Cajanol (BioDeep_00000007937)

 

Secondary id: BioDeep_00000270003, BioDeep_00001029077

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


5-hydroxy-3-(4-hydroxy-2-methoxyphenyl)-7-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

化学式: C17H16O6 (316.0947)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 52.78%

分子结构信息

SMILES: C1(OC)=CC2OCC(C3=CC=C(O)C=C3OC)C(=O)C=2C(O)=C1
InChI: InChI=1S/C17H16O6/c1-21-10-6-13(19)16-15(7-10)23-8-12(17(16)20)11-4-3-9(18)5-14(11)22-2/h3-7,12,18-19H,8H2,1-2H3

描述信息

Isolated from fungus-infected stems of Cajanus cajan (pigeon pea). Cajanol is found in pigeon pea and pulses.
Cajanol is found in pigeon pea. Cajanol is isolated from fungus-infected stems of Cajanus cajan (pigeon pea

同义名列表

4 个代谢物同义名

5-hydroxy-3-(4-hydroxy-2-methoxyphenyl)-7-methoxy-3,4-dihydro-2H-1-benzopyran-4-one; 4,5-Dihydroxy-2,7-dimethoxyisoflavanone; Cajanol; Cajanol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ANXA5, BCL2, CASP3, CASP9, CAT, ENO2, ESR1, FAS, MSMP, PIK3CA, SIRT1
Peripheral membrane protein 2 ANXA5, ESR1
Endoplasmic reticulum membrane 3 BCL2, HMOX1, HSP90B1
Nucleus 8 BCL2, CASP3, CASP9, ESR1, HMOX1, HSP90B1, PARP1, SIRT1
cytosol 15 ANXA5, BCL2, CASP3, CASP9, CAT, ENO2, ESR1, FAS, GPT, HBB, HMOX1, HSP90B1, PARP1, PIK3CA, SIRT1
nuclear body 2 FAS, PARP1
nucleoplasm 5 CASP3, ESR1, HMOX1, PARP1, SIRT1
Cell membrane 4 ABCB1, ENO2, ESR1, FAS
Cytoplasmic side 2 ESR1, HMOX1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 ABCB1
cell surface 3 ABCB1, FAS, TNR
glutamatergic synapse 2 CASP3, TNR
Golgi apparatus 2 ESR1, FAS
neuronal cell body 1 CASP3
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PARP1
plasma membrane 5 ABCB1, ENO2, ESR1, FAS, PIK3CA
Membrane 12 ABCB1, ANXA5, BCL2, CAT, ENO2, ESR1, FAS, HBB, HGF, HMOX1, HSP90B1, PARP1
apical plasma membrane 1 ABCB1
extracellular exosome 9 ABCB1, ANXA5, CAT, CETP, ENO2, FAS, GPT, HBB, HSP90B1
endoplasmic reticulum 3 BCL2, HMOX1, HSP90B1
extracellular space 7 CETP, ENO2, HBB, HGF, HMOX1, MSMP, TNR
perinuclear region of cytoplasm 3 HMOX1, HSP90B1, PIK3CA
Schaffer collateral - CA1 synapse 1 TNR
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CAT, PARP1, SIRT1
protein-containing complex 6 BCL2, CASP9, CAT, ESR1, HSP90B1, PARP1
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 FAS
Secreted 2 CETP, MSMP
extracellular region 7 ANXA5, CAT, CETP, HBB, HGF, HSP90B1, TNR
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
transcription regulator complex 2 ESR1, PARP1
photoreceptor inner segment 1 ENO2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, FAS
Secreted, extracellular space, extracellular matrix 1 TNR
high-density lipoprotein particle 1 CETP
perikaryon 1 ENO2
nucleolus 2 PARP1, SIRT1
midbody 1 HSP90B1
vesicle 1 CETP
Apical cell membrane 1 ABCB1
heterochromatin 1 SIRT1
Membrane raft 2 FAS, TNR
pore complex 1 BCL2
focal adhesion 3 ANXA5, CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
collagen-containing extracellular matrix 3 ANXA5, HSP90B1, TNR
nuclear inner membrane 1 SIRT1
Zymogen granule membrane 1 ANXA5
chromatin 3 ESR1, PARP1, SIRT1
