Frutinone A (BioDeep_00000007107)

   

natural product


代谢物信息卡片


chromeno[3,2-c]chromene-6,7-quinone

化学式: C16H8O4 (264.0423)
中文名称: 灌木远志酮 A
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: C1=CC=C2C(=C1)C3=C(C(=O)C4=CC=CC=C4O3)C(=O)O2
InChI: InChI=1S/C16H8O4/c17-14-9-5-1-3-7-11(9)19-15-10-6-2-4-8-12(10)20-16(18)13(14)15/h1-8H

描述信息

D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors

同义名列表

8 个代谢物同义名

chromeno[4,3-b]chromene-6,7-dione; Frutinone A; chromeno[3,2-c]chromene-6,7-quinone; chromeno[3,2-c]chromene-6,7-dione; ZINC00897930; 38210-27-4; C09008; Frutinone A



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, CYP2C19, ESR1, MAPK1, MAPK14, PIK3CA, PPARG, PTGS2, TP53
Peripheral membrane protein 2 ESR1, PTGS2
Endoplasmic reticulum membrane 3 CYP1A2, CYP2C19, PTGS2
Nucleus 8 AKT1, ESR1, MAPK1, MAPK14, PPARG, PPARGC1A, RFC2, TP53
cytosol 8 AKT1, ESR1, MAPK1, MAPK14, PIK3CA, PPARG, PPARGC1A, TP53
centrosome 2 MAPK1, TP53
nucleoplasm 8 AKT1, ESR1, MAPK1, MAPK14, PPARG, PPARGC1A, RFC2, TP53
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 AKT1, ESR1, TNF
Cytoplasmic side 1 ESR1
lamellipodium 2 AKT1, PIK3CA
Synapse 1 MAPK1
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 2 ESR1, MAPK1
neuronal cell body 1 TNF
postsynapse 1 AKT1
plasma membrane 6 AKT1, CYP2C19, ESR1, MAPK1, PIK3CA, TNF
Membrane 3 AKT1, ESR1, TP53
caveola 2 MAPK1, PTGS2
endoplasmic reticulum 2 PTGS2, TP53
extracellular space 2 IL17A, TNF
perinuclear region of cytoplasm 2 PIK3CA, PPARG
intercalated disc 1 PIK3CA
mitochondrion 3 MAPK1, MAPK14, TP53
protein-containing complex 4 AKT1, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 3 CYP1A2, CYP2C19, PPARG
Microsome membrane 2 CYP1A2, PTGS2
Secreted 1 IL17A
extracellular region 4 IL17A, MAPK1, MAPK14, TNF
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 ESR1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
external side of plasma membrane 2 IL17A, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Early endosome 1 MAPK1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 1 MAPK1
spindle 2 AKT1, MAPK1
Nucleus, PML body 2 PPARGC1A, TP53
PML body 2 PPARGC1A, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK1
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 ESR1, PPARG, PPARGC1A, TP53
phagocytic cup 1 TNF
mitotic spindle 1 MAPK1
cytoskeleton 1 MAPK1
spindle pole 1 MAPK14
site of double-strand break 1 TP53
Membrane, caveola 1 MAPK1
euchromatin 1 ESR1
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 MAPK1
ficolin-1-rich granule lumen 2 MAPK1, MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 MAPK1, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 MAPK1
[Isoform 1]: Nucleus 3 ESR1, PPARGC1A, TP53
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Ctf18 RFC-like complex 1 RFC2
DNA replication factor C complex 1 RFC2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Roslyn S Thelingwani, Kariema Dhansay, Peter Smith, Kelly Chibale, Collen M Masimirembwa. Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa. Xenobiotica; the fate of foreign compounds in biological systems. 2012 Oct; 42(10):989-1000. doi: 10.3109/00498254.2012.681077. [PMID: 22533317]