Scoparon (BioDeep_00000861045)

PANOMIX_OTCML-2023

代谢物信息卡片

5-18-03-00204 (Beilstein Handbook Reference)

化学式: C11H10O4 (206.0579)
中文名称: 滨蒿内酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C=CC(=O)O2)OC
InChI: InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

描述信息

D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].
Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities[1].

同义名列表

32 个代谢物同义名

5-18-03-00204 (Beilstein Handbook Reference); Benzopyran-2-one, 6,7-dimethoxy- (9CI); 2H-1-Benzopyran-2-one, 6,7-dimethoxy-; 6,7-Dimethoxy-2H-1-benzopyran-2-one; 6,7-Dimethoxybenzopyran-2-one; 6,7-Dimethoxy-2-benzopyrone; 6,7-dimethoxychromen-2-one; 6,7-dimethoxy-2-chromenone; Aesculetin dimethyl ether; Esculetin dimethyl ether; Coumarin, 6,7-dimethoxy-; Scopoletin methyl ether; 6,7-dimethoxycoumarin; 6,7-dimethylesculetin; Maybridge4_003009; EINECS 204-369-0; SR-01000631300-1; 254886_ALDRICH; MEGxp0_001422; ZINC00002067; ACon1_002079; AIDS-026315; BRN 0169572; AIDS026315; Escoparone; Scoparone; ST5319943; 120-08-1; Scoparon; C09311; Scoparone; Scoparone

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:9055
KEGG: C09311
PubChem: 8417
ChEMBL: CHEMBL325864
CAS: 120-08-1
PubChem: 11502
KNApSAcK: C00002498
3DMET: B02851
NIKKAJI: J5.319H
medchemexpress: HY-N0228
KNApSAcK: 9055

