Eskel (BioDeep_00000862837)

Main id: BioDeep_00000000750

 

PANOMIX_OTCML-2023


代谢物信息卡片


5H-Furo[3,2-g][1]benzopyran-5-one, 4,9-dimethoxy-7-methyl-

化学式: C14H12O5 (260.0685)
中文名称: 凯林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)C2=C(C3=C(C(=C2O1)OC)OC=C3)OC
InChI: InChI=1S/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-7/h4-6H,1-3H3

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

同义名列表

138 个代谢物同义名

5H-Furo[3,2-g][1]benzopyran-5-one, 4,9-dimethoxy-7-methyl-; 5H-Furo(3,2-g)(1)benzopyran-5-one, 4,9-dimethoxy-7-methyl-; 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g]-[1]benzopyran-5-one; 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one; 4,9-Dimethoxy-7-methyl-5H-furo(3,2-g)(1)benzopyran-5-one; 4,9-dimethoxy-7-methyl-pyrano[3,2-f][1]benzoxol-5-one; 4,9-dimethoxy-7-methyl-pyrano[3,2-f]benzofuran-5-one; 4,9-Dimethoxy-7-methyl-5-oxofuro(3,2-g)-1,2-chromene; 4,9-Dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-[f]indene; 4,9-Dimethoxy-7-methyl-5-oxofuro(3,2-g)(1)benzopyran; 4,9-Dimethoxy-7-methyl-5-oxofuro[3,2-g][1]benzopyran; 4,9-Dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene; 4,9-dimethoxy-7-methylpyrano[3,2-f][1]benzoxol-5-one; 4,9-Dimethoxy-7-methyl-5-oxofuro[3,2-g]-1,2-chromene; 4,9-dimethoxy-7-methyl-5-pyrano[3,2-f]benzofuranone; 5,8-Dimethoxy-2-methyl-4,5-furano-6,7-chromone; 5,8-Dimethoxy-2-methyl-4,5-furo-6,7-chromone; 5-19-06-00320 (Beilstein Handbook Reference); 5,8-Dimethoxy-2-methyl-6,7-furanochromone; WLN: T C566 DO JV MOJ BO1 HO1 L1; Khelline [INN-French]; SDCCGMLS-0003040.P003; Quelina [INN-Spanish]; Khellinum [INN-Latin]; Chellina [Italian]; Prestwick1_000091; Prestwick2_000091; Prestwick3_000091; Khellin [DCF:INN]; Prestwick0_000091; Spectrum5_000154; Spectrum4_001557; EINECS 201-392-8; Spectrum2_000593; Spectrum3_000654; Spectrum_000079; NCGC00023424-04; NCGC00023424-03; NCGC00016327-01; Cardio-khellin; SPECTRUM210866; MEGxp0_000331; BSPBio_000042; DivK1c_000046; KBioGR_002054; BPBio1_000048; Prestwick_287; BSPBio_002287; KBioSS_000479; Ammi-khellin; NINDS_000046; SPBio_001981; KBio2_005615; SMR000058278; LMPK02000027; ACon1_000350; KBio1_000046; KBio2_003047; Simeskellina; Ammivisnagen; KBio2_000479; ACon0_000983; MLS000028448; ZINC00056654; Interkhellin; SPBio_000466; KBio3_001507; AIDS-002654; BRN 0263185; Ammispasmin; Gynokhellan; Ammicardine; IDI1_000046; K2750_SIGMA; Vasokellina; CAS-82-02-0; Chorafurone; Interkellin; Khellanals; Bi-Kellina; Corafurone; Benecardin; Khellamine; Visammimix; Khelline I; Khellinorm; Benekardin; Medekellin; Amicardine; AIDS002654; Methafrone; Visnagalin; Kelicorin; NSC 25509; Amikellin; Viscardan; Ammipuran; AI3-52114; Viscardin; Deltoside; Khelangin; NSC 37744; NSC25509; Kalangin; Khelloyd; Kellosal; Khelfren; Lynamine; Visammin; NSC37744; Kelourin; Mefurina; Kelincor; Vismagen; Khelisem; Euphorin; Visnagen; ST076676; Rykellin; Coronin; Kelicor; Khellin; Chellin; 82-02-0; Amiptan; Ammivin; Kelamin; Kellina; NSC8519; Norkel; Kellin; C09010; IT-033; Keloid; Eskel; Khell; Khellin; Khellin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AHR, ARHGAP45, CYP1A1, EGFR, NLRP3, PIK3CA, PRPF19, PTGS1, PTGS2
Peripheral membrane protein 4 CYP1A1, CYP1B1, PTGS1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 5 CYP1A1, CYP1B1, EGFR, PTGS1, PTGS2
Mitochondrion membrane 1 MAOA
Nucleus 6 AHR, EGFR, KDR, NFKBIZ, NLRP3, PRPF19
cytosol 5 AHR, ARHGAP45, MAOA, NLRP3, PIK3CA
dendrite 1 MAOB
nucleoplasm 2 AHR, PRPF19
Cell membrane 3 EGFR, KDR, TNF
Cytoplasmic side 2 MAOA, MAOB
lamellipodium 1 PIK3CA
ruffle membrane 2 ARHGAP45, EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 NLRP3
cell junction 2 EGFR, KDR
