Classification Term: 1072
Quinoxalines (ontology term: CHEMONTID:0000486)
Compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring." []
found 41 associated metabolites at category metabolite taxonomy ontology rank level.
Ancestor: Benzodiazines
Child Taxonomies: Phenazines and derivatives, Pyrroloquinoxalines, Pyrido[2,3-b]quinoxalines, Pyrido[2,3-g]quinoxalines, Indolo[2,3-b]quinoxalines, Isoindolo[2,1-a]quinoxalines
Ekalux
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals
2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline
2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline is found in animal foods. 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline is a food-related mutagen isolated from cooked meats (especially grilled/barbecued Food-related mutagen isolated from cooked meats (especies grilled/barbecued). 2-Amino-3,8-dimethyl-3H-imidazo[4,5-f]quinoxaline is found in animal foods. CONFIDENCE standard compound; INTERNAL_ID 2292 CONFIDENCE standard compound; INTERNAL_ID 6 D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D009153 - Mutagens
Brimonidine
Brimonidine is only found in individuals that have used or taken this drug. It is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. [Wikipedia]Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EA - Sympathomimetics in glaucoma therapy S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics > S01GA - Sympathomimetics used as decongestants C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists C78283 - Agent Affecting Organs of Special Senses > C29705 - Anti-glaucoma Agent D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D - Dermatologicals Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.
6-Cyano-7-nitroquinoxaline-2,3-dione
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].
Carbadox
Carbadox is found in animal foods. Animal growth promoter especially for pigs. Banned in the EU. Carbadox is a permitted in USA subject to a 45-day withdrawal period (2001) Carbadox is a drug that combats parasite infection. In early 2004 it was banned by the Canadian government as a livestock feed additive and for human consumption. The European Union also forbids the use of Carbadox at any level. It is approved in the United States for use in swine for up to 42 days before slaughter Animal growth promoter especies for pigs. Banned in the EU. Permitted in USA subject to a 45-day withdrawal period (2001) [DFC] D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D009153 - Mutagens D000890 - Anti-Infective Agents
Sulfaquinoxaline
Sulfaquinoxaline is an antimicrobial and a coccidiostat for veterinary use. It is a potential food contaminant in animal products arising from its veterinary use. Antimicrobial, coccidiostat for vet. use. Potential food contaminant in animal products arising from its veterinary use. D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
5-Methylquinoxaline
5-Methylquinoxaline is found in coffee and coffee products. 5-Methylquinoxaline is present in coffee. 5-Methylquinoxaline is a flavouring ingredient. Present in coffee. Flavouring ingredient. 5-Methylquinoxaline is found in coffee and coffee products.
2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline
Pyrolysis production from creatine, threonine and glucose in cooked food. Pyrolysis produced from creatine, threonine and glucose in cooked food. D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D009153 - Mutagens
2-Amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline
2-Amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline is found in animal foods. 2-Amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline is isolated from beef extract. Isolated from beef extract. 2-Amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline is found in animal foods.
3-Methyl-3H-imidazo[4,5-f]quinoxalin-2-amine
3-Methyl-3H-imidazo[4,5-f]quinoxalin-2-amine is found in animal foods. Mutagen found in cooked beef and pork. Mutagen found in cooked beef and pork
2-oxobrimonidine
2-oxobrimonidine is a metabolite of brimonidine. Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or ocular hypertension. It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye through uveoscleral outflow. As a treatment for glaucoma, it is usually given in eyedrop form. (Wikipedia)
3-oxobrimonidine
3-oxobrimonidine is a metabolite of brimonidine. Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or ocular hypertension. It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye through uveoscleral outflow. As a treatment for glaucoma, it is usually given in eyedrop form. (Wikipedia)
(2-Quinoxalinylmethylene)hydrazinecarboxylic acid methyl ester
1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
D004791 - Enzyme Inhibitors
(E)-5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
2-Amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline
Caroverine
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker
N-((6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-proline
Dioxidine
D009676 - Noxae > D009153 - Mutagens D000890 - Anti-Infective Agents
4-[2-(3,4-Dihydro-6,7-dimethoxy-4-methyl-3-oxo-2-quinoxalinyl)ethyl]-3H-1,2,4-triazole-3,5(4H)-dione
6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].
Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-
N-(1-Adamantyl)quinoxaline-2-carboxamide
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5[1]. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor[2][3].
Olaquindox
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
6-Imidazol-1-yl-7-nitro-1,4-dihydroquinoxaline-2,3-dione
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents D002491 - Central Nervous System Agents > D000927 - Anticonvulsants D020011 - Protective Agents
