BzATP (BioDeep_00000009548)
代谢物信息卡片
3-O-(4-Benzoyl)benzoyl ATP
化学式: C24H24N5O15P3 (715.0482)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C(=O)OC3C(OC(C3O)N4C=NC5=C(N=CN=C54)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C24H24N5O15P3/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35)/t16-,19-,20-,23-/m1/s1
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D000345 - Affinity Labels
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34316
- KEGG: C13744
- PubChem: 115205
- Metlin: METLIN69676
- ChEMBL: CHEMBL2407634
- CAS: 81790-82-1
- PMhub: MS000023341
- MetaboLights: MTBLC34316
- PubChem: 586333
- NIKKAJI: J413.969K
- RefMet: BzATP
- KNApSAcK: 34316
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria Anna Maggi, Silvia Bisti, Cristiana Picco. Saffron: Chemical Composition and Neuroprotective Activity.
Molecules (Basel, Switzerland).
2020 Nov; 25(23):. doi:
10.3390/molecules25235618. [PMID: 33260389] - Gokhan Arslan, Bahattin Avci, Süleyman Emre Kocacan, Emil Rzayev, Mustafa Ayyildiz, Erdal Agar. The interaction between P2X7Rs and T-type calcium ion channels in penicillin-induced epileptiform activity.
Neuropharmacology.
2019 05; 149(?):1-12. doi:
10.1016/j.neuropharm.2019.01.027. [PMID: 30695710] - Mauricio Dos-Santos-Pereira, Leonardo Acuña, Sabah Hamadat, Jeremy Rocca, Florencia González-Lizárraga, Rosana Chehín, Julia Sepulveda-Diaz, Elaine Del-Bel, Rita Raisman-Vozari, Patrick P Michel. Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine.
Glia.
2018 11; 66(11):2353-2365. doi:
10.1002/glia.23472. [PMID: 30394585] - Gergely Kovács, Zsuzsanna Környei, Krisztina Tóth, Mária Baranyi, János Brunner, Máté Neubrandt, Ádám Dénes, Beáta Sperlágh. Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia.
Cell calcium.
2018 11; 75(?):1-13. doi:
10.1016/j.ceca.2018.07.010. [PMID: 30098501] - Robert I Menzies, John W R Booth, John J Mullins, Matthew A Bailey, Frederick W K Tam, Jill T Norman, Robert J Unwin. Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.
EBioMedicine.
2017 May; 19(?):73-83. doi:
10.1016/j.ebiom.2017.04.011. [PMID: 28434946] - Wei Wang, Zheng-Hua Xiang, Chun-Lei Jiang, Wei-Zhi Liu, Zhi-Lei Shang. Effects of antidepressants on P2X7 receptors.
Psychiatry research.
2016 Aug; 242(?):281-287. doi:
10.1016/j.psychres.2016.06.001. [PMID: 27318632] - Ewelina Kreft, Robert Kowalski, Maciej Jankowski, Mirosława Szczepańska-Konkel. Renal vasculature reactivity to agonist of P2X7 receptor is increased in streptozotocin-induced diabetes.
Pharmacological reports : PR.
2016 Feb; 68(1):71-4. doi:
10.1016/j.pharep.2015.06.140. [PMID: 26721355] - A R Barros-Barbosa, M G Lobo, F Ferreirinha, P Correia-de-Sá, J M Cordeiro. P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes.
Neuroscience.
2015 Oct; 306(?):74-90. doi:
10.1016/j.neuroscience.2015.08.026. [PMID: 26299340] - Julia M Broström, Zhi-Wei Ye, Anna Axmon, Margareta Littorin, Håkan Tinnerberg, Christian H Lindh, Huiyuan Zheng, Aram Ghalali, Ulla Stenius, Bo A G Jönsson, Johan Högberg. Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Toxicology and applied pharmacology.
2015 Sep; 287(3):222-31. doi:
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Pharmacological research.
2014 Mar; 81(?):34-43. doi:
10.1016/j.phrs.2014.01.003. [PMID: 24508566] - Adolfo E Cuadra, Edward E Custer, Elizabeth L Bosworth, José R Lemos. P2X7 receptors in neurohypophysial terminals: evidence for their role in arginine-vasopressin secretion.
Journal of cellular physiology.
