Diprenorphine (BioDeep_00000008876)

   


代谢物信息卡片


Diprenorphine

化学式: C26H35NO4 (425.25659500000006)
中文名称: 地利洛非
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O
InChI: InChI=1S/C26H35NO4/c1-23(2,29)18-13-24-8-9-26(18,30-3)22-25(24)10-11-27(14-15-4-5-15)19(24)12-16-6-7-17(28)21(31-22)20(16)25/h6-7,15,18-19,22,28-29H,4-5,8-14H2,1-3H3/t18-,19-,22-,24-,25+,26-/m1/s1

描述信息

D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist
Same as: D07863

同义名列表

2 个代谢物同义名

Diprenorphine; CHEMBL353979



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono. Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway. Cells. 2021 10; 10(10):. doi: 10.3390/cells10102651. [PMID: 34685631]
  • Shreya S Bellampalli, Yingshi Ji, Aubin Moutal, Song Cai, E M Kithsiri Wijeratne, Maria A Gandini, Jie Yu, Aude Chefdeville, Angie Dorame, Lindsey A Chew, Cynthia L Madura, Shizhen Luo, Gabriella Molnar, May Khanna, John M Streicher, Gerald W Zamponi, A A Leslie Gunatilaka, Rajesh Khanna. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels. Pain. 2019 Jan; 160(1):117-135. doi: 10.1097/j.pain.0000000000001385. [PMID: 30169422]
  • Katy J Sutcliffe, Graeme Henderson, Eamonn Kelly, Richard B Sessions. Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor. Journal of molecular biology. 2017 06; 429(12):1840-1851. doi: 10.1016/j.jmb.2017.05.009. [PMID: 28502792]
  • Nicolas Tournier, Héric Valette, Marie-Anne Peyronneau, Wadad Saba, Sébastien Goutal, Bertrand Kuhnast, Frédéric Dollé, Jean-Michel Scherrmann, Salvatore Cisternino, Michel Bottlaender. Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2011 Mar; 52(3):415-23. doi: 10.2967/jnumed.110.079608. [PMID: 21321274]
  • Chrisostom Ayebazibwe, Frank N Mwiine, Kirsten Tjørnehøj, Sheila N Balinda, Vincent B Muwanika, Anna R Ademun Okurut, Graham J Belsham, Preben Normann, Hans R Siegismund, Soren Alexandersen. The role of African buffalos (Syncerus caffer) in the maintenance of foot-and-mouth disease in Uganda. BMC veterinary research. 2010 Dec; 6(?):54. doi: 10.1186/1746-6148-6-54. [PMID: 21143994]
  • Henning A Haga, Sandra Wenger, Silje Hvarnes, Oystein Os, Christer M Rolandsen, Erling J Solberg. Plasma lactate concentrations in free-ranging moose (Alces alces) immobilized with etorphine. Veterinary anaesthesia and analgesia. 2009 Nov; 36(6):555-61. doi: 10.1111/j.1467-2995.2009.00498.x. [PMID: 19845927]
  • Aurore André, Gérald Gaibelet, Laurent Le Guyader, Michèle Welby, André Lopez, Chantal Lebrun. Membrane partitioning of various delta-opioid receptor forms before and after agonist activations: the effect of cholesterol. Biochimica et biophysica acta. 2008 Jun; 1778(6):1483-92. doi: 10.1016/j.bbamem.2008.03.017. [PMID: 18423369]
  • Peng Huang, Wei Xu, Su-In Yoon, Chongguang Chen, Parkson Lee-Gau Chong, Ellen M Unterwald, Lee-Yuan Liu-Chen. Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells. Brain research. 2007 Dec; 1184(?):46-56. doi: 10.1016/j.brainres.2007.09.096. [PMID: 17980352]
  • Kenneth M Wannemacher, Prem N Yadav, Richard D Howells. A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells. The Journal of pharmacology and experimental therapeutics. 2007 Nov; 323(2):614-25. doi: 10.1124/jpet.107.125500. [PMID: 17720886]
