SARIN (BioDeep_00000008854)
Secondary id: BioDeep_00001873675
human metabolite blood metabolite
代谢物信息卡片
methyl(propan-2-yloxy)phosphinoyl fluoride
化学式: C4H10FO2P (140.0402422)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)OP(=O)(C)F
InChI: InChI=1S/C4H10FO2P/c1-4(2)7-8(3,5)6/h4H,1-3H3
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D009676 - Noxae > D011042 - Poisons > D002619 - Chemical Warfare Agents
D004791 - Enzyme Inhibitors
同义名列表
12 个代谢物同义名
methyl(propan-2-yloxy)phosphinoyl fluoride; Phosphonofluoridate, ortho-isopropylmethyl; ortho Isopropylmethyl phosphonofluoridate; ortho-Isopropylmethyl phosphonofluoridate; Isopropyl methylphosphonofluoridic acid; Phosphonofluoridate, O-isopropylmethyl; isopropoxy(methyl)phosphinoyl fluoride; O-Isopropylmethyl phosphonofluoridate; O Isopropylmethyl phosphonofluoridate; Gas, sarin; Sarin gas; SARIN
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:75701
- ChEBI: CHEBI:75873
- KEGG: C11764
- PubChem: 7871
- HMDB: HMDB0257497
- Metlin: METLIN69203
- ChEMBL: CHEMBL509554
- MeSH: Sarin
- chemspider: 7583
- CAS: 107-44-8
- PMhub: MS000022557
- PubChem: 13928
- NIKKAJI: J5.059H
- RefMet: Sarin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Md Abdul Shafeeuulla Khan, Nellore Bhanuchander, Jaggavarapu Satyanarayana Reddy, Venkateswaara Rao Anna, Bishwajit Ganguly. Computational exploration of Cu(II)-en chelate-catalyzed hydrolysis of O-isopropyl methylphosphonofluoridate.
Journal of molecular modeling.
2023 Jun; 29(7):211. doi:
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Analytical methods : advancing methods and applications.
2023 01; 15(2):142-153. doi:
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Nature communications.
2022 09; 13(1):5189. doi:
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Toxicology letters.
2022 Aug; 367(?):48-58. doi:
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Analytical and bioanalytical chemistry.
2021 Nov; 413(28):6973-6985. doi:
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2018 Dec; 296(?):34-42. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
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Neurotoxicology.
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2015 Aug; 238(?):161-9. doi:
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Analytical chemistry.
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Brain and nerve = Shinkei kenkyu no shinpo.
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Chemico-biological interactions.
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Chemico-biological interactions.
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The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):516-24. doi:
10.1124/jpet.108.146639. [PMID: 18984651] - Mieko Kanamori-Kataoka, Yasuo Seto. Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R).
Analytical biochemistry.
2009 Feb; 385(1):94-100. doi:
10.1016/j.ab.2008.09.044. [PMID: 18952040] - Leigh L Swaim, Rudolph C Johnson, Yingtao Zhou, Chris Sandlin, John R Barr. Quantification of organophosphorus nerve agent metabolites using a reduced-volume, high-throughput sample processing format and liquid chromatography-tandem mass spectrometry.
Journal of analytical toxicology.
2008 Nov; 32(9):774-7. doi:
10.1093/jat/32.9.774. [PMID: 19021934] - Ashima Saxena, Wei Sun, Paul A Dabisch, Stanley W Hulet, Nicholas B Hastings, Edward M Jakubowski, Robert J Mioduszewski, Bhupendra P Doctor. Efficacy of human serum butyrylcholinesterase against sarin vapor.
Chemico-biological interactions.
2008 Sep; 175(1-3):267-72. doi:
10.1016/j.cbi.2008.05.022. [PMID: 18597747] - D Jun, L Musilova, K Kuca, J Kassa, J Bajgar. Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.
Chemico-biological interactions.
2008 Sep; 175(1-3):421-4. doi:
10.1016/j.cbi.2008.05.004. [PMID: 18617161] - Shi-Jian Ding, John Carr, James E Carlson, Larry Tong, Weihua Xue, Yifeng Li, Lawrence M Schopfer, Bin Li, Florian Nachon, Oluwatoyin Asojo, Charles M Thompson, Steven H Hinrichs, Patrick Masson, Oksana Lockridge. Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Chemical research in toxicology.
2008 Sep; 21(9):1787-94. doi:
10.1021/tx800144z. [PMID: 18707141] - Jeroen Carol-Visser, Marcel van der Schans, Alex Fidder, Albert G Hulst, Ben L M van Baar, Hubertus Irth, Daan Noort. Development of an automated on-line pepsin digestion-liquid chromatography-tandem mass spectrometry configuration for the rapid analysis of protein adducts of chemical warfare agents.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jul; 870(1):91-7. doi:
10.1016/j.jchromb.2008.06.008. [PMID: 18573700] - Raymond F Genovese, Bernard J Benton, John L Oubre, Patrick J Fleming, E Michael Jakubowski, Robert J Mioduszewski. Determination of miosis threshold from whole-body vapor exposure to sarin in African green monkeys.