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 HBB
site of double-strand break 1 PARP1
fibrillar center 1 SIRT1
nuclear envelope 2 PARP1, SIRT1
Melanosome 2 FAS, HSP90B1
euchromatin 2 ESR1, SIRT1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 2 CAT, HBB
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 HSP90B1
platelet alpha granule lumen 1 HGF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 HBB
perineuronal net 1 TNR
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
Sarcoplasmic reticulum lumen 1 HSP90B1
[Isoform 1]: Nucleus 1 ESR1
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
CD95 death-inducing signaling complex 1 FAS
death-inducing signaling complex 2 CASP3, FAS
[Isoform 1]: Cell membrane 1 FAS
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
site of DNA damage 1 PARP1
hemoglobin complex 1 HBB
endocytic vesicle lumen 2 HBB, HSP90B1
haptoglobin-hemoglobin complex 1 HBB
catalase complex 1 CAT
phosphopyruvate hydratase complex 1 ENO2
endoplasmic reticulum chaperone complex 1 HSP90B1
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
tenascin complex 1 TNR
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
glycogen granule 1 FAS
caspase complex 1 CASP9
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Lu Liang, Chang Gao, Meng Luo, Chunjian Zhao, Wei Wang, Chengbo Gu, Jinghua Yu, Yujie Fu. The phytoestrogenic compound cajanol from Pigeonpea roots is associated with the activation of estrogen receptor α-dependent signaling pathway in human prostate cancer cells. Phytotherapy research : PTR. 2013 Dec; 27(12):1834-41. doi: 10.1002/ptr.4937. [PMID: 23420757]
  • J Zhao, C Li, W Wang, C Zhao, M Luo, F Mu, Y Fu, Y Zu, M Yao. Hypocrea lixii, novel endophytic fungi producing anticancer agent cajanol, isolated from pigeon pea (Cajanus cajan [L.] Millsp.). Journal of applied microbiology. 2013 Jul; 115(1):102-13. doi: 10.1111/jam.12195. [PMID: 23495919]
  • Xiao-lei Liu, Xin-jian Zhang, Yu-jie Fu, Yuan-gang Zu, Nan Wu, Lu Liang, Thomas Efferth. Cajanol inhibits the growth of Escherichia coli and Staphylococcus aureus by acting on membrane and DNA damage. Planta medica. 2011 Jan; 77(2):158-63. doi: 10.1055/s-0030-1250146. [PMID: 20803417]
  • Meng Luo, Xia Liu, Yuangang Zu, Yujie Fu, Su Zhang, Liping Yao, Thomas Efferth. Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway. Chemico-biological interactions. 2010 Oct; 188(1):151-60. doi: 10.1016/j.cbi.2010.07.009. [PMID: 20638373]
  • Cheryl Lans. Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine. Journal of ethnobiology and ethnomedicine. 2007 Jan; 3(?):3. doi: 10.1186/1746-4269-3-3. [PMID: 17207273]
  • George Duker-Eshun, Jerzy W Jaroszewski, William A Asomaning, Francis Oppong-Boachie, S Brøgger Christensen. Antiplasmodial constituents of Cajanus cajan. Phytotherapy research : PTR. 2004 Feb; 18(2):128-30. doi: 10.1002/ptr.1375. [PMID: 15022164]
  • Paul S Marley, Rory J Hillocks. Induction of phytoalexins in pigeonpea (Cajanus cajan) in response to inoculation with Fusarium udum and other treatments. Pest management science. 2002 Oct; 58(10):1068-72. doi: 10.1002/ps.586. [PMID: 12400448]