Sinomenine (BioDeep_00000000226)

 

Secondary id: BioDeep_00000410463

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1R,9S,10R)-3-Hydroxy-4,12-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one

化学式: C19H23NO4 (329.1627)
中文名称: 青藤碱
谱图信息: 最多检出来源 Viridiplantae(plant) 43.18%

分子结构信息

SMILES: CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC
InChI: InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3

描述信息

Sinomenine is a morphinane alkaloid.
Sinomenine is a natural product found in Sinomenium acutum, Stephania cephalantha, and other organisms with data available.
Sinomenine is an alkaloid isolated from the root of Sinomenium acutum with immunomodulatory and potential anti-angiogenic and activities. Although the mechanism of action remains to be fully elucidated, sinomenine appears to inhibit endothelial proliferation mediated through basic fibroblast growth factor (bFGF), which may contribute to its anti-angiogenic effect. In Chinese medicine, this agent has a long track-record in treating arthritis, which is accounted by its ability to inhibit proliferation of synovial fibroblasts and lymphocytes. In addition, sinomenine has been shown to suppress expressions of genes involved in inflammation and apoptosis, such as interleukin-6, a pleiotropic inflammatory cytokine and JAK3 (Janus kinase 3), Daxx (death-associated protein 6), plus HSP27 (heat shock 27kDa protein 1), respectively.
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant
D018501 - Antirheumatic Agents
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.366
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.360
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.362
Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].
Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].
Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2].

同义名列表

44 个代谢物同义名

(1R,9S,10R)-3-Hydroxy-4,12-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one; (1R,9S,10S)-3-hydroxy-4,12-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one; morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9alpha,13alpha,14alpha)-; MORPHINAN-6-ONE, 7,8-DIDEHYDRO-4-HYDROXY-3,7-DIMETHOXY-17-METHYL-, (9.ALPHA.,13.ALPHA.,14.ALPHA.)-; morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9alpha,13alpha,14alpha)-; 9-alpha,13-alpha,14-alpha-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-; 7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9-alpha,13-alpha,14-alpha-morphinan-6-one; (9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one; 4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one; 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one; 3-(4-Fluorophenyl)-3-(toluene-4-sulfonylamino)-propionicacid; 4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one; Sinomenine, 0.3 mol chloroform of crystallization; 5-21-13-00516 (Beilstein Handbook Reference); sinomenine A bismethyliodide; INYYVPJSBIVGPH-QHRIQVFBSA-N; Sinomenine hydrochloride; sinomenin hydrochloride; cucoline, hydrochloride; cucoline hydrochloride; Sinomenine (Cucoline); SINOMENINE [WHO-DD]; Spectrum4_001981; Spectrum3_001134; Spectrum2_001242; Spectrum5_001621; BCBcMAP01_000195; SINOMENINE [MI]; UNII-63LT81K70N; Sinomenine,(S); KBio3_002127; Sabianine A; SMP1_000273; 63LT81K70N; Sinomenine; cocculine; SINOMENIN; cucoline; Coculine; cuculine; kukoline; NP51; SNM; Sinomenine



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, CASP3, MAPK14, MAPK8, MTOR, NFE2L2, NLRP3, PTGS2, STAT3, VEGFA
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 3 CD4, MTOR, PTGS2
Nucleus 10 AKT1, CASP3, MAPK14, MAPK8, MPO, MTOR, NFE2L2, NLRP3, STAT3, VEGFA
cytosol 8 AKT1, CASP3, MAPK14, MAPK8, MTOR, NFE2L2, NLRP3, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 8 AKT1, CASP3, MAPK14, MAPK8, MPO, MTOR, NFE2L2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 3 AKT1, CD4, TNF
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 NFE2L2, VEGFA
Golgi membrane 2 MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 2 NFE2L2, NLRP3
Lysosome 2 MPO, MTOR
plasma membrane 6 AKT1, CD4, IFNLR1, NFE2L2, STAT3, TNF
Membrane 5 AKT1, IFNLR1, MTOR, NLRP3, VEGFA
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 1 MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 NLRP3, PTGS2, VEGFA
extracellular space 9 CXCL8, IL10, IL17A, IL2, IL4, IL6, MPO, TNF, VEGFA
adherens junction 1 VEGFA
