Bisbenzimide (BioDeep_00000008535)
Secondary id: BioDeep_00001871857
human metabolite blood metabolite
代谢物信息卡片
2-(4-ethoxyphenyl)-5-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1H-1,3-benzodiazole
化学式: C27H28N6O (452.2324478)
中文名称: 双苯并咪唑
谱图信息:
最多检出来源 Homo sapiens(blood) 29.41%
Reviewed
Last reviewed on 2024-08-14.
Cite this Page
Bisbenzimide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/bisbenzimide (retrieved
2024-09-17) (BioDeep RN: BioDeep_00000008535). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCOC1=CC=C(C=C1)C1=NC2=C(N1)C=CC(=C2)C1=NC2=C(N1)C=C(C=C2)N1CCN(C)CC1
InChI: InChI=1S/C27H28N6O/c1-3-34-21-8-4-18(5-9-21)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-7-20(17-25(23)31-27)33-14-12-32(2)13-15-33/h4-11,16-17H,3,12-15H2,1-2H3,(H,28,30)(H,29,31)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
D011838 - Radiation-Sensitizing Agents
Bisbenzimide. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=23491-52-3 (retrieved 2024-08-14) (CAS RN: 23491-52-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
11 个代谢物同义名
2-(4-ethoxyphenyl)-5-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1H-1,3-benzodiazole; 2,5-Bi-1H-benzimidazole, 2-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-, trihydrochloride; 2-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5-bi-1H-benzimidazole; 2-(4-ETHOXYPHENYL)-5-(4-methyl-1-piperazinyl)-2,5-bi-benzimidazole; 2-(p-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5-bibenzimidazole; Bisbenzimide ethoxide trihydrochloride; Bisbenzimide H 33342; Hoechst 33342; Bisbenzimide; Hoechst33342; Hoe 33342
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:51232
- KEGG: C11189
- PubChem: 1464
- HMDB: HMDB0253196
- Metlin: METLIN68903
- ChEMBL: CHEMBL343002
- chemspider: 1420
- CAS: 23491-52-3
- PMhub: MS000022161
- PDB-CCD: HT1
- NIKKAJI: J283.606H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Margarida M Cordeiro, Hugo A L Filipe, Patrícia Dos Santos, Jaime Samelo, João P Prates Ramalho, Luís M S Loura, Maria J Moreno. Interaction of Hoechst 33342 with POPC Membranes at Different pH Values.
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Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2010 Feb; 42(1):97-9. doi:
10.1016/j.transci.2009.10.011. [PMID: 19932983] - Geise Ribeiro, Marcel Benadiba, Denise de Oliveira Silva, Alison Colquhoun. The novel ruthenium-gamma-linolenic complex [Ru(2)(aGLA)(4)Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitro.
Cell biochemistry and function.
2010 Jan; 28(1):15-23. doi:
10.1002/cbf.1626. [PMID: 19927275] - Soma Datta, Shibnath Mazumder, Debabrata Ghosh, Saibal Dey, Shelley Bhattacharya. Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus.
Toxicology and applied pharmacology.
2009 Dec; 241(3):329-38. doi:
10.1016/j.taap.2009.09.007. [PMID: 19782097] - Edmond Kahn, Sophie Pelloux, Mauhamad Baarine, Taoufik Khalfaoui, Kévin Ragot, Frédérique Frouin, Jean-Marc Riedinger, Yves Tourneur, Gérard Lizard. Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences.
Analytical and quantitative cytology and histology.
2009 Dec; 31(6):380-94. doi:
NULL. [PMID: 20698354] - Therese Bredholt, Elizabeth Ao Dimba, Hanne R Hagland, Line Wergeland, Jørn Skavland, Kjell O Fossan, Karl J Tronstad, Anne C Johannessen, Olav K Vintermyr, Bjørn T Gjertsen. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.
Molecular cancer.
