Citicoline (BioDeep_00000000744)

Main id: BioDeep_00000859284

Secondary id: BioDeep_00000400231, BioDeep_00000400232, BioDeep_00000400312, BioDeep_00000400398

natural product human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


2-(((((((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)-N,N,N-trimethylethanaminium

化学式: C14H26N4O11P2 (488.1073)
中文名称: 尼可林, 脑二磷胆碱, 胞嘧啶核苷二磷酸胆碱, 胞磷胆碱, 尼古林
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 27.6%

分子结构信息

SMILES: C[N+](C)(C)CCOP(=O)(O)OP(=O)([O-])OCC1OC(n2ccc(=N)nc2O)C(O)C1O
InChI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1

描述信息

CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+).
Citicoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.
Citicoline is a nutritional supplement and source of choline and cytidine with potential neuroprotective and nootropic activity. Citicoline, also known as cytidine-5-diphosphocholine or CDP-choline, is hydrolyzed into cytidine and choline in the intestine. Following absorption, both cytidine and choline are dispersed, utilized in various biosynthesis pathways, and cross the blood-brain barrier for resynthesis into citicoline in the brain, which is the rate-limiting product in the synthesis of phosphatidylcholine. This agent also increases acetylcholine (Ach), norepinephrine (NE) and dopamine levels in the central nervous system (CNS). In addition, citicoline is involved in the preservation of sphingomyelin and cardiolipin and the restoration of Na+/K+-ATPase activity. Citicoline also increases glutathione synthesis and glutathione reductase activity, and exerts antiapoptotic effects.
Donor of choline in biosynthesis of choline-containing phosphoglycerides.
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
Acquisition and generation of the data is financially supported in part by CREST/JST.
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
Citicoline (Cytidine diphosphate-choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
Citicoline (Cytidine diphosphate-choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.

同义名列表

84 个代谢物同义名

2-(((((((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)-N,N,N-trimethylethanaminium; {2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]ethyl}trimethylazanium; Cytidine 5-(trihydrogen diphosphate), mono(2-(trimethylammonio)ethyl) ester, hydroxide, inner salt; Cytidine 5-(trihydrogen diphosphate), P-(2-(trimethylammonio)ethyl) ester, inner salt; Cytidine 5-(trihydrogen diphosphate), P-[2-(trimethylammonio)ethyl] ester, inner salt; Cytidine 5-(trihydrogen diphosphate), P-[2-(trimethylammonio)ethyl]ester, inner salt; Choline, hydroxide, 5-ester with cytidine 5-(trihydrogen pyrophosphate), inner salt; 5-O-[(S)-hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine; 5-O-[hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine; Cytidine-5-diphosphocholine sodium salt dihydrate, from yeast, solid; Cytidine diphosphate-choline;CDP-Choline;Cytidine 5-diphosphocholine; [2-CYTIDYLATE-O-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM; Cytidine, 5-pyrophosphate, ester with choline; Choline, ester with cytidine 5-pyrophosphate; Cytidine diphosphate choline (CDPcholine); Choline cytidine 5-pyrophosphate ester; Citidin difosfato de colina [Spanish]; Cytidine 5-(cholinyl pyrophosphate); Cytidine diphosphate choline ester; Cytidine diphosphate cholin ester; Cytidine 5-(choline diphosphate); Cytidindiphosphocholin [German]; Cytidine 5-diphosphoric choline; Choline 5-cytidine diphosphate; Cytidine 5-diphosphate choline; Choline, Cytidine Diphosphate; Diphosphate Choline, Cytidine; Choline cytidine diphosphate; cytidine diphosphate choline; Cytidine choline diphosphate; cytidine diphosphate-choline; Cytidine diphosphorylcholine; CDP-choline (neutral charge); 5-Diphosphocholine, Cytidine; Cytidinediphosphoric choline; Cytidine 5 Diphosphocholine; cytidine 5-diphosphocholine; Cytidine 5-diphosphocholine; RZZPDXZPRHQOCG-OJAKKHQRSA-N; citidin difosfato de colina; Cytidine diphosphocholine; Citicolina [INN-Spanish]; Citicolinum [INN-Latin]; Cytidindiphosphocholin; Citicoline (JP17/INN); Citicoline [INN:JAN]; CDP-colina [Spanish]; CDP-cholin [German]; Nicholin (TN); Choline, CDP; citicholine; cyticholine; Citicolinum; CDP-choline; CDP Choline; Citicolina; CDP-colina; Difosfocin; FT-0623951; Citidoline; CDP-cholin; Citicoline; Cytidoline; Niticolin; Startonyl; Emicholin; Suncholin; Cyscholin; Recofnan; Somazina; Haocolin; Nicholin; Recognan; Cidifos; Citifar; Rexort; Meibis; Ubelin; Ensign; Colite; Cereb; Citicoline; Cytidine 5'-diphosphocholine; CDP-choline



