[6]-Gingerdione (BioDeep_00000008102)

 

Secondary id: BioDeep_00000864617

human metabolite natural product


代谢物信息卡片


1-(4-hydroxy-3-methoxyphenyl)decane-3,5-dione

化学式: C17H24O4 (292.1675)
中文名称: 姜酮
谱图信息: 最多检出来源 Homo sapiens(endogenous) 3.68%

分子结构信息

SMILES: c1(c(ccc(c1)CCC(=O)/C=C(\O)/CCCCC)O)OC
InChI: InChI=1S/C17H24O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,20H,3-7,9,12H2,1-2H3

描述信息

[6]-Gingerdione is found in ginger. [6]-Gingerdione is a constituent of Zingiber officinale (ginger).
Constituent of Zingiber officinale (ginger). [6]-Gingerdione is found in herbs and spices and ginger.

同义名列表

9 个代谢物同义名

1-(4-hydroxy-3-methoxyphenyl)decane-3,5-dione; 1-(4-Hydroxy-3-methoxyphenyl)-3,5-decanedione; 3,5-Decadione, 1-(4-hydroxy-3-methoxyphenyl); 4,7-dichloro-benzo(b)Thiophen-3(2H)-one; 6-Hydrogingerdione; [6]-gingerdione; Gingerdione; Gingerdione; Gingerdione



