Rifamycin (BioDeep_00000009058)
PANOMIX_OTCML-2023 Chemicals and Drugs
代谢物信息卡片
Rifamycin SV
化学式: C37H47NO12 (697.3098102)
中文名称: 利福霉素, 利福霉素
谱图信息:
最多检出来源 Homo sapiens(blood) 0.18%
分子结构信息
SMILES: C1(=CC2NC(=O)C(=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]([C@@H](OC)C=CO[C@]3(C)C(C4=C(C(C)=C(O)C(=C41)C=2O)O3)=O)C)C)O
InChI: InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
描述信息
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AB - Antibiotics
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
S - Sensory organs > S02 - Otologicals > S02A - Antiinfectives > S02AA - Antiinfectives
Same as: D02549
同义名列表
3 个代谢物同义名
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:29673
- ChEBI: CHEBI:26580
- KEGG: C12044
- KEGGdrug: D02549
- PubChem: 6324616
- PubChem: 60907
- Metlin: METLIN41003
- DrugBank: DB11753
- ChEMBL: CHEMBL437765
- LipidMAPS: LMPK05000005
- MeSH: Rifamycins
- CAS: 15105-92-7
- CAS: 6998-60-3
- PMhub: MS000022795
- MetaboLights: MTBLC29673
- PubChem: 14199
- 3DMET: B04414
- NIKKAJI: J8.871D
- RefMet: Rifamycin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 168697 Salinispora arenicola: 10.1021/NP0604580
- 168697 Salinispora arenicola: 10.1021/NP0604580
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yu Wang, Han Fu, Xiao-Jie Shi, Guo-Ping Zhao, Liang-Dong Lyu. Genome-wide screen reveals cellular functions that counteract rifampicin lethality in Escherichia coli.
Microbiology spectrum.
2024 Jan; 12(1):e0289523. doi:
10.1128/spectrum.02895-23. [PMID: 38054714] - Junxiong Cheng, Yafang Chen, Wenfu Cao, Guoqing Zuo. Is rifaximin better than nonabsorbable disaccharides in hepatic encephalopathy?: A meta-analysis.
Medicine.
2021 Dec; 100(51):e28232. doi:
10.1097/md.0000000000028232. [PMID: 34941089] - Khadija A M Glal, Sherief M Abd-Elsalam, Tarek M Mostafa. Nitazoxanide versus rifaximin in preventing the recurrence of hepatic encephalopathy: A randomized double-blind controlled trial.
Journal of hepato-biliary-pancreatic sciences.
2021 Oct; 28(10):812-824. doi:
10.1002/jhbp.947. [PMID: 33768619] - Qiang Zhou, Shu-Ya Peng, Kai Zhang, Guang-Cai Luo, Li Han, Qing-Li He, Gong-Li Tang. A Flavin-Dependent Monooxygenase Mediates Divergent Oxidation of Rifamycin.
Organic letters.
2021 03; 23(6):2342-2346. doi:
10.1021/acs.orglett.1c00485. [PMID: 33683897] - Ying Yuan, Xiaomei Wang, Xiangyi Xu, Yu Liu, Cancan Li, Meng Yang, Yiqing Yang, Zhenkun Ma. Evaluation of a Dual-Acting Antibacterial Agent, TNP-2092, on Gut Microbiota and Potential Application in the Treatment of Gastrointestinal and Liver Disorders.
ACS infectious diseases.
2020 05; 6(5):820-831. doi:
10.1021/acsinfecdis.9b00374. [PMID: 31849218] - A Abdeljelil, A Mahjoub, O Fekih, N Ben Abdessalem, H Mahjoub. [Ligneous conjunctivitis: A diagnosis to consider in the case of a lingering pseudomembranous conjunctivitis!].
Journal francais d'ophtalmologie.
2019 12; 42(10):1139-1142. doi:
10.1016/j.jfo.2019.06.004. [PMID: 31262596] - Pierre Eke, Aundy Kumar, Kuleshwar Prasad Sahu, Louise Nana Wakam, Neelam Sheoran, Mushineni Ashajyothi, Asharani Patel, Fabrice Boyom Fekam. Endophytic bacteria of desert cactus (Euphorbia trigonas Mill) confer drought tolerance and induce growth promotion in tomato (Solanum lycopersicum L.).
Microbiological research.
2019 Nov; 228(?):126302. doi:
10.1016/j.micres.2019.126302. [PMID: 31442862] - Rong Deng, Chenguang Zhou, Dongwei Li, Hao Cai, Siddharth Sukumaran, Montserrat Carrasco-Triguero, Ola Saad, Denise Nazzal, Christopher Lowe, Saroja Ramanujan, Amrita V Kamath. Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus.
mAbs.
2019 Aug; 11(6):1162-1174. doi:
10.1080/19420862.2019.1627152. [PMID: 31219754] - Yanrong Shi, Juanli Zhang, Xiuyu Tian, Xingkang Wu, Tianhong Li, Chunhua Lu, Yuemao Shen. Isolation of 11,12- seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain.
