Cefpirome (BioDeep_00000008538)
Secondary id: BioDeep_00000859004
human metabolite
代谢物信息卡片
1-{[(6R,7R)-2-carboxylato-7-{[(2Z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-5H,6H,7H-cyclopenta[b]pyridin-1-ium
化学式: C22H22N6O5S2 (514.1093)
中文名称: 头孢匹罗
谱图信息:
最多检出来源 Astragalus membranaceus(plant) 52.38%
分子结构信息
SMILES: CO/N=C(/c1csc(=N)[nH]1)\C(=N[C@@H]1C(=O)N2C(=C(C[n+]3cccc4CCCc34)CS[C@H]12)C(=O)[O-])O
InChI: InChI=1S/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/b26-15-/t16-,20-/m1/s1
描述信息
Cefpirome is a fourth-generation cephalosporin. Trade names include Cefrom, Keiten, Broact, Cefir. Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria. It is marketed under the brand name of CEFROM by sanofi aventis group india.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DE - Fourth-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Same as: D07649
同义名列表
15 个代谢物同义名
1-{[(6R,7R)-2-carboxylato-7-{[(2Z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-5H,6H,7H-cyclopenta[b]pyridin-1-ium; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 3-((2,3-Cyclopenteno-1-pyridinium)methyl)-7-(2-syn-methoximino-2-(2-aminothiazole-4-yl)acetamido)ceph-3-em-4-carboxylate; Cefpirome sulphate; Cefpirome sulfate; Cefpiromum; Cefpiroma; CEFPIROME; Metran; HR 810; Cefrom; Cefir; CPR; Cefpirome
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3503
- KEGG: C11199
- PubChem: 5479539
- PubChem: 4487900
- HMDB: HMDB0041852
- Metlin: METLIN1592
- DrugBank: DB13682
- ChEMBL: CHEMBL65794
- Wikipedia: Cefpirome
- chemspider: 4586396
- CAS: 84957-29-9
- PMhub: MS000022165
- PubChem: 13380
- NIKKAJI: J32.848K
- RefMet: Cefpirome
- KNApSAcK: 3503
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Soyoung Kang, June Young Jang, Jongsung Hahn, Dasohm Kim, Jun Yeong Lee, Kyoung Lok Min, Seungwon Yang, Jin Wi, Min Jung Chang. Dose Optimization of Cefpirome Based on Population Pharmacokinetics and Target Attainment during Extracorporeal Membrane Oxygenation.
Antimicrobial agents and chemotherapy.
2020 04; 64(5):. doi:
10.1128/aac.00249-20. [PMID: 32122899] - Vikas Gautam, Johan W Mouton, Marian T Ten Kate, Irma A J M Bakker-Woudenberg, Sebastian van Burgh, Nikolaos Strepis, Corné H W Klaassen, Wil Goessens. Cefpirome Treatment Results in Limited Selection of Stable Derepressed Enterobacter cloacae Mutants in the Intestinal Flora of Rats Treated for an Experimental Klebsiella pneumoniae Pulmonary Infection.
Microbial drug resistance (Larchmont, N.Y.).
2020 Apr; 26(4):341-348. doi:
10.1089/mdr.2018.0473. [PMID: 31657651] - Robert Sauermann, Thomas Feurstein, Rudolf Karch, Maria C Kjellsson, Walter Jäger, Michaela Böhmdorfer, Andreas Püspök, Herbert Langenberger, Thomas Wild, Stefan Winkler, Markus Zeitlinger. Abscess penetration of cefpirome: concentrations and simulated pharmacokinetic profiles in pus.
European journal of clinical pharmacology.
2012 Oct; 68(10):1419-23. doi:
10.1007/s00228-012-1270-1. [PMID: 22441316] - Aurijit Sarkar, Kelcey C Anderson, Glen E Kellogg. Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics.
European journal of medicinal chemistry.
2012 Jun; 52(?):98-110. doi:
10.1016/j.ejmech.2012.03.008. [PMID: 22483632] - J B Bulitta, M Kinzig, C B Landersdorfer, U Holzgrabe, U Stephan, F Sörgel. Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers.
Antimicrobial agents and chemotherapy.
