Corylifolinin (BioDeep_00000000310)

 

Secondary id: BioDeep_00000176448, BioDeep_00000402838

PANOMIX_OTCML-2023


代谢物信息卡片


2-PROPEN-1-ONE, 1-(2,4-DIHYDROXY-3-(3-METHYL-2-BUTEN-1-YL)PHENYL)-3-(4-HYDROXYPHENYL)-, (2E)-

化学式: C20H20O4 (324.13615200000004)
中文名称: 异补骨脂查耳酮, 异补骨脂查尔酮, 补骨脂乙素, 补骨酯乙素, 补骨脂乙素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 11.32%

分子结构信息

SMILES: C1(O)C=CC(C(=O)/C=C/C2C=CC(O)=CC=2)=C(O)C=1C/C=C(\C)/C
InChI: InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+

描述信息

Isobavachalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2 and 4 and a prenyl group at position 3. It has a role as an antibacterial agent, a platelet aggregation inhibitor and a metabolite. It is a polyphenol and a member of chalcones. It is functionally related to a trans-chalcone.
Isobavachalcone is a natural product found in Broussonetia papyrifera, Anthyllis hermanniae, and other organisms with data available.
See also: Angelica keiskei top (part of).
A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2 and 4 and a prenyl group at position 3.
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].

同义名列表

36 个代谢物同义名

2-PROPEN-1-ONE, 1-(2,4-DIHYDROXY-3-(3-METHYL-2-BUTEN-1-YL)PHENYL)-3-(4-HYDROXYPHENYL)-, (2E)-; 2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-; 2-PROPEN-1-ONE, 1-(2,4-DIHYDROXY-3-(3-METHYL-2-BUTENYL)PHENYL)-3-(4-HYDROXYPHENYL)-, (2E)-; 2-Propen-1-one,1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-; (2E)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (2E)-1-[2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (e)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)-phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one; (2E)-1-(2,4-DIHYDROXY-3-(3-METHYL-2-BUTENYL)PHENYL)-3-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE; (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one; (E)-1-(2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 1-(2,4-Dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-; 1-[2,4-Dihydroxy-3-(3-methyl-but-2-enyl)-phenyl]-3-(4-hydroxy-phenyl)-propenone; CHALCONE, 2,4,4-TRIHYDROXY-3-(3-METHYL-2-BUTENYL)-; 2,4,4-Trihydroxy-3-(3-methyl-2-butenyl)chalcone; 2,4,4-Trihydroxy-3-[3-methylbut-3-enyl]chalcone; 2,4,4-trihydroxy-3-prenylchalcone; Isobavachalcone, >=98\\% (HPCE); Corylifolinin(Isobavachalcone); Corylifolinin;Isobacachalcone; DUWPGRAKHMEPCM-IZZDOVSWSA-N; ISOBAVACHALCONE [INCI]; 4-Hydroxyisocordoin; 4-Hydroxyisocordoim; UNII-ZWO2SC993A; Isobacachalcone; Isobavachalcone; Corylifolinin; ZWO2SC993A; 1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; AIDS-046583; 20784-50-3; AIDS046583; C08648