Organic letters.
2019 02; 21(4):900-903. doi:
10.1021/acs.orglett.8b03792. [PMID: 30714736] - Christian Schulz, Kerstin Schütte, Ramiro Vilchez-Vargas, Riccardo Vasapolli, Peter Malfertheiner. Long-Term Effect of Rifaximin with and without Lactulose on the Active Bacterial Assemblages in the Proximal Small Bowel and Faeces in Patients with Minimal Hepatic Encephalopathy.
Digestive diseases (Basel, Switzerland).
2019; 37(2):161-169. doi:
10.1159/000494216. [PMID: 30428474] - Yuhui Zhang, Yixuan Zhang, Peng Li, Ying Wang, Jin Wang, Zhihui Shao, Guoping Zhao. GlnR positive transcriptional regulation of the phosphate-specific transport system pstSCAB in Amycolatopsis mediterranei U32.
Acta biochimica et biophysica Sinica.
2018 Aug; 50(8):757-765. doi:
10.1093/abbs/gmy073. [PMID: 30007316] - Feifei Qi, Chao Lei, Fengwei Li, Xingwang Zhang, Jin Wang, Wei Zhang, Zhen Fan, Weichao Li, Gong-Li Tang, Youli Xiao, Guoping Zhao, Shengying Li. Deciphering the late steps of rifamycin biosynthesis.
Nature communications.
2018 06; 9(1):2342. doi:
10.1038/s41467-018-04772-x. [PMID: 29904078] - Emílio V Lage, Joana Magalhães, Marina Pinheiro, Salette Reis. Effect of the alkyl group in the piperazine N-substitution on the therapeutic action of rifamycins: A drug-membrane interaction study.
Chemico-biological interactions.
2018 Jun; 289(?):75-80. doi:
10.1016/j.cbi.2018.04.027. [PMID: 29709589] - Bradley Reuter, Kara Walter, Julien Bissonnette, Michael D Leise, Jennifer Lai, Puneeta Tandon, Patrick S Kamath, Scott W Biggins, Christopher F Rose, James B Wade, Jasmohan S Bajaj. Assessment of the spectrum of hepatic encephalopathy: A multicenter study.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2018 05; 24(5):587-594. doi:
10.1002/lt.25032. [PMID: 29457869] - S W Zhu, Z J Liu, M Li, H Q Zhu, L P Duan. [Comparison of gut microbiotal compositional analysis of patients with irritable bowel syndrome through different bioinformatics pipelines].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2018 Apr; 50(2):231-238. doi:
NULL. [PMID: 29643520] - Chao Lei, Jingzhi Wang, Yuanyuan Liu, Xinqiang Liu, Guoping Zhao, Jin Wang. A feedback regulatory model for RifQ-mediated repression of rifamycin export in Amycolatopsis mediterranei.
Microbial cell factories.
2018 Jan; 17(1):14. doi:
10.1186/s12934-018-0863-5. [PMID: 29375035] - Nina Kimer, Julie S Pedersen, Juliette Tavenier, Jeffrey E Christensen, Troels M Busk, Lise Hobolth, Aleksander Krag, Waleed Abu Al-Soud, Martin S Mortensen, Søren J Sørensen, Søren Møller, Flemming Bendtsen. Rifaximin has minor effects on bacterial composition, inflammation, and bacterial translocation in cirrhosis: A randomized trial.
Journal of gastroenterology and hepatology.
2018 Jan; 33(1):307-314. doi:
10.1111/jgh.13852. [PMID: 28671712] - Kosuke Kaji, Hiroaki Takaya, Soichiro Saikawa, Masanori Furukawa, Shinya Sato, Hideto Kawaratani, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Akira Mitoro, Hitoshi Yoshiji. Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity.
World journal of gastroenterology.
2017 Dec; 23(47):8355-8366. doi:
10.3748/wjg.v23.i47.8355. [PMID: 29307995] - Agnieszka Gawronska, Marcin Banasiuk, Dominika Lachowicz, Hanna Pituch, Piotr Albrecht, Aleksandra Banaszkiewicz. Metronidazole or Rifaximin for Treatment of Clostridium difficile in Pediatric Patients with Inflammatory Bowel Disease: A Randomized Clinical Trial.
Inflammatory bowel diseases.
2017 12; 23(12):2209-2214. doi:
10.1097/mib.0000000000001249. [PMID: 29084080] - Seung Kak Shin, Oh Sang Kwon, Jong Joon Lee, Yeon Ho Park, Cheol Soo Choi, Sung Hwan Jeong, Duck Joo Choi, Yun Soo Kim, Ju Hyun Kim. Effect of Rifaximin on Hepatic Fibrosis in Bile Duct-ligated Rat Model.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi.