Toxicology.
2008 Feb; 244(2-3):123-32. doi:
10.1016/j.tox.2007.11.004. [PMID: 18096290] - R A Evans, E M Jakubowski, W T Muse, K Matson, S W Hulet, R J Mioduszewski, S A Thomson, A L Totura, J A Renner, C L Crouse. Quantification of sarin and cyclosarin metabolites isopropyl methylphosphonic acid and cyclohexyl methylphosphonic acid in minipig plasma using isotope-dilution and liquid chromatography- time-of-flight mass spectrometry.
Journal of analytical toxicology.
2008 Jan; 32(1):78-85. doi:
10.1093/jat/32.1.78. [PMID: 18269798] - Christopher E Whalley, Jeffrey M McGuire, Dennis B Miller, Edward M Jakubowski, Robert J Mioduszewski, Sandra A Thomson, Lucille A Lumley, John H McDonough, Tsung-Ming A Shih. Kinetics of sarin (GB) following a single sublethal inhalation exposure in the guinea pig.
Inhalation toxicology.
2007 Jun; 19(8):667-81. doi:
10.1080/08958370701353296. [PMID: 17510839] - Aharon Levy, Giora Cohen, Eran Gilat, Joseph Kapon, Shlomit Dachir, Shlomo Abraham, Miriam Herskovitz, Zvi Teitelbaum, Lily Raveh. Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning.
Archives of toxicology.
2007 May; 81(5):353-9. doi:
10.1007/s00204-006-0153-6. [PMID: 17009047] - A Bartling, F Worek, L Szinicz, H Thiermann. Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.
Toxicology.
2007 Apr; 233(1-3):166-72. doi:
10.1016/j.tox.2006.07.003. [PMID: 16904809] - Eugenia Bloch-Shilderman, Aharon Levy. Transient and reversible nephrotoxicity of sarin in rats.
Journal of applied toxicology : JAT.
2007 Mar; 27(2):189-94. doi:
10.1002/jat.1204. [PMID: 17154277] - Raymond F Genovese, John L Oubre, E Michael Jakubowski, Patrick J Fleming, Ashima Saxena, Gary A Rockwood, Prasanthi Tipparaju, Catherine B Willmore. Evaluation of cognitive and biochemical effects of low-level exposure to sarin in rhesus and African green monkeys.
Toxicology.
2007 Feb; 231(1):11-20. doi:
10.1016/j.tox.2006.10.018. [PMID: 17126468] - Bin Li, Lawrence M Schopfer, Steven H Hinrichs, Patrick Masson, Oksana Lockridge. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.
Analytical biochemistry.
2007 Feb; 361(2):263-72. doi:
10.1016/j.ab.2006.11.018. [PMID: 17188226] - Jiri Bajgar, Lucie Bartosova, Kamil Kuca, Daniel Jun, Josef Fusek. Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.
Drug and chemical toxicology.
2007; 30(4):351-9. doi:
10.1080/01480540701522395. [PMID: 17934924] - Hidenori Yamasue, Osamu Abe, Kiyoto Kasai, Motomu Suga, Akira Iwanami, Haruyasu Yamada, Mamoru Tochigi, Toshiyuki Ohtani, Mark A Rogers, Tsukasa Sasaki, Shigeki Aoki, Tadafumi Kato, Nobumasa Kato. Human brain structural change related to acute single exposure to sarin.
Annals of neurology.
2007 Jan; 61(1):37-46. doi:
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Arhiv za higijenu rada i toksikologiju.
2006 Dec; 57(4):391-5. doi:
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Inhalation toxicology.
2006 Dec; 18(14):1091-9. doi:
10.1080/08958370600945598. [PMID: 17050346] - N Yanagisawa, H Morita, T Nakajima. Sarin experiences in Japan: acute toxicity and long-term effects.
Journal of the neurological sciences.
2006 Nov; 249(1):76-85. doi:
10.1016/j.jns.2006.06.007. [PMID: 16962140] - P F Zabrodskiĭ, V G Mandych, V G Germanchuk. [Immunostimulant properties of polyoxidon on the model of acute poisoning with anticholinesterase chemicals in rats].
Eksperimental'naia i klinicheskaia farmakologiia.
2006 Nov; 69(6):37-9. doi:
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Journal of enzyme inhibition and medicinal chemistry.
2006 Oct; 21(5):509-14. doi:
10.1080/14756360600730852. [PMID: 17194019] - J Bajgar, J Fusek, L Bartosova, D Jun, K Kuca. Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents.
Journal of applied toxicology : JAT.
2006 Sep; 26(5):439-43. doi:
10.1002/jat.1158. [PMID: 16915560] - Ofer Cohen, Chanoch Kronman, Lily Raveh, Ohad Mazor, Arie Ordentlich, Avigdor Shafferman. Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Molecular pharmacology.
