Phenformin (BioDeep_00000006577)
Secondary id: BioDeep_00000412906
human metabolite blood metabolite
代谢物信息卡片
1-carbamimidamido-N-(2-phenylethyl)methanimidamide
化学式: C10H15N5 (205.1327)
中文名称: N-苯乙基双胍
谱图信息:
最多检出来源 Homo sapiens(blood) 16.67%
分子结构信息
SMILES: C1=CC=C(C=C1)CCN=C(N)N=C(N)N
InChI: InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
描述信息
A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BA - Biguanides
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98234 - Biguanide Antidiabetic Agent
D007004 - Hypoglycemic Agents > D001645 - Biguanides
同义名列表
21 个代谢物同义名
1-carbamimidamido-N-(2-phenylethyl)methanimidamide; N-Phenethylbiguanide hydrochloride; Phenethylbiguanide hydrochloride; Phenoformine hydrochloride; Phenformin hydrochloride; beta-Phenethylbiguanide; beta-Phenethybiguanide; Phenylethylbiguanide; Phenethyldiguanide; phenethylbiguanide; Phenformine HCL; Phenformin HCL; Phenforminum; Phenformine; Fenformina; PHENFORMIN; Fenformin; beta-Pebg; PEDG; DBI; Phenformin
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:8064
- KEGG: C07673
- KEGGdrug: D08351
- PubChem: 8249
- HMDB: HMDB0015050
- Metlin: METLIN66713
- DrugBank: DB00914
- ChEMBL: CHEMBL170988
- Wikipedia: Phenformin
- MeSH: Phenformin
- chemspider: 7953
- CAS: 114-86-3
- PMhub: MS000019639
- PubChem: 9875
- PDB-CCD: 8CV
- NIKKAJI: J10.592I
- RefMet: Phenformin
- KNApSAcK: 8064
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yining Niu, Tingting Gao, Hongling Ouyang, Yunxiao Zhang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Chondroitin Sulfate-Derived Micelles for Adipose Tissue-Targeted Delivery of Celastrol and Phenformin to Enhance Obesity Treatment.
ACS applied bio materials.
2024 Feb; ?(?):. doi:
10.1021/acsabm.3c01216. [PMID: 38315869] - Traci E LaMoia, Gina M Butrico, Hasini A Kalpage, Leigh Goedeke, Brandon T Hubbard, Daniel F Vatner, Rafael C Gaspar, Xian-Man Zhang, Gary W Cline, Keita Nakahara, Seungwan Woo, Atsuhiro Shimada, Maik Hüttemann, Gerald I Shulman. Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.
Proceedings of the National Academy of Sciences of the United States of America.
2022 03; 119(10):e2122287119. doi:
10.1073/pnas.2122287119. [PMID: 35238637] - Kazuki Heishima, Nobuhiko Sugito, Tomoyoshi Soga, Masashi Nishikawa, Yuko Ito, Ryo Honda, Yuki Kuranaga, Hiroki Sakai, Ryo Ito, Takayuki Nakagawa, Hiroshi Ueda, Yukihiro Akao. Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis.
The Journal of clinical investigation.
2021 09; 131(17):. doi:
10.1172/jci139933. [PMID: 34623325] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Jae-Seon Lee, Ho Lee, Sang Myung Woo, Hyonchol Jang, Yoon Jeon, Hee Yeon Kim, Jaewhan Song, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park, Sung-Sik Han, Soo-Youl Kim. Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse.
Theranostics.
2021; 11(7):3472-3488. doi:
10.7150/thno.53935. [PMID: 33537098] - Michael R Duff, Scott A Gabel, Lars C Pedersen, Eugene F DeRose, Juno M Krahn, Elizabeth E Howell, Robert E London. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
Journal of medicinal chemistry.
2020 08; 63(15):8314-8324. doi:
10.1021/acs.jmedchem.0c00546. [PMID: 32658475] - Xinyu Chen, Alexander Fritz, Rudolf A Werner, Naoko Nose, Yusuke Yagi, Hiroyuki Kimura, Steven P Rowe, Kazuhiro Koshino, Michael Decker, Takahiro Higuchi. Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter.