2011 Jun; 55(6):2927-36. doi:
10.1128/aac.01484-10. [PMID: 21402834] - Jörg Lindenmann, Sylvia A Kugler, Veronika Matzi, Christian Porubsky, Alfred Maier, Peter Dittrich, Wolfgang Graninger, Freyja M Smolle-Jüttner, Christian Joukhadar. High extracellular levels of cefpirome in unaffected and infected lung tissue of patients.
The Journal of antimicrobial chemotherapy.
2011 Jan; 66(1):160-4. doi:
10.1093/jac/dkq413. [PMID: 21081546] - Francis F Arhin, Adam Belley, Geoffrey McKay, Sylvain Beaulieu, Ingrid Sarmiento, Thomas R Parr, Gregory Moeck. Assessment of oritavancin serum protein binding across species.
Antimicrobial agents and chemotherapy.
2010 Aug; 54(8):3481-3. doi:
10.1128/aac.00271-10. [PMID: 20498314] - Somchai Sriwiriyajan, Werawath Mahatthanatrakul. Development of an analytical method for cefpirome in plasma by simplified HPLC technique and its applications.
Arzneimittel-Forschung.
2010; 60(6):336-9. doi:
10.1055/s-0031-1296297. [PMID: 20648924] - April Barbour, Stephan Schmidt, Sreedharan Nair Sabarinath, Maria Grant, Christoph Seubert, Donna Skee, Bindu Murthy, Hartmut Derendorf. Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.
Antimicrobial agents and chemotherapy.
2009 Jul; 53(7):2773-6. doi:
10.1128/aac.01409-08. [PMID: 19364847] - C C Wagner, I Steiner, M Zeitlinger. Daptomycin elimination by CVVH in vitro: evaluation of factors influencing sieving and membrane adsorption.
International journal of clinical pharmacology and therapeutics.
2009 Mar; 47(3):178-86. doi:
10.5414/cpp47178. [PMID: 19281727] - Ashraf M Ahmed, Tadashi Shimamoto. Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.
International journal of antimicrobial agents.
2008 Sep; 32(3):256-61. doi:
10.1016/j.ijantimicag.2008.04.019. [PMID: 18619820] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Neetu Rajput, Vinod K Dumka, Harpal S Sandhu. Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves.
Journal of veterinary science.
2007 Mar; 8(1):21-5. doi:
10.4142/jvs.2007.8.1.21. [PMID: 17322770] - Petra Luckner, Matthias Brandsch. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2005 Jan; 59(1):17-24. doi:
10.1016/j.ejpb.2004.07.008. [PMID: 15567297] - Ilka M Steiner, Herbert Langenberger, Claudia Marsik, Bernhard X Mayer, Milena Fischer, Apostolos Georgopoulos, Markus Müller, Gottfried Heinz, Christian Joukhadar. Effect of norepinephrine on cefpirome tissue concentrations in healthy subjects.
The Journal of antimicrobial chemotherapy.
2004 Mar; 53(3):506-11. doi:
10.1093/jac/dkh111. [PMID: 14749346] - Kiyohito Ishikawa, Shinzaburo Miyakawa, Toshiyuki Tanaka, Yorio Naide, Ryoichi Shiroki, Kiyotaka Hoshinaga. [The trend and susceptibility to antibacterial agents of enterococcus species from urinary tract infections].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2004 Jan; 95(1):25-34. doi:
10.5980/jpnjurol1989.95.25. [PMID: 14978938] - M Nikolovski, Iu Kotsev, P Panchev. [Treatment with cefrom (cefpirom) in severe urological infections].
Khirurgiia.
2004; 60(4-5):39-41. doi:
NULL. [PMID: 16042063] - Jeffrey Lipman, Steven C Wallis, Robert J Boots. Cefepime versus cefpirome: the importance of creatinine clearance.
Anesthesia and analgesia.
2003 Oct; 97(4):1149-1154. doi:
10.1213/01.ane.0000077077.54084.b0. [PMID: 14500173] - M A Zeitlinger, C Marsik, A Georgopoulos, M Müller, G Heinz, C Joukhadar. Target site bacterial killing of cefpirome and fosfomycin in critically ill patients.
International journal of antimicrobial agents.
