Thapsigargin (BioDeep_00000000710)

   

PANOMIX_OTCML-2023 Chemicals and Drugs natural product


代谢物信息卡片


[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

化学式: C34H50O12 (650.3302)
中文名称: 毒胡萝卜素, 毒胡萝卜内酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 27.08%

Reviewed

Last reviewed on 2024-11-06.

Cite this Page

Thapsigargin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/thapsigargin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000710). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C/C=C(/C)C(=O)O[C@H]1C(C)=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@@H](OC(=O)CCC)C[C@](C)(OC(C)=O)[C@H]2[C@@H]1OC(=O)CCCCCCC
InChI: InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1

描述信息

Thapsigargin is an organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. It has a role as an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor and a calcium channel blocker. It is a sesquiterpene lactone, an organic heterotricyclic compound and a butyrate ester.
Thapsigargin is a natural product found in Thapsia gymnesica, Thapsia villosa, and Thapsia garganica with data available.
A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.
C1907 - Drug, Natural Product > C28269 - Phytochemical > C93252 - Sesquiterpene Lactone
D004791 - Enzyme Inhibitors

(-)-Thapsigargin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=67526-95-8 (retrieved 2024-11-06) (CAS RN: 67526-95-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

35 个代谢物同义名

OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OX Y]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER; OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER; Octanoic Acid [3s-[3alpha, 3abeta, 4alpha,6beta, 6abeta, 7beta, 8alpha(Z), 9balpha]]-6-(Acetyloxy)-2,3,-3a,4,5,6,6a,7,8,9b-Decahydro-3,3a-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]furan-7-Yl Ester; Octanoic Acid [3s-[3alpha, 3abeta, 4alpha, 6beta,6abeta, 7beta, 8alpha(Z), 9balpha]]-6-(Acetyloxy)-2,3,-3a,4,5,6,6a,7,8,9b-Decahydro-3,3a-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)oxy]-2-Oxo-4-(1-Oxobutoxy)-Azuleno[4,5-B]furan-7-Yl Ester; Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2-methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)azuleno(4,5-b)furan-7-yl ester, (3S-(3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha))-; octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester; OCTANOIC ACID, (3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-(((2Z)-2-METHYL-1-OXO-2-BUTEN-1-YL)OXY)-2-OXO-4-(1-OXOBUTOXY)AZULENO(4,5-B)FURAN-7-YL ESTER; (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate; (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]f uran-7-yl ester; (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate; Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]fura; Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester, [3S-[3alpha,3abeta,4; octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(-oxobutoxy)azuleno[4,5-b]furan; (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-7-yl octanoate; (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate; 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OX; OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z),; Y]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER; alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]]-; Azuleno[4,5-b]furan, octanoic acid deriv.; Thapsigargin, >=98\\% (HPLC), solid film; n-7-yl ester (9CI); THAPSIGARGIN [MI]; (-)-Thapsigargin; UNII-Z96BQ26RZD; Lopac0_001262; Tox21_501262; Thapsigargin; IDI1_033971; -7-yl ester; Z96BQ26RZD; C34H50O12; TG1; octanoic acid [6-acetyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-(2-methyl-1-oxobut-2-enoxy)-2-oxo-4-(1-oxobutoxy)-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] ester; Thapsigargin



