Khellin (BioDeep_00000000750)

 

Secondary id: BioDeep_00000017476, BioDeep_00000862837

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one

化学式: C14H12O5 (260.0684702)
中文名称: 凯林
谱图信息: 最多检出来源 Homo sapiens(otcml) 22.83%

分子结构信息

SMILES: CC1=CC(=O)C2=C(C3=C(C(=C2O1)OC)OC=C3)OC
InChI: InChI=1S/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-7/h4-6H,1-3H3

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

同义名列表

12 个代谢物同义名

4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one; 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one; Khellinum; Khelloyd; Visammin; Khelline; Quelina; Khellin; Ammivin; Kelamin; Khellin; Khellin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Martin Ndayambaje, Hicham Wahnou, Marieme Sow, Oumaima Chgari, Thierry Habyarimana, Mehdi Karkouri, Youness Limami, Abdallah Naya, Mounia Oudghiri. Exploring the multifaceted effects of Ammi visnaga: subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities. Journal of toxicology and environmental health. Part A. 2024 Feb; 87(4):150-165. doi: 10.1080/15287394.2023.2289430. [PMID: 38037686]
  • Veselina Adımcılar, Neslihan Beyazit, F Bedia Erim. Khellin and visnagin in different organs of Ammi visnaga and Ammi majus. Natural product research. 2023 Jan; 37(1):164-166. doi: 10.1080/14786419.2021.1956924. [PMID: 34569361]
  • X-L Rao, L-L Liu, J Huang, J Chen. Neuroprotective effects of visnagin on cerebral ischemia-reperfusion injury rats and the underlying mechanisms. European review for medical and pharmacological sciences. 2022 06; 26(12):4371-4379. doi: 10.26355/eurrev_202206_29076. [PMID: 35776038]
  • Fatma Abd El-Fattah Ragab, Yassin Mohammed Nissan, M Alaraby Salem, Mamdouh Moawad Ali, Ahmed Abbass Mohamed Abdelrahman Selim. Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity. Natural product research. 2022 May; 36(10):2486-2494. doi: 10.1080/14786419.2021.1907383. [PMID: 33813964]
  • Giulia Vanti, Lucrezia Muti, Mario D'Ambrosio, Lucia Grifoni, Maria Camilla Bergonzi, Cristina Luceri, Anna Rita Bilia. Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule. Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247657. [PMID: 34946734]
  • Mohammad H Abukhalil, Omnia E Hussein, Saleem H Aladaileh, Osama Y Althunibat, Wesam Al-Amarat, Sultan A Saghir, Manal A Alfwuaires, Abdulmohsen I Algefare, Khalid M Alanazi, Farhan K Al-Swailmi, Emadeldin M Kamel, Ayman M Mahmoud. Visnagin prevents isoproterenol-induced myocardial injury by attenuating oxidative stress and inflammation and upregulating Nrf2 signaling in rats. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22906. doi: 10.1002/jbt.22906. [PMID: 34486204]
  • Sonali S Bharate. Enhancing Biopharmaceutical Attributes of Khellin by Amorphous Binary Solid Dispersions. AAPS PharmSciTech. 2021 Oct; 22(8):260. doi: 10.1208/s12249-021-02126-3. [PMID: 34705156]
  • Laura Risaliti, Xuan Yu, Giulia Vanti, Maria Camilla Bergonzi, Meng Wang, Anna Rita Bilia. Hydroxyethyl cellulose hydrogel for skin delivery of khellin loaded in ascosomes: Characterization, in vitro/in vivo performance and acute toxicity. International journal of biological macromolecules. 2021 May; 179(?):217-229. doi: 10.1016/j.ijbiomac.2021.02.206. [PMID: 33662425]
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  • Noha Khalil, Mokhtar Bishr, Mohamed El-Degwy, Mohamed Abdelhady, Mohamed Amin, Osama Salama. Assessment of Conventional Solvent Extraction vs. Supercritical Fluid Extraction of Khella (Ammi visnaga L.) Furanochromones and Their Cytotoxicity. Molecules (Basel, Switzerland). 2021 Feb; 26(5):. doi: 10.3390/molecules26051290. [PMID: 33673560]
  • Jamaan S Ajarem, Ahmad K Hegazy, Gamal A Allam, Ahmed A Allam, Saleh N Maodaa, Ayman M Mahmoud. Effect of Visnagin on Altered Steroidogenesis and Spermatogenesis, and Testicular Injury Induced by the Heavy Metal Lead. Combinatorial chemistry & high throughput screening. 2021; 24(6):758-766. doi: 10.2174/1386207323999200918124639. [PMID: 32957877]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Lakshmi Priya Pasari, Amit Khurana, Pratibha Anchi, Mohd Aslam Saifi, Shivaraju Annaldas, Chandraiah Godugu. Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Apr; 112(?):108629. doi: 10.1016/j.biopha.2019.108629. [PMID: 30798137]
  • Fatma Aydoğmuş-Öztürk, Humera Jahan, Neslihan Beyazit, Keriman Günaydın, Muhammad Iqbal Choudhary. The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144. Molecular biology reports. 2019 Apr; 46(2):1709-1714. doi: 10.1007/s11033-019-04620-1. [PMID: 30694454]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
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