2003 Jun; 21(6):562-7. doi:
10.1016/s0924-8579(03)00047-5. [PMID: 12791470] - Florian Tomaselli, Alfred Maier, Freyja-Maria Smolle-Jüttner. [Pharmacokinetics of antibiotics in inflamed and healthy lung tissue].
Wiener medizinische Wochenschrift (1946).
2003; 153(15-16):342-4. doi:
10.1007/s10354-003-0006-3. [PMID: 13677255] - Christian Joukhadar, Nikolas Klein, Bernhard X Mayer, Nicole Kreischitz, Georg Delle-Karth, Peter Palkovits, Gottfried Heinz, Markus Müller. Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis.
Critical care medicine.
2002 Jul; 30(7):1478-82. doi:
10.1097/00003246-200207000-00013. [PMID: 12130965] - Harald Herkner, Michael Rolf Müller, Nicole Kreischitz, Bernahrd X Mayer, Martin Frossard, Christian Joukhadar, Nikolas Klein, Edith Lackner, Markus Müller. Closed-chest microdialysis to measure antibiotic penetration into human lung tissue.
American journal of respiratory and critical care medicine.
2002 Jan; 165(2):273-6. doi:
10.1164/ajrccm.165.2.2106082. [PMID: 11790667] - J Lipman, S C Wallis, C M Rickard, D Fraenkel. Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing.
Intensive care medicine.
2001 Feb; 27(2):363-70. doi:
10.1007/s001340000741. [PMID: 11396280] - P Pina, B Pangon, Y Rio, H Chardon, A K Lallali, P Y Allouch. [Antibiotic sensitivity of enterobacteria in intensive care units].
Pathologie-biologie.
2000 Jun; 48(5):485-9. doi:
NULL. [PMID: 10949846] - B X Mayer, U Hollenstein, M Brunner, H G Eichler, M Müller. Micellar electrokinetic chromatography for the analysis of cefpirome in microdialysis and plasma samples obtained in vivo from human volunteers.
Electrophoresis.
2000 May; 21(8):1558-64. doi:
10.1002/(sici)1522-2683(20000501)21:8<1558::aid-elps1558>3.0.co;2-n. [PMID: 10832888] - M Banyai, F Thalhammer, I El-Menyawi, G Heinz, F Traunmüller, P Siostrzonek. Pharmacokinetics of cefpirome during continuous venovenous hemofiltration: rationale for an 8-hour dosing interval.
Clinical pharmacology and therapeutics.
2000 Apr; 67(4):368-72. doi:
10.1067/mcp.2000.105352. [PMID: 10801245] - U Hollenstein, M Brunner, B X Mayer, S Delacher, B Erovic, H G Eichler, M Müller. Target site concentrations after continuous infusion and bolus injection of cefpirome to healthy volunteers.
Clinical pharmacology and therapeutics.
2000 Mar; 67(3):229-36. doi:
10.1067/mcp.2000.104266. [PMID: 10741625] - C Bornet, A Davin-Regli, C Bosi, J M Pages, C Bollet. Imipenem resistance of enterobacter aerogenes mediated by outer membrane permeability.
Journal of clinical microbiology.
2000 Mar; 38(3):1048-52. doi:
10.1128/jcm.38.3.1048-1052.2000. [PMID: 10698994] - T S Van der Werf, J W Fijen, N C Van de Merbel, R Spanjersberg, A V Möller, J J Ligtenberg, J E Tulleken, J G Zijlstra, C A Stegeman. Pharmacokinetics of cefpirome in critically ill patients with renal failure treated by continuous veno-venous hemofiltration.
Intensive care medicine.
1999 Dec; 25(12):1427-31. doi:
10.1007/s001340051092. [PMID: 10660852] - D Breilh, C Lavallee, A Fratta, D Ducint, P Cony-Makhoul, M C Saux. Determination of cefepime and cefpirome in human serum by high-performance liquid chromatography using an ultrafiltration for antibiotics serum extraction.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Oct; 734(1):121-7. doi:
10.1016/s0378-4347(99)00343-6. [PMID: 10574197] - J Kaburaki, M Yamada, M Kamikawara, Y Konosu, M Iwase, S Uehara, H Kikuchi. In vivo and in vitro positive interference by cefpirome in measurement of serum creatinine by the Jaffe method.