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(2)

PlantCyc(0)

代谢反应

333 个相关的代谢反应过程信息。

Reactome(90)

BioCyc(5)

WikiPathways(7)

Plant Reactome(231)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, AXIN2, BCL2, BDNF, CA1, CASP3, CAT, CHKA, PLA2G12A, TH, VEGFA
Peripheral membrane protein 2 ACHE, PCYT1A
Endoplasmic reticulum membrane 5 BCL2, CEPT1, HSP90B1, PCYT1A, PEMT
Mitochondrion membrane 1 PEMT
Nucleus 10 ACHE, ALB, AXIN2, BCL2, CASP3, HSP90B1, PCYT1A, PLCZ1, TH, VEGFA
cytosol 12 ALB, AXIN2, BCL2, CA1, CASP3, CAT, CHKA, HSP90B1, PCYT1A, PEMT, PLCZ1, TH
dendrite 2 BDNF, TH
mitochondrial membrane 1 PEMT
centrosome 2 ALB, AXIN2
nucleoplasm 2 CASP3, PLCZ1
Cell membrane 2 ACHE, TNF
Cell projection, axon 1 TH
Multi-pass membrane protein 2 CEPT1, PEMT
Synapse 1 ACHE
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 4 ACHE, ALB, CEPT1, VEGFA
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
smooth endoplasmic reticulum 2 HSP90B1, TH
synaptic vesicle 2 BDNF, TH
Cytoplasm, cytosol 2 CHKA, PCYT1A
plasma membrane 3 ACHE, AXIN2, TNF
terminal bouton 1 TH
Membrane 9 ACHE, BCL2, BDNF, CAT, CEPT1, HSP90B1, PCYT1A, PEMT, VEGFA
axon 2 BDNF, TH
extracellular exosome 4 ALB, CA1, CAT, HSP90B1
endoplasmic reticulum 6 ALB, BCL2, HSP90B1, PCYT1A, PEMT, VEGFA
extracellular space 7 ACHE, ALB, BDNF, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 5 ACHE, BDNF, HSP90B1, PLCZ1, TH
adherens junction 1 VEGFA
mitochondrion 4 BCL2, CAT, PEMT, TH
protein-containing complex 4 ALB, BCL2, CAT, HSP90B1
intracellular membrane-bounded organelle 2 CAT, PEMT
postsynaptic density 1 CASP3
pronucleus 1 PLCZ1
Secreted 7 ACHE, ALB, BDNF, IL6, INS, PLA2G12A, VEGFA
extracellular region 10 ACHE, ALB, BDNF, CAT, HSP90B1, IL6, INS, PLA2G12A, TNF, VEGFA
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
Nucleus membrane 2 BCL2, CEPT1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CEPT1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
perikaryon 1 TH
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TH
nucleolus 1 PLCZ1
Melanosome membrane 1 TH
midbody 1 HSP90B1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 2 PLCZ1, TH
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 CAT, HSP90B1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 VEGFA
neuron projection 1 TH
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 PCYT1A
endosome lumen 1 INS
Lipid droplet 1 CHKA
[Isoform 1]: Endoplasmic reticulum membrane 1 PEMT
Melanosome 1 HSP90B1
side of membrane 1 ACHE
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, BDNF, HSP90B1, IL6, INS
platelet alpha granule lumen 2 ALB, VEGFA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Sarcoplasmic reticulum lumen 1 HSP90B1
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
[Isoform 2]: Endoplasmic reticulum membrane 1 PEMT
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
sperm head 1 PLCZ1
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
endoplasmic reticulum chaperone complex 1 HSP90B1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
[Isoform 1]: Lipid droplet 1 CHKA
glycogen granule 1 PCYT1A