Molecular imaging and biology.
2020 06; 22(3):602-611. doi:
10.1007/s11307-019-01407-5. [PMID: 31332629] - Zhang Honglian, Li Li, Wang Huiyu, Sun Jikai, Li Hongling, Dong Wei, Zhang Meijuan. Rapid detection of the metformin illegally added of in TCM and health food by TLC-IR.
Pakistan journal of pharmaceutical sciences.
2020 May; 33(3):1115-1119. doi:
. [PMID: 33191236] - Lu Gan, Menghuan Guo, Jing Si, Jinhua Zhang, Zhiyuan Liu, Jin Zhao, Fang Wang, Junfang Yan, Hongyan Li, Hong Zhang. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):4202-4210. doi:
10.1080/21691401.2019.1687505. [PMID: 31713449] - Jae-Seon Lee, Seung Hwa Kim, Soohyun Lee, Joon Hee Kang, Seon-Hyeong Lee, Jae-Ho Cheong, Soo-Youl Kim. Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.
Scientific reports.
2019 11; 9(1):16313. doi:
10.1038/s41598-019-52814-1. [PMID: 31705020] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ameet K Mishra, David Dingli. Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells.
Leukemia.
2019 11; 33(11):2695-2709. doi:
10.1038/s41375-019-0470-4. [PMID: 30988378] - Ye Eon Han, Sena Hwang, Jin Hee Kim, Jung Woo Byun, Jin Sook Yoon, Eun Jig Lee. Biguanides Metformin and Phenformin Generate Therapeutic Effects via AMP-Activated Protein Kinase/Extracellular-Regulated Kinase Pathways in an In Vitro Model of Graves' Orbitopathy.
Thyroid : official journal of the American Thyroid Association.
2018 04; 28(4):528-536. doi:
10.1089/thy.2017.0338. [PMID: 29589999] - Magdalena Markowicz-Piasecka, Kristiina M Huttunen, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik, Joanna Sikora. Sulfenamide and sulfonamide derivatives of metformin can exert anticoagulant and profibrinolytic properties.
Chemico-biological interactions.
2018 Mar; 284(?):126-136. doi:
10.1016/j.cbi.2018.02.012. [PMID: 29458015] - Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito. Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.
The Journal of toxicological sciences.
2018; 43(5):339-351. doi:
10.2131/jts.43.339. [PMID: 29743445] - Yanchun Xu, A Gray, D Grahame Hardie, Alper Uzun, Sunil Shaw, James Padbury, Chanika Phornphutkul, Yi-Tang Tseng. A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.
American journal of physiology. Heart and circulatory physiology.
2017 Aug; 313(2):H283-H292. doi:
10.1152/ajpheart.00813.2016. [PMID: 28550180] - Simon J A van Kuijk, Nanda Kumar Parvathaneni, Raymon Niemans, Marike W van Gisbergen, Fabrizio Carta, Daniela Vullo, Silvia Pastorekova, Ala Yaromina, Claudiu T Supuran, Ludwig J Dubois, Jean-Yves Winum, Philippe Lambin. New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
European journal of medicinal chemistry.
2017 Feb; 127(?):691-702. doi:
10.1016/j.ejmech.2016.10.037. [PMID: 27823879] - Kentaro Oh-Hashi, Nao Irie, Takayuki Sakai, Kensuke Okuda, Hideko Nagasawa, Yoko Hirata, Kazutoshi Kiuchi. Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells.
Molecular and cellular biochemistry.
2016 Aug; 419(1-2):29-40. doi:
10.1007/s11010-016-2747-5. [PMID: 27392906] - Su-Yan Dong, Yan-Jie Guo, Ya Feng, Xin-Xin Cui, Sheng-Han Kuo, Te Liu, Yun-Cheng Wu. The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells.
Biochemical and biophysical research communications.
