5-Nitro-2-(3-phenylpropylamino)benzoic acid (BioDeep_00000009520)
Secondary id: BioDeep_00001875145
human metabolite blood metabolite
代谢物信息卡片
5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB]
化学式: C16H16N2O4 (300.1110016)
中文名称: NPPB
谱图信息:
最多检出来源 Homo sapiens(blood) 99%
分子结构信息
SMILES: C1=CC=C(C=C1)CCCNC2=C(C=C(C=C2)[N+](=O)[O-])C(=O)O
InChI: InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
描述信息
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D006133 - Growth Substances > D006131 - Growth Inhibitors
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:34457
- KEGG: C13705
- PubChem: 4549
- HMDB: HMDB0255766
- Metlin: METLIN44306
- ChEMBL: CHEMBL1256759
- Wikipedia: Ventricular natriuretic peptide
- KNApSAcK: C00049007
- chemspider: 4390
- CAS: 107254-86-4
- PMhub: MS000023312
- PubChem: 586294
- PDB-CCD: 7TH
- NIKKAJI: J402.888K
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaodan Wu, Na Zhang, Jianjun Yu, Min Liang, Haojie Xu, Jiamin Hu, Shizhu Lin, Jingjia Qiu, Caizhu Lin, Weilin Liu, Dajun Chai, Kai Zeng. The underlying mechanism of transcription factor IRF1, PRDM1, and ZNF263 involved in the regulation of NPPB rs3753581 on pulse pressure hypertension.
Gene.
2023 Jun; 878(?):147580. doi:
10.1016/j.gene.2023.147580. [PMID: 37339722] - Markus Hahn, Ulrike M Stamer, Markus M Luedi, Malte Book, Heinz U Rieder, Frank Stüber. ASA Status, NPPA/NPPB Haplotype and Coronary Artery Disease Have an Impact on BNP/NT-proBNP Plasma Levels.
Cells.
2022 02; 11(5):. doi:
10.3390/cells11050766. [PMID: 35269388] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Roberta Costa, Davide Antonio Civello, Emanuele Bernardinelli, Simone Vanoni, Michaela Zopf, Giada Scantamburlo, Charity Nofziger, Wolfgang Patsch, Markus Paulmichl, Silvia Dossena. A Potassium-Selective Current Affected by Micromolar Concentrations of Anion Transport Inhibitors.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(3):867-882. doi:
10.1159/000487282. [PMID: 29421809] - Xian-Chen Zhang, Hong-Jian Gao, Tian-Yuan Yang, Hong-Hong Wu, Yu-Mei Wang, Zheng-Zhu Zhang, Xiao-Chun Wan. Anion Channel Inhibitor NPPB-Inhibited Fluoride Accumulation in Tea Plant (Camellia sinensis) Is Related to the Regulation of Ca²⁺, CaM and Depolarization of Plasma Membrane Potential.
International journal of molecular sciences.
2016 Jan; 17(1):. doi:
10.3390/ijms17010057. [PMID: 26742036] - Emanuele Bernardinelli, Roberta Costa, Charity Nofziger, Markus Paulmichl, Silvia Dossena. Effect of Known Inhibitors of Ion Transport on Pendrin (SLC26A4) Activity in a Human Kidney Cell Line.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(5):1984-98. doi:
10.1159/000445559. [PMID: 27161422] - Alexander G Volkov, Eunice K Nyasani, Clayton Tuckett, Esther A Greeman, Vladislav S Markin. Electrophysiology of pumpkin seeds: Memristors in vivo.
Plant signaling & behavior.
2016; 11(4):e1151600. doi:
10.1080/15592324.2016.1151600. [PMID: 26926652] - Misuk Cho, Elizabeth M Henry, Daniel R Lewis, Guosheng Wu, Gloria K Muday, Edgar P Spalding. Block of ATP-binding cassette B19 ion channel activity by 5-nitro-2-(3-phenylpropylamino)-benzoic acid impairs polar auxin transport and root gravitropism.
Plant physiology.
2014 Dec; 166(4):2091-9. doi:
10.1104/pp.114.250860. [PMID: 25324509] - Kai Zheng, Maoyun Chen, Yangfei Xiang, Kaiqi Ma, Fujun Jin, Xiao Wang, Xiaoyan Wang, Shaoxiang Wang, Yifei Wang. Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.
Biochemical and biophysical research communications.
