Domoic acid (BioDeep_00000009537)

 

Secondary id: BioDeep_00000404884

human metabolite natural product


代谢物信息卡片


4-[(2E,4Z)-6-carboxy-6-methylhexa-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid

化学式: C15H21NO6 (311.1369)
中文名称: 海藻酸
谱图信息: 最多检出来源 Escherichia coli(natural_products) 79.31%

分子结构信息

SMILES: C/C(=C/C=C/[C@@H](C)C(=O)O)/[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
InChI: InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3-,8-4+

描述信息

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
Isodomoic acid F is found in mollusks. Isodomoic acid F is isolated from mussels.
Isolated from mussels. Isodomoic acid F is found in mollusks.

同义名列表

11 个代谢物同义名

4-[(2E,4Z)-6-carboxy-6-methylhexa-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid; 2 alpha-Carboxy-4 beta-(5-carboxy-1-methyl-1,3 beta-hexadienyl)-3-pyrrolidineacetic acid; 4-[(4Z)-6-Carboxy-6-methylhexa-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylate; 2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic acid, 9ci; Domoic acid, sodium salt; Isodomoic acid F; (-)-domoic acid; L-Domoic acid; Domoic acid; Domoate; Domoic acid



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

73 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CA2, CA3, DLG4, HDC
Golgi apparatus, trans-Golgi network membrane 1 DLG4
Endoplasmic reticulum membrane 1 GRIA1
Nucleus 3 FOSB, HDC, MGA
cytosol 9 CA1, CA2, CA3, DLG4, EIF4G2, FOSB, GRIA1, HDC, PRKCQ
dendrite 2 GRIA1, GRIK3
nucleoplasm 5 CD2, FOSB, GRIK2, GRIK5, MGA
Cell membrane 11 CA2, CD2, DLG4, GRIA1, GRIA3, GRID1, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5
Lipid-anchor 1 DLG4
Cytoplasmic side 1 DLG4
Cell projection, axon 1 DLG4
Early endosome membrane 2 DLG4, GRIA1
Multi-pass membrane protein 9 GRIA1, GRIA3, GRID1, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, KCNA3
Golgi apparatus membrane 1 DLG4
Synapse 2 DLG4, GRIA1
cell junction 1 DLG4
cell surface 3 CACNG2, CD2, GRIA1
dendritic shaft 1 GRIA1
glutamatergic synapse 7 CACNG2, DLG4, GRIA1, GRID1, GRIK2, GRIK3, KCNA3
Golgi apparatus 1 CD2
Golgi membrane 1 DLG4
neuromuscular junction 2 DLG4, GRIA1
neuronal cell body 1 GRIA1
presynaptic membrane 6 GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, KCNA3
synaptic vesicle 1 DLG4
Presynapse 2 DLG4, GRIA1
plasma membrane 15 CA2, CACNG2, CD2, DLG4, GRIA1, GRIA3, GRID1, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, KCNA3, MGA, PRKCQ
synaptic vesicle membrane 1 GRIA1
terminal bouton 2 GRIK2, GRIK3
Membrane 8 EIF4G2, GRIA1, GRIK2, GRIK3, GRIK4, GRIK5, HDC, KCNA3
apical plasma membrane 1 MGA
axon 4 DLG4, EIF4G2, GRIK3, KCNA3
basolateral plasma membrane 1 DLG4
extracellular exosome 4 CA1, CA2, GRID1, MGA
endoplasmic reticulum 3 DLG4, GRIK2, GRIK5