2016 Feb; 470(2):453-459. doi:
10.1016/j.bbrc.2016.01.013. [PMID: 26768367] - O A Safonova, T N Popova, D V Kryl'skii. [GLUTATHIONE SYSTEM ACTIVITY IN RAT TISSUES UNDER PHENYLETHYL BIGUANIDE ACTION ON THE BACKGROUND OF EXPERIMENTAL BRAIN ISCHEMIA/REPERFUSION DEVELOPMENT].
Eksperimental'naia i klinicheskaia farmakologiia.
2016; 79(1):23-7. doi:
". [PMID: 27159954] - Zongjian Zhu, Weiqin Jiang, Matthew D Thompson, Dimas Echeverria, John N McGinley, Henry J Thompson. Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat.
Cancer prevention research (Philadelphia, Pa.).
2015 Jun; 8(6):518-27. doi:
10.1158/1940-6207.capr-14-0121. [PMID: 25804611] - Sara Granja, Ibtissam Marchiq, Renaud Le Floch, Conceição Souto Moura, Fátima Baltazar, Jacques Pouysségur. Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
Oncotarget.
2015 Mar; 6(9):6708-21. doi:
10.18632/oncotarget.2862. [PMID: 25894929] - Sangeetha Krishnamurthy, Victor W L Ng, Shujun Gao, Min-Han Tan, James L Hedrick, Yi Yan Yang. Codelivery of dual drugs from polymeric micelles for simultaneous targeting of both cancer cells and cancer stem cells.
Nanomedicine (London, England).
2015; 10(18):2819-32. doi:
10.2217/nnm.15.109. [PMID: 26377155] - Khadija El Hadri, Chantal Denoyelle, Lucas Ravaux, Benoit Viollet, Marc Foretz, Bertrand Friguet, Mustapha Rouis, Michel Raymondjean. AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs.
PloS one.
2015; 10(7):e0132498. doi:
10.1371/journal.pone.0132498. [PMID: 26162096] - Magali Balteau, Anne Van Steenbergen, Aurélie D Timmermans, Chantal Dessy, Gaetane Behets-Wydemans, Nicolas Tajeddine, Diego Castanares-Zapatero, Patrick Gilon, Jean-Louis Vanoverschelde, Sandrine Horman, Louis Hue, Luc Bertrand, Christophe Beauloye. AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes.
American journal of physiology. Heart and circulatory physiology.
2014 Oct; 307(8):H1120-33. doi:
10.1152/ajpheart.00210.2014. [PMID: 25128166] - Scott A Fraser, Matthew Davies, Marina Katerelos, Kurt Gleich, Suet-Wan Choy, Rohan Steel, Sandra Galic, Peter F Mount, Bruce E Kemp, David A Power. Activation of AMPK reduces the co-transporter activity of NKCC1.
Molecular membrane biology.
2014 Mar; 31(2-3):95-102. doi:
10.3109/09687688.2014.902128. [PMID: 24702155] - Z Drahota, E Palenickova, R Endlicher, M Milerova, J Brejchova, M Vosahlikova, P Svoboda, L Kazdova, M Kalous, Z Cervinkova, M Cahova. Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties.
Physiological research.
2014; 63(1):1-11. doi:
10.33549/physiolres.932600. [PMID: 24182344] - Mohamed Kodiha, Ali Salimi, Yi Meng Wang, Ursula Stochaj. Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation.
PloS one.
2014; 9(1):e88087. doi:
10.1371/journal.pone.0088087. [PMID: 24498249] - Yoshihisa Sogame, Atsushi Kitamura, Masashi Yabuki, Setsuko Komuro, Mikihisa Takano. Transport of biguanides by human organic cation transporter OCT2.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2013 Jun; 67(5):425-30. doi:
10.1016/j.biopha.2013.02.003. [PMID: 23582785] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Ying Deng, Ning Li, Mei Cui, Zhi-li Xiong, Fa-mei Li. [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Oct; 37(19):2960-3. doi:
10.4268/cjcmm20121926. [PMID: 23270242] - Zhenbo Liu, Fengyan Jia, Wenwen Wang, Cuixia Wang, Yongming Liu. Determination of phenformin hydrochloride using molecular imprinting technology coupled with flow-injection chemiluminescence.