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zhenhua Wang, Meng Yang, Yufan Yang, Yonglin He, Hongwu Qian. Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1. Nature communications. 2023 May; 14(1):2529. doi: 10.1038/s41467-023-38290-2. [PMID: 37137909]
  • Qin Zhang, Hong Zhang, Chun-Mei Yang, Bo Wang, Chen-Yang Li, Qi Li. [Mechanism of active ingredients in Periploca forrestii compound against rheumatoid arthritis based on integrative metabolomics and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(2):507-516. doi: 10.19540/j.cnki.cjcmm.20220913.702. [PMID: 36725240]
  • Cheng Zheng, Mingjin Qu, Yingmiao Liu, Junzhi Wang, Hanjie Ying. Design and optimizing a new CDP-choline in vitro multienzyme producing process starts from d-ribose. Biotechnology and applied biochemistry. 2022 Jun; 69(3):1029-1035. doi: 10.1002/bab.2173. [PMID: 33885187]
  • Hussein M Eid, Adel A Ali, Ahmed M Abdelhaleem Ali, Essam M Eissa, Randa M Hassan, Fatma I Abo El-Ela, Amira H Hassan. Potential Use of Tailored Citicoline Chitosan-Coated Liposomes for Effective Wound Healing in Diabetic Rat Model. International journal of nanomedicine. 2022; 17(?):555-575. doi: 10.2147/ijn.s342504. [PMID: 35153481]
  • Amin Osman Elzupir. Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 Treatment. Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247458. [PMID: 34946540]
  • Meric Kocaturk, Zeki Yilmaz, Mehmet Cansev, Yesim Ozarda, Jose Joaquin Ceron, Ali Buturak, Ismail H Ulus. Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally - Induced endotoxic shock. Research in veterinary science. 2021 Dec; 141(?):116-128. doi: 10.1016/j.rvsc.2021.10.010. [PMID: 34715589]
  • Hyeonseok Jeong, Sujung Yoon, Young-Hoon Sung, Jungyoon Kim, In Kyoon Lyoo, Deborah A Yurgelun-Todd, Perry F Renshaw. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. Journal of psychiatric research. 2021 11; 143(?):215-221. doi: 10.1016/j.jpsychires.2021.09.006. [PMID: 34507102]
  • Cheng Zheng, Rongxin Miao, Yingmiao Liu, Yang Cao, Dong Liu, Junzhi Wang, Hanjie Ying. A Procedure to Design One-Pot Multi-enzyme System for Industrial CDP-Choline Production. Applied biochemistry and biotechnology. 2021 Sep; 193(9):2769-2780. doi: 10.1007/s12010-021-03564-2. [PMID: 34117628]
  • Lucia E Rosas, Lauren M Doolittle, Lisa M Joseph, Hasan El-Musa, Michael V Novotny, Judy M Hickman-Davis, R Duncan Hite, Ian C Davis. Postexposure Liponucleotide Prophylaxis and Treatment Attenuates Acute Respiratory Distress Syndrome in Influenza-infected Mice. American journal of respiratory cell and molecular biology. 2021 06; 64(6):677-686. doi: 10.1165/rcmb.2020-0465oc. [PMID: 33606602]
  • Abeer Salamah, Mostafa Mehrez, Amany Faheem, Doaa El Amrousy. Efficacy of Citicoline as a Neuroprotector in children with post cardiac arrest: a randomized controlled clinical trial. European journal of pediatrics. 2021 Apr; 180(4):1249-1255. doi: 10.1007/s00431-020-03871-6. [PMID: 33169240]
  • Nahed Abdel-Aziz, Enas M Moustafa, Helen N Saada. The impact of citicoline on brain injury in rats subjected to head irradiation. Environmental science and pollution research international. 2021 Feb; 28(8):9742-9752. doi: 10.1007/s11356-020-11101-7. [PMID: 33155111]
