethyl-3,4,5-trihydroxy-2-pyranyl)anthrone; 9(10H)-ANTHRACENONE, 10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-, (S)-; (10S)-10-.BETA.-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; (10S)-10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; (R)-10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)anthracen-9(10H)-one; 1,8-Dihydroxy-10-(beta-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone; 10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-hydroxymethyl-9(10H)-anthrone,(R)-; 10-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; Aloin, United States Pharmacopeia (USP) Reference Standard; Aloin, from Aloe barbadensis Miller leaves, >=97\\%; Aloin, from Curacao aloe, ~50\\%; Aloin, analytical standard; barbaloin, monoglucoside; barbaloin, beta-D-isomer; barbaloin, (S)-isomer; Aloin (Barbaloin); Barbaloin,(S); Tox21_113216; ALOIN A [MI]; Isobarbaloin; Tox21_111495; Aloin [BAN]; Barbaloin-A; Barbaloin A; Barbaloin; Barbalin; Aloin-A; aloin A; Aloinum; (R)-1,8-dihydroxy-3-(hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)anthracen-9(10H)-one; (10R)-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-10-[(2S,3R,4R,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]-9,10-DIHYDROANTHRACEN-9-ONE; (10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one; (1S)-1,5-anhydro-1-[(9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]-D-glucitol; (1S)-1,5-anhydro-1-((9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl)-D-glucitol; 9(10H)-ANTHRACENONE, 10-.BETA.-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-, (10R)-; 9(10H)-ANTHRACENONE, 10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-, (10R)-; 9(10H)-Anthracenone, 10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (R)-; (10R)-10-.BETA.-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; (10R)-10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; 9(10H)-Anthracenone,10-b-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-,(10R)-; 10R-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; 1,8-Dihydroxy-10-(ss-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone; 10-ss-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; AFHJQYHRLPMKHU-WEZNYRQKSA-N; Aloin B; Isobarbaloin; Aloin-B;Isobarbaloin; UNII-69VIB0J2WK; |A-Barbaloin; ALOIN B [MI]; BARBALOIN B; 69VIB0J2WK; alloin; 10-beta-D-Glucopyranosyl-1,8-dihydro-3-(hydroxymethyl)-9(10H)-anthracenone; 1,8-dihydroxy-3-(hydroxymethyl)-10-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one; 10-b-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone, 9CI; 10-(1',5'-Anhydroglucosyl)aloe-emodin-9-anthrone; Ugandaloin; Socaloin; Cafaloin; Jafaloin; Barbaloin; Aloin-B; Aloin(mixture of A&B); Isobarbaloin



数据库引用编号

70 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(4)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

227 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 BCL2, CASP3, CAT, CDH1, CDH2, HMGB1, MAPK14, MTOR, NFE2L2, PIK3CA, PTGS2, RUNX2, STAT3
Peripheral membrane protein 4 GORASP1, HMGB1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 10 BCL2, CASP3, CDH1, HMGB1, HMOX1, MAPK14, MTOR, NFE2L2, RUNX2, STAT3
cytosol 12 BCL2, CASP3, CAT, CDH1, GPT, HMOX1, MAPK14, MTOR, NFE2L2, PIK3CA, RUNX2, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
trans-Golgi network 1 CDH1
centrosome 1 NFE2L2
nucleoplasm 9 CASP3, CDH1, HMGB1, HMOX1, MAPK14, MTOR, NFE2L2, RUNX2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 4 CDH1, CDH2, HMGB1, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 3 CDH1, CDH2, PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