mitochondrion 2 MAPK14, NLRP3
protein-containing complex 2 AKT1, PTGS2
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CD4, IFNLR1
Secreted 8 CXCL8, IL10, IL17A, IL2, IL4, IL6, NLRP3, VEGFA
extracellular region 11 CXCL8, IL10, IL17A, IL2, IL4, IL6, MAPK14, MPO, NLRP3, TNF, VEGFA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
transcription regulator complex 1 STAT3
external side of plasma membrane 3 CD4, IL17A, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
Early endosome 1 CD4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 2 CD4, TNF
spindle 1 AKT1
extracellular matrix 1 VEGFA
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 2 MPO, VEGFA
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
spindle pole 1 MAPK14
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 1 NLRP3
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 3 CD4, IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
azurophil granule lumen 1 MPO
clathrin-coated endocytic vesicle membrane 1 CD4
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhongbao Niu, Xinhong Li, Xiuhua Yang, Zhongwei Sun. Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway. Inflammopharmacology. 2024 Jun; 32(3):2007-2022. doi: 10.1007/s10787-024-01455-6. [PMID: 38573363]
  • Fuqiang Yao, Minghao Xu, Lingjun Dong, Xiao Shen, Yujie Shen, Yisheng Jiang, Ting Zhu, Chu Zhang, Guangmao Yu. Sinomenine attenuates pulmonary fibrosis by downregulating TGF-β1/Smad3, PI3K/Akt and NF-κB signaling pathways. BMC pulmonary medicine. 2024 May; 24(1):229. doi: 10.1186/s12890-024-03050-5. [PMID: 38730387]
  • Mengyao Cui, Yaqing Li, Jing Li, Nini Jia, Wenxuan Cao, Zhengguang Li, Xiang Li, Xiaoqin Chu. Construction of various lipid carriers to study the transdermal penetration mechanism of sinomenine hydrochloride. Journal of microencapsulation. 2024 May; 41(3):157-169. doi: 10.1080/02652048.2024.2324810. [PMID: 38451031]
  • Zhao Gao, Chao Yang, Guangwei Zeng, Ming Lin, Wei Li, Mengna Sun, Yantao Zhang, Beibei Fan, Yogesh Kumar, Kun Yan. Sinomenine protects against atherosclerosis in apolipoprotein E-knockout mice by inhibiting of inflammatory pathway. Inflammopharmacology. 2024 Apr; 32(2):1387-1400. doi: 10.1007/s10787-024-01437-8. [PMID: 38430414]
  • Ling Zhu, Chen Chen, Yuxing Cai, Yalin Li, Lijie Gong, Tianyu Zhu, Lingyi Kong, Jianguang Luo. Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer. European journal of medicinal chemistry. 2024 Mar; 268(?):116250. doi: 10.1016/j.ejmech.2024.116250. [PMID: 38417218]
  • Tianzhu Guan, Ning Li, Xiangxiu Xu, Dan Xiong, Bo Wang, Lixia Xiao, Weikang Yang, Ganghui Chu, Abdulla Yusuf, Jie Zhang, Weiming Yue. Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine. Archives of biochemistry and biophysics. 2024 Mar; 753(?):109928. doi: 10.1016/j.abb.2024.109928. [PMID: 38354876]
  • Ke Fang, Shaoyu Ren, Qian Zhang. Identification and characterization of the metabolites of sinomenine using liquid chromatography combined with benchtop Orbitrap mass spectrometry and nuclear magnetic resonance spectroscopy. Rapid communications in mass spectrometry : RCM. 2024 Feb; 38(3):e9669. doi: 10.1002/rcm.9669. [PMID: 38211350]
  • PanZhen Jiang, Aqeela Zahra, Xi Guo, Jianping Wu. Recent Advances in the Therapeutic Potential of Sinomenine for Cancer Treatment. Pharmacology. 2024 Jan; ?(?):1-10. doi: 10.1159/000536133. [PMID: 38290489]
  • Haojie Ni, Muqiu Liu, Mindie Cao, Lingyu Zhang, Yijing Zhao, Lang Yi, Yanwu Li, Liang Liu, Peixun Wang, Qun Du, Hua Zhou, Yan Dong. Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 171(?):116190. doi: 10.1016/j.biopha.2024.116190. [PMID: 38278026]
  • Jie Yu, Song Wang, Si-Jia Chen, Meng-Jia Zheng, Cun-Rui Yuan, Wei-Dong Lai, Jun-Jun Wen, Wen-Ting You, Pu-Qing Liu, Rajesh Khanna, Yan Jin. Sinomenine ameliorates fibroblast-like synoviocytes dysfunction by promoting phosphorylation and nuclear translocation of CRMP2. Journal of ethnopharmacology. 2024 Jan; 324(?):117704. doi: 10.1016/j.jep.2024.117704. [PMID: 38176664]
  • Ying-Jie Zhang, Zong-Jie Shang, Mei Zheng, Ran Shi. Efficacy and safety of sinomenine for diabetic kidney diseases: A meta-analysis. Medicine. 2023 Dec; 102(52):e36779. doi: 10.1097/md.0000000000036779. [PMID: 38206710]
  • Xiang Gao, Haonan Li, Siyu Wang, Xiaokang Long, Xuehai Guo, Huiming Hua, Dahong Li. Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway. Bioorganic & medicinal chemistry letters. 2023 Nov; 97(?):129545. doi: 10.1016/j.bmcl.2023.129545. [PMID: 37939862]