2017 Nov; 70(5):239-246. doi:
10.4166/kjg.2017.70.5.239. [PMID: 29161793] - El-Sayed Ibrahim, Ayman Alsebaey, Hassan Zaghla, Sabry Moawad Abdelmageed, Khalid Gameel, Eman Abdelsameea. Long-term rifaximin therapy as a primary prevention of hepatorenal syndrome.
European journal of gastroenterology & hepatology.
2017 Nov; 29(11):1247-1250. doi:
10.1097/meg.0000000000000967. [PMID: 28902040] - Chen Li, Li Zhou, Ying Wang, Guoping Zhao, Xiaoming Ding. Conjugation of ϕBT1-derived integrative plasmid pDZL802 in Amycolatopsis mediterranei U32.
Bioengineered.
2017 Sep; 8(5):549-554. doi:
10.1080/21655979.2016.1270808. [PMID: 28045587] - M Pimentel, B D Cash, A Lembo, R A Wolf, R J Israel, P Schoenfeld. Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity.
Digestive diseases and sciences.
2017 09; 62(9):2455-2463. doi:
10.1007/s10620-017-4598-7. [PMID: 28589238] - Kiran Ahire, Archana Sonawale. Comparison of Rifaximin Plus Lactulose with the Lactulose Alone for the Treatment of Hepatic Encephalopathy.
The Journal of the Association of Physicians of India.
2017 Aug; 65(8):42-46. doi:
NULL. [PMID: 28799305] - Yi-An Bi, Renato J Scialis, Sarah Lazzaro, Sumathy Mathialagan, Emi Kimoto, Julie Keefer, Hui Zhang, Anna M Vildhede, Chester Costales, A David Rodrigues, Larry M Tremaine, Manthena V S Varma. Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.
The AAPS journal.
2017 05; 19(3):787-796. doi:
10.1208/s12248-017-0051-2. [PMID: 28188574] - Michael Camilleri, Guy Boeckxstaens. Dietary and pharmacological treatment of abdominal pain in IBS.
Gut.
2017 05; 66(5):966-974. doi:
10.1136/gutjnl-2016-313425. [PMID: 28232472] - Chen Li, Xinqiang Liu, Chao Lei, Han Yan, Zhihui Shao, Ying Wang, Guoping Zhao, Jin Wang, Xiaoming Ding. RifZ (AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei.
Applied and environmental microbiology.
2017 04; 83(8):. doi:
10.1128/aem.03201-16. [PMID: 28159794] - Nina Kimer, Julie Steen Pedersen, Troels Malte Busk, Lise Lotte Gluud, Lise Hobolth, Aleksander Krag, Søren Møller, Flemming Bendtsen. Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double-blind, placebo-controlled trial.
Hepatology (Baltimore, Md.).
2017 02; 65(2):592-603. doi:
10.1002/hep.28898. [PMID: 27775818] - Wolfgang Stremmel, Kathrin V Schmidt, Vera Schuhmann, Frank Kratzer, Sven F Garbade, Claus-Dieter Langhans, Gert Fricker, Jürgen G Okun. Blood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine.
PloS one.
2017; 12(1):e0170742. doi:
10.1371/journal.pone.0170742. [PMID: 28129384] - James H Tabibian, Andrea Gossard, Mounif El-Youssef, John E Eaton, Jan Petz, Roberta Jorgensen, Felicity B Enders, Anilga Tabibian, Keith D Lindor. Prospective Clinical Trial of Rifaximin Therapy for Patients With Primary Sclerosing Cholangitis.
American journal of therapeutics.
2017 Jan; 24(1):e56-e63. doi:
10.1097/mjt.0000000000000102. [PMID: 24914504] - Amr S Hanafy, Ahmad M Hassaneen. Rifaximin and midodrine improve clinical outcome in refractory ascites including renal function, weight loss, and short-term survival.
European journal of gastroenterology & hepatology.
2016 Dec; 28(12):1455-1461. doi:
10.1097/meg.0000000000000743. [PMID: 27622998] - Tien Dong, Andrew Aronsohn, K Gautham Reddy, Helen S Te. Rifaximin Decreases the Incidence and Severity of Acute Kidney Injury and Hepatorenal Syndrome in Cirrhosis.
Digestive diseases and sciences.
2016 12; 61(12):3621-3626. doi:
10.1007/s10620-016-4313-0. [PMID: 27655104] - Emma C Stevenson, Giles A Major, Robin C Spiller, Sarah A Kuehne, Nigel P Minton. Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection.
Journal of clinical microbiology.
2016 11; 54(11):2689-2694. doi:
10.1128/jcm.01025-16. [PMID: 27558181] - Alam García-Heredia, Santos García, José Ángel Merino-Mascorro, Peter Feng, Norma Heredia. Natural plant products inhibits growth and alters the swarming motility, biofilm formation, and expression of virulence genes in enteroaggregative and enterohemorrhagic Escherichia coli.
Food microbiology.