2014 Apr; 446(4):990-6. doi:
10.1016/j.bbrc.2014.03.050. [PMID: 24657267] - Takayuki Suzuki, Jun Suzuki, Shigekazu Nagata. Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
The Journal of biological chemistry.
2014 Mar; 289(11):7438-47. doi:
10.1074/jbc.m113.542324. [PMID: 24478309] - Min-hua Zhang, Xiao-dong Zhuang, Jing-ning Weng. [The effects of chloride channel inhibitor on bFGF-induced proliferation of lens epithelial cells].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology.
2013 Nov; 49(11):1014-9. doi:
NULL. [PMID: 24513004] - Bing Shen, Xiang Li, Fei Wang, Xiaoqiang Yao, Dan Yang. A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells.
PloS one.
2012; 7(4):e34694. doi:
10.1371/journal.pone.0034694. [PMID: 22514656] - Isaac Zepeda-Jazo, Ana María Velarde-Buendía, René Enríquez-Figueroa, Jayakumar Bose, Sergey Shabala, Jesús Muñiz-Murguía, Igor I Pottosin. Polyamines interact with hydroxyl radicals in activating Ca(2+) and K(+) transport across the root epidermal plasma membranes.
Plant physiology.
2011 Dec; 157(4):2167-80. doi:
10.1104/pp.111.179671. [PMID: 21980172] - Bárbara Tavares, Pedro Nuno Dias, Patrícia Domingos, Teresa Fonseca Moura, José Alberto Feijó, Ana Bicho. Calcium-regulated anion channels in the plasma membrane of Lilium longiflorum pollen protoplasts.
The New phytologist.
2011 Oct; 192(1):45-60. doi:
10.1111/j.1469-8137.2011.03780.x. [PMID: 21668885] - Svetlana V Koltsova, Alexandra Platonova, Georgy V Maksimov, Alexander A Mongin, Ryszard Grygorczyk, Sergei N Orlov. Activation of P2Y receptors causes strong and persistent shrinkage of C11-MDCK renal epithelial cells.
American journal of physiology. Cell physiology.
2011 Aug; 301(2):C403-12. doi:
10.1152/ajpcell.00018.2011. [PMID: 21562307] - Suparerk Laohapitakworn, Jirawan Thongbunchoo, La-Iad Nakkrasae, Nateetip Krishnamra, Narattaphol Charoenphandhu. Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO₃⁻ secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH.
American journal of physiology. Cell physiology.
2011 Jul; 301(1):C137-49. doi:
10.1152/ajpcell.00001.2011. [PMID: 21389278] - Liang Hong, Zhi-Zhong Xie, Yan-Hua Du, Yong-Bo Tang, Jing Tao, Xiao-Fei Lv, Jia-Guo Zhou, Yong-Yuan Guan. Alteration of volume-regulated chloride channel during macrophage-derived foam cell formation in atherosclerosis.
Atherosclerosis.
2011 May; 216(1):59-66. doi:
10.1016/j.atherosclerosis.2011.01.035. [PMID: 21338988] - Zhan Yu, Zhi-Xu Zhang, Shenglei Li, Jianbo Gao. Effect of a chloride channel inhibitor, 5-nitro-2-(3-phenylpropylamino)-benzoate, on ovarian cancer cell migration.
Clinical laboratory.
2011; 57(7-8):543-50. doi:
NULL. [PMID: 21888019] - Nao Horio, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, Hiroaki Matsunami, Yuzo Ninomiya. Sour taste responses in mice lacking PKD channels.
PloS one.
2011; 6(5):e20007. doi:
10.1371/journal.pone.0020007. [PMID: 21625513] - M B da Silva, V M A Costa, V R A Pereira, G J B de Albertim, E B B de Melo, D P Bezerra, R P da Silva, C G Rodrigues, C M M Carneiro, L N Yuldasheva, O V Krasilnikov. Ion channels in volume regulation of clonal kidney cells.
Cell proliferation.
2010 Dec; 43(6):529-41. doi:
10.1111/j.1365-2184.2010.00702.x. [PMID: 21039991] - Claudia Sagheddu, Anna Boccaccio, Michele Dibattista, Giorgia Montani, Roberto Tirindelli, Anna Menini. Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
The Journal of physiology.