  • Hongping Gu, Jinrong Li, Yuehan Ni. Sinomenine improves renal fibrosis by regulating mesenchymal stem cell-derived exosomes and affecting autophagy levels. Environmental toxicology. 2023 Oct; 38(10):2524-2537. doi: 10.1002/tox.23890. [PMID: 37436133]
  • Juan-Min Li, Yun-Da Yao, Jin-Fang Luo, Jian-Xin Liu, Lin-Lin Lu, Zhong-Qiu Liu, Yan Dong, Ying Xie, Hua Zhou. Pharmacological mechanisms of sinomenine in anti-inflammatory immunity and osteoprotection in rheumatoid arthritis: A systematic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155114. doi: 10.1016/j.phymed.2023.155114. [PMID: 37816287]
  • Hua Fan, Yang Yang, Qianqian Bai, Dongmei Wang, Xiaofei Shi, Lele Zhang, Yanhui Yang. Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity. Neuromolecular medicine. 2023 Sep; ?(?):. doi: 10.1007/s12017-023-08756-z. [PMID: 37735290]
  • Yan Li, Lei Wang, Jimin Zhang, Bojun Xu, Huakui Zhan. Integrated multi-omics and bioinformatic methods to reveal the mechanisms of sinomenine against diabetic nephropathy. BMC complementary medicine and therapies. 2023 Aug; 23(1):287. doi: 10.1186/s12906-023-04119-0. [PMID: 37580684]
  • Jingwei Yan, Jingqing Yang, Huifen Shen, Rong Gao, Shilong Lv. Sinomenine regulates circTRPM7-related pathway to inhibit gastric cancer cell growth and metastasis. Chemical biology & drug design. 2023 Jul; ?(?):. doi: 10.1111/cbdd.14297. [PMID: 37495546]
  • Juan-Min Li, Hai-Shan Deng, Yun-da Yao, Wei-Ting Wang, Jia-Qin Hu, Yan Dong, Pei-Xun Wang, Liang Liu, Zhong-Qiu Liu, Ying Xie, Lin-Lin Lu, Hua Zhou. Sinomenine ameliorates collagen-induced arthritis in mice by targeting GBP5 and regulating the P2X7 receptor to suppress NLRP3-related signaling pathways. Acta pharmacologica Sinica. 2023 Jul; ?(?):. doi: 10.1038/s41401-023-01124-4. [PMID: 37482570]
  • Jun-Hao Zhang, Wu-Long Wen, Wei-Ye Zhang, Xiao Liang, Xin Sun, Zhan Xiao, Yu-Qiang Zhao, An-Qi Li, Pei-Ran Zhao, Hao-Tian Bai, Jing Yang, Rui Wang. [Treatment of rheumatoid arthritis by injection of sinomenine solid lipid nanoparticles under a fluorescence endoscopic laser confocal microscope]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jul; 48(14):3786-3792. doi: 10.19540/j.cnki.cjcmm.20230424.301. [PMID: 37475070]
  • Blessymole K Alex, Uttpal Anand, Eapen P Koshy, Abhijit Dey, George Thomas. Analysis of non-volatile metabolites and quantitation of the anti-arthritic alkaloid sinomenine from blood fruit (Haematocarpus validus (Miers) Bakh.f. ex Forman). Naunyn-Schmiedeberg's archives of pharmacology. 2023 May; ?(?):. doi: 10.1007/s00210-023-02498-2. [PMID: 37133789]
  • Siwei Wang, Lvzhuo Zhang, Yanhua Zhou, Jiangrong Huang, Zushan Zhou, Zhenzhen Liu. A review on pharmacokinetics of sinomenine and its anti-inflammatory and immunomodulatory effects. International immunopharmacology. 2023 Apr; 119(?):110227. doi: 10.1016/j.intimp.2023.110227. [PMID: 37119677]
  • Ji Chen, Peng Guo, Mingming Han, Kemin Chen, Jie Qin, Fengrui Yang. Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO-1 signaling, the microbiota-gut-brain axis, and hippocampal neuron ferroptosis. Phytotherapy research : PTR. 2023 Apr; ?(?):. doi: 10.1002/ptr.7807. [PMID: 37036428]
  • H Jiang, Q Lu, J Xu, G Huo, Y Cai, S Geng, H Xu, J Zhang, H Li, K Yuan, G Huang. Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis. Scientific reports. 2023 Mar; 13(1):3933. doi: 10.1038/s41598-023-30922-3. [PMID: 36894604]
  • Run Ze Li, Xiao Xiang Guan, Xuan Run Wang, Wei-Qian Bao, Li-Rong Lian, Seong Wang Choi, Fang Yuan Zhang, Pei-Yu Yan, Elaine Lai Han Leung, Hu-Dan Pan, Liang Liu. Sinomenine hydrochloride bidirectionally inhibits progression of tumor and autoimmune diseases by regulating AMPK pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154751. doi: 10.1016/j.phymed.2023.154751. [PMID: 37004400]
  • Yan Zhou, Shuai Chen, Yi Dai, Liunan Wu, Ming Jin, Jie Zhao, Yuan Li, Liming Tang. Sinomenine attenuated dextran sulfate sodium-induced inflammatory responses by promoting 14-3-3θ protein and inhibiting NF-κB signaling. Journal of ethnopharmacology. 2023 Mar; 303(?):116037. doi: 10.1016/j.jep.2022.116037. [PMID: 36526094]