2016 Oct; 59(?):124-32. doi:
10.1016/j.fm.2016.06.001. [PMID: 27375253] - Natalia Zeber-Lubecka, Maria Kulecka, Filip Ambrozkiewicz, Agnieszka Paziewska, Krzysztof Goryca, Jakub Karczmarski, Tymon Rubel, Wojciech Wojtowicz, Piotr Mlynarz, Lukasz Marczak, Roman Tomecki, Michal Mikula, Jerzy Ostrowski. Limited prolonged effects of rifaximin treatment on irritable bowel syndrome-related differences in the fecal microbiome and metabolome.
Gut microbes.
2016 09; 7(5):397-413. doi:
10.1080/19490976.2016.1215805. [PMID: 27662586] - Todd J Zurlinden, Garrett J Eppers, Brad Reisfeld. Physiologically Based Pharmacokinetic Model of Rifapentine and 25-Desacetyl Rifapentine Disposition in Humans.
Antimicrobial agents and chemotherapy.
2016 08; 60(8):4860-8. doi:
10.1128/aac.00031-16. [PMID: 27270284] - M Assem, M Elsabaawy, M Abdelrashed, S Elemam, S Khodeer, W Hamed, A Abdelaziz, G El-Azab. Efficacy and safety of alternating norfloxacin and rifaximin as primary prophylaxis for spontaneous bacterial peritonitis in cirrhotic ascites: a prospective randomized open-label comparative multicenter study.
Hepatology international.
2016 Mar; 10(2):377-85. doi:
10.1007/s12072-015-9688-z. [PMID: 26660707] - Matteo Fornai, Luca Antonioli, Carolina Pellegrini, Rocchina Colucci, Deborah Sacco, Erika Tirotta, Gianfranco Natale, Alessia Bartalucci, Marina Flaibani, Cecilia Renzulli, Emilia Ghelardi, Corrado Blandizzi, Carmelo Scarpignato. Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic.
Pharmacological research.
2016 Feb; 104(?):186-96. doi:
10.1016/j.phrs.2015.12.031. [PMID: 26747402] - M Pimentel. Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea.
Alimentary pharmacology & therapeutics.
2016 Jan; 43 Suppl 1(?):37-49. doi:
10.1111/apt.13437. [PMID: 26618924] - J S Bajaj. Review article: potential mechanisms of action of rifaximin in the management of hepatic encephalopathy and other complications of cirrhosis.
Alimentary pharmacology & therapeutics.
2016 Jan; 43 Suppl 1(?):11-26. doi:
10.1111/apt.13435. [PMID: 26618922] - Qingchen Li, Feifei Dai, Liping Zhu, Jiawei Wang, Yun Jing. [Ocular syndromes in patients with neurobrucellosis].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology.
2015 Dec; 51(12):896-900. doi:
. [PMID: 26888270] - Xin Zeng, Xia Jiao Tang, Xia Sheng, Wu Ni, Hai Guang Xin, Wei Zhong Chen, Cai Feng Jiang, Yong Lin, Jian Shi, Bin Shi, Yue Xiang Chen, Zong Li Yuan, Wei Fen Xie. Does low-dose rifaximin ameliorate endotoxemia in patients with liver cirrhosis: a prospective study.
Journal of digestive diseases.
2015 Nov; 16(11):665-74. doi:
10.1111/1751-2980.12294. [PMID: 26474237] - Heather M Mascio, Christie A Joya, Richard A Plasse, Thomas P Baker, Michael F Flessner, Robert Nee. An unusual cause of acute kidney injury due to oxalate nephropathy in systemic scleroderma.
Clinical nephrology.
2015 Aug; 84(2):111-5. doi:
10.5414/cn108406. [PMID: 25500295] - Naiara Orrego-Lagarón, Miriam Martínez-Huélamo, Anna Vallverdú-Queralt, Rosa M Lamuela-Raventos, Elvira Escribano-Ferrer. High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism.
The British journal of nutrition.
2015 Jul; 114(2):169-80. doi:
10.1017/s0007114515001671. [PMID: 26083965] - Venkatanarayana Gangarapu, Ali Tüzün Ince, Birol Baysal, Yusuf Kayar, Ulkan Kılıç, Özlem Gök, Ömer Uysal, Hakan Şenturk. Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease.
European journal of gastroenterology & hepatology.
2015 Jul; 27(7):840-5. doi:
10.1097/meg.0000000000000348. [PMID: 26043290] - Zhi Hui Shao, Shuang Xi Ren, Xin Qiang Liu, Jian Xu, Han Yan, Guo Ping Zhao, Jin Wang. A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq.
Microbial cell factories.