cell surface 2 EGFR, TNF
glutamatergic synapse 1 EGFR
Golgi apparatus 2 KDR, PTGS1
Golgi membrane 2 EGFR, NLRP3
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 2 MAOB, TNF
Cytoplasm, cytosol 1 NLRP3
endosome 2 EGFR, KDR
plasma membrane 6 ARHGAP45, EGFR, IFNLR1, KDR, PIK3CA, TNF
Membrane 8 ARHGAP45, CYP1B1, EGFR, IFNLR1, LCAT, MAOA, NLRP3, PRPF19
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 2 LCAT, PTGS1
endoplasmic reticulum 3 KDR, NLRP3, PTGS2
extracellular space 5 EGFR, IL10, IL4, LCAT, TNF
perinuclear region of cytoplasm 2 EGFR, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 5 CYP1A1, CYP1B1, MAOA, MAOB, NLRP3
protein-containing complex 3 AHR, EGFR, PTGS2
intracellular membrane-bounded organelle 3 CYP1A1, CYP1B1, PTGS1
Microsome membrane 4 CYP1A1, CYP1B1, PTGS1, PTGS2
Single-pass type I membrane protein 2 EGFR, IFNLR1
Secreted 4 IL10, IL4, LCAT, NLRP3
extracellular region 7 ARHGAP45, IL10, IL4, KDR, LCAT, NLRP3, TNF
Mitochondrion outer membrane 2 MAOA, MAOB
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 2 MAOA, MAOB
[Isoform 2]: Secreted 1 KDR
anchoring junction 1 KDR
transcription regulator complex 1 AHR
photoreceptor outer segment 1 PTGS1
nuclear membrane 1 EGFR
external side of plasma membrane 2 KDR, TNF
high-density lipoprotein particle 1 LCAT
Early endosome 1 KDR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 3 EGFR, KDR, TNF
Cytoplasm, cytoskeleton, spindle 1 PRPF19
focal adhesion 1 EGFR
spindle 1 PRPF19
intracellular vesicle 1 EGFR
nuclear speck 2 NFKBIZ, PRPF19
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 EGFR, KDR
neuron projection 2 PTGS1, PTGS2
chromatin 1 AHR
phagocytic cup 1 TNF
cytoplasmic ribonucleoprotein granule 1 NFKBIZ
spliceosomal complex 1 PRPF19
site of double-strand break 1 PRPF19
Endomembrane system 2 NLRP3, PTGS1
sorting endosome 1 KDR
Lipid droplet 1 PRPF19
microtubule organizing center 1 NLRP3
aryl hydrocarbon receptor complex 1 AHR
Nucleus, nucleoplasm 1 PRPF19
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 ARHGAP45
endoplasmic reticulum lumen 1 PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 ARHGAP45
mitochondrial envelope 1 MAOB
Single-pass type IV membrane protein 2 MAOA, MAOB
clathrin-coated endocytic vesicle membrane 1 EGFR
U2-type catalytic step 1 spliceosome 1 PRPF19
catalytic step 2 spliceosome 1 PRPF19
Prp19 complex 1 PRPF19
U2-type catalytic step 2 spliceosome 1 PRPF19
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Martin Ndayambaje, Hicham Wahnou, Marieme Sow, Oumaima Chgari, Thierry Habyarimana, Mehdi Karkouri, Youness Limami, Abdallah Naya, Mounia Oudghiri. Exploring the multifaceted effects of Ammi visnaga: subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities. Journal of toxicology and environmental health. Part A. 2024 Feb; 87(4):150-165. doi: 10.1080/15287394.2023.2289430. [PMID: 38037686]
  • Veselina Adımcılar, Neslihan Beyazit, F Bedia Erim. Khellin and visnagin in different organs of Ammi visnaga and Ammi majus. Natural product research. 2023 Jan; 37(1):164-166. doi: 10.1080/14786419.2021.1956924. [PMID: 34569361]
  • X-L Rao, L-L Liu, J Huang, J Chen. Neuroprotective effects of visnagin on cerebral ischemia-reperfusion injury rats and the underlying mechanisms. European review for medical and pharmacological sciences. 2022 06; 26(12):4371-4379. doi: 10.26355/eurrev_202206_29076. [PMID: 35776038]
  • Fatma Abd El-Fattah Ragab, Yassin Mohammed Nissan, M Alaraby Salem, Mamdouh Moawad Ali, Ahmed Abbass Mohamed Abdelrahman Selim. Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity. Natural product research. 2022 May; 36(10):2486-2494. doi: 10.1080/14786419.2021.1907383. [PMID: 33813964]