The Keio journal of medicine.
1999 Jun; 48(2):93-6. doi:
10.2302/kjm.48.93. [PMID: 10405525] - A Jacolot, P Incagnoli, A R Edouard, M Tod, O Petitjean, K Samii, O Mimoz. Pharmacokinetics of cefpirome during the posttraumatic systemic inflammatory response syndrome.
Intensive care medicine.
1999 May; 25(5):486-91. doi:
10.1007/s001340050885. [PMID: 10401943] - M Bergeret, J Raymond. In-vitro bactericidal activity of cefpirome and cefamandole in combination with glycopeptides against methicillin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy.
1999 Feb; 43(2):291-4. doi:
10.1093/jac/43.2.291. [PMID: 11252338] - H Sugihara, N Narita, R Takatsu, M Horiuchi, K Yonenami, M Hotta, K Shibahara, T Kamo, Y Negishi. Study of the pharmacokinetics of cefpirome sulphate in the elderly.
Journal of clinical pharmacy and therapeutics.
1998 Oct; 23(5):375-9. doi:
10.1046/j.1365-2710.1998.00176.x. [PMID: 9875686] - I R Friedland, E Sultan, K H Lehr, B Lenfant. Concentrations of cefpirome in cerebrospinal fluid of children with bacterial meningitis after a single intravenous dose.
Antimicrobial agents and chemotherapy.
1998 Jan; 42(1):199-201. doi:
10.1128/aac.42.1.199. [PMID: 9449289] - M Müller, B Rohde, A Kovar, A Georgopoulos, H G Eichler, H Derendorf. Relationship between serum and free interstitial concentrations of cefodizime and cefpirome in muscle and subcutaneous adipose tissue of healthy volunteers measured by microdialysis.
Journal of clinical pharmacology.
1997 Dec; 37(12):1108-13. doi:
10.1002/j.1552-4604.1997.tb04294.x. [PMID: 9506005] - H Elkhaïli, D Pompei, J D Peter, L Linger, J Salmon, D Levêque, S Niedergang, Y Salmon, R C Thierry, H Monteil, F Jehl. [In vivo pharmacokinetic of amikacin and its pharmacodynamic in combination with cefepime, cefpirome and meropenem in an in vitro/ex vivo micropig model].
Pathologie-biologie.
1997 May; 45(5):347-56. doi:
. [PMID: 9296083] - M Nishiyama, T Koh, O Kabutomori, T Yanagihara. [A case of red blood cell(RBC) agglutination on peripheral blood smear and effect of cefpirom sulfate].
Rinsho byori. The Japanese journal of clinical pathology.
1997 May; 45(5):498-500. doi:
NULL. [PMID: 9170980] - Y Mrestani, R Neubert, J Schiewe, A Härtl. Application of capillary zone electrophoresis in cephalosporin analysis.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 690(1-2):321-6. doi:
10.1016/s0378-4347(96)00425-2. [PMID: 9106059] - H Hamazaki, H Hasegawa, A Horiuchi, H Teshima, A Hiraoka, T Masaoka, K Nasu, H Uchino, N Tatsumi, N Inoue, T Kageyama, H Kawagoe, M Tukaguchi, S Hukuhara, T Takahashi, H Takatsuka, A Kanamaru, E Kakishita, K Nagai, H Hara, Y Kanayama, H Sugiyama, T Kitani. [Clinical evaluation of cefpirome sulfate for severe infections in patients with hematological disorders. Hanshin Study Group of Hematopoietic Disorders and Infections].
The Japanese journal of antibiotics.
1997 Jan; 50(1):12-21. doi:
. [PMID: 9059910] - F Thalhammer, S Schmaldienst, I Elmenyawi, M Atteneder, H Burgmann, U Hollenstein, A Georgopoulos, W Graninger, D Putz, A R Rosenkranz, G Mayer, W H Hörl, S Breyer. Multiple-dose pharmacokinetics of cefpirome in long-term hemodialysis with high-flux membranes.
Clinical pharmacology and therapeutics.
1996 Dec; 60(6):645-50. doi:
10.1016/s0009-9236(96)90212-x. [PMID: 8988066] - M Müller, O Haag, T Burgdorff, A Georgopoulos, W Weninger, B Jansen, G Stanek, H Pehamberger, E Agneter, H G Eichler. Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans.