2015 Jun; 14(?):75. doi:
10.1186/s12934-015-0264-y. [PMID: 26041361] - Tarek Mostafa, Gamal Badra, Mahmoud Abdallah. The efficacy and the immunomodulatory effect of rifaximin in prophylaxis of spontaneous bacterial peritonitis in cirrhotic Egyptian patients.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2015 Mar; 26(2):163-9. doi:
10.5152/tjg.2015.7782. [PMID: 25835116] - Lee C Winchester, Anthony T Podany, Joshua S Baldwin, Brian L Robbins, Courtney V Fletcher. Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS.
Journal of pharmaceutical and biomedical analysis.
2015 Feb; 104(?):55-61. doi:
10.1016/j.jpba.2014.11.011. [PMID: 25481085] - Corrado Blandizzi, Giuseppe Claudio Viscomi, Carmelo Scarpignato. Impact of crystal polymorphism on the systemic bioavailability of rifaximin, an antibiotic acting locally in the gastrointestinal tract, in healthy volunteers.
Drug design, development and therapy.
2015; 9(?):1-11. doi:
10.2147/dddt.s72572. [PMID: 25565769] - Jennifer M Colquhoun, Rachel A F Wozniak, Paul M Dunman. Clinically Relevant Growth Conditions Alter Acinetobacter baumannii Antibiotic Susceptibility and Promote Identification of Novel Antibacterial Agents.
PloS one.
2015; 10(11):e0143033. doi:
10.1371/journal.pone.0143033. [PMID: 26558753] - Ali A Wahib, M Negm El-Deen Salem, Mostafa A Ahmed, Yasser M M El-Dessouky, Diaa M El-Tiby, Khaled El-Mola, Abeer M El-Sayed. Evaluation of rifaximin in management of hepatic encephalopathy.
Journal of the Egyptian Society of Parasitology.
2014 Dec; 44(3):677-85. doi:
10.12816/0007871. [PMID: 25643509] - Valérie Martel-Laferrière, Caitlin Homberger, Kian Bichoupan, Douglas T Dieterich. MELD score and antibiotics use are predictors of length of stay in patients hospitalized with hepatic encephalopathy.
BMC gastroenterology.
2014 Oct; 14(?):185. doi:
10.1186/1471-230x-14-185. [PMID: 25326084] - Corrado Blandizzi, Giuseppe Claudio Viscomi, Antonio Marzo, Carmelo Scarpignato. Is generic rifaximin still a poorly absorbed antibiotic? A comparison of branded and generic formulations in healthy volunteers.
Pharmacological research.
2014 Jul; 85(?):39-44. doi:
10.1016/j.phrs.2014.05.001. [PMID: 24836868] - William M Geisler, Maria Luz G Pascual, Judy Mathew, William D Koltun, Franklin Morgan, Byron E Batteiger, Annette Mayes, Sijia Tao, Selwyn J Hurwitz, Chalom Sayada, Raymond F Schinazi. Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women.
Antimicrobial agents and chemotherapy.
2014 Jul; 58(7):4014-9. doi:
10.1128/aac.02521-14. [PMID: 24798277] - Alfonso Fasano, Francesco Bove, Maurizio Gabrielli, Enzo Ragazzoni, Serena Fortuna, Annalisa Tortora, Maria Assunta Zocco, Stefano Marconi, Antonio Gasbarrini, Anna Rita Bentivoglio. Liquid melevodopa versus standard levodopa in patients with Parkinson disease and small intestinal bacterial overgrowth.
Clinical neuropharmacology.
2014 Jul; 37(4):91-5. doi:
10.1097/wnf.0000000000000034. [PMID: 24992085] - Mario Regazzi, Anna Cristina Carvalho, Paola Villani, Alberto Matteelli. Treatment optimization in patients co-infected with HIV and Mycobacterium tuberculosis infections: focus on drug-drug interactions with rifamycins.
Clinical pharmacokinetics.
2014 Jun; 53(6):489-507. doi:
10.1007/s40262-014-0144-3. [PMID: 24777631] - Lisa N Patel, Jason Schairer, Bo Shen. Fecal transplantation therapy for Clostridium difficile-associated pouchitis.
International journal of colorectal disease.
2014 Feb; 29(2):263-4. doi:
10.1007/s00384-013-1771-0. [PMID: 24132529] - Abdel-Nasser Kawde, Yassein Temerk, Nasser Farhan. Adsorptive stripping voltammetry of antibiotics rifamycin SV and rifampicin at renewable pencil electrodes.
Acta chimica Slovenica.
2014; 61(2):398-405. doi:
NULL. [PMID: 25125124] - Susan E Knudson, Divya Awasthi, Kunal Kumar, Alexandra Carreau, Laurent Goullieux, Sophie Lagrange, Hélèn Vermet, Iwao Ojima, Richard A Slayden. A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.
PloS one.
2014; 9(4):e93953. doi:
10.1371/journal.pone.0093953. [PMID: 24736743] - Mi-Sung Kim, Walter Morales, Andres Ardila Hani, Sharon Kim, Gene Kim, Stacy Weitsman, Christopher Chang, Mark Pimentel. The effect of rifaximin on gut flora and Staphylococcus resistance.