  • Gao Xiang, Min Gao, Huirong Qin, Xiaolan Shen, Huilian Huang, Xiaoqiang Hou, Zhitao Feng. Benefit-risk assessment of traditional Chinese medicine preparations of sinomenine using multicriteria decision analysis (MCDA) for patients with rheumatoid arthritis. BMC complementary medicine and therapies. 2023 Feb; 23(1):37. doi: 10.1186/s12906-023-03864-6. [PMID: 36747185]
  • Mao-Si Fan, Yue-Fei Xia, Rui-Han Ye, Ze-Rui Sun, Ming-Yue Wang, Meng-Fei An, Shao-Shi Zhang, Li-Juan Zhang, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng. Sinomenine Hydrochloride Can Ameliorate Benign Prostatic Hyperplasia by Lowering the 5α-Reductase 2 Level and Regulating the Balance between the Proliferation and Apoptosis of Cells. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020803. [PMID: 36677863]
  • Cuili Zhang, Shujie Zhang, Jingjing Liao, Zipeng Gong, Xin Chai, Haining Lyu. Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248645. [PMID: 36557779]
  • Hong Huang, Er-Bing Zhang, Ou-Yang Yi, Han Wu, Guiming Deng, Yu-Ming Huang, Wen-Liang Liu, Jian-Ye Yan, Xiong Cai. Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats. Archives of toxicology. 2022 12; 96(12):3245-3255. doi: 10.1007/s00204-022-03368-1. [PMID: 36040703]
  • Ye Lin, Ouyang Yi, Mingyue Hu, Shengtao Hu, Zhaoli Su, Jin Liao, Wei Wang, Shenzhi Wang, Liang Liu, Bin Liu, Xiong Cai. Multifunctional nanoparticles of sinomenine hydrochloride for treat-to-target therapy of rheumatoid arthritis via modulation of proinflammatory cytokines. Journal of controlled release : official journal of the Controlled Release Society. 2022 08; 348(?):42-56. doi: 10.1016/j.jconrel.2022.05.016. [PMID: 35569587]
  • Amir Rostami, Fatemeh Taleahmad, Narges Haddadzadeh-Niri, Ensiye Joneidi, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghani. Sinomenine Attenuates Trimethyltin-Induced Cognitive Decline via Targeting Hippocampal Oxidative Stress and Neuroinflammation. Journal of molecular neuroscience : MN. 2022 Aug; 72(8):1609-1621. doi: 10.1007/s12031-022-02021-x. [PMID: 35543800]
  • Jingbao Chen, Wu Long, Baoqi Dong, Wenxuan Cao, Xu Yuhang, Yun Meng, Chu Xiaoqin. Hexagonal liquid crystalline system containing cinnamaldehyde for enhancement of skin permeation of sinomenine hydrochloride. Pharmaceutical development and technology. 2022 Jul; 27(6):684-694. doi: 10.1080/10837450.2022.2107011. [PMID: 35880620]
  • Qi Zeng, Long Wang, Sijun Wu, Guangpu Fang, Hai Liu, Zheng Li, Yunfei Hu, Wenlong Li. Dissolution profiles prediction of sinomenine hydrochloride sustained-release tablets using Raman mapping technique. International journal of pharmaceutics. 2022 May; 620(?):121743. doi: 10.1016/j.ijpharm.2022.121743. [PMID: 35427752]
  • Tianyue Zhang, Xu Ouyang, Sanhu Gou, Yun Zhang, Na Yan, Linlin Chang, Beibei Li, Fangyan Zhang, Hui Liu, Jingman Ni. Novel synovial targeting peptide-sinomenine conjugates as a potential strategy for the treatment of rheumatoid arthritis. International journal of pharmaceutics. 2022 Apr; 617(?):121628. doi: 10.1016/j.ijpharm.2022.121628. [PMID: 35245636]
  • Jin-Fang Luo, Yun-Da Yao, Chun-Song Cheng, Chon-Kit Lio, Jian-Xin Liu, Yu-Feng Huang, Fan He, Ying Xie, Liang Liu, Zhong-Qiu Liu, Hua Zhou. Sinomenine increases the methylation level at specific GCG site in mPGES-1 promoter to facilitate its specific inhibitory effect on mPGES-1. Biochimica et biophysica acta. Gene regulatory mechanisms. 2022 04; 1865(3):194813. doi: 10.1016/j.bbagrm.2022.194813. [PMID: 35417776]
  • Zeling Huang, Xiao Mao, Junming Chen, Junjun He, Shanni Shi, Miao Gui, Hongjian Gao, Zhenqiang Hong. Sinomenine hydrochloride injection for knee osteoarthritis: A protocol for systematic review and meta-analysis. Medicine. 2022 Jan; 101(2):e28503. doi: 10.1097/md.0000000000028503. [PMID: 35029203]
  • Yan Luo, Liwei Liu, Jihua Zhao, Yue Jiao, Meiyu Zhang, Guangli Xu, Yumao Jiang. PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An in Vitro and in Vivo Study. Biological & pharmaceutical bulletin. 2022; 45(5):614-624. doi: 10.1248/bpb.b21-01063. [PMID: 35491166]
  • Lang Yi, Junyu Ke, Jiayan Liu, Huili Lai, Yanjun Lv, Chong Peng, Yingkun Zhi, Qun Du, Liang Liu, Peixun Wang, Hua Zhou, Yan Dong. Sinomenine increases adenosine A2A receptor and inhibits NF-κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR. Journal of leukocyte biology. 2021 12; 110(6):1113-1120. doi: 10.1002/jlb.3ma0121-024rrrr. [PMID: 34425026]
