Pantothenic acid (BioDeep_00000000742)

 

Secondary id: BioDeep_00000177899, BioDeep_00000229614, BioDeep_00000399968, BioDeep_00000400301, BioDeep_00000402964, BioDeep_00000413065

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


Metabolite Card


(D,+)-N(alpha-gamma-Dihydroxy-beta,beta-dimethylbutyryl)-beta-alanine

Formula: C9H17NO5 (219.11066720000002)
Chinese Names: 维生素B5, D-泛酸, 泛酸, D-泛酸钙
Spectrum Hits: Top Source Homo sapiens(blood) 0.02%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Pantothenic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pantothenic_acid (retrieved 2024-11-06) (BioDeep RN: BioDeep_00000000742). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Molecular Structure

SMILES: CC(C)(CO)C(C(=O)NCCC(=O)O)O
InChI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)/t7-/m0/s1

Description

(R)-pantothenic acid is a pantothenic acid having R-configuration. It has a role as an antidote to curare poisoning, a human blood serum metabolite and a geroprotector. It is a vitamin B5 and a pantothenic acid. It is a conjugate acid of a (R)-pantothenate.
Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient as it is required to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. Pantothenic acid is the amide between pantoic acid and β-alanine and commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. Pantothenic acid is an ingredient in some hair and skin care products. Only the dextrorotatory (D) isomer of pantothenic acid possesses biological activity. while the levorotatory (L) form may antagonize the effects of the dextrorotatory isomer.
Pantothenic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Pantothenic acid is a natural product found in Chlamydomonas reinhardtii, Arabidopsis thaliana, and other organisms with data available.
Pantothenic Acid is a water-soluble vitamin ubiquitously found in plants and animal tissues with antioxidant property. Vitamin B5 is a component of coenzyme A (CoA) and a part of the vitamin B2 complex. Vitamin B5 is a growth factor and is essential for various metabolic functions, including the metabolism of carbohydrates, proteins, and fatty acids. This vitamin is also involved in the synthesis of cholesterol, lipids, neurotransmitters, steroid hormones, and hemoglobin.
(R)-Pantothenic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
See also: Broccoli (part of).
Pantothenic acid, also called vitamin B5, is a water-soluble vitamin required to sustain life. Pantothenic acid is needed to form coenzyme-A (CoA), and is thus critical in the metabolism and synthesis of carbohydrates, proteins, and fats. Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every food, with high amounts in whole grain cereals, legumes, eggs, meat, and royal jelly. Pantothenic acid is classified as a member of the secondary alcohols. Secondary alcohols are compounds containing a secondary alcohol functional group, with the general structure HOC(R)(R) (R,R=alkyl, aryl). Pantothenic acid is considered to be soluble (in water) and acidic.
(r)-pantothenate, also known as (+)-pantothenic acid or vitamin b5, is a member of the class of compounds known as secondary alcohols. Secondary alcohols are compounds containing a secondary alcohol functional group, with the general structure HOC(R)(R) (R,R=alkyl, aryl) (r)-pantothenate is soluble (in water) and a weakly acidic compound (based on its pKa). (r)-pantothenate can be found in a number of food items such as spirulina, nance, cereals and cereal products, and sparkleberry, which makes (r)-pantothenate a potential biomarker for the consumption of these food products (r)-pantothenate can be found primarily in blood and urine (r)-pantothenate exists in all eukaryotes, ranging from yeast to humans.
D018977 - Micronutrients > D014815 - Vitamins
A pantothenic acid having R-configuration.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID P032; [MS2] KO009182
KEIO_ID P032; [MS3] KO009183
KEIO_ID P032
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

Synonyms

88 synonym names

(D,+)-N(alpha-gamma-Dihydroxy-beta,beta-dimethylbutyryl)-beta-alanine; beta-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R)- (9CI); 3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoic acid; 3-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]propionic acid; .beta.-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R)-; b-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]- (9CI); 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid; 3-((R)-2,4-Dihydroxy-3,3-dimethyl-butyrylamino)-propionic acid; (+)-(R)-3-(2,4-Dihydroxy-3,3-dimethylbutanamido)propanoic acid; beta-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R)-; beta-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-; N-((2R)-2,4-DIHYDROXY-3,3-DIMETHYL-1-OXOBUTYL)-.BETA.-ALANINE; beta-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,(R)-; N-[(2R)-2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl]-beta-alanine; 3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanoic acid; N-((2R)-2,4-DIHYDROXY-3,3-DIMETHYL-1-OXOBUTYL)-beta-ALANINE; (R)-3-(2,4-Dihydroxy-3,3-dimethylbutanamido)propanoic acid; (R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine; N-[(2R)-2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl]-ss-alanine; N-[(2R)-2,4-DIHYDROXY-3,3-DIMETHYLBUTANOYL]-BETA-ALANINE; (R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-b-alanine; D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine; (R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine; 3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoic acid; N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-β-alanine; N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-b-alanine; D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-β-alanine; D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alanine; N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanine; N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine; 4-04-00-02569 (Beilstein Handbook Reference); PANTOTHENIC ACID [ORANGE BOOK]; Kyselina pantothenova [Czech]; ()-pantothenate;()-vitamin B5; Pantothen Pharmaselect (TN); Chick antidermatitis factor; GHOKWGTUZJEAQD-ZETCQYMHSA-N; Pantothenic acid, D- (8CI); PANTOTHENIC ACID [WHO-DD]; PANTOTHENIC ACID (MART.); PANTOTHENIC ACID [VANDF]; (D)-(+)-Pantothenic acid; PANTOTHENIC ACID [MART.]; PANTOTHENIC ACID [HSDB]; PANTOTHENIC ACID [INCI]; VITAMIN B5 [GREEN BOOK]; Pantothenic Acid [BAN]; Pantothenic acid (BAN); Pantothen Pharmaselect; D-(+)-pantothenic acid; delta-Pantothenic acid; Pantothenate, Calcium; Kyselina pantothenova; PANTOTHENIC ACID [MI]; (D)-(+)-Pantothenate; Pantothenic acid, D-; Calcium Pantothenate; (R)-pantothenic acid; (+)-Pantothenic acid; Pantothenic acid (d); D-Pantothenic acid; Pantothenate, Zinc; delta-Pantothenate; VITAMIN B5 [VANDF]; D-(+)-Pantothenate; PANTOTHENOIC ACID; Zinc Pantothenate; Pantotenico acido; pantothenic-acid; (R)-pantothenate; Pantothenic Acid; (+)-Pantothenate; UNII-19F5HK2737; d-pantothenate; PANTOTHENOate; B 5, Vitamin; pantothenate; Vitamin B 5; B5, Vitamin; Vitamin B-5; vitamin B5; 19F5HK2737; Dexol; PAU; D-Pantothenic acid hemicalcium salt; Calcium (+)-pantothenate; Sodium pantothenate; Pantothenic acid(VB5)



Cross Reference

62 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(1)

PlantCyc(0)

Biological Process

485 related biological process reactions.

Reactome(5)

BioCyc(1)

WikiPathways(0)

Plant Reactome(468)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(11)

PharmGKB(0)

20 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



Literature Reference

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