perinuclear region of cytoplasm 1 KCNA3
Schaffer collateral - CA1 synapse 1 CACNG2
adherens junction 2 DLG4, EIF4G2
protein-containing complex 1 CD2
intracellular membrane-bounded organelle 2 FOSB, GRIK1
postsynaptic density 3 DLG4, GRIA1, GRIK2
Single-pass type I membrane protein 1 CD2
extracellular region 1 CD2
cytoplasmic side of plasma membrane 1 CD2
excitatory synapse 2 DLG4, GRIA1
hippocampal mossy fiber to CA3 synapse 4 CACNG2, GRIK2, GRIK4, GRIK5
neuronal cell body membrane 1 GRIA1
centriolar satellite 1 PRKCQ
external side of plasma membrane 2 CD2, GRIA1
dendritic spine 3 DLG4, GRIA1, GRIA3
perikaryon 2 GRIK2, GRIK3
neuron spine 2 DLG4, GRIA1
apical part of cell 1 CA2
cell-cell junction 2 CD2, GRIA1
recycling endosome 1 GRIA1
postsynaptic membrane 9 DLG4, GRIA1, GRIA3, GRID1, GRIK1, GRIK2, GRIK3, GRIK4, KCNA3
presynaptic active zone membrane 1 GRIA1
Membrane raft 1 KCNA3
Cytoplasm, cytoskeleton 1 DLG4
GABA-ergic synapse 1 GRID1
Cell projection, dendritic spine 2 DLG4, GRIA1
Postsynaptic cell membrane 8 GRIA1, GRIA3, GRID1, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5
dendrite cytoplasm 3 DLG4, GRIK2, GRIK3
kainate selective glutamate receptor complex 5 GRIK1, GRIK2, GRIK3, GRIK4, GRIK5
mossy fiber rosette 1 GRIK2
neuron projection 1 DLG4
chromatin 2 FOSB, MGA
cell projection 3 GRIK2, GRIK4, GRIK5
cytoskeleton 1 DLG4
postsynaptic density, intracellular component 1 GRIA1
[Isoform 2]: Cell membrane 1 KCNA3
Recycling endosome membrane 1 GRIA1
AMPA glutamate receptor complex 4 CACNG2, DLG4, GRIA1, GRIA3
Cell projection, dendrite 2 DLG4, GRIA1
tertiary granule membrane 1 MGA
Presynaptic cell membrane 3 GRIK2, GRIK4, GRIK5
myelin sheath 1 CA2
synaptic membrane 2 DLG4, GRIA1
voltage-gated potassium channel complex 1 KCNA3
trans-Golgi network membrane 1 DLG4
MLL1 complex 1 MGA
cortical actin cytoskeleton 1 DLG4
voltage-gated calcium channel complex 1 CACNG2
endocytic vesicle membrane 4 CACNG2, DLG4, GRIA1, GRIA3
cerebellar mossy fiber 2 CACNG2, DLG4
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GRIA1
postsynaptic density membrane 10 CACNG2, DLG4, GRIA1, GRIA3, GRID1, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
ER to Golgi transport vesicle membrane 1 GRIA1
parallel fiber to Purkinje cell synapse 1 GRIA3
calyx of Held 1 KCNA3
Synapse, synaptosome 1 CACNG2
ficolin-1-rich granule membrane 1 MGA
[Isoform 1]: Cell membrane 1 KCNA3
eukaryotic translation initiation factor 4F complex 1 EIF4G2
somatodendritic compartment 1 CACNG2
dendritic spine membrane 1 GRIA1
cortical cytoskeleton 1 DLG4
neuron projection terminus 1 DLG4
proximal dendrite 1 GRIA1
juxtaparanode region of axon 1 DLG4
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1
Golgi cis cisterna 1 DLG4