2014 Mar; 229(3):333-42. doi:
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PloS one.
2014; 9(6):e97452. doi:
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Purinergic signalling.
2013 Dec; 9(4):687-93. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
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2013 Apr; 47(2):109-15. doi:
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PloS one.
2013; 8(5):e63789. doi:
10.1371/journal.pone.0063789. [PMID: 23691096] - Chiara Rigato, Nina Swinnen, Roeland Buckinx, Isabelle Couillin, Jean-Marie Mangin, Jean-Michel Rigo, Pascal Legendre, Hervé Le Corronc. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Aug; 32(34):11559-73. doi:
10.1523/jneurosci.1042-12.2012. [PMID: 22915101] - Vincent Compan, Lauriane Ulmann, Olga Stelmashenko, Jean Chemin, Séverine Chaumont, Francois Rassendren. P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Mar; 32(12):4284-96. doi:
10.1523/jneurosci.6332-11.2012. [PMID: 22442090] - Xu Ji, Yukiko Naito, Go Hirokawa, Huachun Weng, Yumiko Hiura, Rie Takahashi, Naoharu Iwai. P2X(7) receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Feb; 35(2):173-9. doi:
10.1038/hr.2011.153. [PMID: 21918525] - A Di Garbo, S Alloisio, M Nobile. P2X7 receptor-mediated calcium dynamics in HEK293 cells: experimental characterization and modelling approach.
Physical biology.
2012; 9(2):026001. doi:
10.1088/1478-3975/9/2/026001. [PMID: 22473129] - Ingrid Lajdova, Adrian Oksa, Dusan Chorvat, Peter Topor, Viera Spustova. Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.
Kidney & blood pressure research.
2012; 35(1):48-57. doi:
10.1159/000330349. [PMID: 21860249] - Youichirou Higashi, Shohei Segawa, Takaaki Matsuo, Shogo Nakamura, Yukiko Kikkawa, Kentaro Nishida, Kazuki Nagasawa. Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia.
Glia.
2011 Dec; 59(12):1933-45. doi:
10.1002/glia.21235. [PMID: 22253048] - Hirokazu Kurihara, Takashi Sato, Noriko Akimoto, Takayuki Ogura, Akira Ito. Identification and characterization of ABCB1-mediated and non-apoptotic sebum secretion in differentiated hamster sebocytes.
Biochimica et biophysica acta.
2011 Dec; 1811(12):1090-6. doi:
10.1016/j.bbalip.2011.08.011. [PMID: 21889999] - Stephanie Madec, Chiara Rossi, Massimo Chiarugi, Eleonora Santini, Antonio Salvati, Ele Ferrannini, Anna Solini. Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?.
Atherosclerosis.
2011 Dec; 219(2):552-8. doi:
10.1016/j.atherosclerosis.2011.09.012. [PMID: 21978920] - Ming-Yang Chang, Jenn-Kan Lu, Ya-Chung Tian, Yung-Chang Chen, Cheng-Chieh Hung, Yi-Hui Huang, Yau-Hung Chen, Mai-Szu Wu, Chih-Wei Yang, Yi-Chuan Cheng. Inhibition of the P2X7 receptor reduces cystogenesis in PKD.
Journal of the American Society of Nephrology : JASN.
2011 Sep; 22(9):1696-706. doi:
10.1681/asn.2010070728. [PMID: 21636640] - C Crawford, T M Kennedy-Lydon, H Callaghan, C Sprott, R L Simmons, L Sawbridge, H M Syme, R J Unwin, S S P Wildman, C M Peppiatt-Wildman. Extracellular nucleotides affect pericyte-mediated regulation of rat in situ vasa recta diameter.
Acta physiologica (Oxford, England).
2011 Jul; 202(3):241-51. doi:
10.1111/j.1748-1716.2011.02310.x. [PMID: 21624094] - Jing-Hui Chong, Guo-Guang Zheng, Yuan-Yuan Ma, Hai-Yan Zhang, Kun Nie, Yong-Min Lin, Ke-Fu Wu. The hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice.
The Journal of biological chemistry.
2010 Nov; 285(46):36179-87. doi:
10.1074/jbc.m110.128488. [PMID: 20837475] - John P Davies, Louise Robson. Pharmacological properties and physiological function of a P2X-like current in single proximal tubule cells isolated from frog kidney.
