Melitten (BioDeep_00000008537)

 

Secondary id: BioDeep_00001871994

human metabolite blood metabolite


代谢物信息卡片


2-{[2-({6-amino-2-[(2-{[6-amino-2-({2-[(2-{[2-({2-[(2-{[2-({[1-(2-{[2-({2-[(2-{[2-({2-[(6-amino-2-{[2-({2-[(2-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1,3-dihydroxybutylidene)amino]-1,3-dihydroxybutylidene}amino)-1-hydroxyethylidene]amino}-4-methylpentanoyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1,3-dihydroxypropylidene]amino}-1-hydroxy-3-(1H-indol-3-yl)propylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyhexylidene]amino}-5-carbamimidamido-1-hydroxypentylidene)amino]-1-hydroxyhexylidene}amino)-5-carbamimidamido-1-hydroxypentylidene]amino}-N-[1,3-bis(C-hydroxycarbonimidoyl)propyl]pentanediimidic acid

化学式: C131H229N39O31 (2844.7540844)
中文名称: 蜂毒肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(N=C(O)CN)C(O)=NCC(O)=NC(C)C(O)=NC(C(C)C)C(O)=NC(CC(C)C)C(O)=NC(CCCCN)C(O)=NC(C(C)C)C(O)=NC(CC(C)C)C(O)=NC(C(C)O)C(O)=NC(C(C)O)C(O)=NCC(O)=NC(CC(C)C)C(=O)N1CCCC1C(O)=NC(C)C(O)=NC(CC(C)C)C(O)=NC(C(C)CC)C(O)=NC(CO)C(O)=NC(CC1=CNC2=CC=CC=C12)C(O)=NC(C(C)CC)C(O)=NC(CCCCN)C(O)=NC(CCCNC(N)=N)C(O)=NC(CCCCN)C(O)=NC(CCCNC(N)=N)C(O)=NC(CCC(O)=N)C(O)=NC(CCC(O)=N)C(O)=N
InChI: InChI=1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)

