D-Sedoheptulose 7-phosphate (BioDeep_00000837541)

Main id: BioDeep_00000001740

Secondary id: BioDeep_00000013759, BioDeep_00000017912, BioDeep_00001869576

human metabolite Endogenous blood metabolite


代谢物信息卡片


{[(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxy}phosphonic acid

化学式: C7H15O10P (290.0403)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 21.78%

分子结构信息

SMILES: C(C(C(C(C(C(=O)CO)O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C7H15O10P/c8-1-3(9)5(11)7(13)6(12)4(10)2-17-18(14,15)16/h4-8,10-13H,1-2H2,(H2,14,15,16)/t4-,5-,6-,7+/m1/s1

描述信息

D-Sedoheptulose 7-phosphate (CAS: 2646-35-7) is an intermediate of the pentose phosphate pathway (PPP) that has two functions: (1) the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and (2) the formation of ribose residues for nucleotide and nucleic acid biosynthesis (PMID: 16055050). It is formed by transketolase and acted upon (degraded) by transaldolase. Sedoheptulose 7-phosphate can be increased in the blood of patients affected with a transaldolase deficiency, a genetic disorder (PMID: 12881455). Sedoheptulose is a ketoheptose, a monosaccharide with seven carbon atoms and a ketone functional group. It is one of the few heptoses found in nature (Wikipedia).
D-Sedoheptulose 7-phosphate is an intermediate of the Pentose phosphate pathway (PPP) that has two functions: the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and the formation of ribose residues for nucleotide and nucleic acid biosynthesis. (PMID 16055050)

同义名列表

24 个代谢物同义名

{[(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxy}phosphonic acid; [(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxyphosphonic acid; alpha-D-Altro-hept-2-ulopyranose 7-hydrogen phosphoric acid; a-D-Altro-hept-2-ulopyranose 7-hydrogen phosphoric acid; Α-D-altro-hept-2-ulopyranose 7-hydrogen phosphoric acid; alpha-D-Altro-hept-2-ulopyranose 7-hydrogen phosphate; Α-D-altro-hept-2-ulopyranose 7-hydrogen phosphate; a-D-Altro-hept-2-ulopyranose 7-hydrogen phosphate; alpha-D-Sedoheptulopyranose 7-phosphoric acid; Α-D-sedoheptulopyranose 7-phosphoric acid; a-D-Sedoheptulopyranose 7-phosphoric acid; alpha-D-Sedoheptulose 7-phosphoric acid; Α-D-sedoheptulopyranose 7-phosphate; a-D-Sedoheptulose 7-phosphoric acid; a-D-Sedoheptulopyranose 7-phosphate; Α-D-sedoheptulose 7-phosphoric acid; alpha-D-Sedoheptulose 7-phosphate; D-Sedoheptulose 7-phosphoric acid; Α-D-sedoheptulose 7-phosphate; D-Altro-heptulose 7-phosphate; a-D-Sedoheptulose 7-phosphate; D-Sedoheptulose 7-phosphate; Altro-heptulose 7-phosphate; Sedoheptulose 7-phosphate