2010 Nov; 588(Pt 21):4189-204. doi:
10.1113/jphysiol.2010.194407. [PMID: 20837642] - Kun Liu, Manoj Samuel, Melisa Ho, Richard K Harrison, Jeff W Paslay. NPPB structure-specifically activates TRPA1 channels.
Biochemical pharmacology.
2010 Jul; 80(1):113-21. doi:
10.1016/j.bcp.2010.03.005. [PMID: 20226176] - Magaly Rincon-Zachary. A possible mechanism and sequence of events that lead to the Al3+-induced [Ca2+]cyt transients and inhibition of root growth.
Plant signaling & behavior.
2010 Jul; 5(7):881-4. doi:
10.4161/psb.5.7.11973. [PMID: 20495379] - Edyta Glogowska, Agnieszka Dyrda, Anne Cueff, Guillaume Bouyer, Stéphane Egée, Poul Bennekou, Serge L Y Thomas. Anion conductance of the human red cell is carried by a maxi-anion channel.
Blood cells, molecules & diseases.
2010 Apr; 44(4):243-51. doi:
10.1016/j.bcmd.2010.02.014. [PMID: 20226698] - Hana Inoue, Nobuyuki Takahashi, Yasunobu Okada, Masato Konishi. Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.
American journal of physiology. Cell physiology.
2010 Apr; 298(4):C900-9. doi:
10.1152/ajpcell.00450.2009. [PMID: 20107039] - Marco Milanese, Simona Zappettini, Emanuela Jacchetti, Tiziana Bonifacino, Chiara Cervetto, Cesare Usai, Giambattista Bonanno. In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry.
2010 Apr; 113(2):489-501. doi:
10.1111/j.1471-4159.2010.06628.x. [PMID: 20132478] - Ruisheng Liu, Luis A Juncos. GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Feb; 298(2):R453-8. doi:
10.1152/ajpregu.00622.2009. [PMID: 20007513] - Antonella Gradogna, Michael Pusch. Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels.
Frontiers in pharmacology.
2010; 1(?):130. doi:
10.3389/fphar.2010.00130. [PMID: 21833170] - Luciene R Carraro-Lacroix, Lucília M A Lessa, Camila N A Bezerra, Thaíssa D Pessoa, Jackson Souza-Menezes, Marcelo M Morales, Adriana C C Girardi, Gerhard Malnic. Role of CFTR and ClC-5 in modulating vacuolar H+-ATPase activity in kidney proximal tubule.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 26(4-5):563-76. doi:
10.1159/000322324. [PMID: 21063094] - Svjetlana Dolovcak, Shar L Waldrop, J Gregory Fitz, Gordan Kilic. 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) stimulates cellular ATP release through exocytosis of ATP-enriched vesicles.
The Journal of biological chemistry.
2009 Dec; 284(49):33894-903. doi:
10.1074/jbc.m109.046193. [PMID: 19808682] - Miguel Prudêncio, Elvira T Derbyshire, Catarina A Marques, Sanjeev Krishna, Maria M Mota, Henry M Staines. Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells.
Cellular microbiology.
2009 Oct; 11(10):1492-501. doi:
10.1111/j.1462-5822.2009.01342.x. [PMID: 19496788] - Canan Akkaya, Ekaterina Shumilina, Diwakar Bobballa, Verena B Brand, Hasan Mahmud, Florian Lang, Stephan M Huber. The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway.
Pflugers Archiv : European journal of physiology.
2009 Mar; 457(5):1035-47. doi:
10.1007/s00424-008-0572-8. [PMID: 18696103] - Weihong Ma, Hui Hui, Pablo Pelegrin, Annmarie Surprenant. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):409-18. doi:
10.1124/jpet.108.146365. [PMID: 19023039] - Cui Yang, Y W Kwan, S W Seto, George P H Leung. Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle.
Prostaglandins & other lipid mediators.
2008 Dec; 87(1-4):62-7. doi:
10.1016/j.prostaglandins.2008.08.003. [PMID: 18812234] - Jesús M Banales, Tatyana V Masyuk, Pamela S Bogert, Bing Q Huang, Sergio A Gradilone, Seung-Ok Lee, Angela J Stroope, Anatoliy I Masyuk, Juan F Medina, Nicholas F LaRusso. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
The American journal of pathology.
2008 Dec; 173(6):1637-46. doi:
10.2353/ajpath.2008.080125. [PMID: 18988797] - Stephan M Huber, Camelia Lang, Florian Lang, Christophe Duranton. Organic osmolyte channels in malaria-infected erythrocytes.