Antimicrobial agents and chemotherapy.
1996 Dec; 40(12):2703-9. doi:
10.1128/aac.40.12.2703. [PMID: 9124826] - S Munemoto, M Soma, E Kuroda, Y Hamada, M Nakada. [Studies on cerebrospinal fluid penetration of cefpirome in adult with meningitis].
The Japanese journal of antibiotics.
1996 Jun; 49(6):658-62. doi:
. [PMID: 8776632] - O Mimoz, A Jacolot, C Padoin, J Quillard, M Tod, K Louchahi, K Samii, O Petitjean. Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics.
Antimicrobial agents and chemotherapy.
1996 Mar; 40(3):819-21. doi:
10.1128/aac.40.3.819. [PMID: 8851623] - M C Nahata, W J Barson, S K Puri. Pharmacokinetics of cefpirome in pediatric patients.
Antimicrobial agents and chemotherapy.
1995 Oct; 39(10):2348-9. doi:
10.1128/aac.39.10.2348. [PMID: 8619595] - F Itoh, K Sato, T Harauchi, M Hirata, Y Mizushima. [Modification of vancomycin nephrotoxicity by other antibiotics in rats].
The Japanese journal of antibiotics.
1995 Mar; 48(3):380-8. doi:
. [PMID: 7752451] - M G Bergeron, M Bernier. Bactericidal activity of cefpirome (HR 810) against 513 gram-negative bacteria isolated from blood of septicemic patients.
Infection.
1994 Jul; 22(4):299-305. doi:
10.1007/bf01739925. [PMID: 8002094] - B Fantin, R Farinotti, A Thabaut, C Carbon. Conditions for the emergence of resistance to cefpirome and ceftazidime in experimental endocarditis due to Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy.
1994 Mar; 33(3):563-9. doi:
10.1093/jac/33.3.563. [PMID: 8040120] - L M Lamb, J R Hibbard, J V Desiderio, Y H Tsai. Efficacy of cefepime in a Staphylococcus aureus endocarditis rat model.
The Journal of antimicrobial chemotherapy.
1993 Nov; 32 Suppl B(?):95-101. doi:
10.1093/jac/32.suppl_b.95. [PMID: 8150772] - L C Strenkoski, D E Nix. Cefpirome clinical pharmacokinetics.
Clinical pharmacokinetics.
1993 Oct; 25(4):263-73. doi:
10.2165/00003088-199325040-00002. [PMID: 8261711] - N Veys, N Lameire, V Malerczyk, K H Lehr, B Rosenkranz, S Ringoir. Single-dose pharmacokinetics of cefpirome in patients receiving hemodialysis and in patients treated by continuous ambulatory peritoneal dialysis.
Clinical pharmacology and therapeutics.
1993 Oct; 54(4):395-401. doi:
10.1038/clpt.1993.166. [PMID: 8222482] - W A Craig. The pharmacokinetics of cefpirome--rationale for a twelve-hour dosing regimen.
Scandinavian journal of infectious diseases. Supplementum.
1993; 91(?):33-40. doi:
. [PMID: 8290901] - H Shishido, H Nagai, S Miyake, T Kaburagi, K Satoh, K Deguchi. Penetration of cefpirome into sputum in chronic respiratory infections: comparison of administration of 0.5 g and 1.0 g in the same patient.
International journal of clinical pharmacology research.
1993; 13(4):225-9. doi:
. [PMID: 8150549] - I Saito, Y Saiko, T Tahara, Y Hosoi. Penetration of cefpirome into renal and prostatic tissue.
International journal of clinical pharmacology research.
1993; 13(6):317-24. doi:
. [PMID: 8088932] - Y Mine, Y Watanabe, H Sakamoto, K Hatano, K Kuno, Y Higashi, T Kamimura, Y Matsumoto, S Tawara, F Matsumoto. In vitro antibacterial activity of FK037, a novel parenteral broad-spectrum cephalosporin.
The Journal of antibiotics.
1993 Jan; 46(1):71-87. doi:
10.7164/antibiotics.46.71. [PMID: 8436562] - L Verbist. Epidemiology and sensitivity of 8625 ICU and hematology/oncology bacterial isolates in Europe. International Study Group.