  • Yanbing Li, Hongqin Xie, Huiya Zhang. Protective effect of sinomenine against inflammation and oxidative stress in gestational diabetes mellitus in female rats via TLR4/MyD88/NF-κB signaling pathway. Journal of food biochemistry. 2021 11; 45(11):e13952. doi: 10.1111/jfbc.13952. [PMID: 34636046]
  • Ying Wang, Ling Zhao, Wanwen Yuan, Leyi Liang, Ming Li, Xuesong Yu, Yan Wang. A Natural Membrane Vesicle Exosome-based Sinomenine Delivery Platform for Hepatic Carcinoma Therapy. Current topics in medicinal chemistry. 2021 Oct; 21(14):1224-1234. doi: 10.2174/1568026621666210612032004. [PMID: 34126903]
  • Yingbo Lin, Hancheng Li, Ju Peng, Chan Li, Chen Zhu, Yuting Zhou, Zhijie Chen, Jing Li, Chaohua Luo, Zhixian Mo. Decrease of morphine-CPP by sinomenine via mediation of tyrosine hydroxylase, NMDA receptor subunit 2B and opioid receptor in the zebrafish brain. Pakistan journal of pharmaceutical sciences. 2021 Sep; 34(5):1659-1665. doi: . [PMID: 34802999]
  • Liu Liu, Xiaoqin Chu, Chunling Tian, Mengqiu Xia, Lu Zhang, Jianqin Jiang, Shuangying Gui. Chemo Proling and Simultaneous Analysis of Different Combinations of Sinomenii Caulis and Ramulus Cinnamomi Using UHPLC-Q-TOF-MS, GC-MS and HPLC Methods. Journal of chromatographic science. 2021 Jun; 59(7):606-617. doi: 10.1093/chromsci/bmab048. [PMID: 33969409]
  • Wan-Jiao Gao, Jian-Xin Liu, Yie Xie, Pei Luo, Zhong-Qiu Liu, Liang Liu, Hua Zhou. Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine. Pharmacological research. 2021 05; 167(?):105513. doi: 10.1016/j.phrs.2021.105513. [PMID: 33617975]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Hongguang Wu, Koichiro Tahara, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Tetsuji Sawada, Toshihiko Hirano. Effects of sinomenine on the proliferation, cytokine production, and regulatory T-cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients. Drug development research. 2021 04; 82(2):251-258. doi: 10.1002/ddr.21748. [PMID: 33006164]
  • Lingqin Song, Haifeng Zhang, Min Hu, Chengcheng Liu, Yang Zhao, Shuqun Zhang, Di Liu. Sinomenine inhibits hypoxia induced breast cancer side population cells metastasis by PI3K/Akt/mTOR pathway. Bioorganic & medicinal chemistry. 2021 02; 31(?):115986. doi: 10.1016/j.bmc.2020.115986. [PMID: 33412412]
  • Maolin Zhu, Huiyang Wang, Jiawei Chen, Huang Zhu. Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2/STAT3/SOCS1 pathway in streptozotocin-induced diabetic rats. Life sciences. 2021 Jan; 265(?):118855. doi: 10.1016/j.lfs.2020.118855. [PMID: 33278392]
  • Pengbo Geng, Xiaohui Xu, Zhao Gao. Sinomenine Suppress the Vitamin D3 and High Fat Induced Atherosclerosis in Rats via Suppress of Oxidative Stress and Inflammation. Journal of oleo science. 2021; 70(12):1815-1828. doi: 10.5650/jos.ess21255. [PMID: 34866111]
  • Ping Ni, Yue-Qin Liu, Jin-Yu Man, Wang Li, Shan-Shan Xue, Tao-Hong Lu, Zhao-Liang Su, Cheng-Lin Zhou. C16, a novel sinomenine derivatives, promoted macrophage reprogramming toward M2-like phenotype and protected mice from endotoxemia. International journal of immunopathology and pharmacology. 2021 Jan; 35(?):20587384211026786. doi: 10.1177/20587384211026786. [PMID: 34190613]
  • Qiang Li, Wenbin Zhou, Yuyan Wang, Fang Kou, Chunming Lyu, Hai Wei. Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life sciences. 2020 Nov; 261(?):118433. doi: 10.1016/j.lfs.2020.118433. [PMID: 32950572]
  • Yu-Feng Huang, Fan He, Can-Jian Wang, Ying Xie, Yan-Yu Zhang, Zhen Sang, Ping Qiu, Pei Luo, Sheng-Yuan Xiao, Jing Li, Fei-Ci Wu, Liang Liu, Hua Zhou. Discovery of chemical markers for improving the quality and safety control of Sinomenium acutum stem by the simultaneous determination of multiple alkaloids using UHPLC-QQQ-MS/MS. Scientific reports. 2020 08; 10(1):14182. doi: 10.1038/s41598-020-71133-4. [PMID: 32843671]
  • Nina Yin, Yong Xiong, Wenting Tao, Jiaojiao Chen, Zhigang Wang. Sinomenine alleviates lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. Immunopharmacology and immunotoxicology. 2020 Apr; 42(2):147-155. doi: 10.1080/08923973.2020.1732407. [PMID: 32116077]
  • Yang Liu, Yushi Sun, Yuhui Zhou, Xiaojiang Tang, Ke Wang, Yu Ren, Jianjun He. Sinomenine hydrochloride inhibits the progression of plasma cell mastitis by regulating IL-6/JAK2/STAT3 pathway. International immunopharmacology. 2020 Apr; 81(?):106025. doi: 10.1016/j.intimp.2019.106025. [PMID: 31810886]
  • Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma. Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity. Molecular brain. 2020 03; 13(1):30. doi: 10.1186/s13041-020-00569-6. [PMID: 32127013]
  • Xiang Guo, Jinyu Ji, Zhitao Feng, Xiaoqiang Hou, Yanan Luo, Zhigang Mei. A network pharmacology approach to explore the potential targets underlying the effect of sinomenine on rheumatoid arthritis. International immunopharmacology. 2020 Mar; 80(?):106201. doi: 10.1016/j.intimp.2020.106201. [PMID: 31972421]
  • Conrad J Mascarenhas, Renyu Liu, Gordon A Barr. Effects of plant-derived analgesic compounds sinomenine and salvinorin A in infant rats. Journal of integrative medicine. 2020 Mar; 18(2):174-180. doi: 10.1016/j.joim.2020.01.002. [PMID: 31992510]
  • Yan-Fei Fu, Le Li, Pu Fang, Jie Song, Xiao-Hui Sun, Tian-Hua Meng, Hou-Quan Tao. Sinomenine's protective role and mechanism in stress load-induced heart failure. The Journal of pharmacy and pharmacology. 2020 Feb; 72(2):209-217. doi: 10.1111/jphp.13181. [PMID: 31736093]
  • Wei Jiang, Weiming Fan, Tianle Gao, Tao Li, Zhenming Yin, Huihui Guo, Lulu Wang, Yanxing Han, Jian-Dong Jiang. Analgesic Mechanism of Sinomenine against Chronic Pain. Pain research & management. 2020; 2020(?):1876862. doi: 10.1155/2020/1876862. [PMID: 32454918]
  • Le-Nyu Gao, Bing Zhong, Yong Wang. Mechanism Underlying Antitumor Effects of Sinomenine. Chinese journal of integrative medicine. 2019 Nov; 25(11):873-878. doi: 10.1007/s11655-019-3151-2. [PMID: 30826933]
  • Haifeng Yang, Jing Wang, Xiaolan Chen, Chunmao Jiang, Kongwang He, Bin Li, Yiyi Hu. Effects of sinomenine in LPS-associated diseases are related to inhibition of LBP, Mac-1, and L-selectin levels. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):732-737. doi: 10.1111/jvp.12807. [PMID: 31490576]
  • Yifan Wu, Zeng Lin, Zijian Yan, Zhanghong Wang, Xin Fu, Kehe Yu. Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. International immunopharmacology. 2019 Oct; 75(?):105715. doi: 10.1016/j.intimp.2019.105715. [PMID: 31310911]
  • Xiao Liang, Yulin Chen, Li Wu, Abi Maharjan, Balmukunda Regmi, Jiwen Zhang, Shuangying Gui. In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Sep; 117(?):108993. doi: 10.1016/j.biopha.2019.108993. [PMID: 31228805]
  • Tianle Gao, Tiansheng Shi, Zsuzsanna Wiesenfeld-Hallin, Tao Li, Jian-Dong Jiang, Xiao-Jun Xu. Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. European journal of pharmacology. 2019 Jul; 854(?):101-108. doi: 10.1016/j.ejphar.2019.03.061. [PMID: 30954565]
  • Zhi-Tao Feng, Tong Yang, Xiao-Qiang Hou, Han-Yu Wu, Jia-Teng Feng, Bing-Jin Ou, San-Jin Cai, Juan Li, Zhi-Gang Mei. Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 May; 113(?):108759. doi: 10.1016/j.biopha.2019.108759. [PMID: 30856539]
  • Takaaki Komatsu, Soh Katsuyama, Fumihide Takano, Takemasa Okamura, Chikai Sakurada, Minoru Tsuzuki, Kakuyou Ogawa, Atsuhito Kubota, Osamu Morinaga, Kenji Tabata, Tsukasa Sakurada. Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice. Neuroscience letters. 2019 04; 699(?):103-108. doi: 10.1016/j.neulet.2019.01.035. [PMID: 30690119]
  • Run-Yue Huang, Hu-Dan Pan, Jia-Qi Wu, Hua Zhou, Zhan-Guo Li, Ping Qiu, Ying-Yan Zhou, Xiu-Min Chen, Zhi-Xin Xie, Yao Xiao, Qing-Chun Huang, Liang Liu. Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Apr; 57(?):403-410. doi: 10.1016/j.phymed.2018.12.030. [PMID: 30851515]
  • Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Plant-derived alkaloid sinomenine potentiates glucocorticoid pharmacodynamics in mitogen-activated human peripheral blood mononuclear cells by regulating the translocation of glucocorticoid receptor. Phytotherapy research : PTR. 2019 Jan; 33(1):187-196. doi: 10.1002/ptr.6215. [PMID: 30357956]
  • Xiao-Qin Chu, Yong Zhang, Jie Huang, Qian Li, Zheng-Guang Li, Jian-Qin Jiang, Shuang-Ying Gui. The Effect of Prescription on the Framework of Lipid Matrix and In Vitro Properties. Current drug delivery. 2019; 16(8):737-750. doi: 10.2174/1567201816666190620115403. [PMID: 31250753]
  • Hui Song, Jin Wen, He Li, Ya Meng, Yujia Zhang, Nan Zhang, Wensheng Zheng. Enhanced transdermal permeability and drug deposition of rheumatoid arthritis via sinomenine hydrochloride-loaded antioxidant surface transethosome. International journal of nanomedicine. 2019; 14(?):3177-3188. doi: 10.2147/ijn.s188842. [PMID: 31118630]