描述信息

同义名列表

5 个代谢物同义名

2-{[2-({6-amino-2-[(2-{[6-amino-2-({2-[(2-{[2-({2-[(2-{[2-({[1-(2-{[2-({2-[(2-{[2-({2-[(6-amino-2-{[2-({2-[(2-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxyhexylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1,3-dihydroxybutylidene)amino]-1,3-dihydroxybutylidene}amino)-1-hydroxyethylidene]amino}-4-methylpentanoyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1,3-dihydroxypropylidene]amino}-1-hydroxy-3-(1H-indol-3-yl)propylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxyhexylidene]amino}-5-carbamimidamido-1-hydroxypentylidene)amino]-1-hydroxyhexylidene}amino)-5-carbamimidamido-1-hydroxypentylidene]amino}-N-[1,3-bis(C-hydroxycarbonimidoyl)propyl]pentanediimidic acid; Melitten; Melittin; Melitten; Melittin; Mellitin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li. Combination Nano-Delivery Systems Remodel the Immunosuppressive Tumor Microenvironment for Metastatic Triple-Negative Breast Cancer Therapy. Molecular pharmaceutics. 2024 May; 21(5):2148-2162. doi: 10.1021/acs.molpharmaceut.3c00242. [PMID: 38536949]
  • Sein Min, Cyrus Picou, Hye Jin Jeong, Adam Bower, Keunhong Jeong, Jean K Chung. Melittin-Phospholipase A2 Synergism Is Mediated by Liquid-Liquid Miscibility Phase Transition in Giant Unilamellar Vesicles. Langmuir : the ACS journal of surfaces and colloids. 2024 Apr; 40(14):7456-7462. doi: 10.1021/acs.langmuir.3c03920. [PMID: 38546877]
  • Magda Vargas-Pérez, Azucena González-Horta, Hiram Mendoza-Hernández, Myriam Elías-Santos, Karim Acuña-Askar, Luis Jesús Galán-Wong, Hugo Alberto Luna-Olvera. Neochloris oleoabundans cell wall rupture through melittin peptide: a new approach to increase lipid recovery. Biotechnology letters. 2024 Feb; 46(1):97-106. doi: 10.1007/s10529-023-03451-2. [PMID: 38109017]
  • Justus C Stephani, Luca Gerhards, Bishoy Khairalla, Ilia A Solov'yov, Izabella Brand. How do Antimicrobial Peptides Interact with the Outer Membrane of Gram-Negative Bacteria? Role of Lipopolysaccharides in Peptide Binding, Anchoring, and Penetration. ACS infectious diseases. 2024 Jan; ?(?):. doi: 10.1021/acsinfecdis.3c00673. [PMID: 38259029]
  • Jing-Shun Meng, Yun He, Heng-Bin Yang, Li-Ping Zhou, Si-Yuan Wang, Xi-Lin Feng, Omar Yahya Al-Shargi, Xiao-Min Yu, Li-Qing Zhu, Chang-Quan Ling. Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency. Journal of integrative medicine. 2024 Jan; 22(1):72-82. doi: 10.1016/j.joim.2024.01.001. [PMID: 38307819]
  • Xin Jin, Hangyi Wu, Jie Yu, Yanni Cao, Lanyi Zhang, Zhenhai Zhang, Huixia Lv. Glutamate affects self-assembly, protein corona, and anti-4 T1 tumor effects of melittin/vitamin E-succinic acid-(glutamate)n nanoparticles. Journal of controlled release : official journal of the Controlled Release Society. 2024 Jan; 365(?):802-817. doi: 10.1016/j.jconrel.2023.12.013. [PMID: 38092255]
  • Linfu Yang, Wenzheng Zhao, Xueyang Gong, Dan Yue, Yiqiu Liu, Yakai Tian, Kun Dong. Exploring potential network pharmacology-and molecular docking-based mechanism of melittin in treating rheumatoid arthritis. Medicine. 2023 Aug; 102(32):e34728. doi: 10.1097/md.0000000000034728. [PMID: 37565866]
  • Haoning Gong, Xuzhi Hu, Lin Zhang, Ke Fa, Mingrui Liao, Huayang Liu, Giovanna Fragneto, Mario Campana, Jian Ren Lu. How do antimicrobial peptides disrupt the lipopolysaccharide membrane leaflet of Gram-negative bacteria?. Journal of colloid and interface science. 2023 May; 637(?):182-192. doi: 10.1016/j.jcis.2023.01.051. [PMID: 36701864]
  • Diana Harfmann, Adrian Florea. Experimental envenomation with honeybee venom melittin and phospholipase A2 induced multiple ultrastructural changes in adrenocortical mitochondria. Toxicon : official journal of the International Society on Toxinology. 2023 Apr; ?(?):107136. doi: 10.1016/j.toxicon.2023.107136. [PMID: 37116588]
  • Parisa Mansouri Rad, Leila Rahbarnia, Azam Safary, Azizeh ShadiDizaji, Zahra Maani. The Synthetic Antimicrobial Peptide Derived From Melittin Displays Low Toxicity and Anti-infectious Properties. Probiotics and antimicrobial proteins. 2023 Mar; ?(?):. doi: 10.1007/s12602-023-10066-6. [PMID: 36988897]