  • Giulia Vanti, Lucrezia Muti, Mario D'Ambrosio, Lucia Grifoni, Maria Camilla Bergonzi, Cristina Luceri, Anna Rita Bilia. Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule. Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247657. [PMID: 34946734]
  • Mohammad H Abukhalil, Omnia E Hussein, Saleem H Aladaileh, Osama Y Althunibat, Wesam Al-Amarat, Sultan A Saghir, Manal A Alfwuaires, Abdulmohsen I Algefare, Khalid M Alanazi, Farhan K Al-Swailmi, Emadeldin M Kamel, Ayman M Mahmoud. Visnagin prevents isoproterenol-induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22906. doi: 10.1002/jbt.22906. [PMID: 34486204]
  • Sonali S Bharate. Enhancing Biopharmaceutical Attributes of Khellin by Amorphous Binary Solid Dispersions. AAPS PharmSciTech. 2021 Oct; 22(8):260. doi: 10.1208/s12249-021-02126-3. [PMID: 34705156]
  • Laura Risaliti, Xuan Yu, Giulia Vanti, Maria Camilla Bergonzi, Meng Wang, Anna Rita Bilia. Hydroxyethyl cellulose hydrogel for skin delivery of khellin loaded in ascosomes: Characterization, in vitro/in vivo performance and acute toxicity. International journal of biological macromolecules. 2021 May; 179(?):217-229. doi: 10.1016/j.ijbiomac.2021.02.206. [PMID: 33662425]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Jaime Piquero-Casals, Laura Martínez-Martínez, Agustín Alomar, Eduardo Rozas-Muñoz, Candido Juarez, Luis Puig. LRP1/CD91 is highly expressed in monocytes from patients with vitiligo - even after repigmentation. Experimental dermatology. 2021 03; 30(3):390-395. doi: 10.1111/exd.14249. [PMID: 33249636]
  • Noha Khalil, Mokhtar Bishr, Mohamed El-Degwy, Mohamed Abdelhady, Mohamed Amin, Osama Salama. Assessment of Conventional Solvent Extraction vs. Supercritical Fluid Extraction of Khella (Ammi visnaga L.) Furanochromones and Their Cytotoxicity. Molecules (Basel, Switzerland). 2021 Feb; 26(5):. doi: 10.3390/molecules26051290. [PMID: 33673560]
  • Jamaan S Ajarem, Ahmad K Hegazy, Gamal A Allam, Ahmed A Allam, Saleh N Maodaa, Ayman M Mahmoud. Effect of Visnagin on Altered Steroidogenesis and Spermatogenesis, and Testicular Injury Induced by the Heavy Metal Lead. Combinatorial chemistry & high throughput screening. 2021; 24(6):758-766. doi: 10.2174/1386207323999200918124639. [PMID: 32957877]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Lakshmi Priya Pasari, Amit Khurana, Pratibha Anchi, Mohd Aslam Saifi, Shivaraju Annaldas, Chandraiah Godugu. Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Apr; 112(?):108629. doi: 10.1016/j.biopha.2019.108629. [PMID: 30798137]
  • Fatma Aydoğmuş-Öztürk, Humera Jahan, Neslihan Beyazit, Keriman Günaydın, Muhammad Iqbal Choudhary. The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144. Molecular biology reports. 2019 Apr; 46(2):1709-1714. doi: 10.1007/s11033-019-04620-1. [PMID: 30694454]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Maria L Travaini, Gustavo M Sosa, Eduardo A Ceccarelli, Helmut Walter, Charles L Cantrell, Nestor J Carrillo, Franck E Dayan, Kumudini M Meepagala, Stephen O Duke. Khellin and Visnagin, Furanochromones from Ammi visnaga (L.) Lam., as Potential Bioherbicides. Journal of agricultural and food chemistry. 2016 Dec; 64(50):9475-9487. doi: 10.1021/acs.jafc.6b02462. [PMID: 27936681]
  • Roman Pavela, Naděžda Vrchotová, Jan Tříska. Larvicidal activity of extracts from Ammi visnaga Linn. (Apiaceae) seeds against Culex quinquefasciatus Say. (Diptera: Culicidae). Experimental parasitology. 2016 Jun; 165(?):51-7. doi: 10.1016/j.exppara.2016.03.016. [PMID: 26995534]
  • Jihan M Badr, Ghada M Hadad, Khaled Nahriry, Hashem A Hassanean. Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations. Natural product research. 2015; 29(7):593-601. doi: 10.1080/14786419.2014.945170. [PMID: 25111086]