  • Dan Zhang, Yiping Dong, Ying Zhao, Congya Zhou, Yuanjie Qian, Muralidhar L Hegde, Haibo Wang, Suxia Han. Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response. Oncology reports. 2018 Nov; 40(5):2886-2895. doi: 10.3892/or.2018.6693. [PMID: 30226618]
  • Suzi Liu, Qiuhua Chen, Junjun Liu, Xiaoting Yang, Yan Zhang, Fengjie Huang. Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Nov; 107(?):696-702. doi: 10.1016/j.biopha.2018.08.048. [PMID: 30138891]
  • Jinying Ou, Yuting Zhou, Chan Li, Zhijie Chen, Hancheng Li, Miao Fang, Chen Zhu, Chuying Huo, Ken Kin-Lam Yung, Jing Li, Chaohua Luo, Zhixian Mo. Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes. Molecules (Basel, Switzerland). 2018 Sep; 23(9):. doi: 10.3390/molecules23092370. [PMID: 30227624]
  • Feng Qin, Yang Zhao, Wei Shang, Zhi-Ming Zhao, Xin Qian, Bei-Bei Zhang, Hui Cai. Sinomenine relieves oxygen and glucose deprivation-induced microglial activation via inhibition of the SP1/miRNA-183-5p/IκB-α signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2018 Jul; 64(10):140-147. doi: 10.14715/cmb/2018.64.10.23. [PMID: 30084807]
  • Xin Qian, Zhiming Zhao, Wei Shang, Zhihan Xu, Beibei Zhang, Hui Cai. Serum proteomic analysis of the anti‑arthritic effects of sinomenine on rats with collagen‑induced arthritis. Molecular medicine reports. 2018 Jul; 18(1):49-58. doi: 10.3892/mmr.2018.8959. [PMID: 29749546]
  • Xiaoqin Chu, Qian Li, Shuangying Gui, Zhengguang Li, Jiaojiao Cao, Jianqin Jiang. Characterization and In Vitro Permeation Study of Cubic Liquid Crystal Containing Sinomenine Hydrochloride. AAPS PharmSciTech. 2018 Jul; 19(5):2237-2246. doi: 10.1208/s12249-018-1018-z. [PMID: 29740759]
  • Bo Dong. Protective Effects of Sinomenine Against Ankylosing Spondylitis and the Underlying Molecular Mechanisms. Medical science monitor : international medical journal of experimental and clinical research. 2018 May; 24(?):3631-3636. doi: 10.12659/msm.907589. [PMID: 29849019]
  • Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li, Qing Zhu. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. European journal of pharmacology. 2018 Mar; 823(?):105-109. doi: 10.1016/j.ejphar.2018.01.044. [PMID: 29408089]
  • Yumao Jiang, Yue Jiao, Yang Liu, Meiyu Zhang, Zhiguo Wang, Yujuan Li, Tao Li, Xiaoliang Zhao, Danqiao Wang. Sinomenine Hydrochloride Inhibits the Metastasis of Human Glioblastoma Cells by Suppressing the Expression of Matrix Metalloproteinase-2/-9 and Reversing the Endogenous and Exogenous Epithelial-Mesenchymal Transition. International journal of molecular sciences. 2018 Mar; 19(3):. doi: 10.3390/ijms19030844. [PMID: 29538296]
  • Lang Yi, Yan-Jun Lyn, Chong Peng, Rui-Li Zhu, Sha-Sha Bai, Liang Liu, Pei-Xun Wang, Hua Zhou, Yan Dong. Sinomenine inhibits fibroblast-like synoviocyte proliferation by regulating α7nAChR expression via ERK/Egr-1 pathway. International immunopharmacology. 2018 Mar; 56(?):65-70. doi: 10.1016/j.intimp.2018.01.015. [PMID: 29367088]
  • Fei Deng, Yue-Xian Ma, Liang Liang, Ping Zhang, Jing Feng. The pro-apoptosis effect of sinomenine in renal carcinoma via inducing autophagy through inactivating PI3K/AKT/mTOR pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jan; 97(?):1269-1274. doi: 10.1016/j.biopha.2017.11.064. [PMID: 29145153]
  • Yueying Li, Yuntao Liu, Xia Yan, Qing Liu, Yong-Hua Zhao, Da-Wei Wang. Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease. The American journal of Chinese medicine. 2018; 46(8):1727-1741. doi: 10.1142/s0192415x18500878. [PMID: 30525898]
  • Weiwei Liu, Yajie Zhang, Weina Zhu, Chunhua Ma, Jie Ruan, Hongyan Long, Yue Wang. Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets. Frontiers in immunology. 2018; 9(?):2228. doi: 10.3389/fimmu.2018.02228. [PMID: 30319663]
  • Chuanjing Fu, Qi Wang, Xiaofu Zhai, Juemin Gao. Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway. Drug design, development and therapy. 2018; 12(?):77-84. doi: 10.2147/dddt.s154391. [PMID: 29379271]
  • S Işık, M Karaman, S Ç Micili, Ş Çağlayan-Sözmen, H A Bağrıyanık, Z Arıkan-Ayyıldız, N Uzuner, Ö Karaman. Sinomenine ameliorates the airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in a murine model of chronic asthma. Allergologia et immunopathologia. 2018 Jan; 46(1):67-75. doi: 10.1016/j.aller.2017.05.004. [PMID: 28778746]
  • Shu-Ping Chen, Jia Sun, Ya-Qun Zhou, Fei Cao, Cody Braun, Fang Luo, Da-Wei Ye, Yu-Ke Tian. Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades in rat models. Molecular pain. 2018 Jan; 14(?):1744806918793232. doi: 10.1177/1744806918793232. [PMID: 30027795]