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AKT1, ANXA5, ITPR3, MAPK14, PRKX, TNK1
Peripheral membrane protein 2 ANXA5, TNK1
Endoplasmic reticulum membrane 5 ATF6, ATP2A2, HSP90B1, ITPR3, STIM1
Nucleus 7 AKT1, ATF6, HSP90B1, JUN, MAPK14, PLCZ1, PRKX
cytosol 7 AKT1, ANXA5, ATF6, HSP90B1, MAPK14, PLCZ1, PRKCQ
nucleoplasm 8 AKT1, ATF6, ATP2B1, ITPR3, JUN, MAPK14, PLCZ1, PRKX
RNA polymerase II transcription regulator complex 2 ATF6, JUN
Cell membrane 2 AKT1, ATP2B1
lamellipodium 1 AKT1
Multi-pass membrane protein 5 ATP2A2, ATP2B1, CACNA1I, CATSPER3, ITPR3
Golgi apparatus membrane 1 ATF6
Synapse 1 ATP2B1
cell cortex 1 AKT1
glutamatergic synapse 3 AKT1, ATP2B1, MAPK14
Golgi apparatus 1 ATF6
Golgi membrane 1 ATF6
lysosomal membrane 1 EGF
neuronal cell body 1 ITPR3
postsynapse 1 AKT1
presynaptic membrane 1 ATP2B1
sarcolemma 1 ANXA5
smooth endoplasmic reticulum 1 HSP90B1
acrosomal vesicle 1 CATSPER3
plasma membrane 12 AKT1, ATP2A2, ATP2B1, CACNA1I, CATSPER3, EGF, F2, ITPR3, KNG1, PRKCQ, STIM1, TNK1
synaptic vesicle membrane 1 ATP2B1
Membrane 11 AKT1, ANXA5, ATF6, ATP2A2, ATP2B1, CACNA1I, EGF, HSP90B1, ITPR3, STIM1, TNK1
basolateral plasma membrane 1 ATP2B1
brush border 1 ITPR3
extracellular exosome 6 ANXA5, ATP2B1, EGF, F2, HSP90B1, KNG1
endoplasmic reticulum 6 ATF6, ATP2A2, CATSPER3, HSP90B1, ITPR3, STIM1
extracellular space 4 EGF, F2, IL6, KNG1
perinuclear region of cytoplasm 2 HSP90B1, PLCZ1
mitochondrion 1 MAPK14
protein-containing complex 2 AKT1, HSP90B1
intracellular membrane-bounded organelle 1 ATP2B1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 STIM1
Secreted 2 F2, IL6
extracellular region 7 ANXA5, EGF, F2, HSP90B1, IL6, KNG1, MAPK14
transcription regulator complex 1 JUN
centriolar satellite 1 PRKCQ
motile cilium 1 CATSPER3
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ANXA5
microtubule cytoskeleton 1 AKT1
nucleolus 2 ITPR3, PLCZ1
midbody 1 HSP90B1
apical part of cell 1 ITPR3
cell-cell junction 1 AKT1
Single-pass type II membrane protein 1 ATF6
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 PLCZ1
Cytoplasm, cytoskeleton 1 STIM1
focal adhesion 2 ANXA5, HSP90B1
microtubule 1 STIM1
spindle 1 AKT1
sarcoplasmic reticulum 3 ATP2A2, ITPR3, STIM1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 4 ANXA5, F2, HSP90B1, KNG1
lateral plasma membrane 1 ATP2B1
nuclear speck 1 MAPK14
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
chromatin 2 ATF6, JUN
cell projection 1 ATP2B1
Secreted, extracellular space 1 KNG1
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
blood microparticle 2 F2, KNG1
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 ATF6
Cell projection, cilium, flagellum membrane 1 CATSPER3
Melanosome 1 HSP90B1
euchromatin 1 JUN
Presynaptic cell membrane 1 ATP2B1
sperm plasma membrane 1 HSP90B1
plasma membrane raft 1 STIM1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 ITPR3
Golgi lumen 1 F2
endoplasmic reticulum lumen 4 F2, HSP90B1, IL6, KNG1
platelet alpha granule lumen 2 EGF, KNG1
voltage-gated calcium channel complex 1 CACNA1I
Sarcoplasmic reticulum membrane 2 ATP2A2, STIM1
cortical endoplasmic reticulum 1 STIM1
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGF
Sarcoplasmic reticulum lumen 1 HSP90B1
platelet dense tubular network membrane 2 ATP2A2, ITPR3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
ribbon synapse 1 ATP2A2
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 JUN
transport vesicle membrane 1 ITPR3
sperm head 1 PLCZ1
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
endothelial microparticle 1 ANXA5
photoreceptor ribbon synapse 1 ATP2B1
calcium ion-transporting ATPase complex 1 ATP2A2
longitudinal sarcoplasmic reticulum 1 ATP2A2
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus 1 ATF6
CatSper complex 1 CATSPER3