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

83 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Luyao Wang, Ziqiang Wang, Yuhan Ni, Xue Wang, Tingting Zhang, Mengling Hu, Chaoqun Lian, Xiaojing Wang, Jing Zhang. Elucidating the mechanism of action of Isobavachalcone induced autophagy and apoptosis in non-small cell lung cancer by network pharmacology and experimental validation methods. Gene. 2024 Aug; 918(?):148474. doi: 10.1016/j.gene.2024.148474. [PMID: 38670393]
  • Dan Cao, Zunjing Zhang, Xiuzhi Jiang, Tiantian Wu, Yanghui Xiang, Zhongkang Ji, Jing Guo, Xiaoqin Zhang, Kaijin Xu, Zhongda Liu, Ying Zhang. Psoralea corylifolia L. and its active component isobavachalcone demonstrate antibacterial activity against Mycobacterium abscessus. Journal of ethnopharmacology. 2024 Jul; 329(?):118142. doi: 10.1016/j.jep.2024.118142. [PMID: 38583730]
  • Huiwen Zhang, Chengyue Zhu, Jingcheng Zhao, Ruifang Zheng, Jianguo Xing, Zhijian Li, Yun Zhang, Qian Xu. The enhanced hepatotoxicity of isobavachalcone in depigmented zebrafish due to calcium signaling dysregulation and lipid metabolism disorder. Journal of applied toxicology : JAT. 2024 06; 44(6):919-932. doi: 10.1002/jat.4593. [PMID: 38400677]
  • Ya-Li Ren, Jie-Ting Lei, Ting-Rui Zhang, Peng Lu, Dan-Dan Cui, Bo Yang, Gui-Ying Zhao, Fu Peng, Zhi-Xing Cao, Cheng Peng, Yu-Zhi Li. Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo. Phytotherapy research : PTR. 2024 Apr; 38(4):1815-1829. doi: 10.1002/ptr.8143. [PMID: 38349045]
  • Xiuju Yang, Kunqian Cao, Xiaoli Ren, Guangyun Cao, Weizhi Xun, Jiayong Qin, Xia Zhou, Linhong Jin. Field Control Effect and Initial Mechanism: A Study of Isobavachalcone against Blister Blight Disease. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210225. [PMID: 37373374]
  • Xin Liu, Xiaosa Xu, Jinping Li, Liying Shi, Ying Zeng, Siyuan Tang, Wei Liu, Lujuan Jia, Yuhong Li, Jie Zhang. Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells. Bioscience, biotechnology, and biochemistry. 2023 Jun; ?(?):. doi: 10.1093/bbb/zbad075. [PMID: 37291698]
  • Yong-Jun Huang, Xiao-Lin Zhong, Yi-Peng Zang, Ming-Han Yang, Jing Lin, Wei-Min Chen. 3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa. European journal of medicinal chemistry. 2023 May; 257(?):115454. doi: 10.1016/j.ejmech.2023.115454. [PMID: 37210837]
  • Lin Zhao, Yingli Yu, Li Li, Jiarui Wang, Jing Wang, Shijia Su, Jingyi Ding, Yue Zhang, Anhong Wang, Kun Zhou. Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression. Toxicon : official journal of the International Society on Toxinology. 2022 Sep; 216(?):28-36. doi: 10.1016/j.toxicon.2022.06.018. [PMID: 35780971]
  • Shaohui Wang, Qinyun Du, Jiayi Sun, Sang Geng, Yi Zhang. Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental verification. Journal of ethnopharmacology. 2022 Aug; 294(?):115342. doi: 10.1016/j.jep.2022.115342. [PMID: 35525528]
  • Nan Xing, Xianli Meng, Shaohui Wang. Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms. Phytotherapy research : PTR. 2022 Aug; 36(8):3120-3142. doi: 10.1002/ptr.7520. [PMID: 35684981]
  • Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
  • Dingqi Zhang, Sami Hamdoun, Ruihong Chen, Lijun Yang, Chi Kio Ip, Yuanqing Qu, Runfeng Li, Haiming Jiang, Zifeng Yang, Sookja Kim Chung, Liang Liu, Vincent Kam Wai Wong. Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry. Pharmacological research. 2021 10; 172(?):105820. doi: 10.1016/j.phrs.2021.105820. [PMID: 34403732]
  • Mohan Zhang, Qiuping Wu, Ruoxi Zhao, Xuanbao Yao, Xiubo Du, Qiong Liu, Guohua Lv, Shifeng Xiao. Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease. Food & function. 2021 Sep; 12(17):7749-7761. doi: 10.1039/d1fo01306h. [PMID: 34269361]
  • Anna Palko-Łabuz, Maria Błaszczyk, Kamila Środa-Pomianek, Olga Wesołowska. Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154637. [PMID: 34361789]
  • Yuejuan Li, Baichun Hu, Zhibin Wang, Jianhua He, Yaoliang Zhang, Jian Wang, Lijie Guan. Identification of Pyruvate Dehydrogenase E1 as a Potential Target against Magnaporthe oryzae through Experimental and Theoretical Investigation. International journal of molecular sciences. 2021 May; 22(10):. doi: 10.3390/ijms22105163. [PMID: 34068366]