文献列表

  • Miaomiao Du, Jing Wang, Yuan Jin, Jingfeng Fan, Shuaijun Zan, Zelong Li. Response mechanism of microbial community during anaerobic biotransformation of marine toxin domoic acid. Environmental research. 2022 12; 215(Pt 2):114410. doi: 10.1016/j.envres.2022.114410. [PMID: 36154856]
  • Edavalath Methal Ramya, Garlapati Phani Kumar, Yadavalli Chandrasekhar, Kandangath Raghavan Anilakumar. Adaptogenic potential of ginsenosides against domoic acid-induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies. Journal of food biochemistry. 2022 05; 46(5):e14089. doi: 10.1111/jfbc.14089. [PMID: 35102569]
  • Cara L Field, Sophie T Whoriskey, Xianguo Zhao, Mark G Papich. PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2021 Sep; 52(3):872-879. doi: 10.1638/2020-0223. [PMID: 34687502]
  • Emily K Bowers, Raphaela Stimmelmayr, Kathi A Lefebvre. Stability of Domoic Acid in 50\% Methanol Extracts and Raw Fecal Material from Bowhead Whales (Balaena mysticetus). Marine drugs. 2021 Jul; 19(8):. doi: 10.3390/md19080423. [PMID: 34436262]
  • Corinne M Gibble, Raphael M Kudela, Susan Knowles, Barbara Bodenstein, Kathi A Lefebvre. Domoic acid and saxitoxin in seabirds in the United States between 2007 and 2018. Harmful algae. 2021 03; 103(?):101981. doi: 10.1016/j.hal.2021.101981. [PMID: 33980431]
  • Spencer E Fire, Andrea Bogomolni, Robert A DiGiovanni, Greg Early, Tod A Leighfield, Keith Matassa, Glenn A Miller, Kathleen M T Moore, Michael Moore, Misty Niemeyer, Katie Pugliares, Zhihong Wang, Frederick W Wenzel. An assessment of temporal, spatial and taxonomic trends in harmful algal toxin exposure in stranded marine mammals from the U.S. New England coast. PloS one. 2021; 16(1):e0243570. doi: 10.1371/journal.pone.0243570. [PMID: 33406141]
  • Sara Shum, Jing Jing, Rebekah Petroff, Brenda Crouthamel, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen. Maternal-fetal disposition of domoic acid following repeated oral dosing during pregnancy in nonhuman primate. Toxicology and applied pharmacology. 2020 07; 398(?):115027. doi: 10.1016/j.taap.2020.115027. [PMID: 32360744]
  • S Gill, V M Ruvin Kumara. Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells. Marine drugs. 2019 Oct; 17(10):. doi: 10.3390/md17100566. [PMID: 31590222]
  • Kathi A Lefebvre, Betsy Jean Yakes, Elizabeth Frame, Preston Kendrick, Sara Shum, Nina Isoherranen, Bridget E Ferriss, Alison Robertson, Alicia Hendrix, David J Marcinek, Lynn Grattan. Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor. Toxins. 2019 05; 11(5):. doi: 10.3390/toxins11050293. [PMID: 31126088]
  • Thomas M Burbacher, Kimberly S Grant, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Courtney Stanley, Noelle McKain, Jing Jing, Nina Isoherranen. Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model. Neurotoxicology and teratology. 2019 Mar; 72(?):10-21. doi: 10.1016/j.ntt.2019.01.001. [PMID: 30615984]
  • Kathi A Lefebvre, Alicia Hendrix, Barbie Halaska, Padraig Duignan, Sara Shum, Nina Isoherranen, David J Marcinek, Frances M D Gulland. Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals. Harmful algae. 2018 11; 79(?):53-57. doi: 10.1016/j.hal.2018.06.003. [PMID: 30420016]
  • Jing Jing, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Ariel R Topletz, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen. Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates. Drug metabolism and disposition: the biological fate of chemicals. 2018 02; 46(2):155-165. doi: 10.1124/dmd.117.078485. [PMID: 29150543]