Luminescence : the journal of biological and chemical luminescence.
2012 Jul; 27(4):297-301. doi:
10.1002/bio.1350. [PMID: 21990141] - Stephen J Fey, Krzysztof Wrzesinski. Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jun; 127(2):403-11. doi:
10.1093/toxsci/kfs122. [PMID: 22454432] - Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski. Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).
PloS one.
2012; 7(2):e31900. doi:
10.1371/journal.pone.0031900. [PMID: 22363765] - Mohamed Salim, Nahed El-Enany, Fathallah Belal, Mohamed Walash, Gabor Patonay. Simultaneous determination of sitagliptin and metformin in pharmaceutical preparations by capillary zone electrophoresis and its application to human plasma analysis.
Analytical chemistry insights.
2012; 7(?):31-46. doi:
10.4137/aci.s9940. [PMID: 22904611] - Mohamed Kodiha, Dennis Ho-Wo-Cheong, Ursula Stochaj. Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology.
American journal of physiology. Cell physiology.
2011 Dec; 301(6):C1307-15. doi:
10.1152/ajpcell.00309.2011. [PMID: 21918180] - Yoshihisa Sogame, Atsushi Kitamura, Masashi Yabuki, Setsuko Komuro. Liver uptake of biguanides in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2011 Sep; 65(6):451-5. doi:
10.1016/j.biopha.2011.04.022. [PMID: 21880461] - Débora C Damasceno, Yuri K Sinzato, Paula H Lima, Maricelma S de Souza, Kleber E Campos, Bruna Dallaqua, Iracema M Calderon, Marilza V Rudge, Gustavo T Volpato. Effects of exposure to cigarette smoke prior to pregnancy in diabetic rats.
Diabetology & metabolic syndrome.
2011 Aug; 3(?):20. doi:
10.1186/1758-5996-3-20. [PMID: 21851636] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Shan Jiang, Han Chen, Zhigang Wang, Jean-Jack Riethoven, Yuannan Xia, Jess Miner, Michael Fromm. Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes.
The Journal of nutritional biochemistry.
2011 Jul; 22(7):656-64. doi:
10.1016/j.jnutbio.2010.05.005. [PMID: 20965713] - Aldo Olivieri, Daniel Rico, Zhied Khiari, Gary Henehan, Jeff O'Sullivan, Keith Tipton. From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase.
Journal of neural transmission (Vienna, Austria : 1996).
2011 Jul; 118(7):1079-89. doi:
10.1007/s00702-011-0611-z. [PMID: 21373760] - Lingyun Chen, Zhifeng Zhou, Mei Shen, Ande Ma. Simultaneous determination and pharmacokinetic study of metformin and rosiglitazone in human plasma by HPLC-ESI-MS.
Journal of chromatographic science.
2011 Feb; 49(2):94-100. doi:
10.1093/chrsci/49.2.94. [PMID: 21223632] - Vladimir N Anisimov, Lev M Berstein, Irina G Popovich, Mark A Zabezhinski, Peter A Egormin, Tatiana S Piskunova, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova, Irina G Kovalenko, Tatiana E Poroshina. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
Aging.
2011 Feb; 3(2):148-57. doi:
10.18632/aging.100273. [PMID: 21386129] - Offie P Soldin, Sarah H Chung, Donald R Mattison. Sex differences in drug disposition.
Journal of biomedicine & biotechnology.
2011; 2011(?):187103. doi:
10.1155/2011/187103. [PMID: 21403873] - David Hauton. Does long-term metformin treatment increase cardiac lipoprotein lipase?.
Metabolism: clinical and experimental.
2011 Jan; 60(1):32-42. doi:
10.1016/j.metabol.2009.12.015. [PMID: 20153488] - Sergio Polakof, Stéphane Panserat, Paul M Craig, David J Martyres, Elisabeth Plagnes-Juan, Sharareh Savari, Stéphane Aris-Brosou, Thomas W Moon. The metabolic consequences of hepatic AMP-kinase phosphorylation in rainbow trout.
PloS one.