cell junction 2 CDH1, CDH2
cell surface 3 CDH2, HMGB1, TNF
glutamatergic synapse 3 CASP3, CDH1, MAPK14
Golgi apparatus 3 CDH1, GORASP1, NFE2L2
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 CDH1
sarcolemma 1 CDH2
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
endosome 2 CDH1, HMGB1
plasma membrane 7 CDH1, CDH2, HMGB1, NFE2L2, PIK3CA, STAT3, TNF
Membrane 6 BCL2, CAT, CDH1, CDH2, HMOX1, MTOR
apical plasma membrane 1 CDH2
axon 1 CCK
basolateral plasma membrane 1 CDH2
caveola 1 PTGS2
extracellular exosome 3 CAT, CDH1, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, HMGB1, HMOX1, PTGS2
extracellular space 6 CCK, HMGB1, HMOX1, IL10, IL6, TNF
perinuclear region of cytoplasm 3 CDH1, HMOX1, PIK3CA
adherens junction 2 CDH1, CDH2
apicolateral plasma membrane 1 CDH2
intercalated disc 2 CDH2, PIK3CA
mitochondrion 3 BCL2, CAT, MAPK14
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 2 CASP3, CDH2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CDH1, CDH2
Secreted 4 CCK, HMGB1, IL10, IL6
extracellular region 8 CAT, CCK, CDH1, HMGB1, IL10, IL6, MAPK14, TNF
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 HMGB1
transcription regulator complex 2 RUNX2, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH1
external side of plasma membrane 1 TNF
actin cytoskeleton 1 CDH1
apical part of cell 1 CDH2
cell-cell junction 1 CDH2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
presynaptic active zone membrane 1 CDH2
Cell membrane, sarcolemma 1 CDH2
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 CAT, CDH2
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 2 CDH1, CDH2
flotillin complex 1 CDH1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 CDH2
fascia adherens 1 CDH2
lateral plasma membrane 1 CDH1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 CDH2, PTGS2
chromatin 3 NFE2L2, RUNX2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 HMGB1
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 1 MAPK14
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
myelin sheath 1 BCL2
plasma membrane raft 1 CDH2
ficolin-1-rich granule lumen 3 CAT, HMGB1, MAPK14
secretory granule lumen 3 CAT, HMGB1, MAPK14
endoplasmic reticulum lumen 3 CDH2, IL6, PTGS2
transcription repressor complex 1 HMGB1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 CDH2
apical junction complex 1 CDH1
condensed chromosome 1 HMGB1
Cell junction, desmosome 2 CDH1, CDH2
desmosome 2 CDH1, CDH2
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 2 CDH1, CDH2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Junjie Bai, Baolin Qian, Tianying Cai, Yifan Chen, Tongxi Li, Yonglang Cheng, Ziming Wu, Chen Liu, Mingxin Ye, Yichao Du, Wenguang Fu. Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling. Journal of agricultural and food chemistry. 2023 Dec; 71(49):19475-19487. doi: 10.1021/acs.jafc.3c01721. [PMID: 38038700]
  • Meng Yu, Xin-Yu Kong, Tong-Tong Chen, Zhong-Mei Zou. In vivo metabolism combined network pharmacology to identify anti-constipation constituents in Aloe barbadensis Mill. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117200. doi: 10.1016/j.jep.2023.117200. [PMID: 37726070]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Shreya Sikdar Mitra, Mimosa Ghorai, Samapika Nandy, Nobendu Mukherjee, Manoj Kumar, Radha, Arabinda Ghosh, Niraj Kumar Jha, Jarosław Proćków, Abhijit Dey. Barbaloin: an amazing chemical from the 'wonder plant' with multidimensional pharmacological attributes. Naunyn-Schmiedeberg's archives of pharmacology. 2022 12; 395(12):1525-1536. doi: 10.1007/s00210-022-02294-4. [PMID: 36173445]