  • Valeria C D'Agostino, Mariana Degrati, Viviana Sastre, Norma Santinelli, Bernd Krock, Torben Krohn, Silvana L Dans, Mónica S Hoffmeyer. Domoic acid in a marine pelagic food web: Exposure of southern right whales Eubalaena australis to domoic acid on the Península Valdés calving ground, Argentina. Harmful algae. 2017 09; 68(?):248-257. doi: 10.1016/j.hal.2017.09.001. [PMID: 28962985]
  • Abdullah F U H Saeed, Sumei Ling, Jun Yuan, Shihua Wang. The Preparation and Identification of a Monoclonal Antibody against Domoic Acid and Establishment of Detection by Indirect Competitive ELISA. Toxins. 2017 08; 9(8):. doi: 10.3390/toxins9080250. [PMID: 28817087]
  • Yiping Zhang, Dawei Chen, Zhuan Hong. A Rapid LC-HRMS Method for the Determination of Domoic Acid in Urine Using a Self-Assembly Pipette Tip Solid-Phase Extraction. Toxins. 2015 Dec; 8(1):. doi: 10.3390/toxins8010010. [PMID: 26729165]
  • Christiana Wittmaack, Garet P Lahvis, Edward O Keith, Caryn Self-Sullivan. Diagnosing domoic acid toxicosis in the California sea lion (Zalophus californianus) using behavioral criteria: A novel approach. Zoo biology. 2015 Jul; 34(4):314-20. doi: 10.1002/zoo.21217. [PMID: 25962475]
  • Xiaoqian Wang, Tie Gao, Zhuan Hong, Feng Qu. [Affinity capillary electrophoresis for screening proteins interacting with domoic acid]. Se pu = Chinese journal of chromatography. 2015 Jul; 33(7):673-7. doi: 10.3724/sp.j.1123.2015.03026. [PMID: 26672193]
  • Silje-Kristin Jensen, Jean-Pierre Lacaze, Guillaume Hermann, Joanna Kershaw, Andrew Brownlow, Andrew Turner, Ailsa Hall. Detection and effects of harmful algal toxins in Scottish harbour seals and potential links to population decline. Toxicon : official journal of the International Society on Toxinology. 2015 Apr; 97(?):1-14. doi: 10.1016/j.toxicon.2015.02.002. [PMID: 25666120]
  • Bernd Luckas, Katrin Erler, Bernd Krock. Analysis of Marine Biotoxins Using LC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2015; 1308(?):277-97. doi: 10.1007/978-1-4939-2684-8_18. [PMID: 26108513]
  • Jason A Funk, Michael G Janech, Joshua C Dillon, John J Bissler, Brian J Siroky, P Darwin Bell. Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. Journal of the American Society of Nephrology : JASN. 2014 Jun; 25(6):1187-97. doi: 10.1681/asn.2013080836. [PMID: 24511141]
  • Erica L Seubert, Meredith D A Howard, Raphael M Kudela, Thomas N Stewart, R Wayne Litaker, Richard Evans, David A Caron. Development, comparison, and validation using ELISAs for the determination of domoic acid in California sea lion body fluids. Journal of AOAC International. 2014 Mar; 97(2):345-55. doi: 10.5740/jaoacint.sgeseubert. [PMID: 24830146]
  • Benjamin A Neely, Jason A Ferrante, J Mauro Chaves, Jennifer L Soper, Jonas S Almeida, John M Arthur, Frances M D Gulland, Michael G Janech. Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis. PloS one. 2014; 10(4):e0123295. doi: 10.1371/journal.pone.0123295. [PMID: 25919366]
  • Irvin R Schultz, Ann Skillman, Siobhan Sloan-Evans, Dana Woodruff. Domoic acid toxicokinetics in Dungeness crabs: new insights into mechanisms that regulate bioaccumulation. Aquatic toxicology (Amsterdam, Netherlands). 2013 Sep; 140-141(?):77-88. doi: 10.1016/j.aquatox.2013.04.011. [PMID: 23765030]
