C-1027 (BioDeep_00000008654)

   


代谢物信息卡片


C-1027 Chromophore; C-1027

化学式: C43H42ClN3O13 (843.2406)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1Oc2cc(OC)cc(C(=O)OC3COC(=O)CC(N)c4cc(O)c(c(Cl)c4)OC4C#CC=C3C#CC3=CC=CC34OC3OC(C)(C)C(N(C)C)C(O)C3O)c2NC1=O
InChI: InChI=1S/C43H42ClN3O13/c1-21-39(52)46-34-26(17-25(54-6)18-30(34)56-21)40(53)57-31-20-55-33(49)19-28(45)23-15-27(44)37(29(48)16-23)58-32-11-7-9-22(31)12-13-24-10-8-14-43(24,32)60-41-36(51)35(50)38(47(4)5)42(2,3)59-41/h8-10,14-18,28,31-32,35-36,38,41,48,50-51H,1,19-20,45H2,2-6H3,(H,46,52)/b22-9+/t28-,31-,32+,35-,36+,38-,41-,43+/m0/s1

描述信息

An enediyne antibiotic that has formula C43H42ClN3O13. It is a natural product found in Streptomyces globisporus and exhibits antimicrobial and antineoplastic properties.
A natural product found in Streptomyces globisporus and Streptomyces globisporus.
D000970 - Antineoplastic Agents

同义名列表

3 个代谢物同义名

C-1027 Chromophore; C-1027; C-1027 Chromophore; C-1027



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ALB, ANXA5, BCL2, CASP3, CASP7, CASP8, CHEK2, EGFR, ERBB2, MAPK14, VEGFA
Peripheral membrane protein 1 ANXA5
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 3 BCL2, CYP51A1, EGFR
Nucleus 11 ALB, BCL2, CASP3, CASP7, CASP8, CHEK2, EGFR, ERBB2, MAPK14, PARP1, VEGFA
cytosol 9 ALB, ANXA5, BCL2, CASP3, CASP7, CASP8, ERBB2, MAPK14, PARP1
nuclear body 1 PARP1
centrosome 1 ALB
nucleoplasm 7 CASP3, CASP7, CASP8, CHEK2, ERBB2, MAPK14, PARP1
Cell membrane 4 ABCB1, EGFR, ERBB2, PECAM1
lamellipodium 1 CASP8
ruffle membrane 2 EGFR, ERBB2
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
cell junction 2 EGFR, PECAM1
cell surface 4 ABCB1, EGFR, F3, VEGFA
glutamatergic synapse 3 CASP3, EGFR, MAPK14
Golgi apparatus 3 ALB, CHEK2, VEGFA
Golgi membrane 1 EGFR
lysosomal membrane 1 EGF
neuromuscular junction 1 ERBB2
neuronal cell body 1 CASP3
presynaptic membrane 1 ERBB2
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 CASP7, PARP1
endosome 1 EGFR
plasma membrane 7 ABCB1, EGF, EGFR, ERBB2, F3, F7, PECAM1
Membrane 10 ABCB1, ANXA5, BCL2, CYP51A1, EGF, EGFR, ERBB2, F3, PARP1, VEGFA
apical plasma membrane 3 ABCB1, EGFR, ERBB2
basolateral plasma membrane 2 EGFR, ERBB2
extracellular exosome 5 ABCB1, ALB, ANXA5, EGF, PECAM1
endoplasmic reticulum 3 ALB, BCL2, VEGFA
extracellular space 8 ALB, CASP7, EGF, EGFR, F3, F7, PECAM1, VEGFA
perinuclear region of cytoplasm 2 EGFR, ERBB2
adherens junction 1 VEGFA
mitochondrion 4 BCL2, CASP8, MAPK14, PARP1
protein-containing complex 6 ALB, BCL2, CASP8, EGFR, PARP1, PECAM1
intracellular membrane-bounded organelle 1 CYP51A1
Microsome membrane 1 CYP51A1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 4 EGFR, ERBB2, F3, PECAM1
Secreted 3 ALB, F7, VEGFA
extracellular region 7 ALB, ANXA5, EGF, ERBB2, F7, MAPK14, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP51A1
mitochondrial outer membrane 2 BCL2, CASP8
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
anchoring junction 1 ALB
transcription regulator complex 1 PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 3 ANXA5, F3, PECAM1
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 ERBB2
nucleolus 1 PARP1
Early endosome 1 ERBB2
cell-cell junction 1 PECAM1
vesicle 1 F7
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 CASP8
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 2 EGFR, PECAM1
pore complex 1 BCL2
focal adhesion 2 ANXA5, EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
PML body 1 CHEK2
collagen-containing extracellular matrix 3 ANXA5, F3, F7
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
receptor complex 2 EGFR, ERBB2
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 ALB
chromatin 1 PARP1
Chromosome 1 PARP1
cytoskeleton 1 CASP8
centriole 1 ALB
Secreted, extracellular space 1 CASP7
Nucleus, nucleolus 1 PARP1
spindle pole 2 ALB, MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 ALB
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
cell body 1 CASP8
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 PECAM1
Golgi lumen 1 F7
endoplasmic reticulum lumen 2 ALB, F7
platelet alpha granule lumen 3 ALB, EGF, VEGFA
semaphorin receptor complex 1 ERBB2
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
[Isoform 1]: Cell membrane 1 ERBB2
[Isoform Long]: Cell membrane 1 PECAM1
platelet alpha granule membrane 1 PECAM1
site of DNA damage 1 PARP1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
ERBB3:ERBB2 complex 1 ERBB2
serine-type peptidase complex 2 F3, F7
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform Delta15]: Cell junction 1 PECAM1
ciliary transition fiber 1 ALB