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

153 个相关的物种来源信息

282723 - Achillea biserrata: 10.1007/BF00579679
282741 - Achillea impatiens: 10.1007/BF00579978
282761 - Achillea ptarmicifolia: 10.1007/BF00579978
68527 - Aegle marmelos: 10.1016/J.PHYTOCHEM.2011.11.018
416184 - Aeglopsis chevalieri: 10.1021/JO01273A076
231460 - Afraegle paniculata: 10.1016/0031-9422(73)85149-0
430971 - Agathosma capensis: 10.1016/0031-9422(86)88018-9
2486844 - Agathosma ciliaris: 10.1016/0031-9422(86)88018-9
1641042 - Agathosma imbricata: 10.1016/0031-9422(86)88018-9
2486847 - Agathosma lanceolata: 10.1016/0031-9422(86)88018-9
2486848 - Agathosma martiana: 10.1016/0031-9422(86)88018-9
2805000 - Aldama robusta: 10.1016/0305-1978(96)00057-9
2805006 - Aldama tukumanensis: 10.1016/0031-9422(95)00584-6
123498 - Aleurites moluccanus: 10.1016/S0367-326X(00)00314-2
403096 - Allamanda schottii: 10.1021/NP50056A018
665671 - Anisotome pilifera: 10.1016/S0305-1978(02)00047-9
4045 - Apium graveolens: 10.1007/BF00993733
137934 - Aralia bipinnata:
401875 - Artemisia adamsii: 10.1016/S0031-9422(00)83171-4
35608 - Artemisia Annua L.: -
262982 - Artemisia apiacea: 10.1016/S0367-326X(02)00070-9
259893 - Artemisia argyi Lévl.et Vant.: -
72337 - Artemisia campestris: 10.1016/0031-9422(91)83491-3
265783 - Artemisia capillaris:
265783 - Artemisia capillaris Thunb.: -
496566 - Artemisia carvifolia: 10.1016/S0367-326X(02)00070-9
205364 - Artemisia dracunculoides: 10.1016/S0031-9422(00)85199-7
72341 - Artemisia dracunculus:
401909 - Artemisia laciniata: 10.1002/JLAC.198619861208
205371 - Artemisia marschalliana: 10.1016/S0031-9422(00)88402-2
72349 - Artemisia nova: 10.1016/S0021-9673(01)97678-2
72350 - Artemisia reptans: 10.1016/S0031-9422(00)89536-9
72351 - Artemisia scoparia:
72351 - Artemisia scoparia Waldst.et Kit.: -
55611 - Artemisia tridentata: 10.1016/0305-1978(92)90072-L
1177126 - Artemisia turanica: 10.1021/NP50031A025
1811969 - Artemisia vestita: 10.1055/S-1999-13965
48103 - Bupleurum fruticosum: 10.1016/0031-9422(95)00749-0
199751 - Bupleurum salicifolium:
1475378 - Calea ternifolia: 10.3390/MOLECULES22020289
68535 - Casimiroa edulis: 10.1021/NP50037A032
60419 - Castanea mollissima: 10.1080/10286020903451757
136894 - Catunaregam spinosa: 10.1002/CHIN.200844208
864332 - Cedrelopsis grevei:
145490 - Centaurea collina: 10.1016/S0031-9422(00)97993-7
145515 - Centaurea salonitana: 10.1016/S0031-9422(00)97993-7
557631 - Chiliadenus candicans: 10.3109/13880208809053916
558547 - Citrus deliciosa:
64884 - Citrus jambhiri: 10.1094/PHYTO-78-1678
76966 - Citrus japonica: 10.1248/CPB.49.1356
408488 - Citrus kinokuni: 10.1248/CPB.49.1356
307630 - Citrus macrophylla:
171251 - Citrus medica:
85571 - Citrus reticulata:
237573 - Citrus sulcata: 10.1248/CPB.39.2509
488172 - Citrus tamurana: 10.1016/S0031-9422(98)00247-7
37690 - Citrus trifoliata:
55188 - Citrus unshiu: 10.1007/BF00630620
475932 - Citrus wilsonii: 10.1016/S0031-9422(98)00247-7
4047 - Coriandrum sativum: 10.1016/0031-9422(95)00930-2
4129 - Cuscuta reflexa: -
4129 - Cuscuta reflexa: 10.1248/CPB.50.112
906689 - Dendrobium catenatum: 10.1021/JF040017R
161866 - Dendrobium densiflorum:
142614 - Dendrobium moniliforme: 10.1021/JF040017R
142615 - Dendrobium officinale: 10.1021/JF040017R
117978 - Dendrobium thyrsiflorum:
183483 - Dendrobium tosaense: 10.1021/JF040017R
489439 - Deverra tortuosa: 10.1590/S0103-50532003000100008
298346 - Dictamnus albus: 10.1016/S0031-9422(98)00519-6
167917 - Duranta erecta: 10.1248/CPB.50.515