  • Cheng Xu, Kai Yang, Bing Yuan. Non-Gaussian Diffusion of Individual Lipids Unveils the Unique Peptide-Membrane Interaction Dynamics. The journal of physical chemistry letters. 2023 Feb; 14(4):854-862. doi: 10.1021/acs.jpclett.2c03467. [PMID: 36656807]
  • Can Lv, Jiaojiao Chen, Feng Huang, Fanfu Fang, Bai Li. Melittin inhibits the proliferation migration and invasion of HCC cells by regulating ADAMTS9-AS2 demethylation. Toxicon : official journal of the International Society on Toxinology. 2023 Jan; 222(?):106996. doi: 10.1016/j.toxicon.2022.106996. [PMID: 36535531]
  • Zheng Liu, Zhan Fan, Jinxin Liu, Jialu Wang, Mengli Xu, Xinlin Li, Yilun Xu, Yafang Lu, Chenlu Han, Zhihong Zhang. Melittin-Carrying Nanoparticle Suppress T Cell-Driven Immunity in a Murine Allergic Dermatitis Model. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Jan; ?(?):e2204184. doi: 10.1002/advs.202204184. [PMID: 36638280]
  • Alain Bolaño Alvarez, Benjamín Caruso, Steffen B Petersen, Pablo E A Rodríguez, Gerardo D Fidelio. Melittin-solid phospholipid mixed films trigger amyloid-like nano-fibril arrangements at air-water interface. Biochimica et biophysica acta. Biomembranes. 2022 12; 1864(12):184048. doi: 10.1016/j.bbamem.2022.184048. [PMID: 36115495]
  • Liang Sun, Simin Wang, Fujia Tian, Haoqi Zhu, Liang Dai. Organizations of melittin peptides after spontaneous penetration into cell membranes. Biophysical journal. 2022 11; 121(22):4368-4381. doi: 10.1016/j.bpj.2022.10.002. [PMID: 36199252]
  • Tianyi Dou, Clara Zens, Katrin Schröder, Yuan Jiang, Alexey A Makarov, Stephan Kupfer, Dmitry Kurouski. Solid-to-Liposome Conformational Transition of Phosphatidylcholine and Phosphatidylserine Probed by Atomic Force Microscopy, Infrared Spectroscopy, and Density Functional Theory Calculations. Analytical chemistry. 2022 09; 94(38):13243-13249. doi: 10.1021/acs.analchem.2c03061. [PMID: 36107722]
  • Yusuke Miyazaki, Wataru Shinoda. Cooperative antimicrobial action of melittin on lipid membranes: A coarse-grained molecular dynamics study. Biochimica et biophysica acta. Biomembranes. 2022 09; 1864(9):183955. doi: 10.1016/j.bbamem.2022.183955. [PMID: 35526599]
  • Nathan A Delvaux, Kevin G Rice. The reduced-charge melittin analogue MelP5 improves the transfection of non-viral DNA nanoparticles. Journal of peptide science : an official publication of the European Peptide Society. 2022 Aug; 28(8):e3404. doi: 10.1002/psc.3404. [PMID: 35001445]
  • Haoyu Wang, Hao Qin, Győző Garab, Edward S Gasanoff. Short-Chained Alcohols Make Membrane Surfaces Conducive for Melittin Action: Implication for the Physiological Role of Alcohols in Cells. Cells. 2022 06; 11(12):. doi: 10.3390/cells11121928. [PMID: 35741057]
  • C Blake Wilson, Robert Tycko. Millisecond Time-Resolved Solid-State NMR Initiated by Rapid Inverse Temperature Jumps. Journal of the American Chemical Society. 2022 06; 144(22):9920-9925. doi: 10.1021/jacs.2c02704. [PMID: 35617672]
  • Shamish Ganpule, Akshay Kumar Vijaya, Aleksandra Sukova, Giulio Preta. Membrane Cholesterol Content and Lipid Organization Influence Melittin and Pneumolysin Pore-Forming Activity. Toxins. 2022 05; 14(5):. doi: 10.3390/toxins14050346. [PMID: 35622592]
  • Pin-Chiuan Chiou, Wen-Wei Hsu, Yung Chang, Yi-Fan Chen. Molecular packing of lipid membranes and action mechanisms of membrane-active peptides. Colloids and surfaces. B, Biointerfaces. 2022 May; 213(?):112384. doi: 10.1016/j.colsurfb.2022.112384. [PMID: 35151994]
  • Xuan Li, Sen Zhu, Zheng Li, Yu-Qi Meng, Su-Jie Huang, Qi-Yao Yu, Bin Li. Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells. Free radical research. 2022 May; 56(5-6):398-410. doi: 10.1080/10715762.2022.2131551. [PMID: 36194238]
  • Tyler A Jepson, Sarah C Hall, Jean K Chung. Single-molecule phospholipase A2 becomes processive on melittin-induced membrane deformations. Biophysical journal. 2022 04; 121(8):1417-1423. doi: 10.1016/j.bpj.2022.03.019. [PMID: 35314142]