  • Isa Kilicaslan, Selcuk Coskun. Spontaneous stone passage: is it Ammi visnaga effect?. Urological research. 2012 Dec; 40(6):799-800. doi: 10.1007/s00240-012-0509-8. [PMID: 22990409]
  • Karin G Haug, Benjamin Weber, Guenther Hochhaus, Veronika Butterweck. Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats. Planta medica. 2012 Nov; 78(17):1831-6. doi: 10.1055/s-0032-1315393. [PMID: 23096256]
  • Mi-Sun Koo, Selvakumar Subbian, Gilla Kaplan. Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. Cell communication and signaling : CCS. 2012 Jan; 10(1):2. doi: 10.1186/1478-811x-10-2. [PMID: 22280836]
  • Karin G Haug, Benjamin Weber, Guenther Hochhaus, Veronika Butterweck. Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 Jan; 45(1-2):79-89. doi: 10.1016/j.ejps.2011.10.023. [PMID: 22085634]
  • Lei Lei, Shundai Li, Ying Gu. Cellulose synthase complexes: composition and regulation. Frontiers in plant science. 2012; 3(?):75. doi: 10.3389/fpls.2012.00075. [PMID: 22639663]
  • Suwittra Chaemchuen, Suang Rungpragayphan, Yong Poovorawan, Kanitha Patarakul. Identification of candidate host proteins that interact with LipL32, the major outer membrane protein of pathogenic Leptospira, by random phage display peptide library. Veterinary microbiology. 2011 Nov; 153(1-2):178-85. doi: 10.1016/j.vetmic.2011.04.030. [PMID: 21592685]
  • Aslam Khan, Samra Bashir, Saeed R Khan, Anwar H Gilani. Antiurolithic activity of Origanum vulgare is mediated through multiple pathways. BMC complementary and alternative medicine. 2011 Oct; 11(?):96. doi: 10.1186/1472-6882-11-96. [PMID: 22004514]
  • P Vanachayangkul, N Chow, S R Khan, Veronika Butterweck. Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats. Urological research. 2011 Jun; 39(3):189-95. doi: 10.1007/s00240-010-0333-y. [PMID: 21069311]
  • Jean Matthieu Prot, Anne-Sophie Briffaut, Franck Letourneur, Philippe Chafey, Franck Merlier, Yves Grandvalet, Cécile Legallais, Eric Leclerc. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. PloS one. 2011; 6(8):e21268. doi: 10.1371/journal.pone.0021268. [PMID: 21857903]
  • Angelo Aquino, Grazia Graziani, Ornella Franzese, Salvatore P Prete, Enzo Bonmassar, Laura Bonmassar, Stefania D'Atri. Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes. Clinical & developmental immunology. 2011; 2011(?):790460. doi: 10.1155/2011/790460. [PMID: 21603161]
  • Margaret Clarke, Ulrike Engel, Jennifer Giorgione, Annette Müller-Taubenberger, Jana Prassler, Douwe Veltman, Günther Gerisch. Curvature recognition and force generation in phagocytosis. BMC biology. 2010 Dec; 8(?):154. doi: 10.1186/1741-7007-8-154. [PMID: 21190565]
  • Maria Eldh, Karin Ekström, Hadi Valadi, Margareta Sjöstrand, Bob Olsson, Margareta Jernås, Jan Lötvall. Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA. PloS one. 2010 Dec; 5(12):e15353. doi: 10.1371/journal.pone.0015353. [PMID: 21179422]
  • Wayne Chadwick, Randall Brenneman, Bronwen Martin, Stuart Maudsley. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. International journal of Alzheimer's disease. 2010 Dec; 2010(?):604792. doi: 10.4061/2010/604792. [PMID: 21151659]
  • Dongmin Shao, Anthony W Segal, Lodewijk V Dekker. Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin. The international journal of biochemistry & cell biology. 2010 Oct; 42(10):1736-43. doi: 10.1016/j.biocel.2010.07.009. [PMID: 20637895]
  • James R Bamburg, Barbara W Bernstein. Roles of ADF/cofilin in actin polymerization and beyond. F1000 biology reports. 2010 Aug; 2(?):62. doi: 10.3410/b2-62. [PMID: 21173851]
