Maytansine (BioDeep_00000008198)
Secondary id: BioDeep_00000395681
PANOMIX_OTCML-2023 Chemicals and Drugs
代谢物信息卡片
[(16Z,18E)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-[acetyl(methyl)amino]propanoate
化学式: C34H46ClN3O10 (691.2871566)
中文名称: 美坦新
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 0.81%
分子结构信息
SMILES: CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)C)C)C)OC)(NC(=O)O2)O
InChI: InChI=1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11-
描述信息
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
C1907 - Drug, Natural Product
Same as: D04864
Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[1].
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6701
- KEGG: C10606
- KEGGdrug: D04864
- PubChem: 57517213
- PubChem: 5281828
- PubChem: 547450
- Metlin: METLIN40981
- ChEMBL: CHEMBL292702
- LipidMAPS: LMPK04000017
- MeSH: Maytansine
- KNApSAcK: C00002351
- CAS: 35846-53-8
- PMhub: MS000021771
- PubChem: 12789
- PDB-CCD: 3GT
- NIKKAJI: J282.023D
- medchemexpress: HY-13674
- KNApSAcK: 6701
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 490239 - Gymnosporia diversifolia:
- 123430 - Maytenus: 10.1021/NP9803732
- 33090 - Plants: -
- 123460 - Putterlickia verrucosa: 10.1016/S0031-9422(02)00550-2
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ryuto Tomabechi, Miki Miyasato, Taeka Sato, Tappei Takada, Kei Higuchi, Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue. Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A3.
Molecular pharmaceutics.
2023 01; 20(1):491-499. doi:
10.1021/acs.molpharmaceut.2c00741. [PMID: 36458938] - Clemence Pouzin, Leonid Gibiansky, Nathalie Fagniez, Mustapha Chadjaa, Michel Tod, Laurent Nguyen. Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate.
Journal of pharmacokinetics and pharmacodynamics.
2022 06; 49(3):381-394. doi:
10.1007/s10928-021-09799-0. [PMID: 35166967] - Hai-Na Xie, Yu-Yuan Chen, Guo-Biao Zhu, Hai-Hao Han, Xi-Le Hu, Zhi-Qiang Pan, Yi Zang, Dong-Hao Xie, Xiao-Peng He, Jia Li, Tony D James. Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial.
Chemical communications (Cambridge, England).
2022 Apr; 58(32):5029-5032. doi:
10.1039/d1cc06809a. [PMID: 35373789] - Yunlin Fu, Shashank Gorityala, Wenkui Li, David Humphries, Aaron Ledvina, Stephanie Cape, Franck Picard. Sensitive LC-MS/MS quantification of unconjugated maytansinoid DM4 and its metabolite S-methyl-DM4 in human plasma.
Bioanalysis.
2022 Mar; 14(6):357-368. doi:
10.4155/bio-2021-0275. [PMID: 35234045] - Chao Xu, Shaojie Liu, Fa Yang, Keying Zhang, Yu Li, Xiaolong Zhao, Jiayu Zhang, Tong Lu, Shiqi Lu, Yao Jiang, Weijun Qin, Changhong Shi, Rui Zhang, An-Gang Yang, Aizhi Zhao, Donghui Han, Weihong Wen. Antibody-drug conjugates targeting CD248+ myofibroblasts effectively alleviate renal fibrosis in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 02; 36(2):e22102. doi:
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Molecules (Basel, Switzerland).
2021 Jul; 26(15):. doi:
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Journal of chromatographic science.
2021 Jun; 59(7):642-649. doi:
10.1093/chromsci/bmaa122. [PMID: 33420505] - Juan Li, Siyu Guo, Qiang Hua, Fengxian Hu. Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling.
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2021 Jun; 43(6):1143-1154. doi:
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Bioanalysis.
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Cancer research.
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The AAPS journal.
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Journal of pharmaceutical and biomedical analysis.
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Clinical pharmacokinetics.
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Cancer.
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Journal of controlled release : official journal of the Controlled Release Society.
2017 08; 259(?):176-186. doi:
10.1016/j.jconrel.2016.12.011. [PMID: 27986551] - Dennis Eckelmann, Souvik Kusari, Michael Spiteller. Spatial profiling of maytansine during the germination process of Maytenus senegalensis seeds.
Fitoterapia.
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Fetal and pediatric pathology.
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Clinical lung cancer.
2017 01; 18(1):68-76.e2. doi:
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Fitoterapia.
2016 Sep; 113(?):175-81. doi:
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Bioconjugate chemistry.
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Drug metabolism and disposition: the biological fate of chemicals.
2016 07; 44(7):897-910. doi:
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2016 Apr; 39(3):117-26. doi:
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Molecular cancer therapeutics.
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The AAPS journal.
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