Scandinavian journal of infectious diseases. Supplementum.
1993; 91(?):14-24. doi:
NULL. [PMID: 8290899] - E F Legg, J M Guy. Serum creatinine assays in patients receiving the antibiotic Cefpirome (HR 810): a study of three different routine methods compared with a specific HPLC method.
Medical laboratory sciences.
1992 Dec; 49(4):248-51. doi:
NULL. [PMID: 1339927] - Y Kita, T Yamazaki, A Imada. Comparative pharmacokinetics of SCE-2787 and related antibiotics in experimental animals.
Antimicrobial agents and chemotherapy.
1992 Nov; 36(11):2481-6. doi:
10.1128/aac.36.11.2481. [PMID: 1489192] - D Paradis, F Vallée, S Allard, C Bisson, N Daviau, C Drapeau, F Auger, M LeBel. Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, and ciprofloxacin.
Antimicrobial agents and chemotherapy.
1992 Oct; 36(10):2085-92. doi:
10.1128/aac.36.10.2085. [PMID: 1444289] - N Lameire, V Malerczyk, B Drees, K Lehr, B Rosenkranz. Single-dose pharmacokinetics of cefpirome in patients with renal impairment.
Clinical pharmacology and therapeutics.
1992 Jul; 52(1):24-30. doi:
10.1038/clpt.1992.98. [PMID: 1623690] - M Wolff, P Chavanet, A Kazmierczak, A Pechinot, C Dematons, H Portier, B Lenfant. Diffusion of cefpirome into the cerebrospinal fluid of patients with purulent meningitis.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):59-62. doi:
10.1093/jac/29.suppl_a.59. [PMID: 1601758] - C Carbon. Prospective randomized phase II study of intravenous cefpirome 1g or 2g bd in the treatment of hospitalized patients with different infections. Cefpirome Study Group.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):87-94. doi:
10.1093/jac/29.suppl_a.87. [PMID: 1601764] - B H Meyer, F O Muller, H G Luus, B Drees, H J Röthig, M Badian, H G Eckert. Safety, tolerance and pharmacokinetics of cefpirome administered intramuscularly to healthy subjects.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):63-70. doi:
10.1093/jac/29.suppl_a.63. [PMID: 1601759] - H B Lassman, J W Hubbard, B L Chen, S K Puri. Lack of interaction between cefpirome and alcohol.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):47-50. doi:
10.1093/jac/29.suppl_a.47. [PMID: 1601756] - D E Nix, J H Wilton, N Velasquez, J L Budny, H B Lassman, P Mitchell, K Divan, J J Schentag. Cerebrospinal fluid penetration of cefpirome in patients with non-inflamed meninges.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):51-7. doi:
10.1093/jac/29.suppl_a.51. [PMID: 1601757] - H Knothe, V Schäfer, A Sammann, M Badian, P M Shah. Influence of cefpirome on pharyngeal and faecal flora after single and multiple intravenous administrations of cefpirome to healthy volunteers.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):81-6. doi:
10.1093/jac/29.suppl_a.81. [PMID: 1601763] - D Isert, N Klesel, M Limbert, A Markus, G Seibert, E Schrinner. Pharmacokinetics of cefpirome administered intravenously or intramuscularly to rats and dogs.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):31-7. doi:
10.1093/jac/29.suppl_a.31. [PMID: 1601754] - NULL. Cefpirome versus ceftazidime in the treatment of urinary tract infections.
The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):95-104. doi:
10.1093/jac/29.suppl_a.95. [PMID: 1601765] - I Nakayama, Y Akieda, E Yamaji, Y Nitta, M Ohishi, K Katagiri, N Imamura, K Takase. Single- and multiple-dose pharmacokinetics of intravenous cefpirome (HR810) to healthy volunteers.
Journal of clinical pharmacology.
1992 Mar; 32(3):256-66. doi:
10.1002/j.1552-4604.1992.tb03834.x. [PMID: 1564130] - G L Kearns, V A Johnson, I R Hendry, T G Wells. Microanalytical high-performance liquid chromatographic assay for cefpirome in human milk and urine.
Journal of chromatography.