105886 - Eleutherococcus sessiliflorus: 10.1055/S-2002-34925
378924 - Empleurum unicapsulare: 10.1016/0031-9422(86)88018-9
2894177 - Empleurum unicapsularis: 10.1016/0031-9422(86)88018-9
2589437 - Erythroxylum barbatum: 10.1016/S0305-1978(02)00249-1
1873686 - Espeletia spectabilis: 10.1016/0031-9422(80)83072-X
318062 - Euphorbia hirta: 10.1016/S1875-5364(12)60009-0
756622 - Euphorbia iberica: 10.1055/S-2006-960819
371331 - Ferula badhysi: 10.1007/BF00567821
371362 - Ferula linkii: 10.1016/0031-9422(93)85291-X
371375 - Ferula oopoda: 10.1007/BF00567821
126418 - Forsythia suspensa (Thunb.) Vahl: -
38874 - Fraxinus ornus:
469925 - Garcinia conrauana: 10.1021/NP8006364
469930 - Garcinia kola: 10.1021/NP8006364
1009474 - Garcinia multiflora: 10.1021/NP8006364
114476 - Gardenia jasminoides: 10.1021/NP800002Z
63806 - Gomortega keule: 10.1016/0031-9422(91)83506-G
127995 - Gonospermum ferulaceum: 10.1016/0031-9422(90)83068-C
127982 - Gonospermum fruticosum:
127983 - Gonospermum gomerae: 10.1021/NP800474V
1006079 - Haplophyllum ramosissimum:
1006083 - Haplophyllum thesioides: 10.1080/10575639308050059
1898877 - Hibiscus taiwanensis:
549422 - Hortia longifolia: 10.1021/JO00829A053
180498 - Jatropha curcas: 10.1002/HLCA.201000313
271244 - Keetia multiflora: 10.1055/S-2008-1034372
587579 - Khaya senegalensis: 10.1016/0031-9422(95)00093-3
85854 - Magnolia coco:
3406 - Magnolia grandiflora: 10.1016/S0031-9422(00)80557-9
3411 - Magnolia salicifolia: 10.1248/CPB.39.3265
155640 - Melia azedarach: 10.1016/S0367-326X(99)00051-9
1487095 - Melicope borbonica: 10.1016/S0378-8741(98)00137-8
28525 - Menyanthes trifoliata: 10.1086/325638
1048568 - Metalasia capitata: 10.1016/0031-9422(90)83033-W
1048565 - Metalasia cephalotes: 10.1016/0031-9422(90)83033-W
1089418 - Microtropis japonica:
126552 - Olea capensis:
176559 - Pericome caudata: 10.1016/S0031-9422(00)82480-2
282633 - Phebalium squamulosum: 10.1016/0031-9422(92)83450-D
68554 - Phellodendron amurense:
271192 - Pimpinella anisum: 10.1007/BF00993733
1008928 - Pittosporum illicioides: 10.1021/NP8004503
33090 - Plants: -
557757 - Platymiscium yucatanum: 10.1515/HFSG.1998.52.5.459
81514 - Pterocaulon sphacelatum: 10.1071/CH9683079
119185 - Pulicaria arabica: 10.3109/13880208809053916
286923 - Ranunculus laetus: 10.1007/S10600-009-9408-9
147635 - Ranunculus sceleratus: 10.1055/S-2005-873169
376251 - Ranunculus sieboldii: 10.1055/S-2005-873169
1905583 - Rubia wallichiana:
452789 - Ruta angustifolia: 10.1016/S0031-9422(00)84991-2
238933 - Saussurea brunneopilosa: 10.3109/13880209409083006
378320 - Saussurea eopygmaea: 10.3109/13880209409083006
354518 - Skimmia laureola: 10.1016/S0031-9422(00)81759-8
329772 - Solanum dasyphyllum: 10.1021/NP50037A033
126913 - Suaeda maritima: 10.1002/JPS.3030350906
1735025 - Suaeda nudiflora: 10.1002/JPS.3030350906
169606 - Tagetes lucida: 10.1021/JF053071W
183267 - Talipariti tiliaceum: 10.1248/CPB.53.56
23278 - Vahlia capensis: 10.1016/0031-9422(94)00710-B
159071 - Zanthoxylum ailanthoides:
354527 - Zanthoxylum avicennae:
1056465 - Zanthoxylum beecheyanum: 10.1002/JCCS.200400159
2839964 - Zanthoxylum dimorphophyllum: 10.1515/ZNC-2001-7-802
992815 - Zanthoxylum leprieurii: 10.1021/NP50048A057
354528 - Zanthoxylum nitidum:
354530 - Zanthoxylum schinifolium:
328402 - Zanthoxylum simulans: 10.1016/S0031-9422(97)00280-X
2099548 - Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
380129 - 佛手: -
33090 - 半边莲: -
33090 - 川牛膝: -
33090 - 枸骨叶: -
33090 - 柴胡: -
33090 - 白头翁: -
33090 - 肿节风: -
33090 - 艾叶: -
33090 - 茵陈: -
33090 - 葛根: -
33090 - 葛花: -
