1,3,5-Trihydroxyxanthone (BioDeep_00000007873)

 

Secondary id: BioDeep_00000866173

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1,3,5-Trihydroxyxanthone

化学式: C13H8O5 (244.0372)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 92.86%

分子结构信息

SMILES: c1(cc(c2c(c1)oc1c(c2=O)cccc1O)O)O
InChI: InChI=1S/C13H8O5/c14-6-4-9(16)11-10(5-6)18-13-7(12(11)17)2-1-3-8(13)15/h1-5,14-16H

描述信息

A member of the class of xanthones that is xanthone substituted by hydroxy groups at positions 1, 3 and 5. It has been isolated from Anaxagorea luzonensis.

同义名列表

2 个代谢物同义名

1,3,5-Trihydroxyxanthone; 1,3,5-Trihydroxyxanthone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, FDPS, MTOR, PAF1, PIK3C3, PIK3CA, PTGS2, STAT6, TLR4
Peripheral membrane protein 3 CYP1B1, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 CYP1B1, MTOR, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 5 AKT1, MTOR, PAF1, STAT6, TMEM115
autophagosome 1 PIK3C3
cytosol 7 AKT1, FDPS, MTOR, PAF1, PIK3C3, PIK3CA, STAT6
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 5 AKT1, FDPS, MTOR, PAF1, STAT6
RNA polymerase II transcription regulator complex 1 STAT6
Cell membrane 2 AKT1, TLR4
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 2 PAF1, TMEM115
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell surface 1 TLR4
glutamatergic synapse 2 AKT1, PIK3C3
Golgi apparatus 1 TMEM115
Golgi membrane 2 MTOR, TMEM115
lysosomal membrane 2 GAA, MTOR
postsynapse 1 AKT1
Lysosome 2 GAA, MTOR
endosome 1 PIK3C3
plasma membrane 5 AKT1, BCHE, GAA, PIK3CA, TLR4
Membrane 8 AKT1, CYP1B1, FDPS, GAA, MTOR, PAF1, PIK3C3, TLR4
caveola 1 PTGS2
extracellular exosome 1 GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 1 PTGS2
extracellular space 1 BCHE
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 1 CYP1B1
protein-containing complex 2 AKT1, PTGS2
intracellular membrane-bounded organelle 3 CYP1B1, GAA, PAF1
Microsome membrane 3 CYP1B1, MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 2 BCHE, GAA
extracellular region 2 BCHE, GAA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 FDPS
external side of plasma membrane 1 TLR4
microtubule cytoskeleton 1 AKT1
midbody 1 PIK3C3
Early endosome 1 TLR4
cell-cell junction 1 AKT1
vesicle 1 AKT1
spindle 1 AKT1
GABA-ergic synapse 1 PIK3C3
Peroxisome 2 FDPS, PIK3C3
peroxisomal membrane 1 PAF1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
axoneme 1 PIK3C3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
Late endosome 1 PIK3C3
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 STAT6
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 PIK3C3
blood microparticle 1 BCHE
fibrillar center 1 PAF1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
tertiary granule membrane 1 GAA
Golgi cisterna membrane 1 TMEM115
Peroxisome membrane 1 PAF1
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 2 BCHE, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
Golgi apparatus, Golgi stack membrane 1 TMEM115
presynaptic endosome 1 PIK3C3
nuclear envelope lumen 1 BCHE
ficolin-1-rich granule membrane 1 GAA
Cytoplasmic vesicle, phagosome 1 MTOR
postsynaptic endosome 1 PIK3C3
Autolysosome 1 PIK3C3
autolysosome lumen 1 GAA
Cdc73/Paf1 complex 1 PAF1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Jie Liu, Jianrun Zhang, Huailing Wang, Zhijun Liu, Cao Zhang, Zhenlei Jiang, Heru Chen. Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them. European journal of medicinal chemistry. 2017 Jun; 133(?):50-61. doi: 10.1016/j.ejmech.2017.03.068. [PMID: 28376372]
  • Ibrahim Jantan, Fadlina Chany Saputri. Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation. Phytochemistry. 2012 Aug; 80(?):58-63. doi: 10.1016/j.phytochem.2012.05.003. [PMID: 22640928]
  • Chwan-Fwu Lin, Yi-Ju Chen, Yu-Ling Huang, Wen-Fei Chiou, Jen-Hwey Chiu, Chien-Chih Chen. A new auronol from Cudrania cochinchinensis. Journal of Asian natural products research. 2012; 14(7):704-7. doi: 10.1080/10286020.2012.682305. [PMID: 22582907]
  • Gabin Nselapi Louh, Alain Meli Lannang, Celine Djama Mbazoa, Jean Gustave Tangmouo, Justin Komguem, Paula Castilho, Fernande Ngounou Ngninzeko, Naz Qamar, David Lontsi, Muhammad Iqbal Choudhary, Beiban Luc Sondengam. Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv. Phytochemistry. 2008 Feb; 69(4):1013-7. doi: 10.1016/j.phytochem.2007.10.002. [PMID: 18022654]
  • Zhizhen Zhang, Hala N ElSohly, Melissa R Jacob, David S Pasco, Larry A Walker, Alice M Clark. Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta medica. 2002 Jan; 68(1):49-54. doi: 10.1055/s-2002-20049. [PMID: 11842327]