2011; 6(5):e20228. doi:
10.1371/journal.pone.0020228. [PMID: 21625448] - Zongjian Zhu, Weiqin Jiang, Matthew D Thompson, John N McGinley, Henry J Thompson. Metformin as an energy restriction mimetic agent for breast cancer prevention.
Journal of carcinogenesis.
2011; 10(?):17. doi:
10.4103/1477-3163.83043. [PMID: 21799661] - Nada F Zaki, Azhar S Sulaiman, Wasif S Gillani. Clinical evaluation of Dyslipidemia among type II diabetic patients at Public hospital Penang, Malaysia.
International archives of medicine.
2010 Nov; 3(?):34. doi:
10.1186/1755-7682-3-34. [PMID: 21092333] - Kiyoko Bando, Shoko Ochiai, Takeshi Kunimatsu, Jiro Deguchi, Juki Kimura, Hitoshi Funabashi, Takaki Seki. Comparison of potential risks of lactic acidosis induction by biguanides in rats.
Regulatory toxicology and pharmacology : RTP.
2010 Oct; 58(1):155-60. doi:
10.1016/j.yrtph.2010.05.005. [PMID: 20488215] - Jean-Daniel Lalau. Lactic acidosis induced by metformin: incidence, management and prevention.
Drug safety.
2010 Sep; 33(9):727-40. doi:
10.2165/11536790-000000000-00000. [PMID: 20701406] - Anders Frid, Gunnar N Sterner, Magnus Löndahl, Clara Wiklander, Anne Cato, Ellen Vinge, Anders Andersson. Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.
Diabetes care.
2010 Jun; 33(6):1291-3. doi:
10.2337/dc09-1284. [PMID: 20215446] - Alessandro Protti, Riccarda Russo, Paola Tagliabue, Sarah Vecchio, Mervyn Singer, Alain Rudiger, Giuseppe Foti, Anna Rossi, Giovanni Mistraletti, Luciano Gattinoni. Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication.
Critical care (London, England).
2010; 14(1):R22. doi:
10.1186/cc8885. [PMID: 20170489] - Y K Agrawal, P J Gogoi, K Manna, H G Bhatt, V K Jain. A supercritical fluid chromatography/tandem mass spectrometry method for the simultaneous quantification of metformin and gliclazide in human plasma.
Indian journal of pharmaceutical sciences.
2010 Jan; 72(1):50-7. doi:
10.4103/0250-474x.62231. [PMID: 20582190] - Kwangmi Kim, Lin Wang, Inkyu Hwang. Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists.
PloS one.
2009 Nov; 4(11):e7738. doi:
10.1371/journal.pone.0007738. [PMID: 19901985] - A Rune, M E Osler, T Fritz, J R Zierath. Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.
Diabetologia.
2009 Oct; 52(10):2182-9. doi:
10.1007/s00125-009-1465-x. [PMID: 19652946] - Long Ma, Xia Wu, E Ling-Ling, Dong-Sheng Wang, Hong-Chen Liu. The transmembrane transport of metformin by osteoblasts from rat mandible.
Archives of oral biology.
2009 Oct; 54(10):951-62. doi:
10.1016/j.archoralbio.2009.07.010. [PMID: 19700143] - Ronald B Goldberg. Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective.
Diabetes, metabolic syndrome and obesity : targets and therapy.
2009 May; 2(?):11-21. doi:
10.2147/dmsott.s3866. [PMID: 21437115] - Brian G Drew, Stephen J Duffy, Melissa F Formosa, Alaina K Natoli, Darren C Henstridge, Sally A Penfold, Walter G Thomas, Nigora Mukhamedova, Barbora de Courten, Josephine M Forbes, Felicia Y Yap, David M Kaye, Gerrit van Hall, Mark A Febbraio, Bruce E Kemp, Dmitri Sviridov, Gregory R Steinberg, Bronwyn A Kingwell. High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.
Circulation.
2009 Apr; 119(15):2103-11. doi:
10.1161/circulationaha.108.843219. [PMID: 19349317] - Dong Guo, Nashunchaoketu, Jianghua Wang, Xiaohui Liu, Shuhong Wu, Xiumei Zhao, Binghu Yang. [Simultaneous determination of four highly polar anti-diabetic drugs in Chinese traditional patent medicines using high performance liquid chromatography].