  • Alexander Hammers, Marie-Claude Asselin, Federico E Turkheimer, Rainer Hinz, Safiye Osman, Gary Hotton, David J Brooks, John S Duncan, Matthias J Koepp. Balancing bias, reliability, noise properties and the need for parametric maps in quantitative ligand PET: [(11)C]diprenorphine test-retest data. NeuroImage. 2007 Oct; 38(1):82-94. doi: 10.1016/j.neuroimage.2007.06.035. [PMID: 17764977]
  • Peng Huang, Wei Xu, Su-In Yoon, Chongguang Chen, Parkson Lee-Gau Chong, Lee-Yuan Liu-Chen. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Biochemical pharmacology. 2007 Feb; 73(4):534-49. doi: 10.1016/j.bcp.2006.10.032. [PMID: 17141202]
  • Hui Zhao, Horace H Loh, P Y Law. Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization. Molecular pharmacology. 2006 Apr; 69(4):1421-32. doi: 10.1124/mol.105.020024. [PMID: 16415176]
  • G Henriksen, M E Spilker, T Sprenger, A I Hauser, S Platzer, H Boecker, T R Toelle, M Schwaiger, H-J Wester. Gender dependent rate of metabolism of the opioid receptor-PET ligand [18F]fluoroethyldiprenorphine. Nuklearmedizin. Nuclear medicine. 2006; 45(5):197-200. doi: 10.1055/s-0038-1625219. [PMID: 17043729]
  • Sarah von Spiczak, Alan L Whone, Alexander Hammers, Marie-Claude Asselin, Federico Turkheimer, Tobias Tings, Svenja Happe, Walter Paulus, Claudia Trenkwalder, David J Brooks. The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study. Brain : a journal of neurology. 2005 Apr; 128(Pt 4):906-17. doi: 10.1093/brain/awh441. [PMID: 15728657]
  • Jan K Melichar, Susan P Hume, Tim M Williams, Mark R C Daglish, Lindsay G Taylor, Rabia Ahmad, Andrea L Malizia, David J Brooks, Judith S Myles, Anne Lingford-Hughes, David J Nutt. Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studies. The Journal of pharmacology and experimental therapeutics. 2005 Jan; 312(1):309-15. doi: 10.1124/jpet.104.072686. [PMID: 15347732]
  • Bénédicte G Perret, Renaud Wagner, Sandra Lecat, Karl Brillet, Gwénaël Rabut, Bernard Bucher, Franc Pattus. Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors. Protein expression and purification. 2003 Sep; 31(1):123-32. doi: 10.1016/s1046-5928(03)00140-2. [PMID: 12963349]
  • J Mark Quillan, Kurt W Carlson, Chunyan Song, Danxin Wang, Wolfgang Sadée. Differential effects of mu-opioid receptor ligands on Ca(2+) signaling. The Journal of pharmacology and experimental therapeutics. 2002 Sep; 302(3):1002-12. doi: 10.1124/jpet.302.3.1002. [PMID: 12183657]
  • M Shapira, O Keren, M Gafni, Y Sarne. Divers pathways mediate delta-opioid receptor down regulation within the same cell. Brain research. Molecular brain research. 2001 Nov; 96(1-2):142-50. doi: 10.1016/s0169-328x(01)00283-2. [PMID: 11731019]
  • N A Martin, M T Terruso, P L Prather. Agonist Activity of the delta-antagonists TIPP and TIPP-psi in cellular models expressing endogenous or transfected delta-opioid receptors. The Journal of pharmacology and experimental therapeutics. 2001 Jul; 298(1):240-8. doi: . [PMID: 11408548]
  • R El Kouhen, A L Burd, L J Erickson-Herbrandson, C Y Chang, P Y Law, H H Loh. Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization. The Journal of biological chemistry. 2001 Apr; 276(16):12774-80. doi: 10.1074/jbc.m009571200. [PMID: 11278523]
