Ibogamine (BioDeep_00000007241)
natural product
代谢物信息卡片
化学式: C19H24N2 (280.1939)
中文名称:
谱图信息:
最多检出来源 Escherichia coli(natural_products) 55.56%
分子结构信息
SMILES: CCC1CC2C3CC1CN2CCc1c3[nH]c2ccccc12
InChI: InChI=1S/C19H24N2/c1-2-13-9-12-10-16-18-15(7-8-21(11-12)19(13)16)14-5-3-4-6-17(14)20-18/h3-6,12-13,16,19-20H,2,7-11H2,1H3/t12-,13+,16+,19+/m1/s1
描述信息
A monoterpenoid indole alkaloid with formula C19H24N2. It is isolated from the flowering plant genus, Tabernaemontana and exhibits anti-addictive properties.
同义名列表
3 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:5853
- KEGG: C09215
- PubChem: 100217
- PubChem: 442109
- Metlin: METLIN67524
- ChEMBL: CHEMBL5184088
- ChEMBL: CHEMBL467828
- CAS: 481-87-8
- MoNA: CCMSLIB00004679996
- PMhub: MS000214014
- PMhub: MS000020543
- MetaboLights: MTBLC5853
- PubChem: 11406
- KNApSAcK: C00001742
- NIKKAJI: J12.393E
- KNApSAcK: 5853
- LOTUS: LTS0030139
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
26 个相关的物种来源信息
- 4056 - Apocynaceae: LTS0030139
- 2759 - Eukaryota: LTS0030139
- 3398 - Magnoliopsida: LTS0030139
- 35493 - Streptophyta: LTS0030139
- 52860 - Tabernaemontana: LTS0030139
- 761054 - Tabernaemontana calcarea:
- 761054 - Tabernaemontana calcarea: 10.1021/NP020548E
- 761054 - Tabernaemontana calcarea: LTS0030139
- 403124 - Tabernaemontana catharinensis:
- 141615 - Tabernaemontana citrifolia: 10.1002/HLCA.19820650729
- 141615 - Tabernaemontana citrifolia: LTS0030139
- 761058 - Tabernaemontana coffeoides: 10.3987/COM-93-6644
- 1679252 - Tabernaemontana corymbosa:
- 761066 - Tabernaemontana cymosa: 10.1016/0031-9422(95)00050-H
- 52861 - Tabernaemontana divaricata:
- 52861 - Tabernaemontana divaricata: 10.1021/NP060344O
- 52861 - Tabernaemontana divaricata: 10.1039/B301167D
- 52861 - Tabernaemontana divaricata: LTS0030139
- 761067 - Tabernaemontana eglandulosa: 10.1016/S0040-4020(01)91102-0
- 761074 - Tabernaemontana hystrix: 10.1055/S-0029-1243122
- 761081 - Tabernaemontana markgrafiana: 10.1016/S0031-9422(00)89601-6
- 761099 - Tabernaemontana sphaerocarpa: 10.1021/NP900365R
- 761102 - Tabernaemontana vanheurckii: 10.1055/S-2006-959554
- 141617 - Tabernanthe iboga:
- 58023 - Tracheophyta: LTS0030139
- 33090 - Viridiplantae: LTS0030139
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Felix Krengel, Marco V Mijangos, Marisol Reyes-Lezama, Ricardo Reyes-Chilpa. Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae).
Chemistry & biodiversity.
2019 Jul; 16(7):e1900175. doi:
10.1002/cbdv.201900175. [PMID: 31095891] - Hong-Mei Chen, Yu-Ting Yang, Hong-Xiang Li, Zhi-Xing Cao, Xiao-Mei Dan, Ling Mei, Da-Le Guo, Chuan-Xia Song, Yu Dai, Jia Hu, Yun Deng. Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph.
Natural product research.
2016; 30(10):1144-9. doi:
10.1080/14786419.2015.1046132. [PMID: 26140390] - Cédric Mazoyer, Jérémy Carlier, Alexandra Boucher, Michel Péoc'h, Catherine Lemeur, Yvan Gaillard. Fatal case of a 27-year-old male after taking iboga in withdrawal treatment: GC-MS/MS determination of ibogaine and ibogamine in iboga roots and postmortem biological material.
Journal of forensic sciences.
2013 Nov; 58(6):1666-72. doi:
10.1111/1556-4029.12250. [PMID: 23919354] - Tamara Antonio, Steven R Childers, Richard B Rothman, Christina M Dersch, Christine King, Martin Kuehne, William G Bornmann, Amy J Eshleman, Aaron Janowsky, Eric R Simon, Maarten E A Reith, Kenneth Alper. Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation.
PloS one.
2013; 8(10):e77262. doi:
10.1371/journal.pone.0077262. [PMID: 24204784] - Ivo J C Vieira, Walter L B Medeiros, Cecilia S Monnerat, Jucimar J Souza, Leda Mathias, Raimundo Braz-Filho, Angelo C Pinto, Priscila M Sousa, Claudia M Rezende, Rosângela de A Epifanio. Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures.
Anais da Academia Brasileira de Ciencias.
2008 Sep; 80(3):419-26. doi:
10.1590/s0001-37652008000300003. [PMID: 18797794] - Shuang Liang, Hai-sheng Chen, Yong-sheng Jin, Li Jin, Jia Lu, Jing-ling Du. [Study on chemical constituents in rhigome of Ervatamia hainanensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Jul; 32(13):1296-9. doi:
. [PMID: 17879729] - Violeta Kontrimaviciūte, Olivier Mathieu, Jean-Claude Mathieu-Daudé, Paulius Vainauskas, Thierry Casper, Eric Baccino, Françoise M M Bressolle. Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub.
Journal of analytical toxicology.
2006 Sep; 30(7):434-40. doi:
10.1093/jat/30.7.434. [PMID: 16959135] - Marcelo T Andrade, Josélia A Lima, Angelo C Pinto, Claudia M Rezende, Meriane P Carvalho, Rosângela A Epifanio. Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme.
Bioorganic & medicinal chemistry.
2005 Jun; 13(12):4092-5. doi:
10.1016/j.bmc.2005.03.045. [PMID: 15911323] - Christopher W Jenks. Extraction studies of Tabernanthe iboga and Voacanga africana.
Natural product letters.
2002 Feb; 16(1):71-6. doi:
10.1080/1057563029001/4881. [PMID: 11942686]