  • Jennifer Maucher Fuquay, Noah Muha, Zhihong Wang, John S Ramsdell. Elimination kinetics of domoic acid from the brain and cerebrospinal fluid of the pregnant rat. Chemical research in toxicology. 2012 Dec; 25(12):2805-9. doi: 10.1021/tx300434s. [PMID: 23134453]
  • Erica L Seubert, Shane Trussell, John Eagleton, Astrid Schnetzer, Ivona Cetinić, Phil Lauri, Burton H Jones, David A Caron. Algal toxins and reverse osmosis desalination operations: laboratory bench testing and field monitoring of domoic acid, saxitoxin, brevetoxin and okadaic acid. Water research. 2012 Dec; 46(19):6563-73. doi: 10.1016/j.watres.2012.09.042. [PMID: 23079130]
  • Frances M D Gulland, Ailsa J Hall, Denise J Greig, Elizabeth R Frame, Kathleen M Colegrove, Rebecca K N Booth, Sam K Wasser, J Catharine R Scott-Moncrieff. Evaluation of circulating eosinophil count and adrenal gland function in California sea lions naturally exposed to domoic acid. Journal of the American Veterinary Medical Association. 2012 Oct; 241(7):943-9. doi: 10.2460/javma.241.7.943. [PMID: 23013509]
  • Aurélie Lelong, Dianne F Jolley, Philippe Soudant, Hélène Hégaret. Impact of copper exposure on Pseudo-nitzschia spp. physiology and domoic acid production. Aquatic toxicology (Amsterdam, Netherlands). 2012 Aug; 118-119(?):37-47. doi: 10.1016/j.aquatox.2012.03.010. [PMID: 22516673]
  • Jennifer Maucher Fuquay, Noah Muha, Zhihong Wang, John S Ramsdell. Toxicokinetics of domoic acid in the fetal rat. Toxicology. 2012 Mar; 294(1):36-41. doi: 10.1016/j.tox.2012.01.012. [PMID: 22306965]
  • Zhihong Wang, Jennifer Maucher-Fuquay, Spencer E Fire, Christina M Mikulski, Bennie Haynes, Gregory J Doucette, John S Ramsdell. Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of domoic acid in seawater, phytoplankton, and mammalian fluids and tissues. Analytica chimica acta. 2012 Feb; 715(?):71-9. doi: 10.1016/j.aca.2011.12.013. [PMID: 22244169]
  • Jun Lu, Dong-Mei Wu, Yuan-Lin Zheng, Bin Hu, Wei Cheng, Zi-Feng Zhang. Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice. Free radical biology & medicine. 2012 Feb; 52(3):646-659. doi: 10.1016/j.freeradbiomed.2011.11.016. [PMID: 22178976]
  • Michael J Twiner, Leanne J Flewelling, Spencer E Fire, Sabrina R Bowen-Stevens, Joseph K Gaydos, Christine K Johnson, Jan H Landsberg, Tod A Leighfield, Blair Mase-Guthrie, Lori Schwacke, Frances M Van Dolah, Zhihong Wang, Teresa K Rowles. Comparative analysis of three brevetoxin-associated bottlenose dolphin (Tursiops truncatus) mortality events in the Florida Panhandle region (USA). PloS one. 2012; 7(8):e42974. doi: 10.1371/journal.pone.0042974. [PMID: 22916189]
  • Gregory J Doucette, Christina M Mikulski, Kristen L King, Patricia B Roth, Zhihong Wang, Luis F Leandro, Stacey L DeGrasse, Kevin D White, Daniela De Biase, Roxanne M Gillett, Rosalind M Rolland. Endangered North Atlantic right whales (Eubalaena glacialis) experience repeated, concurrent exposure to multiple environmental neurotoxins produced by marine algae. Environmental research. 2012 Jan; 112(?):67-76. doi: 10.1016/j.envres.2011.09.010. [PMID: 22018895]
  • Aurélie Lelong, Hélène Hégaret, Philippe Soudant. Cell-based measurements to assess physiological status of Pseudo-nitzschia multiseries, a toxic diatom. Research in microbiology. 2011 Nov; 162(9):969-81. doi: 10.1016/j.resmic.2011.06.005. [PMID: 21704155]
  • Alexandra Vranyac-Tramoundanas, Joanne C Harrison, Punam M Sawant, D Steven Kerr, Ivan A Sammut. Ischemic cardiomyopathy following seizure induction by domoic Acid. The American journal of pathology. 2011 Jul; 179(1):141-54. doi: 10.1016/j.ajpath.2011.03.017. [PMID: 21703399]