文献列表

  • Abeer Al Otaibi, Sindiyan Al Shaikh Mubarak, Fatimah Al Hejji, Abdulrahman Almasaud, Haya Al Jami, Jahangir Iqbal, Ali Al Qarni, Naif Khalaf Al Harbi, Ahmed Bakillah. Thapsigargin and Tunicamycin Block SARS-CoV-2 Entry into Host Cells via Differential Modulation of Unfolded Protein Response (UPR), AKT Signaling, and Apoptosis. Cells. 2024 Apr; 13(9):. doi: 10.3390/cells13090769. [PMID: 38727305]
  • Huan Zhang, Chao Yang, Songjiao Wang, Aohong Xu, Qian Zhang, Xiuqun Duan, Guofu Gong, Yuxue Wang. Overexpression of salusin‑α upregulates AdipoR2 and activates the PPARα/ApoA5/SREBP‑1c pathway to inhibit lipid synthesis in HepG2 cells. International journal of molecular medicine. 2023 May; 51(5):. doi: 10.3892/ijmm.2023.5244. [PMID: 37026514]
  • Maria H Jäntti, Shelley N Jackson, Jeffrey Kuhn, Ilmari Parkkinen, Sreesha Sree, Joshua J Hinkle, Eija Jokitalo, Leesa J Deterding, Brandon K Harvey. Palmitate and thapsigargin have contrasting effects on ER membrane lipid composition and ER proteostasis in neuronal cells. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022 11; 1867(11):159219. doi: 10.1016/j.bbalip.2022.159219. [PMID: 35981704]
  • Mohammed Samer Shaban, Christin Mayr-Buro, Johanna Meier-Soelch, Benadict Vincent Albert, M Lienhard Schmitz, John Ziebuhr, Michael Kracht. Thapsigargin: key to new host-directed coronavirus antivirals?. Trends in pharmacological sciences. 2022 Jul; 43(7):557-568. doi: 10.1016/j.tips.2022.04.004. [PMID: 35534355]
  • Hassan O J Morad, Suaib Luqman, Larissa Garcia Pinto, Kevin P Cunningham, Bruno Vilar, Georgia Clayton, Manu Shankar-Hari, Peter A McNaughton. Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release. Scientific reports. 2022 06; 12(1):11078. doi: 10.1038/s41598-022-15214-6. [PMID: 35773325]
  • Atousa Khalatbari, Zahra Aghazadeh, Cheng Ji. Adverse Effects of Anti-Covid-19 Drug Candidates and Alcohol on Cellular Stress Responses of Hepatocytes. Hepatology communications. 2022 06; 6(6):1262-1277. doi: 10.1002/hep4.1887. [PMID: 34910385]
  • Duygu Elif Yilmaz, Karin Kirschner, Hasan Demirci, Nina Himmerkus, Sebastian Bachmann, Kerim Mutig. Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells. The Journal of biological chemistry. 2022 03; 298(3):101589. doi: 10.1016/j.jbc.2022.101589. [PMID: 35033536]
  • Eric D Deihl, Luke T Jesikiewicz, Logan J Newman, Peng Liu, Kay M Brummond. Rh(I)-Catalyzed Allenic Pauson-Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on Enantioselectivity. Organic letters. 2022 02; 24(4):995-999. doi: 10.1021/acs.orglett.1c03951. [PMID: 35081313]
  • Wing-Kee Lee, Michelle Maaß, Amy Quach, Nataliya Poscic, Holly Prangley, Erin-Claire Pallott, Jiyoon L Kim, Jason S Pierce, Besim Ogretmen, Anthony H Futerman, Frank Thévenod. Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. The Journal of biological chemistry. 2022 02; 298(2):101492. doi: 10.1016/j.jbc.2021.101492. [PMID: 34915026]