  • Zifei Qin, Peile Wang, Shuyi Duan, Xiaoying Wan, Han Xing, Jing Yang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao. Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters. Journal of pharmaceutical sciences. 2021 05; 110(5):2285-2294. doi: 10.1016/j.xphs.2021.02.013. [PMID: 33610566]
  • Miaojuan Wang, Ligen Lin, Jin-Jian Lu, Xiuping Chen. Pharmacological review of isobavachalcone, a naturally occurring chalcone. Pharmacological research. 2021 03; 165(?):105483. doi: 10.1016/j.phrs.2021.105483. [PMID: 33577976]
  • Shifeng Xiao, Qiuping Wu, Xuanbao Yao, Jiahao Zhang, Weicong Zhong, Junyi Zhao, Qiong Liu, Mohan Zhang. Inhibitory Effects of Isobavachalcone on Tau Protein Aggregation, Tau Phosphorylation, and Oligomeric Tau-Induced Apoptosis. ACS chemical neuroscience. 2021 01; 12(1):123-132. doi: 10.1021/acschemneuro.0c00617. [PMID: 33320518]
  • Peng-Chao Huo, Qing Hu, Sheng Shu, Qi-Hang Zhou, Rong-Jing He, Jie Hou, Xiao-Qing Guan, Dong-Zhu Tu, Xu-Dong Hou, Peng Liu, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors. Bioorganic & medicinal chemistry. 2021 01; 29(?):115853. doi: 10.1016/j.bmc.2020.115853. [PMID: 33214035]
  • Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, Jianxin Chen. Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Journal of medicinal chemistry. 2020 11; 63(22):13205-13227. doi: 10.1021/acs.jmedchem.0c00626. [PMID: 32845145]
  • Wen-Hong Dong, Qiang-Qiang Chu, Shang-Quan Liu, Da-Tong Deng, Qian Xu. Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway. Journal of food biochemistry. 2020 09; 44(9):e13405. doi: 10.1111/jfbc.13405. [PMID: 32710574]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • Zhipeng Li, Qiaoyun Wang, Haiyun Luan, Ming Yang, Yanni Li, Geng Tian, Wenbin He. A novel target TAX1BP1 and P38/Nrf2 pathway independently involved in the anti-neuroinflammatory effect of isobavachalcone. Free radical biology & medicine. 2020 06; 153(?):132-139. doi: 10.1016/j.freeradbiomed.2020.04.011. [PMID: 32311491]
  • Xu-Dong Hou, Li-Lin Song, Yun-Feng Cao, Yi-Nan Wang, Qi Zhou, Sheng-Quan Fang, Da-Chang Wu, Shi-Zhu Zang, Lu Chen, Yue Bai, Guang-Bo Ge, Jie Hou. Pancreatic lipase inhibitory constituents from Fructus Psoraleae. Chinese journal of natural medicines. 2020 May; 18(5):369-378. doi: 10.1016/s1875-5364(20)30043-1. [PMID: 32451094]
  • Yu Wang, Tian-Xin Liu, Tong-Yun Wang, Yan-Dong Tang, Ping Wei. Isobavachalcone inhibits Pseudorabies virus by impairing virus-induced cell-to-cell fusion. Virology journal. 2020 03; 17(1):39. doi: 10.1186/s12985-020-01312-2. [PMID: 32183869]
  • Mengjun Shi, Yiping Cui, Cunyu Liu, Changqin Li, Zhenhua Liu, Wen-Yi Kang. CYPs-mediated drug-drug interactions on psoralidin, isobavachalcone, neobavaisoflavone and daidzein in rats liver microsomes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Feb; 136(?):111027. doi: 10.1016/j.fct.2019.111027. [PMID: 31870919]
  • Navneet Kishore, Pradeep Kumar, Karuna Shanker, Akhilesh Kumar Verma. Human disorders associated with inflammation and the evolving role of natural products to overcome. European journal of medicinal chemistry. 2019 Oct; 179(?):272-309. doi: 10.1016/j.ejmech.2019.06.034. [PMID: 31255927]
  • Xue Liu, Wei Li, Baichun Hu, Mingxing Wang, Jian Wang, Lijie Guan. Identification of isobavachalcone as a potential drug for rice blast disease caused by the fungus Magnaporthe grisea. Journal of biomolecular structure & dynamics. 2019 08; 37(13):3399-3409. doi: 10.1080/07391102.2018.1515117. [PMID: 30132740]
  • Binbin Li, Nansong Xu, Zheng Wan, Li Ma, Huahui Li, Weijie Cai, Xiumei Chen, Zunnan Huang, Zhiwei He. Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway. Oncology reports. 2019 Jun; 41(6):3355-3366. doi: 10.3892/or.2019.7090. [PMID: 30942462]
  • Yanxi Li, Xiaoxue Qin, Penglei Li, Hao Zhang, Tao Lin, Ziwei Miao, Siping Ma. Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells. Drug design, development and therapy. 2019; 13(?):1449-1460. doi: 10.2147/dddt.s192681. [PMID: 31118579]
  • Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Weiqiang Lu, Jin Huang. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018 09; 103(9):1472-1483. doi: 10.3324/haematol.2018.188185. [PMID: 29880605]