Digestive diseases and sciences.
2013 Jun; 58(6):1676-82. doi:
10.1007/s10620-013-2675-0. [PMID: 23589147] - Aneesh S Patel, Elisa M Supan, Shereef N Ali. Toxic epidermal necrolysis associated with rifaximin.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2013 May; 70(10):874-6. doi:
10.2146/ajhp120137. [PMID: 23640348] - Muna Qayed, Amelia Langston, Kuang-Yueh Chiang, Keith August, Joseph A Hilinski, Conrad R Cole, Andre Rogatko, Roberd M Bostick, John T Horan. Rifaximin for preventing acute graft-versus-host disease: impact on plasma markers of inflammation and T-cell activation.
Journal of pediatric hematology/oncology.
2013 May; 35(4):e149-52. doi:
10.1097/mph.0b013e31827e56af. [PMID: 23274384] - Genta Kakiyama, William M Pandak, Patrick M Gillevet, Phillip B Hylemon, Douglas M Heuman, Kalyani Daita, Hajime Takei, Akina Muto, Hiroshi Nittono, Jason M Ridlon, Melanie B White, Nicole A Noble, Pamela Monteith, Michael Fuchs, Leroy R Thacker, Masoumeh Sikaroodi, Jasmohan S Bajaj. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis.
Journal of hepatology.
2013 May; 58(5):949-55. doi:
10.1016/j.jhep.2013.01.003. [PMID: 23333527] - Guy W Neff, Michael Jones, Mark Jonas, Ravi Ravinuthala, David Novick, Tiffany E Kaiser, Nyingi Kemmer. Lack of Clostridium difficile infection in patients treated with rifaximin for hepatic encephalopathy: a retrospective analysis.
Journal of clinical gastroenterology.
2013 Feb; 47(2):188-92. doi:
10.1097/mcg.0b013e318276be13. [PMID: 23314671] - Jasmohan S Bajaj, Douglas M Heuman, Arun J Sanyal, Phillip B Hylemon, Richard K Sterling, R Todd Stravitz, Michael Fuchs, Jason M Ridlon, Kalyani Daita, Pamela Monteith, Nicole A Noble, Melanie B White, Andmorgan Fisher, Masoumeh Sikaroodi, Huzefa Rangwala, Patrick M Gillevet. Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy.
PloS one.
2013; 8(4):e60042. doi:
10.1371/journal.pone.0060042. [PMID: 23565181] - Jie Cheng, Kristopher W Krausz, Naoki Tanaka, Frank J Gonzalez. Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):456-68. doi:
10.1093/toxsci/kfs211. [PMID: 22790967] - Mohamad A Hanouneh, Ibrahim A Hanouneh, Jana G Hashash, Ryan Law, Jamak Modaresi Esfeh, Rocio Lopez, Nyla Hazratjee, Thomas Smith, Nizar N Zein. The role of rifaximin in the primary prophylaxis of spontaneous bacterial peritonitis in patients with liver cirrhosis.
Journal of clinical gastroenterology.
2012 Sep; 46(8):709-15. doi:
10.1097/mcg.0b013e3182506dbb. [PMID: 22878533] - Ramisetti Nageswara Rao, Rajavarapu Mastan Vali, Alamanda Vara Prasada Rao. Determination of rifaximin in rat serum by ionic liquid based dispersive liquid-liquid microextraction combined with RP-HPLC.
Journal of separation science.
2012 Aug; 35(15):1945-52. doi:
10.1002/jssc.201200202. [PMID: 22753340] - Georgios N Kalambokis, Athanasia Mouzaki, Maria Rodi, Konstantinos Pappas, Andreas Fotopoulos, Xanthi Xourgia, Epameinondas V Tsianos. Rifaximin improves systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2012 Jul; 10(7):815-8. doi:
10.1016/j.cgh.2012.02.025. [PMID: 22391344] - Gemma Odena, Mireia Miquel, Anna Serafín, Amparo Galan, Rosa Morillas, Ramon Planas, Ramon Bartolí. Rifaximin, but not growth factor 1, reduces brain edema in cirrhotic rats.
World journal of gastroenterology.
2012 May; 18(17):2084-91. doi:
10.3748/wjg.v18.i17.2084. [PMID: 22563196] - Sumandeep K Gill, Hao Xu, Paul D Kirchhoff, Tomasz Cierpicki, Anjanette J Turbiak, Baojie Wan, Nan Zhang, Kuan-Wei Peng, Scott G Franzblau, George A Garcia, H D Hollis Showalter. Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.
Journal of medicinal chemistry.
2012 Apr; 55(8):3814-26. doi:
10.1021/jm201716n. [PMID: 22452568] - Georgios N Kalambokis, Athanasia Mouzaki, Maria Rodi, Epameinondas V Tsianos. Rifaximin improves thrombocytopenia in patients with alcoholic cirrhosis in association with reduction of endotoxaemia.