  • O A Gromova, I Yu Torshin, T R Grishina, V I Demidov, T E Bogacheva. [Molecular and clinical aspects of the effect of cytidyndiphosphocholine on cognitive functions]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021; 121(5):88-97. doi: 10.17116/jnevro202112105188. [PMID: 34184483]
  • Annagrazia Adornetto, Laura Rombolà, Luigi Antonio Morrone, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta, Rossella Russo. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103158. [PMID: 33081127]
  • Jing Xie, Ming-Qing Tang, Jia Chen, Ya-Han Zhu, Chao-Bo Lei, Hong-Wei He, Xiao-Hong Xu. A sandwich ELISA-like detection of C-reactive protein in blood by citicoline-bovine serum albumin conjugate and aptamer-functionalized gold nanoparticles nanozyme. Talanta. 2020 Sep; 217(?):121070. doi: 10.1016/j.talanta.2020.121070. [PMID: 32498852]
  • Xiguang Feng, Yi Chen, Min Zhang, Miaojie Fang, Cuimei Xiao, Junzhu Chen. Protective effect of citicoline on random flap survival in a rat mode. International immunopharmacology. 2020 Jun; 83(?):106448. doi: 10.1016/j.intimp.2020.106448. [PMID: 32247268]
  • Hadi Samadian, Arian Ehterami, Arash Sarrafzadeh, Hossein Khastar, Mohammad Nikbakht, Aram Rezaei, Leila Chegini, Majid Salehi. Sophisticated polycaprolactone/gelatin nanofibrous nerve guided conduit containing platelet-rich plasma and citicoline for peripheral nerve regeneration: In vitro and in vivo study. International journal of biological macromolecules. 2020 May; 150(?):380-388. doi: 10.1016/j.ijbiomac.2020.02.102. [PMID: 32057876]
  • Azadeh Aminzadeh, Ayda Salarinejad. Citicoline protects against lead-induced oxidative injury in neuronal PC12 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2019 12; 97(6):715-721. doi: 10.1139/bcb-2018-0218. [PMID: 30925221]
  • Shaiba Sana Qureshi, Jeetendra Kumar Gupta, Ahsas Goyal, Harlokesh Narayan Yadav. A novel approach in the management of hyperhomocysteinemia. Medical hypotheses. 2019 Aug; 129(?):109245. doi: 10.1016/j.mehy.2019.109245. [PMID: 31371071]
  • Kamil Synoradzki, Paweł Grieb. Citicoline: A Superior Form of Choline?. Nutrients. 2019 Jul; 11(7):. doi: 10.3390/nu11071569. [PMID: 31336819]
  • Mark B Plotnikov, Galina A Chernysheva, Oleg I Aliev, Vera I Smol'iakova, Tatiana I Fomina, Anton N Osipenko, Victoria S Rydchenko, Yana J Anfinogenova, Andrei I Khlebnikov, Igor A Schepetkin, Dmitriy N Atochin. Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091722. [PMID: 31058815]
  • Jing-Wen Yang, Guang-Xia Shi, Shuai Zhang, Jian-Feng Tu, Li-Qiong Wang, Chao-Qun Yan, Lu-Lu Lin, Bao-Zhen Liu, Jun Wang, San-Feng Sun, Bo-Feng Yang, Li-Yu Wu, Cheng Tan, Sheng Chen, Zhang-Jin Zhang, Marc Fisher, Cun-Zhi Liu. Effectiveness of acupuncture for vascular cognitive impairment no dementia: a randomized controlled trial. Clinical rehabilitation. 2019 Apr; 33(4):642-652. doi: 10.1177/0269215518819050. [PMID: 30672317]
  • Shi-Peng Liang, Qian Chen, Yi-Bing Cheng, Ying-Ying Xue, Hai-Jun Wang. Comparative Effects of Monosialoganglioside versus Citicoline on Apoptotic Factor, Neurological Function and Oxidative Stress in Newborns with Hypoxic-Ischemic Encephalopathy. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2019 Apr; 29(4):324-327. doi: 10.29271/jcpsp.2019.04.324. [PMID: 30925953]