2009 Nov; 8(?):101. doi:
10.1186/1476-4598-8-101. [PMID: 19912650] - Sun Ha Lee, Tae-Hyun Yoo, Bo-Young Nam, Dong Ki Kim, Jin Ji Li, Dong-Sub Jung, Seung-Jae Kwak, Dong-Ryeol Ryu, Seung Hyeok Han, Jung Eun Lee, Sung Jin Moon, Dae Suk Han, Shin-Wook Kang. Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions.
American journal of physiology. Renal physiology.
2009 Nov; 297(5):F1381-90. doi:
10.1152/ajprenal.00101.2009. [PMID: 19710242] - Pradeep Tyagi, Vikas Tyagi, Naoki Yoshimura, Erich Witteemer, Derek Barclay, Patricia A Loughran, Ruben Zamora, Yoram Vodovotz. Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis.
Journal of inflammation (London, England).
2009 Aug; 6(?):23. doi:
10.1186/1476-9255-6-23. [PMID: 19691848] - Jin Boo Jeong, Eul Won Seo, Hyung Jin Jeong. Effect of extracts from pine needle against oxidative DNA damage and apoptosis induced by hydroxyl radical via antioxidant activity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Aug; 47(8):2135-41. doi:
10.1016/j.fct.2009.05.034. [PMID: 19500637] - Tetsuo Mashima, Shigeo Sato, Sachiko Okabe, Satoshi Miyata, Masaaki Matsuura, Yoshikazu Sugimoto, Takashi Tsuruo, Hiroyuki Seimiya. Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.
Cancer science.
2009 Aug; 100(8):1556-62. doi:
10.1111/j.1349-7006.2009.01203.x. [PMID: 19459852] - Baohong Jiang, Lin Zhang, Yingchun Wang, Ming Li, Wanying Wu, Shuhong Guan, Xuan Liu, Min Yang, Junchen Wang, De-an Guo. Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Jul; 47(7):1538-44. doi:
10.1016/j.fct.2009.03.038. [PMID: 19358873] - Zheng Chen, Zhengzheng Li, Gong Peng, Xiaoli Chen, Wenxuan Yin, Michael I Kotlikoff, Zeng-Qiang Yuan, Guangju Ji. Extracellular ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic beta-cells.
Biochemical and biophysical research communications.
2009 May; 382(2):381-4. doi:
10.1016/j.bbrc.2009.03.030. [PMID: 19285037] - Jinghong Zhao, Yunjian Huang, Yaoming Song, Xiaohui Zhao, Jun Jin, Junping Wang, Lan Huang. Low osmolar contrast medium induces cellular injury and disruption of calcium homeostasis in rat glomerular endothelial cells in vitro.
Toxicology letters.
2009 Mar; 185(2):124-31. doi:
10.1016/j.toxlet.2008.12.009. [PMID: 19136047] - Takahiro Ueno, Noboru Fukuda, Akiko Tsunemi, En-Hui Yao, Hiroyuki Matsuda, Kazunobu Tahira, Taro Matsumoto, Koichi Matsumoto, Yoshiaki Matsumoto, Hiroki Nagase, Hiroshi Sugiyama, Tatsuya Sawamura. A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
Journal of hypertension.
2009 Mar; 27(3):508-16. doi:
10.1097/hjh.0b013e3283207fe1. [PMID: 19330905] - Haitao Ge, Xiuqin Kong, Limei Shi, Lijuan Hou, Zhili Liu, Ping Li. Gamma-linolenic acid induces apoptosis and lipid peroxidation in human chronic myelogenous leukemia K562 cells.
Cell biology international.
2009 Mar; 33(3):402-10. doi:
10.1016/j.cellbi.2009.01.014. [PMID: 19356705] - María Sol Brassesco, Ana Paula Montaldi, Elza Tiemi Sakamoto-Hojo. Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide.
Genetics and molecular biology.
2009 Jan; 32(1):144-50. doi:
10.1590/s1415-47572009000100022. [PMID: 21637660] - Anne Vejux, Stéphane Guyot, Thomas Montange, Jean-Marc Riedinger, Edmond Kahn, Gérard Lizard. Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.