  • Min Yao, Gan Li, Long-Yun Zhou, Zhong Zheng, Yue-Li Sun, Shu-Fen Liu, Yong-Jun Wang, Xue-Jun Cui. Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. Cell biology and toxicology. 2022 Jan; ?(?):. doi: 10.1007/s10565-021-09648-3. [PMID: 35028790]
  • Sarah Al-Beltagi, Leah V Goulding, Daniel K E Chang, Kenneth H Mellits, Christopher J Hayes, Pavel Gershkovich, Christopher M Coleman, Kin-Chow Chang. Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin. Virulence. 2021 12; 12(1):2946-2956. doi: 10.1080/21505594.2021.2006960. [PMID: 34793280]
  • Kazuhiro Ogi, Tetsuji Takabayashi, Kaori Tomita, Masafumi Sakashita, Taiyo Morikawa, Takahiro Ninomiya, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda. ORMDL3 overexpression facilitates FcεRI-mediated transcription of proinflammatory cytokines and thapsigargin-mediated PERK phosphorylation in RBL-2H3 cells. Immunity, inflammation and disease. 2021 12; 9(4):1394-1405. doi: 10.1002/iid3.489. [PMID: 34288557]
  • Anqi Kong, Yao Zhang, Bo Ning, Kongdong Li, Zhen Ren, Shuya Dai, Dongfeng Chen, Yang Zhou, Jie Gu, Haifeng Shi. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chemico-biological interactions. 2021 Oct; 348(?):109649. doi: 10.1016/j.cbi.2021.109649. [PMID: 34516972]
  • Mohammed Samer Shaban, Christin Müller, Christin Mayr-Buro, Hendrik Weiser, Johanna Meier-Soelch, Benadict Vincent Albert, Axel Weber, Uwe Linne, Torsten Hain, Ilya Babayev, Nadja Karl, Nina Hofmann, Stephan Becker, Susanne Herold, M Lienhard Schmitz, John Ziebuhr, Michael Kracht. Multi-level inhibition of coronavirus replication by chemical ER stress. Nature communications. 2021 09; 12(1):5536. doi: 10.1038/s41467-021-25551-1. [PMID: 34545074]
  • Simon Ngao Mule, Vinícius De Morais Gomes, Rosangela A M Wailemann, Janaina Macedo-da-Silva, Livia Rosa-Fernandes, Martin R Larsen, Letícia Labriola, Giuseppe Palmisano. HSPB1 influences mitochondrial respiration in ER-stressed beta cells. Biochimica et biophysica acta. Proteins and proteomics. 2021 09; 1869(9):140680. doi: 10.1016/j.bbapap.2021.140680. [PMID: 34051341]
  • Nanami Goto, Shusaku Shibutani, Noboru Miura, Rie Watanabe, Hiroyuki Iwata. Thapsigargin suppresses alpha 1-acid glycoprotein secretion independently of N-glycosylation and ER stress. Biochemical and biophysical research communications. 2021 05; 552(?):30-36. doi: 10.1016/j.bbrc.2021.03.017. [PMID: 33740662]
  • Chinmayee Das, Manoj K Rout, Willem C Wildering, Mathilakath M Vijayan. Cortisol modulates calcium release-activated calcium channel gating in fish hepatocytes. Scientific reports. 2021 05; 11(1):9621. doi: 10.1038/s41598-021-88957-3. [PMID: 33953236]
  • Jung Woo Han, Woon Heo, Donghyuk Lee, Choeun Kang, Hye-Yeon Kim, Ikhyun Jun, Insuk So, Hyuk Hur, Min Goo Lee, Minkyu Jung, Joo Young Kim. Plasma Membrane Localized GCaMP-MS4A12 by Orai1 Co-Expression Shows Thapsigargin- and Ca2+-Dependent Fluorescence Increases. Molecules and cells. 2021 Apr; 44(4):223-232. doi: 10.14348/molcells.2021.2031. [PMID: 33935043]
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