文献列表

  • Liang Li, Lei Hu, Chun-Yan Zhao, Sheng-Hua Zhang, Rong Wang, Yi Li, Rong-Guang Shao, Yong-Su Zhen. The Recombinant and Reconstituted Novel Albumin-Lidamycin Conjugate Shows Lasting Tumor Imaging and Intensively Enhanced Therapeutic Efficacy. Bioconjugate chemistry. 2018 09; 29(9):3104-3112. doi: 10.1021/acs.bioconjchem.8b00456. [PMID: 30105903]
  • Xiaofei Wang, Weijin Sheng, Yangyang Wang, Liang Li, Yi Li, Shenghua Zhang, Xiujun Liu, Shuzhen Chen, Yongsu Zhen. A Macropinocytosis-Intensifying Albumin Domain-Based scFv Antibody and Its Conjugate Directed against K-Ras Mutant Pancreatic Cancer. Molecular pharmaceutics. 2018 06; 15(6):2403-2412. doi: 10.1021/acs.molpharmaceut.8b00234. [PMID: 29757658]
  • Yanqing Wen, Shuzhen Chen, Zhiyun Meng, Hui Gan, Xiaoxia Zhu, Zhuona Wu, Ruolan Gu, Guifang Dou. Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. Biomedical chromatography : BMC. 2012 Mar; 26(3):400-6. doi: 10.1002/bmc.1676. [PMID: 21830226]
  • Yan-qing Wen, Zhi-yun Meng, Shu-zhen Chen, Xiao-xia Zhu, Gui-fang Dou. [Lidamycin metabolism in vitro]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Sep; 46(9):1132-6. doi: NULL. [PMID: 22121787]
  • You-Ping Liu, Quan-Sheng Li, Yu-Rong Huang, Chang-Xiao Liu. Tissue distribution and excretion of 125I-lidamycin in mice and rats. World journal of gastroenterology. 2005 Jun; 11(21):3281-4. doi: 10.3748/wjg.v11.i21.3281. [PMID: 15929183]
  • You-Ping Liu, Quan-Sheng Li, Yu-Rong Huang, Mao-Jin Zhou, Chang-Xiao Liu. Pharmacokinetics of C-1027 in mice as determined by TCA-RA method. World journal of gastroenterology. 2005 Feb; 11(5):717-20. doi: 10.3748/wjg.v11.i5.717. [PMID: 15655829]
  • Shu-zhen Chen, Zhong-ming Tang, Yong-su Zhen. [Studies on the pharmacokinetics of lidamycin in mice and dogs using bioassay]. Yao xue xue bao = Acta pharmaceutica Sinica. 2004 Sep; 39(9):700-4. doi: NULL. [PMID: 15606017]
  • C S Zhou, L N Xu, M Jiang, Y S Zhen. [A monoclonal antibody directed against an enediyne antitumor antibiotic and its preliminary application]. Yao xue xue bao = Acta pharmaceutica Sinica. 1997; 32(1):28-32. doi: NULL. [PMID: 11243214]
  • M M McHugh, J M Woynarowski, L S Gawron, T Otani, T A Beerman. Effects of the DNA-damaging enediyne C-1027 on intracellular SV40 and genomic DNA in green monkey kidney BSC-1 cells. Biochemistry. 1995 Feb; 34(5):1805-14. doi: 10.1021/bi00005a038. [PMID: 7849041]
  • J Li, Y Zhen, Z Yang. [Biodistribution of monoclonal antibody and Fab fragment and antitumor effect of their conjugates on hepatoma xenografts]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 1994 Oct; 16(5):328-33. doi: NULL. [PMID: 7720121]
  • N Sakata, K S Tsuchiya, Y Moriya, H Hayashi, M Hori, T Otani, M Nagai, T Aoyagi. Aminopeptidase activity of an antitumor antibiotic, C-1027. The Journal of antibiotics. 1992 Jan; 45(1):113-7. doi: 10.7164/antibiotics.45.113. [PMID: 1548181]
  • R G Shao, Y S Zhen. [Antitumor activity of new antitumor antibiotic C1027 and its monoclonal antibody assembled conjugate]. Yao xue xue bao = Acta pharmaceutica Sinica. 1992; 27(7):486-91. doi: NULL. [PMID: 1442079]