  • P Vanachayangkul, K Byer, S Khan, V Butterweck. An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Jul; 17(8-9):653-8. doi: 10.1016/j.phymed.2009.10.011. [PMID: 20036111]
  • Lauren G MacNeil, Simon Melov, Alan E Hubbard, Steven K Baker, Mark A Tarnopolsky. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PloS one. 2010 May; 5(5):e10695. doi: 10.1371/journal.pone.0010695. [PMID: 20502695]
  • Toshihide Kimura, Shigeki Taniguchi, Kazuo Toya, Ichiro Niki. Glucose-induced translocation of coronin 3 regulates the retrograde transport of the secretory membrane in the pancreatic beta-cells. Biochemical and biophysical research communications. 2010 May; 395(3):318-23. doi: 10.1016/j.bbrc.2010.03.173. [PMID: 20362548]
  • Reiko Minakami, Yuichi Maehara, Sachiko Kamakura, Osamu Kumano, Kei Miyano, Hideki Sumimoto. Membrane phospholipid metabolism during phagocytosis in human neutrophils. Genes to cells : devoted to molecular & cellular mechanisms. 2010 May; 15(5):409-24. doi: 10.1111/j.1365-2443.2010.01393.x. [PMID: 20384786]
  • Jovita Ponce, David Brea, Montserrat Carrascal, Verónica Guirao, Nuria Degregorio-Rocasolano, Tomás Sobrino, José Castillo, Antonio Dávalos, Teresa Gasull. The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate. Proteomics. 2010 May; 10(10):1954-65. doi: 10.1002/pmic.200900055. [PMID: 20217863]
  • Silvia Volpe, Sylvia Thelen, Thomas Pertel, Martin J Lohse, Marcus Thelen. Polarization of migrating monocytic cells is independent of PI 3-kinase activity. PloS one. 2010 Apr; 5(4):e10159. doi: 10.1371/journal.pone.0010159. [PMID: 20419163]
  • Yuqing Wang, Yingfang Zhu, Yu Ling, Haiyan Zhang, Peng Liu, Frantisek Baluska, Jozef Samaj, Jinxing Lin, Qinli Wang. Disruption of actin filaments induces mitochondrial Ca2+ release to the cytoplasm and [Ca2+]c changes in Arabidopsis root hairs. BMC plant biology. 2010 Mar; 10(?):53. doi: 10.1186/1471-2229-10-53. [PMID: 20334630]
  • Kazuya Tsujita, Toshiki Itoh, Akihiro Kondo, Masaaki Oyama, Hiroko Kozuka-Hata, Yasuhiro Irino, Junya Hasegawa, Tadaomi Takenawa. Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. The Journal of biological chemistry. 2010 Feb; 285(9):6781-9. doi: 10.1074/jbc.m109.057018. [PMID: 20032464]
  • Steven Bassnett, Phillip A Wilmarth, Larry L David. The membrane proteome of the mouse lens fiber cell. Molecular vision. 2009 Nov; 15(?):2448-63. doi: NULL. [PMID: 19956408]
  • Stanko Skugor, Sven Martin Jørgensen, Bjarne Gjerde, Aleksei Krasnov. Hepatic gene expression profiling reveals protective responses in Atlantic salmon vaccinated against furunculosis. BMC genomics. 2009 Oct; 10(?):503. doi: 10.1186/1471-2164-10-503. [PMID: 19878563]
  • Guang-Yuan Ma, Jian-Zhong Zhang, Guo-Rong Yin, Jian-Hong Zhang, Xiao-Li Meng, Fei Zhao. Toxoplasma gondii: proteomic analysis of antigenicity of soluble tachyzoite antigen. Experimental parasitology. 2009 May; 122(1):41-6. doi: 10.1016/j.exppara.2009.01.011. [PMID: 19545523]
  • Till Bretschneider, Kurt Anderson, Mary Ecke, Annette Müller-Taubenberger, Britta Schroth-Diez, Hellen C Ishikawa-Ankerhold, Günther Gerisch. The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization. Biophysical journal. 2009 Apr; 96(7):2888-900. doi: 10.1016/j.bpj.2008.12.3942. [PMID: 19348770]
  • Pattaraporn Vanachayangkul, Veronika Butterweck, Reginald F Frye. Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Mar; 877(7):653-6. doi: 10.1016/j.jchromb.2009.01.014. [PMID: 19188097]
  • Maxine E Whitton, Darren M Ashcroft, Urbà González. Therapeutic interventions for vitiligo. Journal of the American Academy of Dermatology. 2008 Oct; 59(4):713-7. doi: 10.1016/j.jaad.2008.06.023. [PMID: 18793940]