  • Xin-Yu Kong, Tong-Tong Chen, Hong-Wu Zhang, Hong-Mei Jia, Meng Yu, Zhong-Mei Zou. Characterization of the metabolism of aloin A/B and aloesin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomedical chromatography : BMC. 2022 Dec; 36(12):e5483. doi: 10.1002/bmc.5483. [PMID: 35975594]
  • Hui Jiang, Gao-Feng Shi, Yu-Xi Fang, You-Qian Liu, Qi Wang, Xian Zheng, Dong-Jian Zhang, Jian Zhang, Zhi-Qi Yin. Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154403. doi: 10.1016/j.phymed.2022.154403. [PMID: 36075180]
  • Yu Yang, Jiao-Jiao Wu, Jia Xia, Yan Wan, Jin-Feng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao, Cheng Peng. Can aloin develop to medicines or healthcare products?. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113421. doi: 10.1016/j.biopha.2022.113421. [PMID: 36076485]
  • Gong Zhang, Rong Bai, Jianlin Huang, Yafeng Gao, Xiuli Yun, Akber Aisa Haji. Barbaloin attenuates pulmonary fibrosis through TGF-β1/Smads/p38 pathway. The Journal of pharmacy and pharmacology. 2022 Aug; 74(8):1160-1169. doi: 10.1093/jpp/rgac023. [PMID: 35666278]
  • A Wallace Hayes, Roger A Clemens, Peter Pressman. The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage. Toxicology mechanisms and methods. 2022 Jun; 32(5):385-394. doi: 10.1080/15376516.2021.2023828. [PMID: 34979868]
  • Magdalena Westermann, Amma G Adomako-Bonsu, Solveig Thiele, Serhat Sezai Çiçek, Hans-Jörg Martin, Edmund Maser. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives. Chemico-biological interactions. 2022 Feb; 354(?):109823. doi: 10.1016/j.cbi.2022.109823. [PMID: 35065925]
  • Devin S M Lewis, Joanna Ho, Savannah Wills, Anasha Kawall, Avini Sharma, Krishna Chavada, Maximilian C C J C Ebert, Stefania Evoli, Ajay Singh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval. Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro. Scientific reports. 2022 02; 12(1):2145. doi: 10.1038/s41598-022-06104-y. [PMID: 35140265]
  • Mostafa M Abdel-Moniem, Azza M Hassan, Mahmoud M Said, Amr Y Esmat. Iron supplementation ameliorates aloin-induced iron deficiency anemia in rats. Experimental and molecular pathology. 2022 02; 124(?):104740. doi: 10.1016/j.yexmp.2021.104740. [PMID: 34998864]
  • Jianbin Xiao, Siyuan Chen, Youqiang Chen, Jingqian Su. The potential health benefits of aloin from genus Aloe. Phytotherapy research : PTR. 2022 Feb; 36(2):873-890. doi: 10.1002/ptr.7371. [PMID: 35040198]
  • Dazhi Fu, Qiang Ji, Chunxiao Wang, Lei Yu, Rui Yu. Aloin decelerates the progression of hepatocellular carcinoma through circ_0011385/miR-149-5p/WT1 axis. Cell cycle (Georgetown, Tex.). 2021 12; 20(23):2476-2493. doi: 10.1080/15384101.2021.1988227. [PMID: 34720052]
  • Hanyi Hua, Jie Sheng, Yan Cui, Wenyi Zhang, Bin Hu, Yuliang Cheng, Yahui Guo, He Qian. The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111620. [PMID: 34769051]
  • Hao Yuan, Hong Wan, Yi-Kao Hu, Emmanuel Ayodeji Ayeni, Qiang Chang, Chao Ma, Xun Liao. Fishing of α-Glucosidase's Ligands from Aloe vera by α-Glucosidase Functionalized Magnetic Nanoparticles. Molecules (Basel, Switzerland). 2021 Sep; 26(19):. doi: 10.3390/molecules26195840. [PMID: 34641385]
  • Kamil Pawłowicz, Dominika Ludowicz, Marta Karaźniewicz-Łada, Kamil Wdowiak, Judyta Cielecka-Piontek. Analysis of the Composition of Lyophilisates Obtained from Aloe arborescens Gel of Leaves of Different Ages from Controlled Crops. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113204. [PMID: 34071863]
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