Biochemical and biophysical research communications.
2008 Nov; 376(3):514-8. doi:
10.1016/j.bbrc.2008.09.036. [PMID: 18804454] - Christa W Habela, Michelle L Olsen, Harald Sontheimer. ClC3 is a critical regulator of the cell cycle in normal and malignant glial cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Sep; 28(37):9205-17. doi:
10.1523/jneurosci.1897-08.2008. [PMID: 18784301] - William Silverman, Silviu Locovei, Gerhard Dahl. Probenecid, a gout remedy, inhibits pannexin 1 channels.
American journal of physiology. Cell physiology.
2008 Sep; 295(3):C761-7. doi:
10.1152/ajpcell.00227.2008. [PMID: 18596212] - Dhana Raj Boina, Edwin E Lewis, Jeffrey R Bloomquist. Nematicidal activity of anion transport blockers against Meloidogyne incognita, Caenorhabditis elegans and Heterorhabditis bacteriophora.
Pest management science.
2008 Jun; 64(6):646-53. doi:
10.1002/ps.1591. [PMID: 18407564] - DaZheng Wu, Zhibi Hu. Rutaecarpine induces chloride secretion across rat isolated distal colon.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):256-66. doi:
10.1124/jpet.107.131961. [PMID: 18187619] - K Ondrias, L Malekova, O Krizanova. Potassium-chloride promiscuous channels in mitochondrial membranes.
General physiology and biophysics.
2008 Mar; 27(1):38-44. doi:
". [PMID: 18436982] - Anaïs Merckx, Marie-Paule Nivez, Guillaume Bouyer, Pietro Alano, Gordon Langsley, Kirk Deitsch, Serge Thomas, Christian Doerig, Stéphane Egée. Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance.
PLoS pathogens.
2008 Feb; 4(2):e19. doi:
10.1371/journal.ppat.0040019. [PMID: 18248092] - Teruo Shimmen. Electrophysiological characterization of the node in Chara corallina: functional differentiation for wounding response.
Plant & cell physiology.
2008 Feb; 49(2):264-72. doi:
10.1093/pcp/pcn002. [PMID: 18182401] - S J Liu, Y M Sun, D F Tian, Y C He, L Zeng, Y He, C Q Ling, S H Sun. Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma.
British journal of cancer.
2008 Jan; 98(2):363-9. doi:
10.1038/sj.bjc.6604167. [PMID: 18219290] - Yasuhito Taniguchi, Hiroko Tonai-Kachi, Katsuhiro Shinjo. 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist.
Pharmacology.
2008; 82(4):245-9. doi:
10.1159/000157625. [PMID: 18818509] - Angélica López-Rodríguez, Alfonso Cárabez Trejo, Leanne Coyne, Robert F Halliwell, Ricardo Miledi, Ataúlfo Martínez-Torres. The product of the gene GEF1 of Saccharomyces cerevisiae transports Cl- across the plasma membrane.
FEMS yeast research.
2007 Dec; 7(8):1218-29. doi:
10.1111/j.1567-1364.2007.00279.x. [PMID: 17662057] - Shinsaku Tokuda, Naomi Niisato, Yoshinori Marunaka. Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.
Biochemical and biophysical research communications.
2007 Nov; 363(3):566-71. doi:
10.1016/j.bbrc.2007.08.187. [PMID: 17888879] - Lubica Malekova, Jana Tomaskova, Marie Novakova, Peter Stefanik, Juraj Kopacek, Boris Lakatos, Silvia Pastorekova, Olga Krizanova, Albert Breier, Karol Ondrias. Inhibitory effect of DIDS, NPPB, and phloretin on intracellular chloride channels.
Pflugers Archiv : European journal of physiology.
2007 Nov; 455(2):349-57. doi:
10.1007/s00424-007-0300-9. [PMID: 17611769] - Hui Zhang, Nadia Ameen, James E Melvin, Sadasivan Vidyasagar. Acute inflammation alters bicarbonate transport in mouse ileum.
The Journal of physiology.