  • A Hasbi, S Allouche, F Sichel, L Stanasila, D Massotte, G Landemore, J Polastron, P Jauzac. Internalization and recycling of delta-opioid receptor are dependent on a phosphorylation-dephosphorylation mechanism. The Journal of pharmacology and experimental therapeutics. 2000 Apr; 293(1):237-47. doi: NULL. [PMID: 10734175]
  • M Gutiérrez, L Menéndez, A Hidalgo, A Baamonde. Study of the density of opioid receptors in the male mouse brain at different stages of sexual maturation. Methods and findings in experimental and clinical pharmacology. 1999 Sep; 21(7):459-62. doi: NULL. [PMID: 10544387]
  • H K Kramer, E J Simon. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC. Journal of neurochemistry. 1999 Feb; 72(2):594-604. doi: 10.1046/j.1471-4159.1999.0720594.x. [PMID: 9930731]
  • H K Kramer, E J Simon. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. Journal of neurochemistry. 1999 Feb; 72(2):585-93. doi: 10.1046/j.1471-4159.1999.0720585.x. [PMID: 9930730]
  • S Panagiotou, A Hatzoglou, F Calvo, P M Martin, E Castanas. Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems. Journal of cellular biochemistry. 1998 Dec; 71(3):416-28. doi: 10.1002/(sici)1097-4644(19981201)71:3<416::aid-jcb10>3.0.co;2-y. [PMID: 9831078]
  • J G Li, R B Raffa, P Cheung, T B Tzeng, L Y Liu-Chen. Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor. European journal of pharmacology. 1998 Aug; 354(2-3):227-37. doi: 10.1016/s0014-2999(98)00444-0. [PMID: 9754924]
  • R A Weeks, V J Cunningham, P Piccini, S Waters, A E Harding, D J Brooks. 11C-diprenorphine binding in Huntington's disease: a comparison of region of interest analysis with statistical parametric mapping. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1997 Sep; 17(9):943-9. doi: 10.1097/00004647-199709000-00003. [PMID: 9307607]
  • A D Blake, G Bot, S Li, J C Freeman, T Reisine. Differential agonist regulation of the human kappa-opioid receptor. Journal of neurochemistry. 1997 May; 68(5):1846-52. doi: 10.1046/j.1471-4159.1997.68051846.x. [PMID: 9109509]
  • X Zhu, C Wang, Z Cheng, Y Wu, D Zhou, G Pei. The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation. Biochemical and biophysical research communications. 1997 Mar; 232(2):513-6. doi: 10.1006/bbrc.1997.6324. [PMID: 9125212]
  • A D Blake, G Bot, J C Freeman, T Reisine. Differential opioid agonist regulation of the mouse mu opioid receptor. The Journal of biological chemistry. 1997 Jan; 272(2):782-90. doi: 10.1074/jbc.272.2.782. [PMID: 8995364]
  • P Y Law, T M McGinn, K M Campbell, L E Erickson, H H Loh. Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner. Molecular pharmacology. 1997 Jan; 51(1):152-60. doi: 10.1124/mol.51.1.152. [PMID: 9016358]
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  • M C Prevett, V J Cunningham, D J Brooks, D R Fish, J S Duncan. Opiate receptors in idiopathic generalised epilepsy measured with [11C]diprenorphine and positron emission tomography. Epilepsy research. 1994 Sep; 19(1):71-7. doi: 10.1016/0920-1211(94)90090-6. [PMID: 7813416]
  • A K Jones, V J Cunningham, S K Ha-Kawa, T Fujiwara, Q Liyii, S K Luthra, J Ashburner, S Osman, T Jones. Quantitation of [11C]diprenorphine cerebral kinetics in man acquired by PET using presaturation, pulse-chase and tracer-only protocols. Journal of neuroscience methods. 1994 Mar; 51(2):123-34. doi: 10.1016/0165-0270(94)90002-7. [PMID: 8051944]
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