1992 Feb; 574(2):356-60. doi:
10.1016/0378-4347(92)80053-s. [PMID: 1618972] - Y Ogata, H Suzuki, T Saruta. [Pharmacokinetics of cefpirome (CPR) in patients with impaired renal function].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
1991 Dec; 65(12):1514-8. doi:
10.11150/kansenshogakuzasshi1970.65.1514. [PMID: 1783801] - S Kulkarni, A P Wilson, R N Grüneberg, C Filipiak, C T Samuell. Interference of cefpirome with the measurement of plasma creatinine.
The Journal of antimicrobial chemotherapy.
1991 Oct; 28(4):617-9. doi:
10.1093/jac/28.4.617. [PMID: 1761460] - M H Wilcox, A Pithie, G Smith, T A Moreland, P G Davey, R G Finch. Relationship between cefpirome clearance, serum creatinine, weight and age in patients treated for infection.
The Journal of antimicrobial chemotherapy.
1991 Aug; 28(2):291-9. doi:
10.1093/jac/28.2.291. [PMID: 1778859] - N Iwai, H Nakamura, M Miyazu, Y Watanabe, Y Taneda. [Laboratory and clinical studies on cefpirome in pediatrics].
The Japanese journal of antibiotics.
1991 Jul; 44(7):748-69. doi:
. [PMID: 1886201] - F L Sapico, V J Ginunas, J Z Montgomerie, H N Canawati. Cefpirome, alone and in combination with gentamicin for enterococcal pyelonephritis in the rodent model.
Diagnostic microbiology and infectious disease.
1991 Jul; 14(4):297-300. doi:
10.1016/0732-8893(91)90020-g. [PMID: 1909613] - D R Baldwin, S R Maxwell, D Honeybourne, J M Andrews, J P Ashby, R Wise. The penetration of cefpirome into the potential sites of pulmonary infection.
The Journal of antimicrobial chemotherapy.
1991 Jul; 28(1):79-86. doi:
10.1093/jac/28.1.79. [PMID: 1769946] - K Nagano, N Nakayama, Y Tuji, H Miyazoe. [Laboratory and clinical studies on cefpirome in pediatrics].
The Japanese journal of antibiotics.
1991 May; 44(5):543-51. doi:
. [PMID: 1880934] - I Saito, Y Saiko, M Yokozawa, K Ono, T Tahara, Y Hosoi. [A basic study on cefpirome].
Hinyokika kiyo. Acta urologica Japonica.
1991 Apr; 37(4):441-6. doi:
. [PMID: 1909830] - T Nishimura, K Tabuki, S Aoki, M Takagi. [Laboratory and clinical studies of cefpirome in pediatric field].
The Japanese journal of antibiotics.
1991 Apr; 44(4):454-61. doi:
. [PMID: 1880924] - S Nakazawa, H Sato, Y Hirama, A Narita, K Matsumoto, S Nakazawa, H Suzuki, Y Nakanishi, K Nagao, K Niino. [Pharmacokinetic and clinical evaluation of cefpirome in the pediatric field].
The Japanese journal of antibiotics.
1991 Apr; 44(4):426-39. doi:
. [PMID: 1880921] - K Kuno, A Ogawa, H Takeuchi, K Tomita, O Kito, H Andou, Y Takimoto. [Bacteriological, pharmacokinetic and clinical studies of cefpirome in the field of pediatrics].
The Japanese journal of antibiotics.
1991 Apr; 44(4):440-6. doi:
. [PMID: 1880922] - S Matsuoka, Y Takahashi, Y Kuroda. [Clinical evaluation of cefpirome in pediatric field].
The Japanese journal of antibiotics.
1991 Apr; 44(4):462-5. doi:
. [PMID: 1880925] - U Kohdera, M Woo, M Kino, H Kawasaki, J Suzukawa, M Nakamura, S Cho, Y Hirabayashi, H Higashino, Y Kobayashi. [Pharmacokinetic and clinical study of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):213-22. doi:
. [PMID: 2041161] - T Haruta, S Kuroki, K Okura, M Yamakawa, H Nigami, M Naramura, N Yoshida, Y Kobayashi. [Pharmacokinetic and clinical studies of cefpirome in pediatric field].
The Japanese journal of antibiotics.