The Journal of membrane biology.
2010 Oct; 237(2-3):79-91. doi:
10.1007/s00232-010-9308-8. [PMID: 20972559] - Lijun Liu, Jie Zou, Xing Liu, Lin-Hua Jiang, Junying Li. Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor.
European journal of pharmacology.
2010 Aug; 640(1-3):15-9. doi:
10.1016/j.ejphar.2010.04.036. [PMID: 20452342] - Luz María G Carrasquero, Esmerilda G Delicado, Lucía Sánchez-Ruiloba, Teresa Iglesias, Maria Teresa Miras-Portugal. Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes.
Glia.
2010 Jun; 58(8):984-95. doi:
10.1002/glia.20980. [PMID: 20222145] - C Csölle, B Sperlágh. Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors.
Journal of neuroimmunology.
2010 Feb; 219(1-2):38-46. doi:
10.1016/j.jneuroim.2009.11.011. [PMID: 20022387] - Fabio Bianco, Cristiana Perrotta, Luisa Novellino, Maura Francolini, Loredana Riganti, Elisabetta Menna, Laura Saglietti, Edward H Schuchman, Roberto Furlan, Emilio Clementi, Michela Matteoli, Claudia Verderio. Acid sphingomyelinase activity triggers microparticle release from glial cells.
The EMBO journal.
2009 Apr; 28(8):1043-54. doi:
10.1038/emboj.2009.45. [PMID: 19300439] - Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim, George I Gorodeski. Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
BMC cancer.
2009 Apr; 9(?):114. doi:
10.1186/1471-2407-9-114. [PMID: 19379509] - Weihong Ma, Hui Hui, Pablo Pelegrin, Annmarie Surprenant. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):409-18. doi:
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Neuropharmacology.
2009 Jan; 56(1):223-9. doi:
10.1016/j.neuropharm.2008.06.012. [PMID: 18602931] - Raffaella Barbieri, Susanna Alloisio, Stefano Ferroni, Mario Nobile. Differential crosstalk between P2X7 and arachidonic acid in activation of mitogen-activated protein kinases.
Neurochemistry international.
2008 Dec; 53(6-8):255-62. doi:
10.1016/j.neuint.2008.05.001. [PMID: 18804898] - Ramin Raouf, Anne-Julie Chabot-Doré, Ariel R Ase, Dominique Blais, Philippe Séguéla. Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation.
Neuropharmacology.
2007 Sep; 53(4):496-504. doi:
10.1016/j.neuropharm.2007.06.010. [PMID: 17675190] - Doreen Milius, Helke Gröger-Arndt, Doychin Stanchev, Christine Lange-Dohna, Steffen Rossner, Beata Sperlagh, Kerstin Wirkner, Peter Illes. Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells.
Toxicology.
2007 Aug; 238(1):60-9. doi:
10.1016/j.tox.2007.05.028. [PMID: 17618031] - H Jiang, A G Zhu, M Mamczur, J R Falck, K M Lerea, J C McGiff. Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids.
British journal of pharmacology.
2007 Aug; 151(7):1033-40. doi:
10.1038/sj.bjp.0707311. [PMID: 17558440] - Anna Solini, Eleonora Santini, Daniele Chimenti, Paola Chiozzi, Federico Pratesi, Sabina Cuccato, Simonetta Falzoni, Roberto Lupi, Ele Ferrannini, Giuseppe Pugliese, Francesco Di Virgilio. Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1537-47. doi:
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Molecular pharmacology.
2006 Jun; 69(6):1975-83. doi:
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Journal of biochemistry.
2006 May; 139(5):831-6. doi:
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Nucleosides, nucleotides & nucleic acids.
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Journal of neurochemistry.
2005 Dec; 95(5):1421-37. doi:
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International journal of immunopathology and pharmacology.
2005 Jul; 18(3):417-30. doi:
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The Journal of biological chemistry.
2005 Jan; 280(4):2653-8. doi:
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American journal of physiology. Cell physiology.
2004 Nov; 287(5):C1349-58. doi:
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The Journal of biological chemistry.
2004 Apr; 279(17):16918-26. doi:
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Journal of autonomic pharmacology.
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European journal of biochemistry.
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British journal of pharmacology.
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