The Journal of nutritional biochemistry.
2009 Jan; 20(1):45-61. doi:
10.1016/j.jnutbio.2007.12.001. [PMID: 18495460] - Eun-Young Lee, Pan-Young Jeong, Sun-Young Kim, Yhong-Hee Shim, David J Chitwood, Young-Ki Paik. Effects of sterols on the development and aging of Caenorhabditis elegans.
Methods in molecular biology (Clifton, N.J.).
2009; 462(?):167-79. doi:
10.1007/978-1-60327-115-8_11. [PMID: 19160668] - Lipeng Wang, Markos Leggas, Mamta Goswami, Philip E Empey, Patrick J McNamara. N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) as a chemical ATP-binding cassette transporter family G member 2 (Abcg2) knockout model to study nitrofurantoin transfer into milk.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Dec; 36(12):2591-6. doi:
10.1124/dmd.108.021980. [PMID: 18799806] - Isao Kobayashi, Hiroko Kusakabe, Hideaki Toda, Tadaaki Moritomo, Tomoko Takahashi, Teruyuki Nakanishi. In vivo characterization of primitive hematopoietic cells in clonal ginbuna crucian carp (Carassius auratus langsdorfii).
Veterinary immunology and immunopathology.
2008 Nov; 126(1-2):74-82. doi:
10.1016/j.vetimm.2008.06.008. [PMID: 18674821] - Jong Bin Kim, Eunyoung Ko, Wonshik Han, Incheol Shin, Seo Young Park, Dong-Young Noh. Berberine diminishes the side population and ABCG2 transporter expression in MCF-7 breast cancer cells.
Planta medica.
2008 Nov; 74(14):1693-700. doi:
10.1055/s-0028-1088313. [PMID: 18951337] - Grzegorz Wicher, Asa Fex-Svenningsen, Isabel Velsecchi, Yves Charnay, Hakan Aldskogius. Extracellular clusterin promotes neuronal network complexity in vitro.
Neuroreport.
2008 Oct; 19(15):1487-91. doi:
10.1097/wnr.0b013e32830fe4d1. [PMID: 18797303] - Sanjai K Addla, Mick D Brown, Claire A Hart, Vijay A C Ramani, Noel W Clarke. Characterization of the Hoechst 33342 side population from normal and malignant human renal epithelial cells.
American journal of physiology. Renal physiology.
2008 Sep; 295(3):F680-7. doi:
10.1152/ajprenal.90286.2008. [PMID: 18614618] - In-Hwan Lee, Hui-Young Kim, Myunghye Kim, Ji-Sook Hahn, Seung R Paik. Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein.
Neurochemical research.
2008 Jul; 33(7):1393-400. doi:
10.1007/s11064-008-9598-8. [PMID: 18322792] - Zhigang Wang, Xiaobo Tang, Yumei Li, Changlian Leu, Lei Guo, Xiaodong Zheng, Daling Zhu. 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells.
European journal of pharmacology.
2008 Jun; 588(1):9-17. doi:
10.1016/j.ejphar.2008.03.045. [PMID: 18455723] - Kou Motani, Keiichi Tabata, Yumiko Kimura, Soichiro Okano, Yasuko Shibata, Yoshimitsu Abiko, Hisashi Nagai, Toshihiro Akihisa, Takashi Suzuki. Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma.
Biological & pharmaceutical bulletin.
2008 Apr; 31(4):618-26. doi:
10.1248/bpb.31.618. [PMID: 18379052] - Tamás I Orbán, László Seres, Csilla Ozvegy-Laczka, N Barry Elkind, Balázs Sarkadi, László Homolya. Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transporter.
Biochemical and biophysical research communications.
2008 Mar; 367(3):667-73. doi:
10.1016/j.bbrc.2007.12.172. [PMID: 18182157] - P Zhou, D J Liu, M Cang, Y Z Ma, D S Yang, H J Li, L M Wang, S Bou, H L Feng. TGFalpha and EGFR in ovine preimplantation embryos and effects on development.