  • Su Myat Phyu, Chih-Chung Tseng, Tim Andrew Davies Smith. CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor. Magma (New York, N.Y.). 2019 Apr; 32(2):227-235. doi: 10.1007/s10334-018-0719-3. [PMID: 30446846]
  • Cheng Zheng, Zhenjian Li, Haifeng Yang, Tianyi Zhang, Huanqing Niu, Dong Liu, Junzhi Wang, Hanjie Ying. Computation-aided rational design of a halophilic choline kinase for cytidine diphosphate choline production in high-salt condition. Journal of biotechnology. 2019 Jan; 290(?):59-66. doi: 10.1016/j.jbiotec.2018.11.008. [PMID: 30445133]
  • Cecilia Zazueta, Mabel Buelna-Chontal, Arturo Macías-López, Nadia G Román-Anguiano, Héctor González-Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda-Frausto, Rafael Bojalil, Alejandro Silva-Palacios, Rodrigo Velázquez-Espejel, Sonia Galvan Arzate, Francisco Correa. Cytidine-5'-Diphosphocholine Protects the Liver From Ischemia/Reperfusion Injury Preserving Mitochondrial Function and Reducing Oxidative Stress. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2018 08; 24(8):1070-1083. doi: 10.1002/lt.25179. [PMID: 29679463]
  • M Castro-Gago, D Dacruz, C Gomez-Lado, J Eiris-Punal. [Treatment of choline kinase beta deficiency with citicoline]. Revista de neurologia. 2018 07; 67(1):40. doi: . [PMID: 29923598]
  • Sapto Yuliani, Mustofa, Ginus Partadiredja. Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats. Drug and chemical toxicology. 2018 Jan; 41(1):62-71. doi: 10.1080/01480545.2017.1293087. [PMID: 28440093]
  • J H Kim, B Y Choi, A R Kho, S H Lee, J H Jeong, D K Hong, S H Lee, M Sohn, O H Ryu, M-G Choi, S W Suh. Acetylcholine precursor, citicoline (cytidine 5'-diphosphocholine), reduces hypoglycaemia-induced neuronal death in rats. Journal of neuroendocrinology. 2018 01; 30(1):. doi: 10.1111/jne.12567. [PMID: 29247563]
  • Yixiong Chen, Bing Li, Kai Cen, Yuzhen Lu, Siwei Zhang, Chengshu Wang. Diverse effect of phosphatidylcholine biosynthetic genes on phospholipid homeostasis, cell autophagy and fungal developments in Metarhizium robertsii. Environmental microbiology. 2018 01; 20(1):293-304. doi: 10.1111/1462-2920.13998. [PMID: 29159973]
  • E Yu Solovyeva, A N Karneev, A V Chekanov, O A Baranova, V A Shchelkonogov, A M Sinebryukhova, K I Farakhova, G M Sorokoumova. [The study of the membrane-protective potential of the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018 ; 118(1):18-22. doi: 10.17116/jnevro20181181118-22. [PMID: 29460900]
  • Mabel Buelna-Chontal, Martha Franco, Luz Hernández-Esquivel, Natalia Pavón, José S Rodríguez-Zavala, Francisco Correa, Ricardo Jasso, Gregorio Pichardo-Ramos, José Santamaría, Héctor González-Pacheco, Virgilia Soto, Jorge L Díaz-Ruíz, Edmundo Chávez. CDP-choline circumvents mercury-induced mitochondrial damage and renal dysfunction. Cell biology international. 2017 Dec; 41(12):1356-1366. doi: 10.1002/cbin.10871. [PMID: 28884894]
  • Ahmed O Abdel-Zaher, Mostafa M Hamdy, Mahran S Abdel-Rahman, Doaa H Abd El-Hamid. Protective effect of citicoline against aluminum-induced cognitive impairments in rats. Toxicology and industrial health. 2017 Apr; 33(4):308-317. doi: 10.1177/0748233716641869. [PMID: 27178312]
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