Se pu = Chinese journal of chromatography.
2009 Mar; 27(2):211-5. doi:
". [PMID: 19626851] - Iria Nieto-Vazquez, Sonia Fernández-Veledo, Cristina de Alvaro, Margarita Lorenzo. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.
Diabetes.
2008 Dec; 57(12):3211-21. doi:
10.2337/db07-1062. [PMID: 18796617] - Jun-Fang Zhang, Jia-Yu Yang, Jin Wen, Ding-Yong Wang, Min Yang, Qiu-Qiong Liu. [Experimental studies on hypoglycemic effects of total flavonoid from Toona sinensis].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2008 Nov; 31(11):1712-4. doi:
. [PMID: 19260289] - M M Wanjari, A W There, M R Tajne, C T Chopde, S N Umathe. Rapid and Simple RPHPLC Method for the Estimation of Metformin in Rat Plasma.
Indian journal of pharmaceutical sciences.
2008 Mar; 70(2):198-202. doi:
10.4103/0250-474x.41455. [PMID: 20046712] - C K Ching, C K Lai, W T Poon, Ernest N P Wong, W W Yan, Albert Y W Chan, Tony W L Mak. Hazards posed by a banned drug--phenformin is still hanging around.
Hong Kong medical journal = Xianggang yi xue za zhi.
2008 Feb; 14(1):50-4. doi:
NULL. [PMID: 18239244] - Shuai Chen, Jane Murphy, Rachel Toth, David G Campbell, Nick A Morrice, Carol Mackintosh. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.
The Biochemical journal.
2008 Jan; 409(2):449-59. doi:
10.1042/bj20071114. [PMID: 17995453] - Holly J Clarke, Francine Gregoire, Fang Ma, Robert Martin, Spring Zhao, Brian E Lavan. Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-gamma Agonist.
PPAR research.
2008; 2008(?):465715. doi:
10.1155/2008/465715. [PMID: 18815616] - Peter J Little, Narin Osman, Stephanie T de Dios, Nelly Cemerlang, Mandy Ballinger, Julie Nigro. Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions.
Cardiovascular diabetology.
2007 Oct; 6(?):33. doi:
10.1186/1475-2840-6-33. [PMID: 17963526] - Kathryn M Geraghty, Shuai Chen, Jean E Harthill, Adel F Ibrahim, Rachel Toth, Nick A Morrice, Franck Vandermoere, Greg B Moorhead, D Grahame Hardie, Carol MacKintosh. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.
The Biochemical journal.
2007 Oct; 407(2):231-41. doi:
10.1042/bj20070649. [PMID: 17617058] - Lu Zhang, Yuan Tian, Zunjian Zhang, Yun Chen. Simultaneous determination of metformin and rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):91-8. doi:
10.1016/j.jchromb.2007.04.002. [PMID: 17459785] - Stephanie T de Dios, Karen V Frontanilla, Julie Nigro, Mandy L Ballinger, Melanie E Ivey, Elizabeth A Cawson, Peter J Little. Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.
Journal of diabetes and its complications.
2007 Mar; 21(2):108-17. doi:
10.1016/j.jdiacomp.2006.03.003. [PMID: 17331859] - Cun-Gang Ding, Zhen Zhou, Qing-Hua Ge, Xiao-Jin Zhi, Li-Li Ma. Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2007 Feb; 21(2):132-8. doi:
10.1002/bmc.723. [PMID: 17221919] - Wei-Lin Li, Ju-Lan Wu, Bing-Ru Ren, Jian Chen, Chang-Gen Lu. Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae.
The American journal of Chinese medicine.
2007; 35(4):705-11. doi:
10.1142/s0192415x07005193. [PMID: 17708636] - Alfred J Lewy, Jennifer N Rough, Jeannine B Songer, Neelam Mishra, Krista Yuhas, Jonathan S Emens. The phase shift hypothesis for the circadian component of winter depression.