2007 Jun; 581(Pt 3):1221-33. doi:
10.1113/jphysiol.2007.129262. [PMID: 17395634] - Hiroaki Miyazaki, Atsushi Shiozaki, Naomi Niisato, Yoshinori Marunaka. Physiological significance of hypotonicity-induced regulatory volume decrease: reduction in intracellular Cl- concentration acting as an intracellular signaling.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1411-7. doi:
10.1152/ajprenal.00244.2006. [PMID: 17244897] - Takuto Fujii, Yuta Ohira, Yasuo Itomi, Yuji Takahashi, Shinji Asano, Magotoshi Morii, Noriaki Takeguchi, Hideki Sakai. Inhibition of P-type ATPases by [(dihydroindenyl)oxy]acetic acid (DIOA), a K+ -Cl- cotransporter inhibitor.
European journal of pharmacology.
2007 Apr; 560(2-3):123-6. doi:
10.1016/j.ejphar.2006.12.031. [PMID: 17303113] - L X Chen, L Y Zhu, T J C Jacob, L W Wang. Roles of volume-activated Cl- currents and regulatory volume decrease in the cell cycle and proliferation in nasopharyngeal carcinoma cells.
Cell proliferation.
2007 Apr; 40(2):253-67. doi:
10.1111/j.1365-2184.2007.00432.x. [PMID: 17472731] - Henry M Staines, Abdulnaser Alkhalil, Richard J Allen, Hugo R De Jonge, Elvira Derbyshire, Stéphane Egée, Hagai Ginsburg, David A Hill, Stephan M Huber, Kiaran Kirk, Florian Lang, Godfrey Lisk, Eugene Oteng, Ajay D Pillai, Kempaiah Rayavara, Sherin Rouhani, Kevin J Saliba, Crystal Shen, Tsione Solomon, Serge L Y Thomas, Patrick Verloo, Sanjay A Desai. Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
International journal for parasitology.
2007 Apr; 37(5):475-82. doi:
10.1016/j.ijpara.2006.12.013. [PMID: 17292372] - Lauren Johnston, Gary Laverty. Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2007 Mar; 146(3):327-34. doi:
10.1016/j.cbpa.2006.11.025. [PMID: 17258485] - Akira Takahashi, Shin-ichi Miyoshi, Noriko Takata, Masayuki Nakano, Akiko Hamamoto, Kazuaki Mawatari, Nagakatsu Harada, Sumio Shinoda, Yutaka Nakaya. Haemolysin produced by Vibrio mimicus activates two Cl- secretory pathways in cultured intestinal-like Caco-2 cells.
Cellular microbiology.
2007 Mar; 9(3):583-95. doi:
10.1111/j.1462-5822.2006.00809.x. [PMID: 17026482] - S L'Hoste, H Barriere, R Belfodil, I Rubera, C Duranton, M Tauc, C Poujeol, J Barhanin, P Poujeol. Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.
American journal of physiology. Renal physiology.
2007 Feb; 292(2):F628-38. doi:
10.1152/ajprenal.00132.2006. [PMID: 17003225] - Edward A Lock, Celia J Reed, Gilbert R Kinsey, Rick G Schnellmann. Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells.
Toxicology.
2007 Jan; 229(1-2):79-90. doi:
10.1016/j.tox.2006.10.003. [PMID: 17097791] - Masaaki Nakayama, Jyunzo Hisatsune, Eiki Yamasaki, Yoshito Nishi, Akihiro Wada, Hisao Kurazono, Jan Sap, Kinnosuke Yahiro, Joel Moss, Toshiya Hirayama. Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 Cells.
Infection and immunity.
2006 Dec; 74(12):6571-80. doi:
10.1128/iai.00356-06. [PMID: 17030583] - Renaud Beauwens, Len Best, Nicolas Markadieu, Raphael Crutzen, Karim Louchami, Peter Brown, Allen P Yates, Willy J Malaisse, Abdullah Sener. Stimulus-secretion coupling of hypotonicity-induced insulin release in BRIN-BD11 cells.
Endocrine.
2006 Dec; 30(3):353-63. doi:
10.1007/s12020-006-0014-3. [PMID: 17526948] - Yan-Li Pi, Ji-Hua Ma, Pei-Hua Zhang, Jing-Jing Duan. [Calcium-dependent chloride channels in plasma membrane of oocytes from toad, Bufo bufo gargarizans].
Sheng li xue bao : [Acta physiologica Sinica].