  • Orest Szczurko, Heather S Boon. A systematic review of natural health product treatment for vitiligo. BMC dermatology. 2008 May; 8(?):2. doi: 10.1186/1471-5945-8-2. [PMID: 18498646]
  • Tsuyoshi Hayashi, Masaki Miyake, Takashi Fukui, Noriko Sugaya, Takashi Daimon, Saotomo Itoh, Teruaki Oku, Tsutomu Tsuji, Satoshi Toyoshima, Yasuyuki Imai. Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella. Biological & pharmaceutical bulletin. 2008 May; 31(5):861-5. doi: 10.1248/bpb.31.861. [PMID: 18451508]
  • Hanaa M Sayed, Mahmoud H Mohamed, Salwa F Farag, Gamal A Mohamed, Peter Proksch. A new steroid glycoside and furochromones from Cyperus rotundus L. Natural product research. 2007 Apr; 21(4):343-50. doi: 10.1080/14786410701193056. [PMID: 17479423]
  • Koichi Suzuki, Fumihiko Takeshita, Noboru Nakata, Norihisa Ishii, Masahiko Makino. Localization of CORO1A in the macrophages containing Mycobacterium leprae. Acta histochemica et cytochemica. 2006 Aug; 39(4):107-12. doi: 10.1267/ahc.06010. [PMID: 17327897]
  • Paras K Anand, Deepak Kaul, Meera Sharma. Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. The international journal of biochemistry & cell biology. 2006; 38(4):600-9. doi: 10.1016/j.biocel.2005.10.021. [PMID: 16352457]
  • H Fai Poon, Susan A Farr, William A Banks, William M Pierce, Jon B Klein, John E Morley, D Allan Butterfield. Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. Brain research. Molecular brain research. 2005 Jul; 138(1):8-16. doi: 10.1016/j.molbrainres.2005.02.020. [PMID: 15932783]
  • Lie-Chwen Lin, Kuo-Yi Yang, Yen-Fei Chen, Shau-Chun Wang, Tung-Hu Tsai. Measurement of daphnoretin in plasma of freely moving rat by liquid chromatography. Journal of chromatography. A. 2005 May; 1073(1-2):285-9. doi: 10.1016/j.chroma.2004.09.041. [PMID: 15909531]
  • Donald W Cockcroft. Asthma and therapeutics: recombinant therapies in asthma. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2005 Mar; 1(1):34-41. doi: 10.1186/1710-1492-1-1-34. [PMID: 20529233]
  • Aleksei Krasnov, Heikki Koskinen, Petri Pehkonen, Caird E Rexroad, Sergey Afanasyev, Hannu Mölsä. Gene expression in the brain and kidney of rainbow trout in response to handling stress. BMC genomics. 2005 Jan; 6(?):3. doi: 10.1186/1471-2164-6-3. [PMID: 15634361]
  • Vasily Rybakin, Maria Stumpf, Andrea Schulze, Irina V Majoul, Angelika A Noegel, Andreas Hasse. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. FEBS letters. 2004 Aug; 573(1-3):161-7. doi: 10.1016/j.febslet.2004.07.066. [PMID: 15327992]
  • C P Cordero, S Gómez-González, C J León-Acosta, S J Morantes-Medina, F A Aristizabal. Cytotoxic activity of five compounds isolated from Colombian plants. Fitoterapia. 2004 Mar; 75(2):225-7. doi: 10.1016/j.fitote.2003.12.017. [PMID: 15030931]
  • René Houtman, Jeroen Krijgsveld, Mirjam Kool, Edwin P Romijn, Frank A Redegeld, Frans P Nijkamp, Albert J R Heck, Ian Humphery-Smith. Lung proteome alterations in a mouse model for nonallergic asthma. Proteomics. 2003 Oct; 3(10):2008-18. doi: 10.1002/pmic.200300469. [PMID: 14625863]
  • Ken-ichi Mawatari, Satoshi Mashiko, Mitsuo Watanabe, Kazuya Nakagomi. Fluorometric determination of khellin in human urine and serum by high-performance liquid chromatography using postcolumn photoirradiation. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2003 Jul; 19(7):1071-3. doi: 10.2116/analsci.19.1071. [PMID: 12880095]
  • C Gleye, B Akendengue, A Laurens, R Hocquemiller. Coronin from roots of Annona muricata, a putative intermediate in acetogenin biosynthesis (1). Planta medica. 2001 Aug; 67(6):570-2. doi: 10.1055/s-2001-16481. [PMID: 11509986]