  • Hyemin Gu, Hyun-Jin An, Mi-Gyeong Gwon, Seongjae Bae, Jaechan Leem, Sun-Jae Lee, Sang-Mi Han, Christos C Zouboulis, Kwan-Kyu Park. Bee Venom and Its Major Component Melittin Attenuated Cutibacterium acnes- and IGF-1-Induced Acne Vulgaris via Inactivation of Akt/mTOR/SREBP Signaling Pathway. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063152. [PMID: 35328573]
  • Mohammed Ghalib Enayathullah, Yash Parekh, Sarena Banu, Sushma Ram, Ramakrishnan Nagaraj, Bokara Kiran Kumar, Mohammed M Idris. Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection. Scientific reports. 2022 03; 12(1):3446. doi: 10.1038/s41598-022-07341-x. [PMID: 35236909]
  • Carole Yaacoub, Rim Wehbe, Yahya Salma, Dany El-Obeid, Romeo El Bersaoui, Bruno Coutard, Ziad Fajloun. Apis mellifera syriaca Venom: Evaluation of Its Anticoagulant Effect, Proteolytic Activity, and Cytotoxicity along with Its Two Main Compounds-MEL and PLA2-On HeLa Cancer Cells. Molecules (Basel, Switzerland). 2022 Mar; 27(5):. doi: 10.3390/molecules27051653. [PMID: 35268753]
  • Rasoul Mirzaei, Mohammad Yousef Alikhani, Carla Renata Arciola, Iraj Sedighi, Rasoul Yousefimashouf, Kamran Pooshang Bagheri. Prevention, inhibition, and degradation effects of melittin alone and in combination with vancomycin and rifampin against strong biofilm producer strains of methicillin-resistant Staphylococcus epidermidis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Mar; 147(?):112670. doi: 10.1016/j.biopha.2022.112670. [PMID: 35123230]
  • Joyce El-Beyrouthy, Michelle M Makhoul-Mansour, Eric C Freeman. Studying the Mechanics of Membrane Permeabilization through Mechanoelectricity. ACS applied materials & interfaces. 2022 Feb; 14(4):6120-6130. doi: 10.1021/acsami.1c19880. [PMID: 35073482]
  • Dalibor Kodrík, Václav Krištůfek, Zdeňka Svobodová. Bee year: Basic physiological strategies to cope with seasonality. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2022 02; 264(?):111115. doi: 10.1016/j.cbpa.2021.111115. [PMID: 34775045]
  • Francesca Troilo, Marco Pedretti, Carlo Travaglini-Allocatelli, Alessandra Astegno, Adele Di Matteo. Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides. Biochemical and biophysical research communications. 2022 01; 590(?):103-108. doi: 10.1016/j.bbrc.2021.12.077. [PMID: 34974297]
  • Anqi Wang, Yuan Zheng, Wanxin Zhu, Liuxin Yang, Yang Yang, Jinliang Peng. Melittin-Based Nano-Delivery Systems for Cancer Therapy. Biomolecules. 2022 01; 12(1):. doi: 10.3390/biom12010118. [PMID: 35053266]
  • Xiaoliang Xie, Yumei Li, Haixia Zhu, Lin Chen, Deta Chen, Shengming Lin, Tianyou Fan. Melittin Inhibits Growth of Human Osteosarcoma 143B Cells through Induction of Apoptosis via Suppressing the Wnt/β-catenin Signaling Pathway. Anti-cancer agents in medicinal chemistry. 2022; 22(18):3172-3181. doi: 10.2174/1871520622666220509121627. [PMID: 35579132]
  • Izabella Brand, Bishoy Khairalla. Structural changes in the model of the outer cell membrane of Gram-negative bacteria interacting with melittin: an in situ spectroelectrochemical study. Faraday discussions. 2021 12; 232(0):68-85. doi: 10.1039/d0fd00039f. [PMID: 34542116]
  • Ran Ye, Yuan Zheng, Yang Chen, Xiaohui Wei, Sanyuan Shi, Yuetan Chen, Wanxin Zhu, Anqi Wang, Liuxin Yang, Yuhong Xu, Jinliang Peng. Stable Loading and Delivery of Melittin with Lipid-Coated Polymeric Nanoparticles for Effective Tumor Therapy with Negligible Systemic Toxicity. ACS applied materials & interfaces. 2021 Dec; 13(47):55902-55912. doi: 10.1021/acsami.1c17618. [PMID: 34793125]
  • Xiong-Ya Wang, Dong-Zhang Cai, Xin Li, Su-Fen Bai, Feng-Ming Yan. Identification and Physicochemical Properties of the Novel Hemolysin(s) From Oral Secretions of Helicoverpa armigera (Lepidoptera: Noctuidae). Journal of insect science (Online). 2021 Nov; 21(6):. doi: 10.1093/jisesa/ieab082. [PMID: 34750634]
  • Ghada H Mansour, Mohammed A El-Magd, Dalia H Mahfouz, Ismail A Abdelhamid, Magda F Mohamed, Nada S Ibrahim, Abdel Hady A Abdel Wahab, Emad M Elzayat. Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells. Bioorganic chemistry. 2021 11; 116(?):105329. doi: 10.1016/j.bioorg.2021.105329. [PMID: 34544028]