2006 Oct; 58(5):471-6. doi:
. [PMID: 17041732] - N Lambot, P Lybaert, A Boom, J Delogne-Desnoeck, A M Vanbellinghen, G Graff, P Lebrun, S Meuris. Evidence for a clathrin-mediated recycling of albumin in human term placenta.
Biology of reproduction.
2006 Jul; 75(1):90-7. doi:
10.1095/biolreprod.105.050021. [PMID: 16495477] - Yohkazu Matsushima, Shigeaki Muto, Junichi Taniguchi, Masashi Imai. Mechanism of iodide transport in the rabbit cortical collecting duct.
Clinical and experimental nephrology.
2006 Jun; 10(2):102-10. doi:
10.1007/s10157-006-0417-8. [PMID: 16791395] - Kaa-Sandra N Chee, Joerg Kistler, Paul J Donaldson. Roles for KCC transporters in the maintenance of lens transparency.
Investigative ophthalmology & visual science.
2006 Feb; 47(2):673-82. doi:
10.1167/iovs.05-0336. [PMID: 16431967] - Anna Segalla, Ildiko Szabo, Paola Costantini, Giorgio Mario Giacometti. Study of the effect of ion channel modulators on photosynthetic oxygen evolution.
Journal of chemical information and modeling.
2005 Nov; 45(6):1691-700. doi:
10.1021/ci0501802. [PMID: 16309275] - Shin-Ichiro Fujimoto, Naomi Niisato, Tohru Sugimoto, Yoshinori Marunaka. Quercetin and NPPB-induced diminution of aldosterone action on Na+ absorption and ENaC expression in renal epithelium.
Biochemical and biophysical research communications.
2005 Oct; 336(2):401-7. doi:
10.1016/j.bbrc.2005.08.096. [PMID: 16129409] - Aliye Uc, Russell F Husted, Radhamma L Giriyappa, Bradley E Britigan, John B Stokes. Hemin induces active chloride secretion in Caco-2 cells.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Aug; 289(2):G202-8. doi:
10.1152/ajpgi.00518.2004. [PMID: 15805100] - Tomoko Ueda-Nishimura, Naomi Niisato, Hiroaki Miyazaki, Yuji Naito, Norimasa Yoshida, Toshikazu Yoshikawa, Hoyoku Nishino, Yoshinori Marunaka. Synergic action of insulin and genistein on Na+/K+/2Cl- cotransporter in renal epithelium.
Biochemical and biophysical research communications.
2005 Jul; 332(4):1042-52. doi:
10.1016/j.bbrc.2005.05.046. [PMID: 15925323] - Susan Pratt, Robert L Shepard, Ramani A Kandasamy, Paul A Johnston, William Perry, Anne H Dantzig. The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Molecular cancer therapeutics.
2005 May; 4(5):855-63. doi:
10.1158/1535-7163.mct-04-0291. [PMID: 15897250] - Luca Raiteri, Sara Stigliani, Laura Patti, Cesare Usai, Giovanna Bucci, Alberto Diaspro, Maurizio Raiteri, Giambattista Bonanno. Activation of gamma-aminobutyric acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal.
Journal of neuroscience research.
2005 May; 80(3):424-33. doi:
10.1002/jnr.20437. [PMID: 15789377] - Pauline Cavelier, David Attwell. Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices.
The Journal of physiology.
2005 Apr; 564(Pt 2):397-410. doi:
10.1113/jphysiol.2004.082131. [PMID: 15695241] - Paul Linsdell. Location of a common inhibitor binding site in the cytoplasmic vestibule of the cystic fibrosis transmembrane conductance regulator chloride channel pore.
The Journal of biological chemistry.
2005 Mar; 280(10):8945-50. doi:
10.1074/jbc.m414354200. [PMID: 15634668] - Chiz-Tzung Chang, Marcelle Bens, Edith Hummler, Sheerazed Boulkroun, Laurent Schild, Jacques Teulon, Bernard C Rossier, Alain Vandewalle. Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome.
The Journal of physiology.
2005 Jan; 562(Pt 1):271-84. doi:
10.1113/jphysiol.2004.077933. [PMID: 15513933] - S S Garber, M A Messerli, M Hubert, R Lewis, K Hammar, E Indyk, P J S Smith. Monitoring Cl- movement in single cells exposed to hypotonic solution.
The Journal of membrane biology.
2005 Jan; 203(2):101-10. doi:
10.1007/s00232-005-0735-x. [PMID: 15981714] - Florian Nolte, Oliver Friedrich, Markus Rojewski, Rainer H A Fink, Hubert Schrezenmeier, Sixten Körper. Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells.
