Phthalazone (BioDeep_00000009916)

   


代谢物信息卡片


1(2H)-PHTHALAZINONE

化学式: C8H6N2O (146.048)
中文名称: 2,3-二氮杂萘酮, 1(2H)-酞嗪酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=NNC2=O
InChI: InChI=1S/C8H6N2O/c11-8-7-4-2-1-3-6(7)5-9-10-8/h1-5H,(H,10,11)

描述信息

同义名列表

5 个代谢物同义名

1(2H)-PHTHALAZINONE; Phthalazin-1-one; Phthalazone; 1(2H)-Phthalazinone; 1(2H)-Phthalazinone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, BRCA1, CASP3, EGFR, ROCK1, ROCK2, TP53BP1, XDH
Peripheral membrane protein 3 ACHE, ROCK1, ROCK2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, PARP16, STING1
Nucleus 12 ACHE, BRCA1, BRCA2, CASP3, CD274, EGFR, KDR, PARP1, PDE4B, ROCK2, TP53BP1, TRIM33
autophagosome 1 STING1
cytosol 9 BRCA2, CASP3, PARP1, PARP16, PDE4B, ROCK1, ROCK2, STING1, XDH
nuclear body 3 BRCA1, PARP1, TP53BP1
centrosome 3 BRCA2, PDE4B, ROCK2
nucleoplasm 8 BRCA1, BRCA2, CASP3, CD274, PARP1, STING1, TP53BP1, TRIM33
Cell membrane 10 ABCB1, ACHE, CD274, EGFR, KDR, PDE4B, PROKR2, ROCK1, ROCK2, STING1
lamellipodium 1 ROCK1
ruffle membrane 1 EGFR
Early endosome membrane 2 CD274, EGFR
Multi-pass membrane protein 3 ABCB1, PROKR2, STING1
Golgi apparatus membrane 2 ROCK1, STING1
Synapse 1 ACHE
cell junction 2 EGFR, KDR
cell surface 5 ABCB1, ACHE, EGFR, ENPP1, TNFRSF10B
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 2 ACHE, KDR
Golgi membrane 3 EGFR, ROCK1, STING1
lysosomal membrane 1 ENPP1
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
synaptic vesicle 1 PDE4B
Cytoplasm, cytosol 1 PARP1
endosome 3 EGFR, KDR, STING1
plasma membrane 12 ABCB1, ACHE, BRCA1, CD274, EGFR, ENPP1, KDR, PROKR2, ROCK1, ROCK2, STING1, TNFRSF10B
Membrane 10 ABCB1, ACHE, BRCA1, BRCA2, EGFR, ENPP1, PARP1, PARP16, ROCK1, TNFRSF10B
apical plasma membrane 2 ABCB1, EGFR
basolateral plasma membrane 2 EGFR, ENPP1
extracellular exosome 2 ABCB1, CD274
endoplasmic reticulum 2 KDR, PARP16
extracellular space 4 ACHE, EGFR, ENPP1, XDH
perinuclear region of cytoplasm 4 ACHE, EGFR, PDE4B, STING1
Schaffer collateral - CA1 synapse 1 ROCK1
mitochondrion 1 PARP1
protein-containing complex 4 BRCA1, BRCA2, EGFR, PARP1
postsynaptic density 2 CASP3, PDE4B
Single-pass type I membrane protein 2 CD274, EGFR
Secreted 2 ACHE, ENPP1
extracellular region 3 ACHE, KDR, ROCK1
Mitochondrion outer membrane 1 STING1
mitochondrial outer membrane 1 STING1
excitatory synapse 1 PDE4B
[Isoform 2]: Secreted 1 KDR
Extracellular side 1 ACHE
anchoring junction 1 KDR
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BRCA2, ROCK2
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD274, KDR
actin cytoskeleton 1 CD274
dendritic spine 1 PDE4B
Z disc 1 PDE4B
cytoplasmic vesicle 1 STING1
nucleolus 1 PARP1
Early endosome 1 KDR
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 ROCK1
Cytoplasm, perinuclear region 1 STING1
Membrane raft 2 EGFR, KDR
Cytoplasm, cytoskeleton 1 ROCK1
focal adhesion 1 EGFR
Peroxisome 2 STING1, XDH
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 XDH
secretory granule 1 BRCA2
Cell projection, ruffle 1 ROCK1
ruffle 1 ROCK1
receptor complex 2 EGFR, KDR
chromatin 2 PARP1, TRIM33
Cytoplasmic vesicle, autophagosome membrane 1 STING1
autophagosome membrane 1 STING1
Chromosome 3 BRCA1, PARP1, TP53BP1
cytoskeleton 2 ROCK1, ROCK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 ROCK1
centriole 1 ROCK1
cytoplasmic ribonucleoprotein granule 1 ROCK2
[Isoform 5]: Cytoplasm 1 BRCA1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 3 BRCA2, PARP1, TP53BP1
Basolateral cell membrane 1 ENPP1
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 2 PARP1, TP53BP1
serine/threonine protein kinase complex 1 STING1
nuclear envelope 2 PARP1, PARP16
Recycling endosome membrane 1 CD274
Endomembrane system 1 ROCK2
sorting endosome 1 KDR
Chromosome, centromere, kinetochore 1 TP53BP1
lateral element 2 BRCA1, BRCA2
Cytoplasmic vesicle membrane 1 STING1
cytoplasmic stress granule 1 ROCK1
side of membrane 1 ACHE
replication fork 1 TP53BP1
ubiquitin ligase complex 1 BRCA1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 ROCK1
secretory granule membrane 1 STING1
male germ cell nucleus 1 BRCA1
voltage-gated calcium channel complex 1 PDE4B
kinetochore 1 TP53BP1
XY body 1 BRCA1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 STING1
Single-pass type IV membrane protein 1 PARP16
clathrin-coated endocytic vesicle membrane 1 EGFR
ribonucleoprotein complex 1 BRCA1
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD274
[Isoform 4]: Secreted 1 CD274
intracellular non-membrane-bounded organelle 1 BRCA1
DNA repair complex 3 BRCA1, BRCA2, TP53BP1
BRCA1-C complex 1 BRCA1
site of DNA damage 1 PARP1
bleb 1 ROCK1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
[Isoform H]: Cell membrane 1 ACHE
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane 1 ENPP1
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted 1 ENPP1
gamma-tubulin complex 1 PDE4B
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 2 BRCA1, BRCA2
BRCA2-MAGE-D1 complex 1 BRCA2
endoplasmic reticulum tubular network 1 PARP16
[Isoform PDE4B5]: Cytoplasm 1 PDE4B
Cell projection, bleb 1 ROCK1
STING complex 1 STING1
[Isoform 2]: Endomembrane system 1 CD274


文献列表

  • Kaustav Biswas, Tanya A N Peterkin, Marian C Bryan, Leyla Arik, Sonya G Lehto, Hong Sun, Feng-Yin Hsieh, Cen Xu, Robert T Fremeau, Jennifer R Allen. Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists. Journal of medicinal chemistry. 2011 Oct; 54(20):7232-46. doi: 10.1021/jm200808v. [PMID: 21902230]
  • G R Madhavan, R Chakrabarti, S K Kumar, P Misra, R N Mamidi, V Balraju, K Kasiram, R K Babu, J Suresh, B B Lohray, V B Lohrayb, J Iqbal, R Rajagopalan. Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents. European journal of medicinal chemistry. 2001 Jul; 36(7-8):627-37. doi: 10.1016/s0223-5234(01)01257-0. [PMID: 11600232]