  • Michael J Twiner, Spencer Fire, Lori Schwacke, Leigh Davidson, Zhihong Wang, Steve Morton, Stephen Roth, Brian Balmer, Teresa K Rowles, Randall S Wells. Concurrent exposure of bottlenose dolphins (Tursiops truncatus) to multiple algal toxins in Sarasota Bay, Florida, USA. PloS one. 2011 Mar; 6(3):e17394. doi: 10.1371/journal.pone.0017394. [PMID: 21423740]
  • Birgül Mazmanci, Tolga Cavaş. Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid. Toxicon : official journal of the International Society on Toxinology. 2010 Apr; 55(4):734-8. doi: 10.1016/j.toxicon.2009.11.003. [PMID: 19931299]
  • Milton Levin, Dhanashree Joshi, Andrew Draghi, Frances M Gulland, David Jessup, Sylvain De Guise. Immunomodulatory effects upon in vitro exposure of California sea lion and southern sea otter peripheral blood leukocytes to domoic acid. Journal of wildlife diseases. 2010 Apr; 46(2):541-50. doi: 10.7589/0090-3558-46.2.541. [PMID: 20688647]
  • A E Thessen, T M Soniat, Q Dortch, G J Doucette. Crassostrea virginica grazing on toxic and non-toxic diatoms. Toxicon : official journal of the International Society on Toxinology. 2010 Feb; 55(2-3):570-9. doi: 10.1016/j.toxicon.2009.10.011. [PMID: 19835902]
  • Melissa A Perry, Catherine L Ryan, R Andrew Tasker. Effects of low dose neonatal domoic acid administration on behavioural and physiological response to mild stress in adult rats. Physiology & behavior. 2009 Aug; 98(1-2):53-9. doi: 10.1016/j.physbeh.2009.04.009. [PMID: 19375434]
  • T S Zabka, T Goldstein, C Cross, R W Mueller, C Kreuder-Johnson, S Gill, F M D Gulland. Characterization of a degenerative cardiomyopathy associated with domoic acid toxicity in California sea lions (Zalophus californianus). Veterinary pathology. 2009 Jan; 46(1):105-19. doi: 10.1354/vp.46-1-105. [PMID: 19112124]
  • Tracey Goldstein, Tanja S Zabka, Robert L Delong, Elizabeth A Wheeler, Gina Ylitalo, Sibel Bargu, Mary Silver, Tod Leighfield, Frances Van Dolah, Gregg Langlois, Inga Sidor, J Lawrence Dunn, Frances M D Gulland. The role of domoic acid in abortion and premature parturition of California sea lions (Zalophus californianus) on San Miguel Island, California. Journal of wildlife diseases. 2009 Jan; 45(1):91-108. doi: 10.7589/0090-3558-45.1.91. [PMID: 19204339]
  • Yihong Zhang, Naushaba Nayeem, Tim Green. Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding. Molecular pharmacology. 2008 Oct; 74(4):1163-9. doi: 10.1124/mol.108.048819. [PMID: 18664604]
  • Iain Shaw, Aoife O'Reilly, Margaret Charleton, Marian Kane. Development of a high-affinity anti-domoic acid sheep scFv and its use in detection of the toxin in shellfish. Analytical chemistry. 2008 May; 80(9):3205-12. doi: 10.1021/ac7024199. [PMID: 18384202]
  • Elena V Piletska, Fernando Navarro Villoslada, Iva Chianella, Alessandra Bossi, Kal Karim, Michael J Whitcombe, Sergey A Piletsky, Gregory J Doucette, John S Ramsdell. Extraction of domoic acid from seawater and urine using a resin based on 2-(trifluoromethyl)acrylic acid. Analytica chimica acta. 2008 Mar; 610(1):35-43. doi: 10.1016/j.aca.2008.01.032. [PMID: 18267137]
  • Jennifer M Maucher, John S Ramsdell. Maternal-fetal transfer of domoic acid in rats at two gestational time points. Environmental health perspectives. 2007 Dec; 115(12):1743-6. doi: 10.1289/ehp.10446. [PMID: 18087593]
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