Chymostatin (BioDeep_00000008594)

   


代谢物信息卡片


2-[[1-(2-Amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid

化学式: C31H41N7O6 (607.3118166)
中文名称: 胰凝乳蛋白酶抑制剂
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C(=O)O
InChI: InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors

同义名列表

3 个代谢物同义名

Chymostatin; 2-[[1-(2-Amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid; Chymostatin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Malwina M Roszkowska-Chojecka, Iwona Baranowska, Olga Gawrys, Janusz Sadowski, Agnieszka Walkowska, Malgorzata Kalisz, Anna Litwiniuk, Elzbieta Kompanowska-Jezierska. Role of chymase in blood pressure control, plasma and tissue angiotensin II, renal Haemodynamics, and excretion in spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):392-401. doi: 10.1080/10641963.2021.1890762. [PMID: 33687310]
  • Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras. The Journal of biological chemistry. 2021 Jan; 296(?):100242. doi: 10.1074/jbc.ra120.015188. [PMID: 33380422]
  • Miaojuan Qiu, Suchun Li, Lizi Jin, Pinning Feng, Yonglun Kong, Xiaoduo Zhao, Yu Lin, Yunyun Xu, Chunling Li, Weidong Wang. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells. Lipids in health and disease. 2018 Jul; 17(1):183. doi: 10.1186/s12944-018-0818-1. [PMID: 30064425]
  • Chen Yang, Hong-Wei Song, Wei Liu, Xue-Song Dong, Zhi Liu. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation. 2018 Feb; 41(1):122-133. doi: 10.1007/s10753-017-0670-x. [PMID: 28940034]
  • Rui Chen, Ge Jin, Thomas M McIntyre. The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF. The Journal of biological chemistry. 2017 06; 292(24):10112-10122. doi: 10.1074/jbc.m116.771642. [PMID: 28455445]
  • Oliver Domenig, Arndt Manzel, Nadja Grobe, Eva Königshausen, Christopher C Kaltenecker, Johannes J Kovarik, Johannes Stegbauer, Susan B Gurley, Dunja van Oyen, Marlies Antlanger, Michael Bader, Daisy Motta-Santos, Robson A Santos, Khalid M Elased, Marcus D Säemann, Ralf A Linker, Marko Poglitsch. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. Scientific reports. 2016 09; 6(?):33678. doi: 10.1038/srep33678. [PMID: 27649628]
  • Malwina Monika Roszkowska-Chojecka, Agnieszka Walkowska, Olga Gawryś, Iwona Baranowska, Małgorzata Kalisz, Anna Litwiniuk, Lidia Martyńska, Elżbieta Kompanowska-Jezierska. Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat. Experimental physiology. 2015 Sep; 100(9):1093-105. doi: 10.1113/ep085325. [PMID: 26011164]
  • Jianping Li, Shaiban Jubair, Joseph S Janicki. Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling. Hypertension (Dallas, Tex. : 1979). 2015 Feb; 65(2):328-34. doi: 10.1161/hypertensionaha.114.04238. [PMID: 25403608]
  • Norihito Moniwa, Jasmina Varagic, Stephen W Simington, Sarfaraz Ahmad, Sayaka Nagata, Jessica L Voncannon, Carlos M Ferrario. Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. American journal of physiology. Heart and circulatory physiology. 2013 Sep; 305(5):H644-50. doi: 10.1152/ajpheart.00210.2013. [PMID: 23812388]
  • Jana Rykl, Joachim Thiemann, Sandra Kurzawski, Thomas Pohl, Johan Gobom, Walter Zidek, Hartmut Schlüter. Renal cathepsin G and angiotensin II generation. Journal of hypertension. 2006 Sep; 24(9):1797-807. doi: 10.1097/01.hjh.0000242404.91332.be. [PMID: 16915029]
  • Kurt Wallner, Chen Li, Prediman K Shah, Kai-Jin Wu, Stephen M Schwartz, Behrooz G Sharifi. EGF-Like domain of tenascin-C is proapoptotic for cultured smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology. 2004 Aug; 24(8):1416-21. doi: 10.1161/01.atv.0000134299.89599.53. [PMID: 15178565]
  • Carlos F Santos, Marcos Antonio V Caprio, Eduardo B Oliveira, Maria Cristina O Salgado, Daniela N Schippers, Diane H Munzenmaier, Andrew S Greene. Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme. American journal of physiology. Heart and circulatory physiology. 2003 Aug; 285(2):H775-83. doi: 10.1152/ajpheart.00818.2002. [PMID: 12714330]
  • Messias S Santos-Neto, Stephen L Carrithers, André F Carvalho, Helena S A Monteiro, Richard N Greenberg, Leonard R Forte, Manassés C Fonteles. Guanylin and its lysine-containing analogue in the isolated perfused rat kidney: interaction with chymotrypsin inhibitor. Pharmacology & toxicology. 2003 Mar; 92(3):114-20. doi: 10.1034/j.1600-0773.2003.920302.x. [PMID: 12753425]
  • Malay Mandai, Sudip Das, Tapati Chakraborti, Sajal Chakraborti. Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2*-) in plasma membrane of bovine pulmonary vascular smooth muscle. Indian journal of biochemistry & biophysics. 2002 Dec; 39(6):390-6. doi: . [PMID: 22905396]
  • Hirobumi Tokuyama, Koichi Hayashi, Hiroto Matsuda, Eiji Kubota, Masanori Honda, Ken Okubo, Ichiro Takamatsu, Satoru Tatematsu, Yuri Ozawa, Shu Wakino, Takao Saruta. Differential regulation of elevated renal angiotensin II in chronic renal ischemia. Hypertension (Dallas, Tex. : 1979). 2002 Jul; 40(1):34-40. doi: 10.1161/01.hyp.0000022060.13995.ed. [PMID: 12105135]