Liver international : official journal of the International Association for the Study of the Liver.
2012 Mar; 32(3):467-75. doi:
10.1111/j.1478-3231.2011.02650.x. [PMID: 22098272] - Karim M Eltawil, Marie Laryea, Kevork Peltekian, Michele Molinari. Rifaximin vs. conventional oral therapy for hepatic encephalopathy: a meta-analysis.
World journal of gastroenterology.
2012 Feb; 18(8):767-77. doi:
10.3748/wjg.v18.i8.767. [PMID: 22371636] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758. [PMID: 21965623] - Jasmohan S Bajaj, Jason M Ridlon, Phillip B Hylemon, Leroy R Thacker, Douglas M Heuman, Sean Smith, Masoumeh Sikaroodi, Patrick M Gillevet. Linkage of gut microbiome with cognition in hepatic encephalopathy.
American journal of physiology. Gastrointestinal and liver physiology.
2012 Jan; 302(1):G168-75. doi:
10.1152/ajpgi.00190.2011. [PMID: 21940902] - Hua Yuan, Wei Zhao, Yi Zhong, Jin Wang, Zhongjun Qin, Xiaoming Ding, Guo-Ping Zhao. Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B.
Acta biochimica et biophysica Sinica.
2011 Dec; 43(12):948-56. doi:
10.1093/abbs/gmr091. [PMID: 21986914] - Zhihui Shao, Jin Gao, Xiaoming Ding, Jin Wang, Juishen Chiao, Guoping Zhao. Identification and functional analysis of a nitrate assimilation operon nasACKBDEF from Amycolatopsis mediterranei U32.
Archives of microbiology.
2011 Jul; 193(7):463-77. doi:
10.1007/s00203-011-0690-0. [PMID: 21424691] - Mark Pimentel, Walter Morales, Sam-Ryong Jee, Kimberly Low, Laura Hwang, Venkata Pokkunuri, Jim Mirocha, Jeffrey Conklin, Christopher Chang. Antibiotic prophylaxis prevents the development of a post-infectious phenotype in a new rat model of post-infectious IBS.
Digestive diseases and sciences.
2011 Jul; 56(7):1962-6. doi:
10.1007/s10620-010-1548-z. [PMID: 21222158] - A F D Di Stefano, A Rusca, L Loprete, M J Dröge, L Moro, A Assandri. Systemic absorption of rifamycin SV MMX administered as modified-release tablets in healthy volunteers.
Antimicrobial agents and chemotherapy.
2011 May; 55(5):2122-8. doi:
10.1128/aac.01504-10. [PMID: 21402860] - A G Evdokimova, A É Radzevich, A V Tomova, V V Evdokimov, E V Kovalenko, L V Zhukolenko. [Optimization of treatment of patients with chronic cardiac insufficiency of the ischemic genesis and hobnail liver].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
2011; 56(5-6):64-8. doi:
NULL. [PMID: 22145233] - Simone Maccaferri, Beatrice Vitali, Annett Klinder, Sofia Kolida, Maurice Ndagijimana, Luca Laghi, Fiorella Calanni, Patrizia Brigidi, Glenn R Gibson, Adele Costabile. Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system.
The Journal of antimicrobial chemotherapy.
2010 Dec; 65(12):2556-65. doi:
10.1093/jac/dkq345. [PMID: 20852272] - M Furnari, A Parodi, L Gemignani, E G Giannini, S Marenco, E Savarino, L Assandri, V Fazio, D Bonfanti, S Inferrera, V Savarino. Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth.
Alimentary pharmacology & therapeutics.
2010 Oct; 32(8):1000-6. doi:
10.1111/j.1365-2036.2010.04436.x. [PMID: 20937045] - Wei Zhao, Yi Zhong, Hua Yuan, Jin Wang, Huajun Zheng, Ying Wang, Xufeng Cen, Feng Xu, Jie Bai, Xiaobiao Han, Gang Lu, Yongqiang Zhu, Zhihui Shao, Han Yan, Chen Li, Nanqiu Peng, Zilong Zhang, Yunyi Zhang, Wei Lin, Yun Fan, Zhongjun Qin, Yongfei Hu, Baoli Zhu, Shengyue Wang, Xiaoming Ding, Guo-Ping Zhao. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.
Cell research.
2010 Oct; 20(10):1096-108. doi:
10.1038/cr.2010.87. [PMID: 20567260] - Feray Kockar, Selma Sinan, Hatice Yildirim, Oktay Arslan. Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro.
Journal of enzyme inhibition and medicinal chemistry.
2010 Oct; 25(5):715-9. doi:
10.3109/14756360903555266. [PMID: 20429781] - P Sharma, V E Holmes, R Elsby, C Lambert, D Surry. Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions.
Xenobiotica; the fate of foreign compounds in biological systems.
