546-18-9 (BioDeep_00000860567)
Main id: BioDeep_00000003826
Secondary id: BioDeep_00000174888
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C24H40O2 (360.3028)
中文名称: 5β-胆烷酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 87.5%
分子结构信息
SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCCC4)C)C
InChI: InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis[1].
同义名列表
26 个代谢物同义名
(4R)-4-[(5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; (4R)-4-[(5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid; Androstane-17-butanoic acid, .gamma.-methyl-, (5.beta.,17.beta.)-; Androstane-17-butanoic acid, gamma-methyl-, (5beta,17beta)-; (5beta,17beta)-gamma-methylandrostane-17-butanoic acid; Cholan-24-oic acid, (5beta)- (9CI); 5beta-Cholan-24-oic acid (8CI); Cholan-24-oic acid, (5.beta.)-; 5.beta.-Cholan-24-oic acid; (5beta)-cholan-24-oic acid; 5beta-Cholan-24-oic Acid; 5.beta.-Cholanoic acid; 5.beta.-Cholanic acid; 5beta-Cholanoic acid; 5beta-Cholanic acid; 5β-cholanoic acid; Ursocholanic acid; Cholanoic acid; LMST04010441; CHEBI:36238; L 596205-0; NSC 18161; NSC18161; 546-18-9; 5β-Cholanic acid; 5beta-Cholanic acid
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:36238
- KEGG: C19642
- PubChem: 92803
- ChEMBL: CHEMBL429432
- CAS: 546-18-9
- PubChem: 124490294
- RefMet: 5beta-Cholanoic acid
- RefMet: Cholanoic acid
- medchemexpress: HY-W127512
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - 泽兰: -
- 33090 - 相思子: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Julia F Nepper, Yin C Lin, Douglas B Weibel. Rcs Phosphorelay Activation in Cardiolipin-Deficient Escherichia coli Reduces Biofilm Formation.
Journal of bacteriology.
2019 05; 201(9):. doi:
10.1128/jb.00804-18. [PMID: 30782633] - Simon Chewchuk, Tyler Boorman, Derek Edwardson, Amadeo M Parissenti. Bile Acids Increase Doxorubicin Sensitivity in ABCC1-expressing Tumour Cells.
Scientific reports.
2018 04; 8(1):5413. doi:
10.1038/s41598-018-23496-y. [PMID: 29615646] - Claudia Luengo-Alonso, Juan José Torrado, Maria Paloma Ballesteros, Alessio Malfanti, Sara Bersani, Stefano Salmaso, Paolo Caliceti. A novel performing PEG-cholane nanoformulation for Amphotericin B delivery.
International journal of pharmaceutics.
2015 Nov; 495(1):41-51. doi:
10.1016/j.ijpharm.2015.08.070. [PMID: 26319629] - Joo In Jung, Ashleigh R Price, Thomas B Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H Koo, Gideon Shapiro, Kevin M Felsenstein, Todd E Golde. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.
Molecular neurodegeneration.
2015 Jul; 10(?):29. doi:
10.1186/s13024-015-0021-z. [PMID: 26169917] - Tieshi Li, Lara Longobardi, Froilan Granero-Molto, Timothy J Myers, Yun Yan, Anna Spagnoli. Use of glycol chitosan modified by 5beta-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesis.
Journal of controlled release : official journal of the Controlled Release Society.
2010 May; 144(1):101-8. doi:
10.1016/j.jconrel.2010.01.021. [PMID: 20116406] - Anna N Bukiya, Jacob McMillan, Abby L Parrill, Alejandro M Dopico. Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.
Journal of lipid research.
2008 Nov; 49(11):2441-51. doi:
10.1194/jlr.m800286-jlr200. [PMID: 18650555] - Ho-Young Hwang, In-San Kim, Ick Chan Kwon, Yong-Hee Kim. Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society.
2008 May; 128(1):23-31. doi:
10.1016/j.jconrel.2008.02.003. [PMID: 18374444] - Jong-Ho Kim, Yoo-Shin Kim, Kyeongsoon Park, Eunah Kang, Seulki Lee, Hae Yun Nam, Kwangmeyung Kim, Jae Hyung Park, Dae Yoon Chi, Rang-Woon Park, In-San Kim, Kuiwon Choi, Ick Chan Kwon. Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy.
Biomaterials.
2008 Apr; 29(12):1920-30. doi:
10.1016/j.biomaterials.2007.12.038. [PMID: 18289669] - Hyuk Sang Yoo, Jung Eun Lee, Hesson Chung, Ick Chan Kwon, Seo Young Jeong. Self-assembled nanoparticles containing hydrophobically modified glycol chitosan for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society.
2005 Mar; 103(1):235-43. doi:
10.1016/j.jconrel.2004.11.033. [PMID: 15710514] - Junichi Fukuchi, Ching Song, Qing Dai, Richard A Hiipakka, Shutsung Liao. 5beta-Cholane activators of the farnesol X receptor.
The Journal of steroid biochemistry and molecular biology.
2005 Mar; 94(4):311-8. doi:
10.1016/j.jsbmb.2004.11.012. [PMID: 15857750] - Katsuhiko Ariga, Takashi Nakanishi, Yukiko Terasaka, Hiromitsu Tsuji, Daisuke Sakai, Jun-ichi Kikuchi. Piezoluminescence at the air-water interface through dynamic molecular recognition driven by lateral pressure application.
Langmuir : the ACS journal of surfaces and colloids.
2005 Feb; 21(3):976-81. doi:
10.1021/la0477845. [PMID: 15667177] - Yi-ling Ding, Ling-ling Tan, Wen Deng. [Clinical analysis of intrahepatic cholestasis during pregnancy in 150 patients].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2003 Dec; 28(6):645-7. doi:
NULL. [PMID: 15804082] - H Sqalli-Houssaini, C Pierlot, J P Kusnierz, B Parmentier, F Martin-Nizard, S Lestavel-Delattre, A Tartar, J C Fruchart, C Sergheraert, P Duriez. Preparation of anti-HIV-low-density lipoprotein complexes for delivery of anti-HIV drugs via the low-density lipoprotein pathways.
Biotechnology therapeutics.
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Clinica chimica acta; international journal of clinical chemistry.
1986 Dec; 161(2):221-31. doi:
10.1016/0009-8981(86)90215-9. [PMID: 2433077] - D V Waterhous, S Barnes, D D Muccio. Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5 beta-cholanoic acid.
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The Journal of nutrition.
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The Journal of biological chemistry.
1963 Dec; 238(?):3840-52. doi:
NULL. [PMID: 14086715] - H DANIELSSON, P ENEROTH, K HELLSTROM, J SJOVALL. Synthesis of some 3beta-hydroxylated bile acids and the isolation of 3beta, 12alpha-dihydroxy-5beta-cholanic acid from feces.
The Journal of biological chemistry.
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NULL. [PMID: 14024950] - L PERIC-GOLIA, R S JONES. Conversion of mevalonic acid-2-C14 to biliary cholesterol and cholanic acids in the guinea pig.
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1961 Aug; 107(?):856-8. doi:
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