Swerchirin (BioDeep_00000866239)

Main id: BioDeep_00000007870

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


9H-Xanthen-9-one, 1,8-dihydroxy-3,5-dimethoxy- (9CI)

化学式: C15H12O6 (288.0634)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c2c(c1)oc1c(c2=O)c(ccc1OC)O)O)OC
InChI: InChI=1S/C15H12O6/c1-19-7-5-9(17)12-11(6-7)21-15-10(20-2)4-3-8(16)13(15)14(12)18/h3-6,16-17H,1-2H3



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

96 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AIMP2, ANG, ANXA5, BCL2L1, CAT, CDK2, IKBKB, NR3C1, PTGS2
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 2 P4HTM, PTGS2
Mitochondrion membrane 1 BCL2L1
Nucleus 5 AIMP2, ANG, CDK2, IKBKB, NR3C1
cytosol 8 AIMP2, ANG, ANXA5, BCL2L1, CAT, CDK2, IKBKB, NR3C1
nuclear body 1 CSF1
centrosome 3 BCL2L1, CDK2, NR3C1
nucleoplasm 2 CDK2, NR3C1
Cell membrane 2 CSF1, TNF
Cytoplasmic side 2 BCL2L1, GORASP1
Golgi apparatus membrane 1 GORASP1
Synapse 1 NR3C1
cell surface 1 TNF
Golgi apparatus 1 GORASP1
Golgi membrane 2 GORASP1, INS
growth cone 1 ANG
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 ANG, TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 AIMP2, BCL2L1
Lysosome 1 GAA
endosome 1 CDK2
plasma membrane 6 CSF1, CSF2, GAA, IFNLR1, SERPINE1, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 8 AIMP2, ANXA5, CAT, CSF1, GAA, IFNLR1, NR3C1, P4HTM
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, GAA, SERPINE1
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BCL2L1, P4HTM, PTGS2
extracellular space 8 ANG, CSF1, CSF2, IL3, IL6, INS, SERPINE1, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 CSF1
mitochondrion 3 BCL2L1, CAT, NR3C1
protein-containing complex 3 CAT, NR3C1, PTGS2
intracellular membrane-bounded organelle 3 CAT, CSF2, GAA
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 2 CSF1, IFNLR1
Secreted 7 ANG, CSF2, GAA, IL3, IL6, INS, SERPINE1
extracellular region 11 ANG, ANXA5, CAT, CSF1, CSF2, GAA, IL3, IL6, INS, SERPINE1, TNF
cytoplasmic side of plasma membrane 1 IKBKB
Mitochondrion outer membrane 1 BCL2L1
Single-pass membrane protein 1 BCL2L1
mitochondrial outer membrane 1 BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 3 BCL2L1, CAT, NR3C1
transcription regulator complex 1 CDK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 BCL2L1, CDK2, NR3C1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 1 BCL2L1
Bcl-2 family protein complex 1 BCL2L1
nuclear membrane 1 BCL2L1
CD40 receptor complex 1 IKBKB
external side of plasma membrane 2 ANXA5, TNF
actin cytoskeleton 1 ANG
nucleolus 1 ANG
recycling endosome 1 TNF
Single-pass type II membrane protein 2 P4HTM, TNF
Membrane raft 2 IKBKB, TNF
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 2 ANXA5, CAT
spindle 1 NR3C1
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ANXA5, SERPINE1
nuclear speck 1 NR3C1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 1 NR3C1
phagocytic cup 1 TNF
Chromosome 2 ANG, NR3C1
Nucleus, nucleolus 1 ANG
chromosome, telomeric region 1 CDK2
serine/threonine protein kinase complex 1 IKBKB
nuclear envelope 1 CDK2
endosome lumen 1 INS
Nucleus, nucleoplasm 1 NR3C1
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 CSF1, IL6, INS, PTGS2
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 1 SERPINE1
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
vesicle membrane 1 ANXA5
IkappaB kinase complex 1 IKBKB
Cajal body 1 CDK2
ficolin-1-rich granule membrane 1 GAA
