(+)-Fargesin (BioDeep_00000000781)

 

Secondary id: BioDeep_00000230071

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


1,3-Benzodioxole, 5-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-, (1S-(1alpha,3aalpha,4beta,6aalpha))-

化学式: C21H22O6 (370.1416312)
中文名称: 辛夷脂素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 21.43%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC5=C(C=C4)OCO5)OC
InChI: InChI=1S/C21H22O6/c1-22-16-5-3-12(7-18(16)23-2)20-14-9-25-21(15(14)10-24-20)13-4-6-17-19(8-13)27-11-26-17/h3-8,14-15,20-21H,9-11H2,1-2H3

描述信息

Fargesin is a lignan.
Planinin is a natural product found in Piper mullesua and Magnolia coco with data available.
Constituent of Artemisia absinthium (wormwood). (+)-Fargesin is found in alcoholic beverages and herbs and spices.
(+)-Spinescin is found in herbs and spices. (+)-Spinescin is a constituent of sassafras root.
Fargesin is a bioactive neolignan isolated from magnolia plants, with antihypertensive and anti-inflammatory effects[1][2][3].
Fargesin is a bioactive neolignan isolated from magnolia plants, with antihypertensive and anti-inflammatory effects[1][2][3].

同义名列表

9 个代谢物同义名

1,3-Benzodioxole, 5-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-, (1S-(1alpha,3aalpha,4beta,6aalpha))-; 5-[(3R,3aS,6S,6aS)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole; 5-[4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2H-1,3-benzodioxole; 2-(3,4-Dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo(3,3,0)octane; 5-[4-(3,4-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxole; Methylpluviatilol; (+)-Fargesin; Fargesin; Planinin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuting Zhang, Rui Ma, Juan Wang. Protective effects of fargesin on cadmium-induced lung injury through regulating aryl hydrocarbon receptor. Journal of biochemical and molecular toxicology. 2022 Nov; 36(11):e23197. doi: 10.1002/jbt.23197. [PMID: 35983679]
  • Gang Wang, Jia-Hui Gao, Lin-Hao He, Xiao-Hua Yu, Zhen-Wang Zhao, Jin Zou, Feng-Jiao Wen, Li Zhou, Xiang-Jun Wan, Chao-Ke Tang. Fargesin alleviates atherosclerosis by promoting reverse cholesterol transport and reducing inflammatory response. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 05; 1865(5):158633. doi: 10.1016/j.bbalip.2020.158633. [PMID: 31988050]
  • Bei Yue, Yi-Jing Ren, Jing-Jing Zhang, Xiao-Ping Luo, Zhi-Lun Yu, Gai-Yan Ren, A-Ning Sun, Chao Deng, Zheng-Tao Wang, Wei Dou. Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice. Molecules (Basel, Switzerland). 2018 Jun; 23(6):. doi: 10.3390/molecules23061380. [PMID: 29880739]
  • Vinod Bhatt, Sushila Sharma, Neeraj Kumar, Upendra Sharma, Bikram Singh. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. Journal of pharmaceutical and biomedical analysis. 2017 Jan; 132(?):46-55. doi: 10.1016/j.jpba.2016.09.035. [PMID: 27693952]
  • Sha Sha, Dandan Xu, Yanwei Wang, Weifang Zhao, Xiaoni Li. Antihypertensive effects of fargesin in vitro and in vivo via attenuating oxidative stress and promoting nitric oxide release. Canadian journal of physiology and pharmacology. 2016 Aug; 94(8):900-6. doi: 10.1139/cjpp-2015-0615. [PMID: 27409158]
  • Yan-qun Liu, Sheng-hui Yang, Qiang Liu, Gang Pei, Wei-wei Pan, Min Liu, Cai-yun Peng. [Study on chemical constituents of Zanthoxyli cortex's ethyl acetate extract]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Nov; 36(11):1792-5. doi: . [PMID: 24956821]
  • Young-Sil Lee, Byung-Yoon Cha, Sun-Sil Choi, Yumiko Harada, Bong-Keun Choi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo. Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice. BioFactors (Oxford, England). 2012 Jul; 38(4):300-8. doi: 10.1002/biof.1022. [PMID: 22674784]
  • Ji Hyun Jeong, Dong Kyun Kim, Hye Young Ji, Sei Ryang Oh, Hyung-Kyu Lee, Hye Suk Lee. Liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry for the simultaneous determination of dimethoxyaschantin, dimethylliroresinol, dimethylpinoresinol, epimagnolin A, fargesin and magnolin in rat plasma. Biomedical chromatography : BMC. 2011 Aug; 25(8):879-89. doi: 10.1002/bmc.1538. [PMID: 21058411]
  • Jin Ah Baek, Yang Deok Lee, Chan Bog Lee, Hyeon Kyu Go, Jin Pyo Kim, Jeong Ju Seo, Yang Keun Rhee, A Mi Kim, Dong Jib Na. Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells. Nitric oxide : biology and chemistry. 2009 Mar; 20(2):122-8. doi: 10.1016/j.niox.2008.10.003. [PMID: 18976718]