  • Shantanu Guha, Ryan P Ferrie, Jenisha Ghimire, Cristina R Ventura, Eric Wu, Leisheng Sun, Sarah Y Kim, Gregory R Wiedman, Kalina Hristova, Wimley C Wimley. Applications and evolution of melittin, the quintessential membrane active peptide. Biochemical pharmacology. 2021 11; 193(?):114769. doi: 10.1016/j.bcp.2021.114769. [PMID: 34543656]
  • Edward Gasanoff, Yipeng Liu, Feng Li, Paul Hanlon, Győző Garab. Bee Venom Melittin Disintegrates the Respiration of Mitochondria in Healthy Cells and Lymphoblasts, and Induces the Formation of Non-Bilayer Structures in Model Inner Mitochondrial Membranes. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011122. [PMID: 34681781]
  • Masoumeh Sadat Mousavi Maleki, Mosayeb Rostamian, Hamid Madanchi. Antimicrobial peptides and other peptide-like therapeutics as promising candidates to combat SARS-CoV-2. Expert review of anti-infective therapy. 2021 10; 19(10):1205-1217. doi: 10.1080/14787210.2021.1912593. [PMID: 33844613]
  • Fei Jia, Peiru Chen, Dali Wang, Yehui Sun, Mengqi Ren, Yuyan Wang, Xueyan Cao, Lei Zhang, Yang Fang, Xuyu Tan, Hao Lu, Jiansong Cai, Xueguang Lu, Ke Zhang. Bottlebrush Polymer-Conjugated Melittin Exhibits Enhanced Antitumor Activity and Better Safety Profile. ACS applied materials & interfaces. 2021 Sep; 13(36):42533-42542. doi: 10.1021/acsami.1c14285. [PMID: 34472829]
  • Guangsheng Du, Penghui He, Jiaxuan Zhao, Chunting He, Min Jiang, Zhihua Zhang, Zhibing Zhang, Xun Sun. Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment. Journal of controlled release : official journal of the Controlled Release Society. 2021 08; 336(?):537-548. doi: 10.1016/j.jconrel.2021.07.005. [PMID: 34237400]
  • Sreetama Pal, Hirak Chakraborty, Amitabha Chattopadhyay. Lipid Headgroup Charge Controls Melittin Oligomerization in Membranes: Implications in Membrane Lysis. The journal of physical chemistry. B. 2021 08; 125(30):8450-8459. doi: 10.1021/acs.jpcb.1c02499. [PMID: 34254509]
  • Haixia Zhu, Deta Chen, Xiaoliang Xie, Yumei Li, Tianyou Fan. Melittin inhibits lung metastasis of human osteosarcoma: Evidence of wnt/β-catenin signaling pathway participation. Toxicon : official journal of the International Society on Toxinology. 2021 Jul; 198(?):132-142. doi: 10.1016/j.toxicon.2021.04.024. [PMID: 33930393]
  • Kumaresh Pillur Tamilarasu, Takshak Shankar, Ankita Kabi. Unusual case of recurrent hypoglycaemia in multiple bee sting envenomation. BMJ case reports. 2021 Jul; 14(7):. doi: 10.1136/bcr-2021-242440. [PMID: 34312127]
  • Zabih Mir Hassani, Mohammad Nabiuni, Kazem Parivar, Somayeh Abdirad, Latifeh Karimzadeh. Melittin inhibits the expression of key genes involved in tumor microenvironment formation by suppressing HIF-1α signaling in breast cancer cells. Medical oncology (Northwood, London, England). 2021 Jun; 38(7):77. doi: 10.1007/s12032-021-01526-6. [PMID: 34076777]
  • Hiroyuki Koide, Hikaru Suzuki, Hiroki Ochiai, Hiromichi Egami, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai. Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles. Biochemical and biophysical research communications. 2021 05; 555(?):32-39. doi: 10.1016/j.bbrc.2021.03.073. [PMID: 33812056]
  • Alicia S Ombredane, Laise R de Andrade, Raphael S Bonadio, Willie O Pinheiro, Ricardo B de Azevedo, Graziella A Joanitti. Melittin sensitizes skin squamous carcinoma cells to 5-fluorouracil by affecting cell proliferation and survival. Experimental dermatology. 2021 05; 30(5):710-716. doi: 10.1111/exd.14289. [PMID: 33523510]
  • Jhonatha Mota Teixeira-Cruz, Marcelo Abrahão Strauch, Marcos Monteiro-Machado, Matheus Silva Tavares-Henriques, João Alfredo de Moraes, Luís Eduardo Ribeiro da Cunha, Rui Seabra Ferreira, Benedito Barraviera, Luis Eduardo M Quintas, Paulo A Melo. A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization. Toxins. 2021 01; 13(1):. doi: 10.3390/toxins13010030. [PMID: 33466223]
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  • Teresa Kreinest, Ines Volkmer, Martin S Staege. Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells. International journal of molecular sciences. 2020 Dec; 22(1):. doi: 10.3390/ijms22010343. [PMID: 33396195]
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