2010 Jan; 40(1):24-37. doi:
10.3109/00498250903351013. [PMID: 19919292] - R Nageswara Rao, R Mastan Vali, Dhananjay D Shinde. On-line 2D-LC-ESI/MS/MS determination of rifaximin in rat serum.
Biomedical chromatography : BMC.
2009 Nov; 23(11):1145-50. doi:
10.1002/bmc.1236. [PMID: 19444797] - Indi Trehan, Robert J Shulman, Ching-Nan Ou, Kenneth Maleta, Mark J Manary. A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy.
The American journal of gastroenterology.
2009 Sep; 104(9):2326-33. doi:
10.1038/ajg.2009.270. [PMID: 19491826] - R Nageswara Rao, Dhananjay D Shinde, Sachin B Agawane. Rapid determination of rifaximin in rat serum and urine by direct injection on to a shielded hydrophobic stationary phase by HPLC.
Biomedical chromatography : BMC.
2009 Jun; 23(6):563-7. doi:
10.1002/bmc.1149. [PMID: 19101925] - J Vlachogiannakos, A S Saveriadis, N Viazis, I Theodoropoulos, K Foudoulis, S Manolakopoulos, S Raptis, D G Karamanolis. Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis.
Alimentary pharmacology & therapeutics.
2009 May; 29(9):992-9. doi:
10.1111/j.1365-2036.2009.03958.x. [PMID: 19210289] - S M Finegold, D Molitoris, M-L Väisänen. Study of the in vitro activities of rifaximin and comparator agents against 536 anaerobic intestinal bacteria from the perspective of potential utility in pathology involving bowel flora.
Antimicrobial agents and chemotherapy.
2009 Jan; 53(1):281-6. doi:
10.1128/aac.00441-08. [PMID: 18955526] - Antonio Tursi, Giovanni Brandimarte, Walter Elisei, Gian Marco Giorgetti, Cosimo Damiano Inchingolo, Fabio Aiello. Faecal calprotectin in colonic diverticular disease: a case-control study.
International journal of colorectal disease.
2009 Jan; 24(1):49-55. doi:
10.1007/s00384-008-0595-9. [PMID: 18941760] - Eric Garver, Erin D Hugger, Shawn P Shearn, Anuradha Rao, Paul A Dawson, Charles B Davis, Chao Han. Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Dec; 36(12):2492-8. doi:
10.1124/dmd.108.022285. [PMID: 18755851] - NULL. [Bacterially induced traveler's diarrhea. Local antibiosis effective without systemic effects].
MMW Fortschritte der Medizin.
2008 Nov; 150(45):48-9. doi:
NULL. [PMID: 19058391] - Vadim V Mozhaev, Lyudmila V Mozhaeva, Peter C Michels, Yuri L Khmelnitsky. Extractive biotransformation for production of metabolites of poorly soluble compounds: synthesis of 32-hydroxy-rifalazil.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Oct; 36(10):1998-2004. doi:
10.1124/dmd.108.021832. [PMID: 18606743] - David N Taylor, Robin McKenzie, Anna Durbin, Colleen Carpenter, Robert Haake, A Louis Bourgeois. Systemic pharmacokinetics of rifaximin in volunteers with shigellosis.
Antimicrobial agents and chemotherapy.
2008 Mar; 52(3):1179-81. doi:
10.1128/aac.01108-07. [PMID: 18086855] - Marita Larsson, Feng Han. Determination of rifalazil in dog plasma by liquid-liquid extraction and LC-MS/MS: quality assessment by incurred sample analysis.
Journal of pharmaceutical and biomedical analysis.
2007 Nov; 45(4):616-24. doi:
10.1016/j.jpba.2007.09.006. [PMID: 17942263] - Ji-Dong Yang, Shi-Xing Deng, Zhong-Fang Liu, Ling Kong, Shao-Pu Liu. Fluorescence quenching of serum albumin by rifamycin antibiotics and their analytical application.
Luminescence : the journal of biological and chemical luminescence.
2007 Nov; 22(6):559-66. doi:
10.1002/bio.1001. [PMID: 17768708] - Ernesto Cristiano Lauritano, Anna Lisa Bilotta, Maurizio Gabrielli, Emidio Scarpellini, Andrea Lupascu, Antonio Laginestra, Marialuisa Novi, Sandra Sottili, Michele Serricchio, Giovanni Cammarota, Giovanni Gasbarrini, Alfredo Pontecorvi, Antonio Gasbarrini. Association between hypothyroidism and small intestinal bacterial overgrowth.
The Journal of clinical endocrinology and metabolism.
2007 Nov; 92(11):4180-4. doi:
10.1210/jc.2007-0606. [PMID: 17698907] - Marita Larsson, Arthur F Michaelis, Yongdong Zhu, Kumar Ramu. Determination of rifalazil, a potent antibacterial agent, in human plasma by liquid-liquid extraction and LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Nov; 859(1):103-10. doi:
10.1016/j.jchromb.2007.09.013. [PMID: 17936092]