Brimonidine (BioDeep_00000006624)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

化学式: C11H10BrN5 (291.011952)
中文名称: 溴莫尼定
谱图信息: 最多检出来源 Danio rerio(blood) 55.56%

分子结构信息

SMILES: BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12
InChI: InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

描述信息

Brimonidine is only found in individuals that have used or taken this drug. It is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. [Wikipedia]Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EA - Sympathomimetics in glaucoma therapy
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics > S01GA - Sympathomimetics used as decongestants
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78283 - Agent Affecting Organs of Special Senses > C29705 - Anti-glaucoma Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D - Dermatologicals
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

同义名列表

25 个代谢物同义名

5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate; 5-Bromo-6-(imidazolidinylideneamino)quinoxaline; Brimonidine tartrate (1:1), (S-(r*,r*))-isomer; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline; 5-Bromo-6-(imidazolin-2-ylamino)quinoxaline; Brimonidine tartrate, (R-(r*,r*))-isomer; Brimonidine tartrate (1:1); Tartrate, brimonidine; Brimonidine tartrate; Purite, brimonidine; Brimonidine purite; Ratio brimonidine; Ratio-brimonidine; RatioBrimonidine; Brimonidinum; brimonidine; Bromoxidine; Brimonidina; Alphagan p; Alphagan; Sanrosa; Mirvaso; UK 14304; AGN190342

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:3175
KEGG: C07886
KEGG: C75796
KEGGdrug: D07540
PubChem: 2435
HMDB: HMDB0014627
Metlin: METLIN66757
DrugBank: DB00484
ChEMBL: CHEMBL844
Wikipedia: Brimonidine
MeSH: Brimonidine Tartrate
chemspider: 2341
CAS: 59803-98-4
PMhub: MS000019693
PubChem: 10088
PDB-CCD: J59
NIKKAJI: J23.694B
RefMet: Brimonidine
medchemexpress: HY-B0659

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Taiichiro Chikama, Koichiro Shinji, Chika Yokota, Ken Hayashi, Yoshiaki Kiuchi. Inflammatory Cells and Lipid Deposits Detected by in Vivo Confocal Microscopy in Brimonidine Tartrate Ophthalmic Solution-Related Corneal Disorders: A Case Series. Ocular immunology and inflammation. 2023 Nov; 31(9):1842-1847. doi: 10.1080/09273948.2022.2137045. [PMID: 36306423]
Xiaohui Wang, Rui Zhang, Bin Chen, Ting Zhang, Xinghua Jin, Ping Gao. Preliminary evaluation of the efficacy and safety of brimonidine for deep sedation. Fundamental & clinical pharmacology. 2023 Aug; ?(?):. doi: 10.1111/fcp.12944. [PMID: 37612481]
Yunli Xu, Hongyi Li. In vitro and in vivo evaluation of brimonidine loaded silica nanoparticles-laden silicone contact lenses to manage glaucoma. Journal of biomaterials applications. 2022 08; 37(2):333-343. doi: 10.1177/08853282221090880. [PMID: 35482359]
Iria Brocos-Mosquera, Ane M Gabilondo, Rebeca Diez-Alarcia, Carolina Muguruza, Amaia M Erdozain, J Javier Meana, Luis F Callado. α2A- and α2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2021 11; 52(?):3-11. doi: 10.1016/j.euroneuro.2021.05.012. [PMID: 34237656]
Prakash K Soni, T R Saini. Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach. Drug development and industrial pharmacy. 2021 Nov; 47(11):1847-1866. doi: 10.1080/03639045.2022.2070198. [PMID: 35484943]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Sven Schnichels, José Hurst, Jan Willem de Vries, Sami Ullah, Katharina Frößl, Agnieszka Gruszka, Marina Löscher, Karl-Ulrich Bartz-Schmidt, Martin S Spitzer, Andreas Herrmann. Improved Treatment Options for Glaucoma with Brimonidine-Loaded Lipid DNA Nanoparticles. ACS applied materials & interfaces. 2021 Mar; 13(8):9445-9456. doi: 10.1021/acsami.0c18626. [PMID: 33528240]
Gen Suzuki, Eriko Kunikane, Wakasa Shigemi, Keisuke Shinno, Seiko Kozai, Masaaki Kurata, Akio Kawamura. Ocular and systemic pharmacokinetics of brimonidine and brinzolamide after topical administration in rabbits: comparison between fixed-combination and single-drug formulations. Current eye research. 2021 03; 46(3):380-386. doi: 10.1080/02713683.2020.1800046. [PMID: 32706598]
Yuka Kasuya, Ichiya Sano, Shinji Makino. Interstitial Keratitis with Lipid Keratopathy Mimicking Corneal Opacity Induced by Brimonidine Tartrate Eye Drops. Klinische Monatsblatter fur Augenheilkunde. 2020 12; 237(12):1466-1467. doi: 10.1055/a-1265-7105. [PMID: 33285590]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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Xi Han, Yang Liu, Wendy R Kam, David A Sullivan. Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells. Experimental eye research. 2018 05; 170(?):20-28. doi: 10.1016/j.exer.2018.02.009. [PMID: 29452108]
Xiaochen Pang, Jiawei Li, Jiaxin Pi, Dongli Qi, Pan Guo, Nan Li, Yumei Wu, Zhidong Liu. Increasing efficacy and reducing systemic absorption of brimonidine tartrate ophthalmic gels in rabbits. Pharmaceutical development and technology. 2018 Mar; 23(3):231-239. doi: 10.1080/10837450.2017.1328693. [PMID: 28488447]
Noha S El-Salamouni, Ragwa M Farid, Amal H El-Kamel, Safaa S El-Gamal. Nanostructured lipid carriers for intraocular brimonidine localisation: development, in-vitro and in-vivo evaluation. Journal of microencapsulation. 2018 Jan; 35(1):102-113. doi: 10.1080/02652048.2018.1425753. [PMID: 29310481]
Alexandra Robciuc, Joanna Witos, Suvi-Katriina Ruokonen, Antti H Rantamäki, Pierre-Jean Pisella, Susanne K Wiedmer, Juha M Holopainen. Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes. Cornea. 2017 Oct; 36(10):1249-1255. doi: 10.1097/ico.0000000000001322. [PMID: 28825921]
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Noha S El-Salamouni, Ragwa M Farid, Amal H El-Kamel, Safaa S El-Gamal. Effect of sterilization on the physical stability of brimonidine-loaded solid lipid nanoparticles and nanostructured lipid carriers. International journal of pharmaceutics. 2015 Dec; 496(2):976-83. doi: 10.1016/j.ijpharm.2015.10.043. [PMID: 26498372]
Ko Eun Kim, Inseok Jang, Hyungwon Moon, Yu Jeong Kim, Jin Wook Jeoung, Ki Ho Park, Hyuncheol Kim. Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model. Investigative ophthalmology & visual science. 2015 Aug; 56(9):5641-9. doi: 10.1167/iovs.15-16538. [PMID: 26313300]
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