33090 - 青果: -
496566 - 青蒿: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	12	BCL2, CASP3, CYP1A1, MAPK14, MYD88, NFKBIA, NLRP3, NR1I3, PIK3CA, PTGS2, STAT3, TLR4
Peripheral membrane protein	2	CYP1A1, PTGS2
Endosome membrane	2	MYD88, TLR4
Endoplasmic reticulum membrane	4	BCL2, CYP1A1, CYP1A2, PTGS2
Nucleus	8	BCL2, CASP3, MAPK14, MYD88, NFKBIA, NLRP3, NR1I3, STAT3
cytosol	10	BCL2, CASP3, GPT, MAPK14, MYD88, NFKBIA, NLRP3, NR1I3, PIK3CA, STAT3
nucleoplasm	5	CASP3, MAPK14, NFKBIA, NR1I3, STAT3
RNA polymerase II transcription regulator complex	1	STAT3
Cell membrane	2	TLR4, TNF
lamellipodium	1	PIK3CA
Golgi apparatus membrane	1	NLRP3
cell surface	3	MYD88, TLR4, TNF
glutamatergic synapse	2	CASP3, MAPK14
Golgi membrane	2	INS, NLRP3
mitochondrial inner membrane	1	CYP1A1
neuronal cell body	2	CASP3, TNF
Cytoplasm, cytosol	1	NLRP3
plasma membrane	8	IFNLR1, IGHE, MYD88, NFKBIA, PIK3CA, STAT3, TLR4, TNF
Membrane	4	BCL2, IFNLR1, NLRP3, TLR4
caveola	1	PTGS2
extracellular exosome	1	GPT
endoplasmic reticulum	3	BCL2, NLRP3, PTGS2
extracellular space	5	CCL2, IGHE, IL6, INS, TNF
perinuclear region of cytoplasm	2	PIK3CA, TLR4
intercalated disc	1	PIK3CA
mitochondrion	4	BCL2, CYP1A1, MAPK14, NLRP3
protein-containing complex	3	BCL2, MYD88, PTGS2
intracellular membrane-bounded organelle	2	CYP1A1, CYP1A2
Microsome membrane	3	CYP1A1, CYP1A2, PTGS2
postsynaptic density	1	CASP3
Single-pass type I membrane protein	3	IFNLR1, IGHE, TLR4
Secreted	4	CCL2, IL6, INS, NLRP3
extracellular region	7	CCL2, IGHE, IL6, INS, MAPK14, NLRP3, TNF
Mitochondrion outer membrane	1	BCL2
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	1	BCL2
transcription regulator complex	1	STAT3
Nucleus membrane	1	BCL2
Bcl-2 family protein complex	1	BCL2
nuclear membrane	1	BCL2
external side of plasma membrane	2	TLR4, TNF
Early endosome	1	TLR4
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
Mitochondrion inner membrane	1	CYP1A1
Membrane raft	1	TNF
pore complex	1	BCL2
Cytoplasm, cytoskeleton	1	NR1I3
nuclear speck	1	MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center	1	NLRP3
Inflammasome	1	NLRP3
interphase microtubule organizing center	1	NLRP3
NLRP3 inflammasome complex	1	NLRP3
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
Cell projection, ruffle	1	TLR4
ruffle	1	TLR4
receptor complex	1	TLR4
neuron projection	1	PTGS2
chromatin	2	NR1I3, STAT3
IgE immunoglobulin complex	1	IGHE
phagocytic cup	2	TLR4, TNF
cytoskeleton	1	NR1I3
spindle pole	1	MAPK14
[Isoform 2]: Cell membrane	1	IGHE
Endomembrane system	1	NLRP3
endosome lumen	1	INS
microtubule organizing center	1	NLRP3
myelin sheath	1	BCL2
lipopolysaccharide receptor complex	1	TLR4
ficolin-1-rich granule lumen	1	MAPK14
secretory granule lumen	2	INS, MAPK14
Golgi lumen	1	INS
endoplasmic reticulum lumen	3	IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex	1	PIK3CA
phosphatidylinositol 3-kinase complex, class IA	1	PIK3CA
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
extrinsic component of cytoplasmic side of plasma membrane	1	MYD88
death-inducing signaling complex	1	CASP3
extrinsic component of plasma membrane	1	MYD88
[Isoform 3]: Cell membrane	1	IGHE
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
[Isoform 1]: Secreted	1	IGHE
IgE B cell receptor complex	1	IGHE
immunoglobulin complex, circulating	1	IGHE
interleukin-6 receptor complex	1	IL6
BAD-BCL-2 complex	1	BCL2
I-kappaB/NF-kappaB complex	1	NFKBIA
phosphatidylinositol 3-kinase complex, class IB	1	PIK3CA
interleukin-28 receptor complex	1	IFNLR1
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF

文献列表

Tianyi Zhao, Shiyi Lun, Maoying Yan, JongPil Park, Shumin Wang, Changbao Chen. 6,7-Dimethoxycoumarin, Gardenoside and Rhein combination improves non-alcoholic fatty liver disease in rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117646. doi: 10.1016/j.jep.2023.117646. [PMID: 38135236]
Jinxiang Luo, Huijun Xie, Wei Ding, Yongqiang Zhang. Photodegradation of the pure and formulated scoparone in liquid solutions: kinetics and mechanism. Environmental technology. 2024 Jan; 45(1):87-98. doi: 10.1080/09593330.2022.2099312. [PMID: 35796037]
Sha Huang, Luping Lin, Yifei Ma, Qing Zhu, Ningna Weng. Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer. European journal of pharmacology. 2023 Oct; 959(?):176091. doi: 10.1016/j.ejphar.2023.176091. [PMID: 37805132]
Miaoqing Ye, Chunyan Liu, Jiaojiao Liu, Fenping Lu, Jingdong Xue, Fenping Li, Yinghui Tang. Scoparone inhibits the development of hepatocellular carcinoma by modulating the p38 MAPK/Akt/NF-κB signaling in nonalcoholic fatty liver disease mice. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23851. [PMID: 37436232]
Hongping Shen, Yiting Wei, Qunying Yang, Yili Cai, Keqi Zhu, Xueqin Chen. Scoparone induces both apoptosis and ferroptosis via multiple mechanisms in non-small-cell lung cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Jun; 91(?):105627. doi: 10.1016/j.tiv.2023.105627. [PMID: 37315743]
Juan Zou, Yuanyuan Li, Jingyi Cai, Xiaotian Peng, Lincong Zhang, Tian Tian, Tianming Wang, Rong Shi, Jiasheng Wu, Yueming Ma. Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 Jan; 1215(?):123570. doi: 10.1016/j.jchromb.2022.123570. [PMID: 36542898]
Min Wei, Ting Li, Houkang Cao, Haiyan He, Chaoyue Yang, Yifan Yin, Huijie Lu, Petr Novák, Kefeng Zhang, Ya Gao. The effects of scoparone on alcohol and high-fat diet-induced liver injury revealed by RNA sequencing. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113770. doi: 10.1016/j.biopha.2022.113770. [PMID: 36182737]
Kyung-Ran Park, Bomi Kim, Joon Yeop Lee, Ho-Jin Moon, Il Keun Kwon, Hyung-Mun Yun. Effects of Scoparone on differentiation, adhesion, migration, autophagy and mineralization through the osteogenic signalling pathways. Journal of cellular and molecular medicine. 2022 08; 26(16):4520-4529. doi: 10.1111/jcmm.17476. [PMID: 35796406]
Hong Zhou, Fenglin Wan, Fuyou Guo, Jinlin Liu, Wei Ding. High value-added application of a renewable bioresource as acaricide: Investigation the mechanism of action of scoparone against Tetranychus cinnabarinus. Journal of advanced research. 2022 05; 38(?):29-39. doi: 10.1016/j.jare.2021.08.013. [PMID: 35572395]
Joanna Kowalczyk, Barbara Budzyńska, Łukasz Kurach, Daniele Pellegata, Nesrine S El Sayed, Jürg Gertsch, Krystyna Skalicka-Woźniak. Neuropsychopharmacological profiling of scoparone in mice. Scientific reports. 2022 01; 12(1):822. doi: 10.1038/s41598-021-04741-3. [PMID: 35039558]
Xiaoyan Huang, Ya Gao, Houkang Cao, Jun Li, Siyi Mo, Ting Li, Jianzhao Wu, Kai Guo, Riming Wei, Kefeng Zhang. Effects of scoparone on non-alcoholic fatty liver disease revealed by RNA sequencing. Frontiers in endocrinology. 2022; 13(?):1004284. doi: 10.3389/fendo.2022.1004284. [PMID: 36157436]
Hong Zhou, Jinlin Liu, Fenglin Wan, Fuyou Guo, Yeshuang Ning, Sisi Liu, Wei Ding. Insight into the mechanism of action of scoparone inhibiting egg development of Tetranychus cinnabarinus Boisduval. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Aug; 246(?):109055. doi: 10.1016/j.cbpc.2021.109055. [PMID: 33894369]
Linmao Lyu, Jiazheng Chen, Wei Wang, Tao Yan, Jiamao Lin, Hongmei Gao, Hui Li, Ruijuan Lv, Feng Xu, Lijun Fang, Yuguo Chen. Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress. Journal of cellular and molecular medicine. 2021 03; 25(6):3136-3148. doi: 10.1111/jcmm.16304. [PMID: 33560596]
Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
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