  • J Moniakis, S Funamoto, M Fukuzawa, J Meisenhelder, T Araki, T Abe, R Meili, T Hunter, J Williams, R A Firtel. An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. Genes & development. 2001 Mar; 15(6):687-98. doi: 10.1101/gad.871001. [PMID: 11274054]
  • T Kobayashi, S Tsunawaki, H Seguchi. Evaluation of the process for superoxide production by NADPH oxidase in human neutrophils: evidence for cytoplasmic origin of superoxide. Redox report : communications in free radical research. 2001; 6(1):27-36. doi: 10.1179/135100001101536003. [PMID: 11333112]
  • O Schimmer, P Rauch. Inhibition of metabolic activation of the promutagens, benzo[a]pyrene, 2-aminofluorene and 2-aminoanthracene by furanochromones in Salmonella typhimurium. Mutagenesis. 1998 Jul; 13(4):385-9. doi: 10.1093/mutage/13.4.385. [PMID: 9717176]
  • J Duarte, F Pérez-Vizcaíno, A I Torres, A Zarzuelo, J Jiménez, J Tamargo. Vasodilator effects of visnagin in isolated rat vascular smooth muscle. European journal of pharmacology. 1995 Nov; 286(2):115-22. doi: 10.1016/0014-2999(95)00418-k. [PMID: 8605947]
  • A S Carlin, J E Simmons, S K el-Arini, G K Shiu. Determination of khellin in serum by gas chromatography. Journal of chromatography. 1993 May; 614(2):324-7. doi: 10.1016/0378-4347(93)80325-x. [PMID: 8314946]
  • H el Naser, E Abdel Ghaffar, S S Mahmoud. Hypocholesterolemic effect of khellin and methoxsalen in male albino rats. Arzneimittel-Forschung. 1992 Feb; 42(2):140-2. doi: . [PMID: 1610424]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]
  • J B Hudson. Plant photosensitizers with antiviral properties. Antiviral research. 1989 Sep; 12(2):55-74. doi: 10.1016/0166-3542(89)90070-3. [PMID: 2688551]
  • G G Franchi, L Bovalini, P Martelli, S Ferri, E Sbardellati. High performance liquid chromatography analysis of the furanochromones khellin and visnagin in various organs of Ammi visnaga (L.) Lam. at different developmental stages. Journal of ethnopharmacology. 1985 Nov; 14(2-3):203-12. doi: 10.1016/0378-8741(85)90088-1. [PMID: 4094467]
  • T J Stevens, W A Phillips, C E Day. Comparative effects of khellin and timefurone on serum parameters in normal male cynomolgus monkeys. Journal of medical primatology. 1985; 14(5):255-62. doi: . [PMID: 4057238]
  • T J Stevens, B W Jones, T J Vidmar, J J Moran, D S Manni, C E Day. Hypocholesterolemic effect of khellin and khelloside in female cynomolgus monkeys. Arzneimittel-Forschung. 1985; 35(8):1257-60. doi: . [PMID: 3865654]
  • J H Cardellina, T M Swager. Native American food and medicinal plants, 5. Isolation of the lipid altering visnagin from Musineon divaricatum. Journal of natural products. 1984 Nov; 47(6):1060. doi: 10.1021/np50036a040. [PMID: 6533266]
  • P Martelli, L Bovalini, S Ferri, G G Franchi. Rapid separation and quantitative determination of khellin and visnagin in Ammi visnaga (L.) Lam. fruits by high-performance liquid chromatography. Journal of chromatography. 1984 Sep; 301(1):297-302. doi: 10.1016/s0021-9673(01)89202-5. [PMID: 6438143]
  • R B Gammill, C E Day, P E Schurr. Khellin analogues. 1. General topological requirements for lipid-altering activity in furochromones. Journal of medicinal chemistry. 1983 Dec; 26(12):1672-4. doi: 10.1021/jm00366a002. [PMID: 6644736]
  • C Harvengt, J P Desager. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. International journal of clinical pharmacology research. 1983; 3(5):363-6. doi: . [PMID: 6678829]
  • A El-Yazigi, S A Said. Khellin determination in human serum and urine by high-performance liquid chromatography. Journal of pharmaceutical sciences. 1980 Dec; 69(12):1434-6. doi: 10.1002/jps.2600691222. [PMID: 7463331]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]