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
condensed chromosome 1 CDK2
serine protease inhibitor complex 1 SERPINE1
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
[Isoform Alpha]: Cytoplasm 1 NR3C1
cyclin-dependent protein kinase holoenzyme complex 1 CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
peptidase inhibitor complex 1 SERPINE1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
interleukin-6 receptor complex 1 IL6
CSF1-CSF1R complex 1 CSF1
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Lan Luo, Haibo Zhao, Qian Luo. Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2018 Jan; 23(1):111-116. doi: . [PMID: 29552769]
  • Susanna Phoboo, Marcia Da Silva Pinto, Ana Cristina Lopes Barbosa, Dipayan Sarkar, Prasanta C Bhowmik, Pramod Kumar Jha, Kalidas Shetty. Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst. Phytotherapy research : PTR. 2013 Feb; 27(2):227-35. doi: 10.1002/ptr.4714. [PMID: 22523004]
  • Jing Jia, Tao Chen, Ping Wang, Guichen Chen, Jinmao You, Yongjun Liu, Yulin Li. Preparative separation of methylswertianin, swerchirin and decussatin from the Tibetan medicinal plant Swertia mussotii using high-speed counter-current chromatography. Phytochemical analysis : PCA. 2012 Jul; 23(4):332-6. doi: 10.1002/pca.1362. [PMID: 22052665]
  • Yi Yuan, Baosong Cui, Ying Zhang, Shuai Li. [Xanthones of Comastoma pedunlulatum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jun; 35(12):1577-9. doi: 10.4268/cjcmm20101216. [PMID: 20815211]
  • Jin Zhang, Mi-Jeong Ahn, Qi Shi Sun, Ki-Yoon Kim, Yun Ha Hwang, Jei Man Ryu, Jinwoong Kim. Inhibitors of bone resorption from Halenia corniculata. Archives of pharmacal research. 2008 Jul; 31(7):850-5. doi: 10.1007/s12272-001-1237-y. [PMID: 18704326]
  • Homa Hajimehdipoor, Zhina Sadeghi, Sara Elmi, Azadeh Elmi, Mahmoud Ghazi-Khansari, Yaghoub Amanzadeh, Seyyed-Esmaeal Sadat-Ebrahimi. Protective effects of Swertia longifolia Boiss. and its active compound, swerchirin, on paracetamol-induced hepatotoxicity in mice. The Journal of pharmacy and pharmacology. 2006 Feb; 58(2):277-80. doi: 10.1211/jpp.58.2.0017. [PMID: 16451758]
  • Huiling Yang, Chenxu Ding, Yuanwen Duan, Jianquan Liu. Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. Journal of ethnopharmacology. 2005 Apr; 98(1-2):31-5. doi: 10.1016/j.jep.2004.12.015. [PMID: 15763361]
  • B Q Ya, L C Nian, C Li, X P Gen. Protective effect of swerchirin on hematopoiesis in 60Co-irradiated mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 1999 May; 6(2):85-8. doi: 10.1016/s0944-7113(99)80040-3. [PMID: 10374245]
  • A M Saxena, M B Bajpai, P S Murthy, S K Mukherjee. Mechanism of blood sugar lowering by a swerchirin-containing hexane fraction (SWI) of Swertia chirayita. Indian journal of experimental biology. 1993 Feb; 31(2):178-81. doi: . [PMID: 8500831]
  • M B Bajpai, R K Asthana, N K Sharma, S K Chatterjee, S K Mukherjee. Hypoglycemic effect of swerchirin from the hexane fraction of Swertia chirayita. Planta medica. 1991 Apr; 57(2):102-4. doi: 10.1055/s-2006-960041. [PMID: 1891489]
  • I Agata, H Sekizaki, A Sakushima, S Nishibe, S Hisada, K Kimura. [Studies on the constituents of medicinal plants in Hokkaido. I. On the whole herb of Swertia tetrapetala Pall. (1) (author's transl)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1981 Nov; 101(11):1067-71. doi: 10.1248/yakushi1947.101.11_1067. [PMID: 7343662]