1991 Feb; 44(2):223-33. doi:
. [PMID: 1828275] - Y Toyonaga, K Yamori, N Sakaguchi, M Sugita, K Kawamura, K Seo. [Pharmacokinetic and clinical evaluation of cefpirome in the pediatric field].
The Japanese journal of antibiotics.
1991 Feb; 44(2):184-206. doi:
. [PMID: 2041159] - Y Sato, S Iwata, H Akita, K Sunakawa. [Pharmacokinetic and clinical studies on cefpirome in pediatrics].
The Japanese journal of antibiotics.
1991 Feb; 44(2):168-83. doi:
NULL. [PMID: 2041158] - H Meguro, R Fujii, T Tajima, T Abe. [Clinical evaluation of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):160-7. doi:
NULL. [PMID: 2041157] - H S Jafari, X Sáez-Llorens, O Ramilo, S L Shelton, G H McCracken. Pharmacokinetics and antibacterial efficacy of cefpirome (HR 810) in experimental Escherichia coli and Haemophilus influenzae type b meningitis.
Antimicrobial agents and chemotherapy.
1991 Feb; 35(2):220-3. doi:
10.1128/aac.35.2.220. [PMID: 2024953] - K Kida, T Morimoto, H Matsuda, M Murase. [Pharmacokinetical and clinical study of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):234-40. doi:
NULL. [PMID: 2041162] - T Ihara, H Kamiya, M Ito, M Sakurai. [Pharmacokinetics and clinical evaluation of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):207-12. doi:
NULL. [PMID: 2041160] - H Wakiguchi, M Fujieda, A Maeda, Y Shimazaki, N Ohishi, S Kido, T Takechi, K Takeda, H Maeda, H Morita. [Clinical efficacy of cefpirome against various infectious diseases in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):241-5. doi:
NULL. [PMID: 2041163] - T Haruta, K Okura, S Kuroki, Y Kobayashi. [Transferability of cefpirome to cerebrospinal fluid of rabbits with meningitis caused by Staphylococcus aureus].
The Japanese journal of antibiotics.
1991 Jan; 44(1):58-61. doi:
NULL. [PMID: 2041148] - R Okamoto, A Tamura, T Yoshida, I Komiya, H Ogino, S Inouye, S Kondo, M Inoue, S Mitsuhashi. In vitro and in vivo antibacterial activities of ME1220 and ME1221, novel cephalosporins.
Drugs under experimental and clinical research.
1991; 17(4):205-12. doi:
NULL. [PMID: 1794294] - S Iwata, M Ikeda, E Isohata, Y Kin, T Yokota, Y Kusumoto, Y Sato, H Akita, T Oikawa, K Sunakawa. [The influence of cefpirome on intestinal bacterial flora].
The Japanese journal of antibiotics.
1991 Jan; 44(1):62-83. doi:
NULL. [PMID: 2041149] - S Inoue, H Morioka, R Satoh, Y Yoshida, M Omosu, T Kobayashi. [Antigenicity study of cefpirome sulfate].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):129-45. doi:
10.2131/jts.15.supplementiii_129. [PMID: 2074601] - T Deki, A Matsuoka, K Marutani, T Nakagawa, K Masuda, T Matsuzawa, K Horiuchi, T Ohishi, T Ohtani, R Niki. [Nephrotoxicity of cefpirome sulfate in rabbits--single and multiple intravenous administration].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):173-200. doi:
10.2131/jts.15.supplementiii_173. [PMID: 2074603] - T Deki, S Higo, Y Sakamaki, T Uchiyama, T Ohtani, S Kokuba, Y Kumagai. [Six-month intraperitoneal toxicity study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):11-52. doi:
10.2131/jts.15.supplementiii_11. [PMID: 2074600] - O Sugiyama, K Tanaka, M Toya, S Igarashi, K Watanabe, S Watanabe, K Tsuji, Y Kumagai. [Fertility study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):53-64. doi:
10.2131/jts.15.supplementiii_53. [PMID: 2074604] - O Sugiyama, K Tanaka, M Toya, S Igarashi, K Watanabe, S Watanabe, K Tsuji, Y Kumagai. [Teratological study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):65-89. doi:
10.2131/jts.15.supplementiii_65. [PMID: 2074605]