FEBS letters.
2004 Dec; 578(1-2):85-9. doi:
10.1016/j.febslet.2004.10.075. [PMID: 15581621] - Hongyu Li, Iain A Findlay, David N Sheppard. The relationship between cell proliferation, Cl- secretion, and renal cyst growth: a study using CFTR inhibitors.
Kidney international.
2004 Nov; 66(5):1926-38. doi:
10.1111/j.1523-1755.2004.00967.x. [PMID: 15496164] - Ling Wei, Ai Ying Xiao, Chun Jin, Aizhen Yang, Zhong Yang Lu, Shan Ping Yu. Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons.
Pflugers Archiv : European journal of physiology.
2004 Jun; 448(3):325-34. doi:
10.1007/s00424-004-1277-2. [PMID: 15057559] - Nils C Gauthier, Vittorio Ricci, Pierre Gounon, Anne Doye, Michel Tauc, Philippe Poujeol, Patrice Boquet. Glycosylphosphatidylinositol-anchored proteins and actin cytoskeleton modulate chloride transport by channels formed by the Helicobacter pylori vacuolating cytotoxin VacA in HeLa cells.
The Journal of biological chemistry.
2004 Mar; 279(10):9481-9. doi:
10.1074/jbc.m312040200. [PMID: 14676190] - Antonella Liantonio, Michael Pusch, Alessandra Picollo, Patrizia Guida, Annamaria De Luca, Sabata Pierno, Giuseppe Fracchiolla, Fulvio Loiodice, Paolo Tortorella, Diana Conte Camerino. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers.
Journal of the American Society of Nephrology : JASN.
2004 Jan; 15(1):13-20. doi:
10.1097/01.asn.0000103226.28798.ea. [PMID: 14694153] - N P Matveyeva, D S Andreyuk, I P Yermakov. Transport of Cl- across the plasma membrane during pollen grain germination in tobacco.
Biochemistry. Biokhimiia.
2003 Nov; 68(11):1247-51. doi:
10.1023/b:biry.0000009140.50032.3d. [PMID: 14640968] - M Wegmann, R M Nüsing. Prostaglandin E2 stimulates sodium reabsorption in MDCK C7 cells, a renal collecting duct principal cell model.
Prostaglandins, leukotrienes, and essential fatty acids.
2003 Nov; 69(5):315-22. doi:
10.1016/j.plefa.2003.06.002. [PMID: 14580365] - M L Olsen, S Schade, S A Lyons, M D Amaral, H Sontheimer. Expression of voltage-gated chloride channels in human glioma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003 Jul; 23(13):5572-82. doi:
. [PMID: 12843258] - Mayandi Sivaguru, Sharon Pike, Walter Gassmann, Tobias I Baskin. Aluminum rapidly depolymerizes cortical microtubules and depolarizes the plasma membrane: evidence that these responses are mediated by a glutamate receptor.
Plant & cell physiology.
2003 Jul; 44(7):667-75. doi:
10.1093/pcp/pcg094. [PMID: 12881494] - H Barrière, I Rubera, R Belfodil, M Tauc, N Tonnerieux, C Poujeol, J Barhanin, P Poujeol. Swelling-activated chloride and potassium conductance in primary cultures of mouse proximal tubules. Implication of KCNE1 protein.
The Journal of membrane biology.
2003 Jun; 193(3):153-70. doi:
10.1007/s00232-003-2014-z. [PMID: 12962276] - Gary Laverty, Colleen McWilliams, Amanda Sheldon, Sighvatur S Arnason. PTH stimulates a Cl(-)-dependent and EIPA-sensitive current in chick proximal tubule cells in culture.
American journal of physiology. Renal physiology.
2003 May; 284(5):F987-95. doi:
10.1152/ajprenal.00281.2002. [PMID: 12505864] - Ya-Juan Zheng, Tetsushi Furukawa, Kimitaka Tajimi, Nobuya Inagaki. Cl- channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle.
Journal of cellular physiology.
2003 Mar; 194(3):376-83. doi:
10.1002/jcp.10218. [PMID: 12548557] - Kristian R Giles, Mark Humphries, Andrew Abell, Ashley Garrill. The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K+ channels of the alga Nitella hookeri.