  • Hyejin Lee, Hua Li, Minson Kweon, Youngsook Choi, Min Jung Kim, Jae-Ha Ryu. Isobavachalcone from Angelica keiskei Inhibits Adipogenesis and Prevents Lipid Accumulation. International journal of molecular sciences. 2018 Jun; 19(6):. doi: 10.3390/ijms19061693. [PMID: 29882838]
  • Hae Seong Song, Sunphil Jang, Se Chan Kang. Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Feb; 40(?):37-47. doi: 10.1016/j.phymed.2017.12.030. [PMID: 29496173]
  • Kai Li, Qiusheng Zheng, Xiaoyu Chen, Yunchao Wang, Dan Wang, Jianning Wang. Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells. Oxidative medicine and cellular longevity. 2018; 2018(?):1915828. doi: 10.1155/2018/1915828. [PMID: 30410640]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Shuai Ji, Kuan Chen, Wei Song, Xue Qiao, Min Ye. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. Bioorganic & medicinal chemistry. 2017 10; 25(20):5522-5530. doi: 10.1016/j.bmc.2017.08.018. [PMID: 28835349]
  • Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. Bioorganic & medicinal chemistry. 2017 07; 25(14):3706-3713. doi: 10.1016/j.bmc.2017.05.009. [PMID: 28522265]
  • Siti Awanis Abdullah, Shajarahtunnur Jamil, Norazah Basar, Siti Mariam Abdul Lathiff, Norzafneza Mohd Arriffin. Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities. Natural product research. 2017 May; 31(10):1113-1120. doi: 10.1080/14786419.2016.1222387. [PMID: 27564208]
  • Kai Li, Shuai Ji, Wei Song, Yi Kuang, Yan Lin, Shunan Tang, Zexu Cui, Xue Qiao, Siwang Yu, Min Ye. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra. Journal of natural products. 2017 02; 80(2):334-346. doi: 10.1021/acs.jnatprod.6b00783. [PMID: 28140583]
  • Haoran Jing, Shaoxia Wang, Min Wang, Wenliang Fu, Chao Zhang, Donggang Xu. Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway. PloS one. 2017; 12(1):e0169560. doi: 10.1371/journal.pone.0169560. [PMID: 28060896]
  • Louis P Sandjo, Milene H de Moraes, Victor Kuete, Blaise C Kamdoum, Bonaventure T Ngadjui, Mario Steindel. Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi. Bioorganic & medicinal chemistry letters. 2016 Apr; 26(7):1772-5. doi: 10.1016/j.bmcl.2016.02.044. [PMID: 26906638]
  • Dong-Xue Sun, Guang-Bo Ge, Pei-Pei Dong, Yun-Feng Cao, Zhi-Wei Fu, Rui-Xue Ran, Xue Wu, Yan-Yan Zhang, Hui-Ming Hua, Zhenying Zhao, Zhong-Ze Fang. Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1). Xenobiotica; the fate of foreign compounds in biological systems. 2016; 46(6):503-10. doi: 10.3109/00498254.2015.1091521. [PMID: 26560012]
  • Hong-Mei Li, Jae Kyoung Lee, Li-Juan Nie, Qiang Huo, Tao Ma, Jae Kyung Sohng, Young-Soo Hong, Cheng-Zhu Wu. Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase. Archives of pharmacal research. 2015 Dec; 38(12):2208-15. doi: 10.1007/s12272-015-0658-8. [PMID: 26374247]
  • Xin-Xin Wang, Xia Lv, Shi-Yang Li, Jie Hou, Jing Ning, Jia-Yue Wang, Yun-Feng Cao, Guang-Bo Ge, Bin Guo, Ling Yang. Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi). Toxicology and applied pharmacology. 2015 Nov; 289(1):70-8. doi: 10.1016/j.taap.2015.09.003. [PMID: 26348140]
  • Guangguo Tan, Tiehong Yang, Huayan Miao, Hao Chen, Yifeng Chai, Hong Wu. Characterization of Compounds in Psoralea corylifolia Using High-Performance Liquid Chromatography Diode Array Detection, Time-of-Flight Mass Spectrometry and Quadrupole Ion Trap Mass Spectrometry. Journal of chromatographic science. 2015 Oct; 53(9):1455-62. doi: 10.1093/chromsci/bmv038. [PMID: 25903696]
  • Tao Ma, Li-Juan Nie, Hong-Mei Li, Qiang Huo, Yu-Xin Zhang, Cheng-Zhu Wu. Determination of isobavachalcone in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2015 Mar; 107(?):50-5. doi: 10.1016/j.jpba.2014.12.023. [PMID: 25575171]
  • Abubaker M A Morgan, Hyun Woo Lee, Sang-Hyun Lee, Chi-Hwan Lim, Hae-Dong Jang, Young Ho Kim. Anti-osteoporotic and antioxidant activities of chemical constituents of the aerial parts of Ducrosia ismaelis. Bioorganic & medicinal chemistry letters. 2014 Aug; 24(15):3434-9. doi: 10.1016/j.bmcl.2014.05.077. [PMID: 24953601]
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