Animal reproduction science.
2008 Mar; 104(2-4):370-81. doi:
10.1016/j.anireprosci.2007.02.024. [PMID: 17412533] - M Suzuki, T Tanaka. Development of Meteorus pulchricornis and regulation of its noctuid host, Pseudaletia separata.
Journal of insect physiology.
2007 Oct; 53(10):1072-8. doi:
10.1016/j.jinsphys.2007.06.006. [PMID: 17675053] - Constance Temm, Jesus H Dominguez. Microcirculation: nexus of comorbidities in diabetes.
American journal of physiology. Renal physiology.
2007 Aug; 293(2):F486-93. doi:
10.1152/ajprenal.00503.2006. [PMID: 17494088] - A Pál, D Méhn, E Molnár, S Gedey, P Mészáros, T Nagy, H Glavinas, T Janáky, O von Richter, G Báthori, L Szente, P Krajcsi. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.
The Journal of pharmacology and experimental therapeutics.
2007 Jun; 321(3):1085-94. doi:
10.1124/jpet.106.119289. [PMID: 17347325] - Jing-Xian Xu, Eiichi Morii, Yalan Liu, Naoto Nakamichi, Jun-Ichiro Ikeda, Hayato Kimura, Katsuyuki Aozasa. High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells: high expression of CD55 as a novel character for side-population.
Experimental cell research.
2007 May; 313(9):1877-85. doi:
10.1016/j.yexcr.2007.03.006. [PMID: 17428472] - Shanmiao Gou, Tao Liu, Chunyou Wang, Tao Yin, Kai Li, Ming Yang, Jing Zhou. Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties.
Pancreas.
2007 May; 34(4):429-35. doi:
10.1097/mpa.0b013e318033f9f4. [PMID: 17446842] - Yang-ja Lee, Shin-ichi Miyake, Hideaki Wakita, David C McMullen, Yoshiaki Azuma, Sungyoung Auh, John M Hallenbeck. Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2007 May; 27(5):950-62. doi:
10.1038/sj.jcbfm.9600395. [PMID: 16955077] - Xuesheng Zheng, Gang Shen, Xiaofeng Yang, Weiguo Liu. Most C6 cells are cancer stem cells: evidence from clonal and population analyses.
Cancer research.
2007 Apr; 67(8):3691-7. doi:
10.1158/0008-5472.can-06-3912. [PMID: 17440081] - Yan-Nian Jiang, Yi-Hung Li, Meng-Wei Ke, Ting-Yu Tseng, Yueh-Bih Tang, Mu-Chiou Huang, Winston Teng-Kuei Cheng, Yu-Ten Ju. Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis.
Cancer cell international.
2007 Mar; 7(?):1. doi:
10.1186/1475-2867-7-1. [PMID: 17331262] - Oleg Tsinkalovsky, Audun Osland Vik-Mo, Sara Ferreira, Ole Didrik Laerum, Anders Fjose. Zebrafish kidney marrow contains ABCG2-dependent side population cells exhibiting hematopoietic stem cell properties.
Differentiation; research in biological diversity.
2007 Mar; 75(3):175-83. doi:
10.1111/j.1432-0436.2006.00130.x. [PMID: 17288542] - Vishal Chanana, Siddharth Majumdar, Praveen Rishi. Involvement of caspase-3, lipid peroxidation and TNF-alpha in causing apoptosis of macrophages by coordinately expressed Salmonella phenotype under stress conditions.
Molecular immunology.
2007 Mar; 44(7):1551-8. doi:
10.1016/j.molimm.2006.08.022. [PMID: 17027970] - Isao Kobayashi, Tadaaki Moritomo, Mituru Ototake, Teruyuki Nakanishi. Isolation of side population cells from ginbuna carp (Carassius auratus langsdorfii) kidney hematopoietic tissues.
Developmental and comparative immunology.
2007; 31(7):696-707. doi:
10.1016/j.dci.2006.10.003. [PMID: 17129605]