  • L Modliński. [Experiences with nephrolith in the treatment of patients with kidney calculi]. Zeitschrift fur Urologie und Nephrologie. 1977 Jun; 70(6):429-35. doi: NULL. [PMID: 333815]
  • A V Grunin. [Photometric determination of bismuth in vicalin and vicair]. Farmatsiia. 1974 Sep; 23(5):74. doi: ". [PMID: 4464153]
  • S Ljubojević, H Hadzijahić, M Perinović, M Grujić, B Rizvanbegović, I Bratović, J Nikolić. [Vicalin in the treatment of gastroduodenal ulcer]. Medicinski arhiv. 1974 Sep; 28(5):511-4. doi: ". [PMID: 4615219]
  • L Csupor. [In-vitro studies on the problem 'galenic preparations or pure substance']. Planta medica. 1972 Dec; 22(4):365-77. doi: 10.1055/s-0028-1099621. [PMID: 4677019]
  • L Modliński. [Results of pharmacological therapy in 500 patients with urinary calculi]. Polski przeglad chirurgiczny. 1971 Jun; 43(6):991-1000. doi: ". [PMID: 5571687]
  • M S Karawya, G Nour, A Sina. Estimation of the non-glycosidal chromone and coumarin contents in fruits and extracts of Ammi visnaga. Planta medica. 1971 Apr; 19(4):368-77. doi: 10.1055/s-0028-1099655. [PMID: 5573548]
  • T Beyrich. [Furocoumarin of Pastinaca sativa L. A study on the question of xanthotoxin content of a plant of the temperate zone]. Die Pharmazie. 1966 Jun; 21(6):365-73. doi: ". [PMID: 4175582]
  • Z Blazek, F Starý. [Qualitative and quantitative changes in the furocoumarin content in Ammi majus L. in the course of vegetation]. Mitteilungen. Deutsche Pharmazeutische Gesellschaft. 1965 Jul; 35(7):117-27. doi: ". [PMID: 5898849]
  • R WEISSBERG. [TREATMENT OF VITILIGO BY EXTRACTS OF THE PLANT AMMI MAIUS]. Harefuah. 1964 Jun; 66(?):371-4. doi: ". [PMID: 14173932]
  • G SORCINI, M DILORENZO, F SCIARRA, P LOTTI, L CIAMPALINI. [DETERMINATION OF PLASMA TESTOSTERONE IN ANORCHID SUBJECTS. CONSIDERATIONS ON THE ORIGIN AND SIGNIFICANCE OF URINARY ANDROGEN CATABOLITES]. Folia endocrinologica. 1963 Oct; 16(?):495-9. doi: NULL. [PMID: 14114703]
  • A R LUZHIS, Ie S RYSS. [CLINICAL SIGNIFICANCE OF THE DETERMINATION OF UROPEPSINOGEN IN PEPTIC ULCER]. Vestnik Akademii meditsinskikh nauk SSSR. 1963; 18(?):60-5. doi: NULL. [PMID: 14133795]
  • M A ANGARSKAIA, V E SOKOLOVA. [On combined effects of cordigit and khellin]. Farmakologiia i toksikologiia. 1961 Jul; 24(?):448-54. doi: ". [PMID: 13861564]
  • M A ANGARSKAIA, V E SOKOLOVA, Ia I KHADZHAI. [On pharmacology of corulin]. Farmakologiia i toksikologiia. 1961 Mar; 24(?):163-8. doi: ". [PMID: 13683527]
  • T BAYTOP. [Research on the fruit of the plant Ammi visnaga L. (pick-tooth)]. Tip Fakultesi mecmuasi. 1960; 23(?):703-12. doi: ". [PMID: 13688142]
  • O WETZEL. [Treatment of coronary insufficiency]. Hippokrates. 1958 Feb; 29(3):81-3. doi: ". [PMID: 13512991]
  • H H WITTIG. [Testing of coronary dilatating substances in angina pectoris]. Die Medizinische. 1957 May; ?(20):760-3. doi: ". [PMID: 13440445]
  • H GOING, H D KEMPE. [Effect on experimentally induced arrhythmias of cardiac plant drugs (Rauwolfia serpentina, khellin, camphor, R. Valerianae)]. Archives internationales de pharmacodynamie et de therapie. 1956 Sep; 107(3-4):255-70. doi: ". [PMID: 13363498]
  • A R FISCHER. [Management of chronic cardiac insufficiency with crataegutt and stenocrat]. Munchener medizinische Wochenschrift (1950). 1956 Apr; 98(17):605-6. doi: ". [PMID: 13334448]
  • J DELPHAUT, C HEDEL. [Micro determination of khellin in biological fluids]. Bulletin de la Societe de chimie biologique. 1953; 35(3-4):368-9. doi: NULL. [PMID: 13094361]
  • E GADERMANN, H HAMM. [Renal clearance tests during khelline administration]. Klinische Wochenschrift. 1952 Oct; 30(39-40):931-4. doi: 10.1007/bf01471371. [PMID: 13001157]