Bioorganic & medicinal chemistry letters.
2003 Jan; 13(2):293-5. doi:
10.1016/s0960-894x(02)00920-4. [PMID: 12482443] - E K Hoffmann, E Hoffmann, F Lang, J A Zadunaisky. Control of Cl- transport in the operculum epithelium of Fundulus heteroclitus: long- and short-term salinity adaptation.
Biochimica et biophysica acta.
2002 Nov; 1566(1-2):129-39. doi:
10.1016/s0005-2736(02)00587-4. [PMID: 12421544] - Jia Wang, Laura D Carbone, Mitchell A Watsky. Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes.
Investigative ophthalmology & visual science.
2002 Oct; 43(10):3202-8. doi:
NULL. [PMID: 12356825] - Laura Zonia, Sofia Cordeiro, Jaroslav Tupý, José A Feijó. Oscillatory chloride efflux at the pollen tube apex has a role in growth and cell volume regulation and is targeted by inositol 3,4,5,6-tetrakisphosphate.
The Plant cell.
2002 Sep; 14(9):2233-49. doi:
. [PMID: 12215517] - Naomi Niisato, Kyosuke Nishio, Yoshinori Marunaka. Activation of CFTR Cl(-) channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells.
Life sciences.
2002 Jul; 71(10):1199-207. doi:
10.1016/s0024-3205(02)01824-6. [PMID: 12095540] - Jean-Marc Philippe, Jean-Marc Dubois, Beatrice Rouzaire-Dubois, Pierre-François Cartron, François Vallette, Nicolas Morel. Functional expression of V-ATPases in the plasma membrane of glial cells.
Glia.
2002 Mar; 37(4):365-73. doi:
10.1002/glia.10041. [PMID: 11870875] - Wen Liu, Tetsuji Morimoto, Yoshiaki Kondo, Kazuie Iinuma, Shinichi Uchida, Sei Sasaki, Fumiaki Marumo, Masashi Imai. Analysis of NaCl transport in thin ascending limb of Henle's loop in CLC-K1 null mice.
American journal of physiology. Renal physiology.
2002 Mar; 282(3):F451-7. doi:
10.1152/ajprenal.0192.2001. [PMID: 11832425] - Y Ren, H Yu, H Wang, O A Carretero, J L Garvin. Nystatin and valinomycin induce tubuloglomerular feedback.
American journal of physiology. Renal physiology.
2001 Dec; 281(6):F1102-8. doi:
10.1152/ajprenal.00357.2000. [PMID: 11704561] - X Wang, K Haga, Y Nishizaki, M Iino. Blue-light-dependent osmoregulation in protoplasts of Phaseolus vulgaris Pulvini.
Plant & cell physiology.
2001 Dec; 42(12):1363-72. doi:
10.1093/pcp/pce173. [PMID: 11773529] - A Mithöfer, J Fliegmann, A Daxberger, C Ebel, G Neuhaus-Url, A A Bhagwat, D L Keister, J Ebel. Induction of H(2)O(2) synthesis by beta-glucan elicitors in soybean is independent of cytosolic calcium transients.
FEBS letters.
2001 Nov; 508(2):191-5. doi:
10.1016/s0014-5793(01)03054-x. [PMID: 11718714] - B Noh, A S Murphy, E P Spalding. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development.
The Plant cell.
2001 Nov; 13(11):2441-54. doi:
10.1105/tpc.010350. [PMID: 11701880] - M Iino, C Long, X Wang. Auxin- and abscisic acid-dependent osmoregulation in protoplasts of Phaseolus vulgaris pulvini.
Plant & cell physiology.
2001 Nov; 42(11):1219-27. doi:
10.1093/pcp/pce157. [PMID: 11726706] - F Tombola, L Morbiato, G Del Giudice, R Rappuoli, M Zoratti, E Papini. The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia.
The Journal of clinical investigation.
2001 Sep; 108(6):929-37. doi:
10.1172/jci13045. [PMID: 11560962] - M Bens, J P Duong Van Huyen, F Cluzeaud, J Teulon, A Vandewalle. CFTR disruption impairs cAMP-dependent Cl(-) secretion in primary cultures of mouse cortical collecting ducts.
American journal of physiology. Renal physiology.
2001 Sep; 281(3):F434-42. doi:
10.1152/ajprenal.2001.281.3.f434. [PMID: 11502593]