  • C Kyriakides, W G Austen, Y Wang, J Favuzza, L Kobzik, F D Moore, H B Hechtman. Mast cells mediate complement activation after acid aspiration. Shock (Augusta, Ga.). 2001 Jul; 16(1):21-4. doi: 10.1097/00024382-200116010-00004. [PMID: 11442310]
  • P K Chatterjee, P A Brown, S Cuzzocrea, K Zacharowski, K N Stewart, H Mota-Filipe, M C McDonald, C Thiemermann. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney international. 2001 Jun; 59(6):2073-83. doi: 10.1046/j.1523-1755.2001.00722.x. [PMID: 11380809]
  • D Messdaghi, K Dietz. Characterization of an extracellular chymostatin-sensitive serine protease preferentially expressed in young plant tissues. Biochimica et biophysica acta. 2000 Jul; 1480(1-2):107-16. doi: 10.1016/s0167-4838(00)00092-3. [PMID: 10899613]
  • Y Matsuda, S Oshio, T Yazaki, T Umeda, S Akihama. The effect of some proteinase inhibitors on liquefaction of human semen. Human reproduction (Oxford, England). 1994 Apr; 9(4):664-8. doi: 10.1093/oxfordjournals.humrep.a138568. [PMID: 8046020]
  • D J Grab, M K Shaw, C W Wells, Y Verjee, D C Russo, P Webster, J Naessens, W R Fish. The transferrin receptor in African trypanosomes: identification, partial characterization and subcellular localization. European journal of cell biology. 1993 Oct; 62(1):114-26. doi: NULL. [PMID: 8269969]
  • K Noda, M Sasaguri, M Ideishi, M Ikeda, K Arakawa. Role of locally formed angiotensin II and bradykinin in the reduction of myocardial infarct size in dogs. Cardiovascular research. 1993 Feb; 27(2):334-40. doi: 10.1093/cvr/27.2.334. [PMID: 8472285]
  • B Baur, K J Dietz, K Winter. Regulatory protein phosphorylation of phosphoenolpyruvate carboxylase in the facultative crassulacean-acid-metabolism plant Mesembryanthemum crystallinum L. European journal of biochemistry. 1992 Oct; 209(1):95-101. doi: 10.1111/j.1432-1033.1992.tb17265.x. [PMID: 1396723]
  • D Gingras, P Ménard, R Béliveau. Protein carboxyl methylation in kidney brush-border membranes. Biochimica et biophysica acta. 1991 Jul; 1066(2):261-7. doi: 10.1016/0005-2736(91)90196-f. [PMID: 1854790]
  • I Sakaida, M E Kyle, J L Farber. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Molecular pharmacology. 1990 Mar; 37(3):435-42. doi: . [PMID: 2314391]
  • T Yamaguchi, M Fukase, M Nishikawa, T Fujimi, T Fujita. Parathyroid hormone degradation by chymotrypsin-like endopeptidase in the opossum kidney cell. Endocrinology. 1988 Dec; 123(6):2812-7. doi: 10.1210/endo-123-6-2812. [PMID: 3058460]
  • K N Christie. Chymostatin has no apparent beneficial effect on muscular dystrophy in the mdx mouse. Journal of the neurological sciences. 1988 Apr; 84(2-3):341-6. doi: 10.1016/0022-510x(88)90138-4. [PMID: 3379449]
  • R Seger, Y Yarden, O Kashles, D Goldblatt, J Schlessinger, S Shaltiel. The epidermal growth factor receptor as a substrate for a kinase-splitting membranal proteinase. The Journal of biological chemistry. 1988 Mar; 263(7):3496-500. doi: 10.1016/s0021-9258(18)69098-2. [PMID: 2830286]
  • A Nakanishi, K Morita, M Oka, N Katsunuma. Evidence against a possible involvement of the serine, and thiol proteases in the exocytotic mechanism of catecholamine secretion in cultured bovine adrenal medullary cells. Biochemistry international. 1986 Nov; 13(5):799-807. doi: NULL. [PMID: 3101693]
  • K Komatsu, A Matsui, S Satoh. Beneficial effect of chymostatin on dystrophic mice. Experimental neurology. 1986 Jul; 93(1):110-6. doi: 10.1016/0014-4886(86)90150-0. [PMID: 3732454]
  • D Hudig, D Redelman, L L Minning. The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage. Journal of immunology (Baltimore, Md. : 1950). 1984 Nov; 133(5):2647-54. doi: . [PMID: 6384370]
  • C Glabe, M Buchalter, W J Lennarz. Studies on the interactions of sperm with the surface of the sea urchin egg. Developmental biology. 1981 Jun; 84(2):397-406. doi: 10.1016/0012-1606(81)90408-5. [PMID: 20737878]
  • M Yamada, T Watanabe, S Harino, H Fukui, H Wada. The effects of protease inhibitors on histidine decarboxylase activities and assay of enzyme in various rat tissues. Biochimica et biophysica acta. 1980 Oct; 615(2):458-64. doi: 10.1016/0005-2744(80)90511-2. [PMID: 7417458]
  • N T Neff, G N DeMartino, A L Goldberg. The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes. Journal of cellular physiology. 1979 Dec; 101(3):439-57. doi: 10.1002/jcp.1041010311. [PMID: 528571]
  • C D Gerson, N Cohen. Folic acid absorption in regional enteritis. The American journal of clinical nutrition. 1976 Feb; 29(2):182-6. doi: 10.1093/ajcn/29.2.182. [PMID: 3108]
  • D W Robinson, G E Bradford. Cellular response to selection for rapid growth in mice. Growth. 1969 Sep; 33(3):221-9. doi: NULL. [PMID: 5354004]