Hydroxychlor (BioDeep_00000009715)
Secondary id: BioDeep_00001873959
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H11Cl3O2 (315.9825)
中文名称: 1,1,1-三氯-2,2-二(4-羟基苯基)乙烷
谱图信息:
最多检出来源 Homo sapiens(blood) 99.58%
分子结构信息
SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)O)C(Cl)(Cl)Cl)O
InChI: InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
描述信息
同义名列表
19 个代谢物同义名
alpha,alpha-Bis(4-hydroxyphenyl)-beta,beta,beta-trichloroethane; 4-[2,2,2-trichloro-1-(4-hydroxyphenyl)ethyl]phenol; 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2,2-bis(p-hydroxyphenyl)ethane; 2,2-Bis(4-hydroxyphenyl)-1,1,1-trichloroethane; a,a-Bis(4-hydroxyphenyl)-b,b,b-trichloroethane; 1,1-Bis(p-hydroxyphenyl)-2,2,2-trichloroethane; 2,2-Bis(p-hydroxyphenyl)-1,1,1-trichloroethane; Α,α-bis(4-hydroxyphenyl)-β,β,β-trichloroethane; 1,1-Bis(4-hydroxyphenyl)-2,2,2-trichloroethane; Phenol,4,4-(2,2,2-trichloroethylidene)bis-; p,P-(2,2,2-trichloroethylidene)diphenol; 4,4-(2,2,2-Trichloroethylidene)diphenol; p,P-hydroxy-DDT; Hydroxychlor; p,P-HO-DDT; HPTE CPD; HPTE; 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:34025
- KEGG: C14136
- PubChem: 76302
- HMDB: HMDB0253260
- Metlin: METLIN69827
- ChEMBL: CHEMBL196585
- Wikipedia: HPTE
- chemspider: 68781
- CAS: 124042-17-7
- CAS: 2971-36-0
- PMhub: MS000023526
- PubChem: 7846950
- PDB-CCD: 27N
- NIKKAJI: J42.984H
- RefMet: 1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane
- KNApSAcK: 34025
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae.
Plant physiology.
2017 Aug; 174(4):2146-2165. doi:
10.1104/pp.17.00433. [PMID: 28652262] - Jingjing Guo, Haiyun Deng, Hongzhi Li, Qiqi Zhu, Binghai Zhao, Bingbing Chen, Yanhui Chu, Ren-Shan Ge. Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11β-hydroxysteroid dehydrogenase activities in vitro.
Toxicology letters.
2013 Mar; 218(1):18-23. doi:
10.1016/j.toxlet.2013.01.002. [PMID: 23333641] - Beatrice A Nyagode, Margaret O James, Kevin M Kleinow. Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus).
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Apr; 108(2):320-9. doi:
10.1093/toxsci/kfp018. [PMID: 19181613] - Yucel Akgul, Raymond C Derk, Terence Meighan, K Murali Krishna Rao, Eisuke P Murono. The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells.
Reproductive toxicology (Elmsford, N.Y.).
2008 Jan; 25(1):67-75. doi:
10.1016/j.reprotox.2007.10.007. [PMID: 18065196] - Eisuke P Murono, Raymond C Derk, Yucel Akgul. In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity.
Reproductive toxicology (Elmsford, N.Y.).
2006 Feb; 21(2):148-53. doi:
10.1016/j.reprotox.2005.08.005. [PMID: 16226009] - Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
Chemical research in toxicology.
2003 Oct; 16(10):1338-58. doi:
10.1021/tx030011g. [PMID: 14565775] - Mari S Golub, Casey E Hogrefe, Stacey L Germann, Bill L Lasley, Kala Natarajan, Alice F Tarantal. Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys.
Toxicological sciences : an official journal of the Society of Toxicology.
2003 Jul; 74(1):103-13. doi:
10.1093/toxsci/kfg090. [PMID: 12730626] - Stephen H Safe, Lea Pallaroni, Kyungsil Yoon, Kevin Gaido, Susan Ross, Donald McDonnell. Problems for risk assessment of endocrine-active estrogenic compounds.
Environmental health perspectives.
2002 Dec; 110 Suppl 6(?):925-9. doi:
10.1289/ehp.02110s6925. [PMID: 12634121] - Li You, Mercedes Casanova, Erika J Bartolucci, Mary W Fryczynski, David C Dorman, Jeffrey I Everitt, Kevin W Gaido, Susan M Ross, Henry d'A Heck Hd. Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Mar; 66(1):91-104. doi:
10.1093/toxsci/66.1.91. [PMID: 11861976] - S H Safe, L Pallaroni, K Yoon, K Gaido, S Ross, B Saville, D McDonnellc. Toxicology of environmental estrogens.
Reproduction, fertility, and development.
2001; 13(4):307-15. doi:
10.1071/rd00108. [PMID: 11800169] - J Matthews, T Celius, R Halgren, T Zacharewski. Differential estrogen receptor binding of estrogenic substances: a species comparison.
The Journal of steroid biochemistry and molecular biology.
2000 Nov; 74(4):223-34. doi:
10.1016/s0960-0760(00)00126-6. [PMID: 11162928] - D M Klotz, S C Hewitt, K S Korach, R P Diaugustine. Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha.
Endocrinology.
2000 Sep; 141(9):3430-9. doi:
10.1210/endo.141.9.7649. [PMID: 10965916]