  • Miao Fang, Junkui Li, Daoqi Zhu, Chaohua Luo, Chan Li, Chen Zhu, Menglin Fan, Ken Kin-Lam Yung, Zhixian Mo. Effect of Sinomenine on the Morphine-Dependence and Related Neural Mechanisms in Mice. Neurochemical research. 2017 Dec; 42(12):3587-3596. doi: 10.1007/s11064-017-2407-5. [PMID: 29116553]
  • Lian Li, Zhigang Luo, Zhe Song, Liwen Zheng, Tuo Chen. Pre-transplant infusion of donor-derived dendritic cells maintained at the immature stage by sinomenine increases splenic Foxp3+ Tregs in recipient rats after renal allotransplantation. Transplant immunology. 2017 12; 45(?):22-28. doi: 10.1016/j.trim.2017.08.004. [PMID: 28802587]
  • Bin Zhao, Lei Liu, Jun Mao, Kun Liu, Weiwang Fan, Jiheng Liu, Zhiwei Zhang, Quanlin Li. Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Dec; 96(?):1036-1044. doi: 10.1016/j.biopha.2017.11.123. [PMID: 29198924]
  • Juan Wang, Yan Wei, Ya-Rong Fei, Li Fang, Hang-Sheng Zheng, Chao-Feng Mu, Fan-Zhu Li, Yong-Sheng Zhang. Preparation of mixed monoterpenes edge activated PEGylated transfersomes to improve the in vivo transdermal delivery efficiency of sinomenine hydrochloride. International journal of pharmaceutics. 2017 Nov; 533(1):266-274. doi: 10.1016/j.ijpharm.2017.09.059. [PMID: 28943208]
  • Lufen Huang, Yan Dong, Jianlin Wu, Peixun Wang, Hua Zhou, Ting Li, Liang Liu. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacological research. 2017 Nov; 125(Pt B):150-160. doi: 10.1016/j.phrs.2017.08.014. [PMID: 28867637]
  • Yumao Jiang, Yue Jiao, Zhiguo Wang, Tao Li, Yang Liu, Yujuan Li, Xiaoliang Zhao, Danqiao Wang. Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth through Reactive Oxygen Species Generation and Autophagy-Lysosome Pathway Activation: An In Vitro and In Vivo Study. International journal of molecular sciences. 2017 Sep; 18(9):. doi: 10.3390/ijms18091945. [PMID: 28891980]
  • Juerong Chen, Bing Zhong, Yong Wang. Agranulocytosis Induced by Sinomenine Hydrochloride. The American journal of case reports. 2017 Sep; 18(?):959-962. doi: 10.12659/ajcr.904519. [PMID: 28874654]
  • Huifang Xiong, Liang Tian, Zihan Zhao, Shuping Chen, Qiaoyun Zhao, Junbo Hong, Yong Xie, Nanjin Zhou, Yingjun Fu. The sinomenine enteric-coated microspheres suppressed the TLR/NF-κB signaling in DSS-induced experimental colitis. International immunopharmacology. 2017 Sep; 50(?):251-262. doi: 10.1016/j.intimp.2017.06.033. [PMID: 28711031]
  • Haifeng Yang, Chunmao Jiang, Xiaolan Chen, Kongwang He, Yiyi Hu. Protective effects of sinomenine against LPS-induced inflammation in piglets. Microbial pathogenesis. 2017 Sep; 110(?):573-577. doi: 10.1016/j.micpath.2017.07.044. [PMID: 28757275]
  • Biao Zhou, Xiaolong Lu, Zhi Tang, Dan Liu, Youliang Zhou, Peng Zeng, Hui Xiong. Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jun; 90(?):835-841. doi: 10.1016/j.biopha.2017.03.084. [PMID: 28437887]
  • Ru-Bing Yao, Zhi-Ming Zhao, Ling-Jie Zhao, Hui Cai. Sinomenine inhibits the inflammatory responses of human fibroblast-like synoviocytes via the TLR4/MyD88/NF-κB signaling pathway in rheumatoid arthritis. Die Pharmazie. 2017 Jun; 72(6):355-360. doi: 10.1691/ph.2017.6946. [PMID: 29442025]
  • Bei-Hua Bao, An Kang, Yang Zhao, Qi Shen, Jun-Song Li, Liu-Qing Di, Jian-Xin Li. A selective HPLC-MS/MS method for quantification of SND-117 in rat plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 May; 1052(?):60-65. doi: 10.1016/j.jchromb.2017.03.008. [PMID: 28359984]
  • Shuo Li, Jing Han, Dong-Sheng Wang, Qi Yang, Bin Feng, Wen-Bo Kang, Le Yang, Gang Liu, Ming-Gao Zhao. Sinomenine attenuates chronic inflammatory pain in mice. Metabolic brain disease. 2017 02; 32(1):211-219. doi: 10.1007/s11011-016-9889-8. [PMID: 27585465]
  • Shun Feng, Lijun Zhu, Zhisheng Huang, Haojia Wang, Hong Li, Hua Zhou, Linlin Lu, Ying Wang, Zhongqiu Liu, Liang Liu. Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic. Drug design, development and therapy. 2017; 11(?):1737-1752. doi: 10.2147/dddt.s136313. [PMID: 28670109]
  • Cheng Jiang, Yun-Long Tong, Dan Zhang, Li-Zhi Liu, Ju-Fei Wang. Sinomenine prevents the development of cardiomyopathy in diabetic rats by inhibiting inflammatory responses and blocking activation of NF-κB. General physiology and biophysics. 2017 Jan; 36(1):65-74. doi: 10.4149/gpb_2016033. [PMID: 27901470]