Tropoflavin (BioDeep_00000000154)
Main id: BioDeep_00000277124
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
化学式: C15H10O4 (254.0579)
中文名称: 7,8-二羟基黄酮水合物, 7,8-二羟基黄酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O
InChI: InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
描述信息
7,8-dihydroxyflavone is a dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimers, Parkinsons, and Huntingtons. It has a role as a plant metabolite, a tropomyosin-related kinase B receptor agonist, an antidepressant, an antioxidant and an antineoplastic agent.
A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimers, Parkinsons, and Huntingtons.
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
同义名列表
35 个代谢物同义名
7,8-dihydroxy-2-phenyl-chromen-4-one;7,8-Dihydroxyflavone; 2(1H)-Pentalenone, 4,5,6,6a-tetrahydro-1,3-dimethyl-; 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-; 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-; 5-18-04-00079 (Beilstein Handbook Reference); 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; 7,8-Dihydroxyflavone hydrate, >=98\\% (HPLC); 7,8-dihydroxy-2-phenyl-4H-chromen-4-one; 7,8-Dihydroxy-2-phenyl-4-benzopyrone; 7,8-Dihydroxy-2-phenyl-chromen-4-one; 7,8-dihydroxy-2-phenylchromen-4-one; 7,8-dihydroxy-2-phenylchromone; 7,8-Dihydroxyflavone hydrate; 7,8-Dihydroxy-flavone; 7,8-Dihydroxyflavone; 6,7-dihydroxyflavone; Spectrum4_001823; Spectrum2_000952; Spectrum3_000213; Spectrum5_000585; 7,8-diOH-Flavone; UNII-ADB6MA8ZV2; MEGxp0_001683; DivK1c_000371; KBio2_004135; Tox21_501075; KBio2_006703; KBio3_001325; KBio2_001567; KBio1_000371; IDI1_000371; ADB6MA8ZV2; DHF, 7,8-; 7,8-DHF; 8-DHF
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:140464
- KEGG: C74948
- PubChem: 1880
- HMDB: HMDB0247297
- ChEMBL: CHEMBL75267
- Wikipedia: Tropoflavin
- MeSH: 6,7-dihydroxyflavone
- ChemIDplus: 0038183038
- chemspider: 1809
- CAS: 38183-03-8
- medchemexpress: HY-W013372
- MetaboLights: MTBLC140464
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 33090 - Plants: -
- 33090 - 白头翁: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Man-Ru Zhang, Bang-Yun Zuo, Yu-Chen Song, Dan-Dan Guo, Qing-Liu Li, Jin-Xiu Lyu, Hua Zhu, Jing Zhao, Peng-Zhou Hang. BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments.
Toxicology and applied pharmacology.
2024 May; 486(?):116951. doi:
10.1016/j.taap.2024.116951. [PMID: 38705401] - Ying Xu, Xueting Wang, Ziyang Xu, Fengwei Sun, Yue Tian. Tbx2 Knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis.
Toxicological sciences : an official journal of the Society of Toxicology.
2023 Jul; ?(?):. doi:
10.1093/toxsci/kfad071. [PMID: 37494465] - Kaimei Lu, Liyan Zhao, Yonghai Zhang, Fan Yang, Huiwen Zhang, Jie Wang, Bin Li, Guimei Ji, Jianqiang Yu, Hanxiang Ma. Bupivacaine reduces GlyT1 expression by potentiating the p-AMPKα/BDNF signalling pathway in spinal astrocytes of rats.
Scientific reports.
2022 01; 12(1):1378. doi:
10.1038/s41598-022-05478-3. [PMID: 35082359] - Rajib Paul, Joyobrato Nath, Satinath Paul, Muhammed Khairujjaman Mazumder, Banashree Chetia Phukan, Rubina Roy, Pallab Bhattacharya, Anupom Borah. Suggesting 7,8-dihydroxyflavone as a promising nutraceutical against CNS disorders.
Neurochemistry international.
2021 09; 148(?):105068. doi:
10.1016/j.neuint.2021.105068. [PMID: 34022252] - Fan Xue, Zhenlei Zhao, Yanpei Gu, Jianxin Han, Keqiang Ye, Ying Zhang. 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
eLife.
2021 07; 10(?):. doi:
10.7554/elife.64872. [PMID: 34227467] - Ansab Akhtar, Jatinder Dhaliwal, Sangeeta Pilkhwal Sah. 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance.
Psychopharmacology.
2021 Jul; 238(7):1991-2009. doi:
10.1007/s00213-021-05826-7. [PMID: 33774703] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Sarah Ötzkan, Walter E Muller, W Gibson Wood, Gunter P Eckert. Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice.
Neuromolecular medicine.
2021 03; 23(1):130-139. doi:
10.1007/s12017-020-08640-0. [PMID: 33377988] - Zhenlei Zhao, Fan Xue, Yanpei Gu, Jianxin Han, Yingxian Jia, Keqiang Ye, Ying Zhang. Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.
Molecular metabolism.
2021 03; 45(?):101149. doi:
10.1016/j.molmet.2020.101149. [PMID: 33352311] - Priyanka Sharma, Guojun Wu, Deeptha Kumaraswamy, Natalie Burchat, Hong Ye, Yongjia Gong, Liping Zhao, Yan Y Lam, Harini Sampath. Sex-Dependent Effects of 7,8-Dihydroxyflavone on Metabolic Health Are Associated with Alterations in the Host Gut Microbiome.