Dialogues in clinical neuroscience.
2007; 9(3):291-300. doi:
NULL. [PMID: 17969866] - Kenta Imai, Kouichi Inukai, Yuichi Ikegami, Takuya Awata, Shigehiro Katayama. LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells.
Biochemical and biophysical research communications.
2006 Dec; 351(3):595-601. doi:
10.1016/j.bbrc.2006.10.056. [PMID: 17083919] - Edward P C Lai, Sherry Y Feng. Solid phase extraction--non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 843(1):94-9. doi:
10.1016/j.jchromb.2006.05.030. [PMID: 16787767] - Jean E Harthill, Sarah E M Meek, Nick Morrice, Mark W Peggie, Jonas Borch, Barry H C Wong, Carol Mackintosh. Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.
The Plant journal : for cell and molecular biology.
2006 Jul; 47(2):211-23. doi:
10.1111/j.1365-313x.2006.02780.x. [PMID: 16771775] - A Holstein, E-H Egberts. [Traditional contraindications to the use of metformin -- more harmful than beneficial?].
Deutsche medizinische Wochenschrift (1946).
2006 Jan; 131(3):105-10. doi:
10.1055/s-2006-924934. [PMID: 16418951] - A Mark Evans, Kirsteen J W Mustard, Christopher N Wyatt, Chris Peers, Michelle Dipp, Prem Kumar, Nicholas P Kinnear, D Grahame Hardie. Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?.
The Journal of biological chemistry.
2005 Dec; 280(50):41504-11. doi:
10.1074/jbc.m510040200. [PMID: 16199527] - A Holstein, M Stumvoll. Contraindications can damage your health--is metformin a case in point?.
Diabetologia.
2005 Dec; 48(12):2454-9. doi:
10.1007/s00125-005-0026-1. [PMID: 16283245] - Peter F Mount, Rebecca E Hill, Scott A Fraser, Vicki Levidiotis, Frosa Katsis, Bruce E Kemp, David A Power. Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177.
American journal of physiology. Renal physiology.
2005 Nov; 289(5):F1103-15. doi:
10.1152/ajprenal.00458.2004. [PMID: 15914772] - Emine Meral Inelman, Giulia Gasparini, Giuliano Enzi. HIV/AIDS in older adults: a case report and literature review.
Geriatrics.
2005 Sep; 60(9):26-30. doi:
. [PMID: 16153142] - Marie Daval, Francine Diot-Dupuy, Raymond Bazin, Isabelle Hainault, Benoît Viollet, Sophie Vaulont, Eric Hajduch, Pascal Ferré, Fabienne Foufelle. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes.
The Journal of biological chemistry.
2005 Jul; 280(26):25250-7. doi:
10.1074/jbc.m414222200. [PMID: 15878856] - Naoko Kimura, Masahiro Okuda, Ken-ichi Inui. Metformin transport by renal basolateral organic cation transporter hOCT2.
Pharmaceutical research.
2005 Feb; 22(2):255-9. doi:
10.1007/s11095-004-1193-3. [PMID: 15783073] - Vladimir N Anisimov, Svetlana V Ukraintseva, Ivan V Anikin, Irina G Popovich, Mark A Zabezhinski, Lev M Bertsein, Alexander V Arutjunyan, Donald K Ingram, Mark A Lane, George S Roth. Effects of phentermine and phenformin on biomarkers of aging in rats.
Gerontology.
2005 Jan; 51(1):19-28. doi:
10.1159/000081430. [PMID: 15591752] - Yingwu Wang, Yunbiao Tang, Jingkai Gu, J Paul Fawcett, Xu Bai. Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Sep; 808(2):215-9. doi:
10.1016/j.jchromb.2004.05.006. [PMID: 15261814] - Ashish Sharma, Sylvie Pilote, Pierre M Bélanger, Marie Arsenault, Bettina A Hamelin. A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study.
British journal of clinical pharmacology.
2004 Sep; 58(3):288-97. doi:
10.1111/j.1365-2125.2004.02162.x. [PMID: 15327588] - Kazuto Yamazaki, Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazunobu Kira, Takao Saeki, Isao Tanaka. The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight.
