D-Sedoheptulose 7-phosphate (BioDeep_00000837541)

Main id: BioDeep_00000001740

Secondary id: BioDeep_00000013759, BioDeep_00000017912, BioDeep_00001869576

human metabolite Endogenous blood metabolite


代谢物信息卡片


{[(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxy}phosphonic acid

化学式: C7H15O10P (290.040282)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 2.33%

分子结构信息

SMILES: C(C(C(C(C(C(=O)CO)O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C7H15O10P/c8-1-3(9)5(11)7(13)6(12)4(10)2-17-18(14,15)16/h4-8,10-13H,1-2H2,(H2,14,15,16)/t4-,5-,6-,7+/m1/s1

描述信息

D-Sedoheptulose 7-phosphate (CAS: 2646-35-7) is an intermediate of the pentose phosphate pathway (PPP) that has two functions: (1) the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and (2) the formation of ribose residues for nucleotide and nucleic acid biosynthesis (PMID: 16055050). It is formed by transketolase and acted upon (degraded) by transaldolase. Sedoheptulose 7-phosphate can be increased in the blood of patients affected with a transaldolase deficiency, a genetic disorder (PMID: 12881455). Sedoheptulose is a ketoheptose, a monosaccharide with seven carbon atoms and a ketone functional group. It is one of the few heptoses found in nature (Wikipedia).
D-Sedoheptulose 7-phosphate is an intermediate of the Pentose phosphate pathway (PPP) that has two functions: the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and the formation of ribose residues for nucleotide and nucleic acid biosynthesis. (PMID 16055050)

同义名列表

24 个代谢物同义名

{[(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxy}phosphonic acid; [(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxyphosphonic acid; alpha-D-Altro-hept-2-ulopyranose 7-hydrogen phosphoric acid; a-D-Altro-hept-2-ulopyranose 7-hydrogen phosphoric acid; Α-D-altro-hept-2-ulopyranose 7-hydrogen phosphoric acid; alpha-D-Altro-hept-2-ulopyranose 7-hydrogen phosphate; Α-D-altro-hept-2-ulopyranose 7-hydrogen phosphate; a-D-Altro-hept-2-ulopyranose 7-hydrogen phosphate; alpha-D-Sedoheptulopyranose 7-phosphoric acid; Α-D-sedoheptulopyranose 7-phosphoric acid; a-D-Sedoheptulopyranose 7-phosphoric acid; alpha-D-Sedoheptulose 7-phosphoric acid; Α-D-sedoheptulopyranose 7-phosphate; a-D-Sedoheptulose 7-phosphoric acid; a-D-Sedoheptulopyranose 7-phosphate; Α-D-sedoheptulose 7-phosphoric acid; alpha-D-Sedoheptulose 7-phosphate; D-Sedoheptulose 7-phosphoric acid; Α-D-sedoheptulose 7-phosphate; D-Altro-heptulose 7-phosphate; a-D-Sedoheptulose 7-phosphate; D-Sedoheptulose 7-phosphate; Altro-heptulose 7-phosphate; Sedoheptulose 7-phosphate



数据库引用编号

15 个数据库交叉引用编号

分类词条

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alexander Klaus, Tim Baldensperger, Roman Fiedler, Matthias Girndt, Marcus A Glomb. Influence of Transketolase-Catalyzed Reactions on the Formation of Glycolaldehyde and Glyoxal Specific Posttranslational Modifications under Physiological Conditions. Journal of agricultural and food chemistry. 2018 Feb; 66(6):1498-1508. doi: 10.1021/acs.jafc.7b05472. [PMID: 29400466]
  • Johan Ceusters, Christof Godts, Darin Peshev, Rudy Vergauwen, Natalia Dyubankova, Eveline Lescrinier, Maurice P De Proft, Wim Van den Ende. Sedoheptulose accumulation under CO₂ enrichment in leaves of Kalanchoë pinnata: a novel mechanism to enhance C and P homeostasis?. Journal of experimental botany. 2013 Apr; 64(6):1497-507. doi: 10.1093/jxb/ert010. [PMID: 23378377]
  • M M Wamelink, D E Smith, E E Jansen, N M Verhoeven, E A Struys, C Jakobs. Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine. Journal of inherited metabolic disease. 2007 Oct; 30(5):735-42. doi: 10.1007/s10545-007-0590-2. [PMID: 17603756]
  • A J Zera. Inhibition of phosphoglucose isomerase allozymes from the wing polymorphic waterstrider, Limnoporus canaliculatus, by pentose shunt metabolites. Biochemical genetics. 1987 Apr; 25(3-4):205-23. doi: 10.1007/bf00499314. [PMID: 3606558]
  • F H BRUNS, E DUNWALD, E NOLTMANN. [Metabolism of ribose-5-phosphate in hemolysates. III. Quantitative determination of sedoheptulose-7-phosphate and some properties of the transketolase of erythrocytes and blood serum]. Biochemische Zeitschrift. 1958; 330(6):497-508. doi: NULL. [PMID: 13596392]
  • . . . . doi: . [PMID: 18775706]