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AIMP2, ALOX5, BCL2, CASP3, CASP9, CCND2, CDC25A, FNTA, HDAC2, PTGS1, PTGS2, SREBF1
Peripheral membrane protein 4 ALOX5, CYP1B1, PTGS1, PTGS2
Endoplasmic reticulum membrane 6 BCL2, CYP1B1, PTGS1, PTGS2, SIGMAR1, SREBF1
Nucleus 9 AIMP2, BCL2, CASP3, CASP9, CCND2, CDC25A, CEBPA, HDAC2, SREBF1
cytosol 10 AIMP2, ALOX5, BCL2, CASP3, CASP9, CCND2, CDC25A, FNTA, SIGMAR1, SREBF1
centrosome 1 CCND2
nucleoplasm 7 ALOX5, CASP3, CCND2, CDC25A, CEBPA, HDAC2, SREBF1
RNA polymerase II transcription regulator complex 1 CEBPA
Cell membrane 2 SIGMAR1, TNF
Multi-pass membrane protein 1 SREBF1
Golgi apparatus membrane 1 SREBF1
cell surface 1 TNF
glutamatergic synapse 2 CASP3, SIGMAR1
Golgi apparatus 1 PTGS1
Golgi membrane 1 SREBF1
growth cone 1 SIGMAR1
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 AIMP2, ALOX5
plasma membrane 2 FNTA, TNF
Membrane 5 AIMP2, BCL2, CYP1B1, HDAC2, SIGMAR1
caveola 1 PTGS2
extracellular exosome 1 PTGS1
endoplasmic reticulum 4 BCL2, PTGS2, SIGMAR1, SREBF1
extracellular space 2 ALOX5, TNF
perinuclear region of cytoplasm 1 ALOX5
mitochondrion 3 BCL2, CASP9, CYP1B1
protein-containing complex 5 BCL2, CASP9, HDAC2, PTGS2, SREBF1
intracellular membrane-bounded organelle 3 CEBPA, CYP1B1, PTGS1
Microsome membrane 3 CYP1B1, PTGS1, PTGS2
postsynaptic density 2 CASP3, SIGMAR1
ESC/E(Z) complex 1 HDAC2
extracellular region 2 ALOX5, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, SIGMAR1
mitochondrial outer membrane 1 BCL2
anchoring junction 1 SIGMAR1
transcription regulator complex 1 CEBPA
photoreceptor outer segment 1 PTGS1
Nucleus membrane 3 ALOX5, BCL2, CCND2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 ALOX5, BCL2, CCND2
external side of plasma membrane 1 TNF
cytoplasmic vesicle 1 SIGMAR1
nucleolus 2 CCND2, CEBPA
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 1 TNF
pore complex 1 BCL2
Nucleus inner membrane 2 PTGS2, SIGMAR1
Nucleus outer membrane 2 PTGS2, SIGMAR1
nuclear inner membrane 2 PTGS2, SIGMAR1
nuclear outer membrane 2 PTGS2, SIGMAR1
neuron projection 2 PTGS1, PTGS2
chromatin 4 CCND2, CEBPA, HDAC2, SREBF1
microtubule associated complex 1 FNTA
phagocytic cup 1 TNF
chromosome, telomeric region 1 HDAC2
nuclear envelope 3 ALOX5, SIGMAR1, SREBF1
Nucleus envelope 2 ALOX5, SIGMAR1
Endomembrane system 1 PTGS1
Lipid droplet 1 SIGMAR1
Cytoplasmic vesicle membrane 1 SREBF1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 ALOX5
histone deacetylase complex 1 HDAC2
NuRD complex 1 HDAC2
postsynaptic density membrane 1 SIGMAR1
ER to Golgi transport vesicle membrane 1 SREBF1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
apoptosome 1 CASP9
[Isoform 2]: Cytoplasm 1 CCND2
Sin3-type complex 1 HDAC2
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
cyclin-dependent protein kinase holoenzyme complex 1 CCND2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Nucleus intermembrane space 1 ALOX5
BAD-BCL-2 complex 1 BCL2
cyclin D2-CDK4 complex 1 CCND2
C/EBP complex 1 CEBPA
CHOP-C/EBP complex 1 CEBPA
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA
[Isoform 4]: Nucleus, nucleolus 1 CEBPA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Pavan Gollapalli, Aditya S J Rao, Hanumanthappa Manjunatha, Gnanasekaran Tamizh Selvan, Praveenkumar Shetty, Nalilu Suchetha Kumari. Systems Pharmacology and Pharmacokinetics Strategy to Decode Bioactive Ingredients and Molecular Mechanisms from Zingiber officinale as Phyto-therapeutics against Neurological Diseases. Current drug discovery technologies. 2023; 20(1):e250822207996. doi: 10.2174/1570163819666220825141356. [PMID: 36028974]
  • Tamilvelan Manjunathan, Ajay Guru, Jesu Arokiaraj, Pushparathinam Gopinath. 6-Gingerol and Semisynthetic 6-Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish. Chemistry & biodiversity. 2021 Dec; 18(12):e2100650. doi: 10.1002/cbdv.202100650. [PMID: 34599795]
  • Feng Li, Viriya Nitteranon, Xiaozhen Tang, Jin Liang, Guodong Zhang, Kirk L Parkin, Qiuhui Hu. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food chemistry. 2012 Nov; 135(2):332-7. doi: 10.1016/j.foodchem.2012.04.145. [PMID: 22868095]
  • Yohei Katsuyama, Yasuo Ohnishi, Sueharu Horinouchi. Production of dehydrogingerdione derivatives in Escherichia coli by exploiting a curcuminoid synthase from Oryza sativa and a β-oxidation pathway from Saccharomyces cerevisiae. Chembiochem : a European journal of chemical biology. 2010 Sep; 11(14):2034-41. doi: 10.1002/cbic.201000379. [PMID: 20836122]
  • Eun Mi Koh, Hye Jin Kim, Sohee Kim, Woo Hyuck Choi, Yeon Hee Choi, Shi Yong Ryu, Young Sup Kim, Woo Suk Koh, Shin-Young Park. Modulation of macrophage functions by compounds isolated from Zingiber officinale. Planta medica. 2009 Feb; 75(2):148-51. doi: 10.1055/s-0028-1088347. [PMID: 19031369]
  • R Charles, S N Garg, S Kumar. New gingerdione from the rhizomes of Zingiber officinale. Fitoterapia. 2000 Dec; 71(6):716-8. doi: 10.1016/s0367-326x(00)00215-x. [PMID: 11077185]
  • D L Flynn, M F Rafferty, A M Boctor. Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds. Prostaglandins, leukotrienes, and medicine. 1986 Oct; 24(2-3):195-8. doi: 10.1016/0262-1746(86)90126-5. [PMID: 3467378]