Nutrients.
2021 Feb; 13(2):. doi:
10.3390/nu13020637. [PMID: 33669347] - Ismail S Zaitoun, Yong-Seok Song, Andrew Suscha, Mohamed El Ragaby, Christine M Sorenson, Nader Sheibani. 7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy.
PloS one.
2021; 16(12):e0260793. doi:
10.1371/journal.pone.0260793. [PMID: 34855884] - Hatice Keser, Şeniz Doğramacı, Elif Şahin, Neslihan Sağlam, Mehmet Erdem, Ahmet Alver, Selcen Aydin-Abidin. The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice.
General physiology and biophysics.
2020 Sep; 39(5):471-479. doi:
10.4149/gpb_2020022. [PMID: 33084600] - Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fang. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period.
Progress in neuro-psychopharmacology & biological psychiatry.
2020 07; 101(?):109939. doi:
10.1016/j.pnpbp.2020.109939. [PMID: 32243998] - Dinesh Kumar, Durgesh Kumar Dwivedi, Mangala Lahkar, Ashok Jangra. Hepatoprotective potential of 7,8-Dihydroxyflavone against alcohol and high-fat diet induced liver toxicity via attenuation of oxido-nitrosative stress and NF-κB activation.
Pharmacological reports : PR.
2019 Dec; 71(6):1235-1243. doi:
10.1016/j.pharep.2019.07.002. [PMID: 31670060] - Eszter Fliszár-Nyúl, Violetta Mohos, Tímea Bencsik, Beáta Lemli, Sándor Kunsági-Máté, Miklós Poór. Interactions of 7,8-Dihydroxyflavone with Serum Albumin as well as with CYP2C9, CYP2C19, CYP3A4, and Xanthine Oxidase Biotransformation Enzymes.
Biomolecules.
2019 10; 9(11):. doi:
10.3390/biom9110655. [PMID: 31731555] - John Wood, Margaret Chui Ling Tse, Xiuying Yang, Daniel Brobst, Zhixue Liu, Brian Pak Shing Pang, Wing Suen Chan, Aung Moe Zaw, Billy K C Chow, Keqiang Ye, Chi Wai Lee, Chi Bun Chan. BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle.
Metabolism: clinical and experimental.
2018 10; 87(?):113-122. doi:
10.1016/j.metabol.2018.06.007. [PMID: 29935237] - Min-Wang Zhang, She-Feng Zhang, Zhen-Hua Li, Fang Han. 7,8-Dihydroxyflavone reverses the depressive symptoms in mouse chronic mild stress.
Neuroscience letters.
2016 Dec; 635(?):33-38. doi:
10.1016/j.neulet.2016.10.035. [PMID: 27773794] - Ji Won Choi, Chang Won Lee, Jisun Lee, Doo Jin Choi, Jae Kyung Sohng, Yong Il Park. 7,8-Dihydroxyflavone inhibits adipocyte differentiation via antioxidant activity and induces apoptosis in 3T3-L1 preadipocyte cells.
Life sciences.
2016 Jan; 144(?):103-12. doi:
10.1016/j.lfs.2015.11.028. [PMID: 26631505] - Qian Ren, Ji-Chun Zhang, Min Ma, Yuko Fujita, Jin Wu, Kenji Hashimoto. 7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine.
Psychopharmacology.
2014 Jan; 231(1):159-66. doi:
10.1007/s00213-013-3221-7. [PMID: 23934209] - Vadim Bernard-Gauthier, Mehdi Boudjemeline, Pedro Rosa-Neto, Alexander Thiel, Ralf Schirrmacher. Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one.
Bioorganic & medicinal chemistry.
2013 Dec; 21(24):7816-29. doi:
10.1016/j.bmc.2013.10.012. [PMID: 24183588] - Aurélie Blugeot, Cyril Rivat, Elodie Bouvier, Jenny Molet, Amandine Mouchard, Brigitte Zeau, Christophe Bernard, Jean-Jacques Benoliel, Chrystel Becker. Vulnerability to depression: from brain neuroplasticity to identification of biomarkers.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Sep; 31(36):12889-99. doi:
10.1523/jneurosci.1309-11.2011. [PMID: 21900567] - K Kozics, Z Valovicova, D Slamenova. Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells.
Neoplasma.
2011; 58(6):516-24. doi:
10.4149/neo_2011_06_516. [PMID: 21895405] - Cristina Muñoz-Abellán, Cristina Rabasa, Nuria Daviu, Roser Nadal, Antonio Armario. Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence?.
PloS one.
2011; 6(6):e21426. doi:
10.1371/journal.pone.0021426. [PMID: 21731743] - Yunbao Liu, Muraleedharan G Nair. An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.
Journal of natural products.
2010 Jul; 73(7):1193-5. doi:
10.1021/np1000945. [PMID: 20565070] - J Zhao, P Mak, A Tchoudakova, G Callard, S Chen. Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes.
General and comparative endocrinology.
2001 Aug; 123(2):180-91. doi:
10.1006/gcen.2001.7661. [PMID: 11482939] - R S Zand, D J Jenkins, E P Diamandis. Steroid hormone activity of flavonoids and related compounds.
Breast cancer research and treatment.
2000 Jul; 62(1):35-49. doi:
10.1023/a:1006422302173. [PMID: 10989984] - C Q Hu, K Chen, Q Shi, R E Kilkuskie, Y C Cheng, K H Lee. Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.
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