European journal of pharmacology.
2004 Mar; 488(1-3):213-8. doi:
10.1016/j.ejphar.2004.02.019. [PMID: 15044053] - Edoardo Mannucci, Matteo Monami, Giulio Masotti, Niccolò Marchionni. All-cause mortality in diabetic patients treated with combinations of sulfonylureas and biguanides.
Diabetes/metabolism research and reviews.
2004 Jan; 20(1):44-7. doi:
10.1002/dmrr.411. [PMID: 14737744] - Ashwani Kumar, Kenneth Nugent, Aroon Kalakunja, Floyd Pirtle. Severe acidosis in a patient with type 2 diabetes mellitus, hypertension, and renal failure.
Chest.
2003 May; 123(5):1726-9. doi:
10.1378/chest.123.5.1726. [PMID: 12740293] - Kalitsa Filioussi, Stefanos Bonovas, Thomas Katsaros. Should we screen diabetic patients using biguanides for megaloblastic anaemia?.
Australian family physician.
2003 May; 32(5):383-4. doi:
NULL. [PMID: 12772378] - De-Sheng Wang, Hiroyuki Kusuhara, Yukio Kato, Johan W Jonker, Alfred H Schinkel, Yuichi Sugiyama. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Molecular pharmacology.
2003 Apr; 63(4):844-8. doi:
10.1124/mol.63.4.844. [PMID: 12644585] - Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, D Grahame Hardie. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Journal of biology.
2003; 2(4):28. doi:
10.1186/1475-4924-2-28. [PMID: 14511394] - Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazuto Yamazaki, Kazunobu Kira, Takao Saeki, Isao Tanaka. Enhanced secretion of glucagon-like peptide 1 by biguanide compounds.
Biochemical and biophysical research communications.
2002 Nov; 298(5):779-84. doi:
10.1016/s0006-291x(02)02565-2. [PMID: 12419322] - Takehito Yamamoto, Makiko Kusama, Kumi Matsuno, Erika Sugiyama, Yasuhiko Yamada, Tatsuji Iga. A new method for determination of buformin in plasma and urine by ion-paired reversed-phase HPLC with ultraviolet detection.
Biomedical chromatography : BMC.
2002 Oct; 16(7):453-4. doi:
10.1002/bmc.182. [PMID: 12378556] - De-Sheng Wang, Johan W Jonker, Yukio Kato, Hiroyuki Kusuhara, Alfred H Schinkel, Yuichi Sugiyama. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
The Journal of pharmacology and experimental therapeutics.
2002 Aug; 302(2):510-5. doi:
10.1124/jpet.102.034140. [PMID: 12130709] - E Porchezhian, S H Ansari, N K Shreedharan. Antihyperglycemic activity of Euphrasia officinale leaves.
Fitoterapia.
2000 Sep; 71(5):522-6. doi:
10.1016/s0367-326x(00)00204-5. [PMID: 11449500] - C L Kaul. Role of sympathetic nervous system in experimental hypertension and diabetes mellitus.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1999 Jan; 21(1-2):95-112. doi:
10.3109/10641969909068653. [PMID: 10052646] - J D Lalau, J M Race. Lactic acidosis in metformin therapy.
Drugs.
1999; 58 Suppl 1(?):55-60; discussion 75. doi:
10.2165/00003495-199958001-00013. [PMID: 10576527] - H Hohage, K Hess, C Jahl, J Greven, E Schlatter. Renal and blood pressure effects of moxonidine and clonidine in spontaneously hypertensive rats.
Clinical nephrology.
1997 Dec; 48(6):346-52. doi:
NULL. [PMID: 9438092] - F Mariano, F Goia, R Vincenti, L Capra, G Lanza, V Curto, P L Cavalli. [Insufficient correction of blood bicarbonate levels in biguanide lactic acidosis treated with CVVH and bicarbonate replacement fluids].
Minerva urologica e nefrologica = The Italian journal of urology and nephrology.
1997 Sep; 49(3):133-6. doi:
NULL. [PMID: 9432735]