2006 Sep; 70(3):1121-31. doi:
10.1124/mol.106.026179. [PMID: 16801396] - Jie Zhu, Yuguan Ze, Chi Zhang, Yuhui Zang, Haiqin Lu, Ping Chu, Manji Sun, Junchuan Qin. High-level expression of recombinant human paraoxonase 1 Q in silkworm larvae (Bombyx mori).
Applied microbiology and biotechnology.
2006 Aug; 72(1):103-108. doi:
10.1007/s00253-005-0246-9. [PMID: 16331452] - Kouichiro Tsuge, Yasuo Seto. Detection of human butyrylcholinesterase-nerve gas adducts by liquid chromatography-mass spectrometric analysis after in gel chymotryptic digestion.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jun; 838(1):21-30. doi:
10.1016/j.jchromb.2006.02.054. [PMID: 16569519] - Gary B Quistad, Karl J Fisher, Sarah C Owen, Rebecka Klintenberg, John E Casida. Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates.
Toxicology and applied pharmacology.
2005 Jun; 205(2):149-56. doi:
10.1016/j.taap.2004.09.018. [PMID: 15893542] - Mamoru Tochigi, Toshiyuki Otani, Hidenori Yamasue, Kiyoto Kasai, Tadafumi Kato, Akira Iwanami, Nobumasa Kato, Tsukasa Sasaki. Support for relationship between serum cholinesterase and post-traumatic stress disorder; 5-year follow-ups of victims of the Tokyo subway sarin poisoning.
Neuroscience research.
2005 Jun; 52(2):129-31. doi:
10.1016/j.neures.2005.03.012. [PMID: 15876465] - Cuiling Feng, Jianwei Xie. [Determination of five nerve agents in contaminated serum by gas chromatography].
Se pu = Chinese journal of chromatography.
2005 Jan; 23(1):108. doi:
NULL. [PMID: 15881381] - Qing Li, Yukiyo Hirata, Tomoyuki Kawada, Masayasu Minami. Elevated frequency of sister chromatid exchanges of lymphocytes in sarin-exposed victims of the Tokyo sarin disaster 3 years after the event.
Toxicology.
2004 Sep; 201(1-3):209-17. doi:
10.1016/j.tox.2004.04.014. [PMID: 15297034] - Lucie Sevelová, Jirí Bajgar, Ashima Saxena, Bhupendra P Doctor. Protective effect of equine butyrylcholinesterase in inhalation intoxication of rats with sarin: determination of blood and brain cholinesterase activities.
Inhalation toxicology.
2004 Jul; 16(8):531-6. doi:
10.1080/08958370490442511. [PMID: 15204744] - E M Jakubowski, J M McGuire, R A Evans, J L Edwards, S W Hulet, B J Benton, J S Forster, D C Burnett, W T Muse, K Matson, C L Crouse, R J Mioduszewski, S A Thomson. Quantitation of fluoride ion released sarin in red blood cell samples by gas chromatography-chemical ionization mass spectrometry using isotope dilution and large-volume injection.
Journal of analytical toxicology.
2004 Jul; 28(5):357-63. doi:
10.1093/jat/28.5.357. [PMID: 15239856] - Carla E A M Degenhardt, Kees Pleijsier, Marcel J van der Schans, Jan P Langenberg, Kerry E Preston, Maria I Solano, V L Maggio, John R Barr. Improvements of the fluoride reactivation method for the verification of nerve agent exposure.
Journal of analytical toxicology.
2004 Jul; 28(5):364-71. doi:
10.1093/jat/28.5.364. [PMID: 15239857] - Kazim Husain, Satu M Somani. Persistent/delayed toxic effects of low-dose sarin and pyridostigmine under physical stress (exercise) in mice.
Indian journal of physiology and pharmacology.
2004 Apr; 48(2):150-64. doi:
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Central European journal of public health.
2004 Mar; 12 Suppl(?):S80-2. doi:
NULL. [PMID: 15141989] - T K Adams, B R Capacio, J R Smith, C E Whalley, W D Korte. The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples.
Drug and chemical toxicology.
2004 Feb; 27(1):77-91. doi:
10.1081/dct-120027901. [PMID: 15038250] - Kai Tuovinen. Function of plasma and microsomal enzymes in soman toxicity.
Drug and chemical toxicology.
2004 Feb; 27(1):69-75. doi:
10.1081/dct-120027900. [PMID: 15038249] - Yacov Ashani, Shlomi Pistinner. Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model.
Toxicological sciences : an official journal of the Society of Toxicology.
2004 Feb; 77(2):358-67. doi:
10.1093/toxsci/kfh012. [PMID: 14600276] - L Taysse, J-H Calvet, J Buée, D Christin, S Delamanche, P Breton. Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
Toxicology.
2003 Jun; 188(2-3):197-209. doi:
10.1016/s0300-483x(03)00086-6. [PMID: 12767691]