数据库引用编号

15 个数据库交叉引用编号

分类词条

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, FAS, G6PD, GAPDH, GPI, HBS1L, PFDN5, PNP, SHPK, TALDO1, UBE2D1
Peripheral membrane protein 3 CACNB2, G6PD, HSD17B6
Endoplasmic reticulum membrane 1 TKT
Nucleus 7 AKT1, GAPDH, MYB, PFDN5, TAL1, TALDO1, UBE2D1
cytosol 14 AKT1, FAS, G6PD, GAPDH, GPI, HBS1L, MYB, PFDN5, PNP, RPE, SHPK, TALDO1, TKT, UBE2D1
nuclear body 2 FAS, TKT
nucleoplasm 5 AKT1, MYB, TAL1, TKT, UBE2D1
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 4 AKT1, CACNB2, FAS, TKT
Cytoplasmic side 1 CACNB2
lamellipodium 1 AKT1
Early endosome membrane 1 HSD17B6
cell cortex 1 AKT1
cell surface 1 FAS
glutamatergic synapse 1 AKT1
Golgi apparatus 1 FAS
Golgi membrane 1 INS
lysosomal membrane 1 GAA
postsynapse 1 AKT1
sarcolemma 1 CACNB2
Cytoplasm, cytosol 2 G6PD, GAPDH
Lysosome 1 GAA
Presynapse 1 CACNB2
plasma membrane 6 AKT1, CACNB2, FAS, GAA, GAPDH, TKT
Membrane 9 AKT1, DGCR2, FAS, G6PD, GAA, GAPDH, GPI, HBS1L, MYB
apical plasma membrane 1 TKT
extracellular exosome 10 FAS, G6PD, GAA, GAPDH, GPI, HBS1L, PNP, RPE, TALDO1, TKT
Lysosome membrane 1 GAA
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 3 GPI, INS, PNP
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 GAPDH
protein-containing complex 2 AKT1, UBE2D1
intracellular membrane-bounded organelle 4 G6PD, GAA, GAPDH, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 2 FAS, TKT
Secreted 4 GAA, GPI, INS, PNP
extracellular region 4 GAA, GPI, INS, PNP
cytoplasmic side of plasma membrane 1 G6PD
transcription regulator complex 1 TAL1
centriolar satellite 1 G6PD
ciliary membrane 1 GPI
nuclear membrane 1 GAPDH
external side of plasma membrane 1 FAS
actin cytoskeleton 1 TKT
microtubule cytoskeleton 2 AKT1, GAPDH
cell-cell junction 1 AKT1
vesicle 3 AKT1, GAPDH, TKT
Cell membrane, sarcolemma 1 CACNB2
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 1 FAS
Cytoplasm, cytoskeleton 1 GAPDH
focal adhesion 1 TKT
spindle 1 AKT1
Peroxisome 1 TKT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
receptor complex 1 TKT
ciliary basal body 1 AKT1
chromatin 1 TAL1
cytoskeleton 1 GAPDH
endosome lumen 1 INS
Lipid droplet 1 GAPDH
tertiary granule membrane 1 GAA
Melanosome 1 FAS
intermediate filament cytoskeleton 1 PFDN5
ubiquitin ligase complex 1 UBE2D1
ficolin-1-rich granule lumen 2 GPI, PNP
secretory granule lumen 3 GPI, INS, PNP
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 MYB
voltage-gated calcium channel complex 1 CACNB2
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 2 HBS1L, TALDO1
ribonucleoprotein complex 1 GAPDH
[Isoform 1]: Nucleus 1 TALDO1
prefoldin complex 1 PFDN5
ficolin-1-rich granule membrane 1 GAA
CD95 death-inducing signaling complex 1 FAS
death-inducing signaling complex 1 FAS
[Isoform 1]: Cell membrane 1 FAS
GAIT complex 1 GAPDH
cytosolic ribosome 1 HBS1L
autolysosome lumen 1 GAA
photoreceptor ribbon synapse 1 CACNB2
glycogen granule 1 FAS
L-type voltage-gated calcium channel complex 1 CACNB2
Dom34-Hbs1 complex 1 HBS1L


文献列表

  • Alexander Klaus, Tim Baldensperger, Roman Fiedler, Matthias Girndt, Marcus A Glomb. Influence of Transketolase-Catalyzed Reactions on the Formation of Glycolaldehyde and Glyoxal Specific Posttranslational Modifications under Physiological Conditions. Journal of agricultural and food chemistry. 2018 Feb; 66(6):1498-1508. doi: 10.1021/acs.jafc.7b05472. [PMID: 29400466]
  • Johan Ceusters, Christof Godts, Darin Peshev, Rudy Vergauwen, Natalia Dyubankova, Eveline Lescrinier, Maurice P De Proft, Wim Van den Ende. Sedoheptulose accumulation under CO₂ enrichment in leaves of Kalanchoë pinnata: a novel mechanism to enhance C and P homeostasis?. Journal of experimental botany. 2013 Apr; 64(6):1497-507. doi: 10.1093/jxb/ert010. [PMID: 23378377]
  • M M Wamelink, D E Smith, E E Jansen, N M Verhoeven, E A Struys, C Jakobs. Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine. Journal of inherited metabolic disease. 2007 Oct; 30(5):735-42. doi: 10.1007/s10545-007-0590-2. [PMID: 17603756]
  • A J Zera. Inhibition of phosphoglucose isomerase allozymes from the wing polymorphic waterstrider, Limnoporus canaliculatus, by pentose shunt metabolites. Biochemical genetics. 1987 Apr; 25(3-4):205-23. doi: 10.1007/bf00499314. [PMID: 3606558]
  • F H BRUNS, E DUNWALD, E NOLTMANN. [Metabolism of ribose-5-phosphate in hemolysates. III. Quantitative determination of sedoheptulose-7-phosphate and some properties of the transketolase of erythrocytes and blood serum]. Biochemische Zeitschrift. 1958; 330(6):497-508. doi: NULL. [PMID: 13596392]
  • . . . . doi: . [PMID: 18775706]