Chymostatin (BioDeep_00000008594)

   


代谢物信息卡片


2-[[1-(2-Amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid

  化学式: C31H41N7O6 (607.3118)
中文名称: 胰凝乳蛋白酶抑制剂
  谱图信息: 最多检出来源 Mus musculus(plant) 0.19%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C(=O)O
InChI: InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)


描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors

同义名列表

3 个代谢物同义名

Chymostatin; 2-[[1-(2-Amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid; Chymostatin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ACE, ALB, CTSG, DMD, EDN1, ELANE, MME, PRKX
Peripheral membrane protein 3 CTSB, CTSG, DMD
Nucleus 4 ALB, CTSG, DMD, PRKX
cytosol 4 ALB, CTSG, DMD, ELANE
dendrite 1 MME
phagocytic vesicle 1 ELANE
trans-Golgi network 1 MME
centrosome 1 ALB
nucleoplasm 1 PRKX
Cell membrane 5 ACE, AGTR1, AGTR2, CTSG, MME
Cytoplasmic side 1 DMD
Cytoplasmic granule 1 CTSG
Multi-pass membrane protein 2 AGTR1, AGTR2
Synapse 3 DMD, MME, TAC1
cell surface 4 DMD, ELANE, MME, PLAU
Golgi apparatus 2 ALB, SERPINA1
neuronal cell body 2 MME, TAC1
sarcolemma 1 DMD
synaptic vesicle 1 MME
Cytoplasm, cytosol 1 CTSG
Lysosome 4 ACE, CTSA, CTSB, CTSG
Presynapse 1 MME
endosome 1 ACE
plasma membrane 8 ACE, AGTR1, AGTR2, CTSG, DMD, MME, PLAU, REN
Membrane 7 ACE, AGTR1, CTSA, CTSG, DMD, MME, REN
apical plasma membrane 1 CTSB
axon 2 MME, TAC1
brush border 1 MME
extracellular exosome 11 ACE, AGT, ALB, CPVL, CTSA, CTSB, CTSG, ELANE, MME, PLAU, SERPINA1
endoplasmic reticulum 3 ALB, CTSA, SERPINA1
extracellular space 13 ACE, AGT, ALB, CTRL, CTSB, CTSG, EDN1, ELANE, IL6, PLAU, REN, SERPINA1, TAC1
lysosomal lumen 1 CTSA
perinuclear region of cytoplasm 1 CTSB
protein-containing complex 2 ALB, DMD
intracellular membrane-bounded organelle 3 CTSA, CTSG, SERPINA1
filopodium 1 DMD
Single-pass type I membrane protein 1 ACE
Secreted 8 ACE, AGT, ALB, CTSG, EDN1, IL6, PLAU, REN
extracellular region 13 ACE, AGT, ALB, CTSA, CTSB, CTSG, EDN1, ELANE, IL6, PLAU, REN, SERPINA1, TAC1
basal part of cell 1 EDN1
Extracellular side 1 CTSB
anchoring junction 1 ALB
external side of plasma membrane 3 ACE, CTSB, PLAU
Z disc 1 DMD
cytoplasmic vesicle 1 MME
Early endosome 1 MME
apical part of cell 1 REN
COPII-coated ER to Golgi transport vesicle 1 SERPINA1
Single-pass type II membrane protein 1 MME
postsynaptic membrane 1 DMD
Apical cell membrane 1 CTSB
Cell membrane, sarcolemma 1 DMD
Membrane raft 2 DMD, MME
Cytoplasm, cytoskeleton 1 DMD
focal adhesion 2 MME, PLAU
collagen-containing extracellular matrix 5 AGT, CTSB, CTSG, ELANE, SERPINA1
secretory granule 2 CTSG, ELANE
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 1 DMD
ciliary basal body 1 ALB
cytoskeleton 1 DMD
centriole 1 ALB
Secreted, extracellular space 1 CTSB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 2 AGT, ALB
sperm midpiece 1 ACE
specific granule membrane 1 PLAU
tertiary granule membrane 1 PLAU
Melanosome 1 CTSB
cytoplasmic stress granule 1 CTSG
filopodium membrane 1 DMD
basal plasma membrane 1 ACE
ficolin-1-rich granule lumen 2 CTSB, SERPINA1
secretory granule membrane 1 MME
endoplasmic reticulum lumen 3 ALB, IL6, SERPINA1
transcription repressor complex 1 ELANE
platelet alpha granule lumen 2 ALB, SERPINA1
specific granule lumen 1 ELANE
transport vesicle 1 EDN1
azurophil granule lumen 3 CTSA, CTSG, ELANE
serine-type endopeptidase complex 1 PLAU
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 SERPINA1
Single-pass type IV membrane protein 1 DMD
costamere 1 DMD
dystrophin-associated glycoprotein complex 1 DMD
serine protease inhibitor complex 1 PLAU
Cytoplasmic vesicle, phagosome 1 ELANE
cell-substrate junction 1 DMD
protein complex involved in cell-matrix adhesion 1 PLAU
peptidase inhibitor complex 1 CTSB
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
interleukin-6 receptor complex 1 IL6
endolysosome lumen 1 CTSB
neuron projection terminus 2 DMD, MME
syntrophin complex 1 DMD
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

  • Malwina M Roszkowska-Chojecka, Iwona Baranowska, Olga Gawrys, Janusz Sadowski, Agnieszka Walkowska, Malgorzata Kalisz, Anna Litwiniuk, Elzbieta Kompanowska-Jezierska. Role of chymase in blood pressure control, plasma and tissue angiotensin II, renal Haemodynamics, and excretion in spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):392-401. doi: 10.1080/10641963.2021.1890762. [PMID: 33687310]
  • Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras. The Journal of biological chemistry. 2021 Jan; 296(?):100242. doi: 10.1074/jbc.ra120.015188. [PMID: 33380422]
  • Miaojuan Qiu, Suchun Li, Lizi Jin, Pinning Feng, Yonglun Kong, Xiaoduo Zhao, Yu Lin, Yunyun Xu, Chunling Li, Weidong Wang. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells. Lipids in health and disease. 2018 Jul; 17(1):183. doi: 10.1186/s12944-018-0818-1. [PMID: 30064425]
  • Chen Yang, Hong-Wei Song, Wei Liu, Xue-Song Dong, Zhi Liu. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation. 2018 Feb; 41(1):122-133. doi: 10.1007/s10753-017-0670-x. [PMID: 28940034]
  • Rui Chen, Ge Jin, Thomas M McIntyre. The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF. The Journal of biological chemistry. 2017 06; 292(24):10112-10122. doi: 10.1074/jbc.m116.771642. [PMID: 28455445]
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