Halofantrine (BioDeep_00000006556)
Secondary id: BioDeep_00001868227
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol
化学式: C26H30Cl2F3NO (499.1656)
中文名称: 卤方特瑞
谱图信息:
最多检出来源 Homo sapiens(blood) 5.17%
分子结构信息
SMILES: CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O
InChI: InChI=1S/C26H30Cl2F3NO/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3
描述信息
Halofantrine is a drug used to treat malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme heme polymerase), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:94392
- KEGG: C07634
- KEGGdrug: D08033
- PubChem: 37393
- HMDB: HMDB0015349
- Metlin: METLIN3155
- DrugBank: DB01218
- ChEMBL: CHEMBL1107
- Wikipedia: Halofantrine
- chemspider: 34303
- CAS: 66051-76-1
- CAS: 69756-53-2
- CAS: 66051-74-9
- PMhub: MS000019618
- ChEBI: CHEBI:5612
- PubChem: 9836
- NIKKAJI: J18.879D
- KNApSAcK: 5612
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
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10.1124/mol.119.115964. [PMID: 31515284] - Ben J Boyd, Malinda Salim, Andrew J Clulow, Gisela Ramirez, Anna C Pham, Adrian Hawley. The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs.
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2017 Aug; 117(?):308-314. doi:
10.1016/j.ejpb.2017.04.023. [PMID: 28465239] - Maria Høtoft Michaelsen, Kishor M Wasan, Olena Sivak, Anette Müllertz, Thomas Rades. The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).
The AAPS journal.
2016 Jan; 18(1):180-6. doi:
10.1208/s12248-015-9832-7. [PMID: 26486790] - Isha Taneja, Kanumuri Siva Rama Raju, Sheelendra Pratap Singh, Muhammad Wahajuddin. Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.
Scientific reports.
2015 Nov; 5(?):17264. doi:
10.1038/srep17264. [PMID: 26602250] - Vasiliy Korotchenko, Ramadas Sathunuru, Lucia Gerena, Diana Caridha, Qigui Li, Mara Kreishman-Deitrick, Philip L Smith, Ai J Lin. Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives.
Journal of medicinal chemistry.
2015 Apr; 58(8):3411-31. doi:
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Malaria journal.
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Journal of pharmaceutical sciences.
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The Korean journal of parasitology.
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Journal of pharmaceutical sciences.
2012 Sep; 101(9):3540-6. doi:
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Chirality.
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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Journal of controlled release : official journal of the Controlled Release Society.
2012 May; 160(1):25-32. doi:
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Molecular pharmaceutics.
2011 Aug; 8(4):1132-9. doi:
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Asian Pacific journal of tropical medicine.
2011 Apr; 4(4):253-8. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2011 Mar; 42(4):416-22. doi:
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Journal of pharmaceutical and biomedical analysis.
2011 Jan; 54(1):168-72. doi:
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British journal of pharmacology.
2010 Nov; 161(6):1427-40. doi:
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Chirality.
2010 Feb; 22(2):275-83. doi:
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African journal of traditional, complementary, and alternative medicines : AJTCAM.
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Journal of clinical pharmacy and therapeutics.
2009 Dec; 34(6):677-82. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Nov; 331(2):700-9. doi:
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Journal of pharmaceutical sciences.
2009 Jul; 98(7):2516-28. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(11-12):1133-9. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 Oct; 35(3):211-8. doi:
10.1016/j.ejps.2008.07.003. [PMID: 18675904] - Oluwatosin A Adaramoye, Dorcas O Osaimoje, Adewale M Akinsanya, Chiaka M Nneji, Michael A Fafunso, Olusegun G Ademowo. Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats.
Basic & clinical pharmacology & toxicology.
2008 Apr; 102(4):412-8. doi:
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European journal of clinical pharmacology.
2008 Jan; 64(1):77-81. doi:
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Therapeutic drug monitoring.
2007 Apr; 29(2):203-6. doi:
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Chirality.
2007 Jan; 19(1):22-33. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2006 May; 34(5):729-33. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Apr; 41(1):315-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2006 Feb; 316(2):881-91. doi:
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Pharmaceutical research.
2005 Nov; 22(11):1863-70. doi:
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2005 Jul; 298(2):328-32. doi:
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British journal of clinical pharmacology.
2004 Jul; 58(1):52-5. doi:
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Antimicrobial agents and chemotherapy.
2004 Jul; 48(7):2624-32. doi:
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Journal of pharmaceutical sciences.
2004 May; 93(5):1110-21. doi:
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Antimicrobial agents and chemotherapy.
2004 Apr; 48(4):1222-8. doi:
10.1128/aac.48.4.1222-1228.2004. [PMID: 15047523] - Michelle P McIntosh, William N Charman, Michael Campbell, Christopher J H Porter. Influence of physicochemical properties on the patterns of association of a series of aliphatic esters of halofantrine with plasma lipoproteins.
Journal of controlled release : official journal of the Controlled Release Society.
2004 Mar; 95(2):275-89. doi:
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Pharmaceutical research.
2004 Feb; 21(2):245-53. doi:
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Pharmaceutical research.
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The Journal of pharmacy and pharmacology.
2004 Jan; 56(1):69-77. doi:
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Journal of pharmaceutical sciences.
2003 Nov; 92(11):2217-28. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2003 Sep; 20(1):91-7. doi:
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Pharmaceutical research.
2003 Sep; 20(9):1460-5. doi:
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Biopharmaceutics & drug disposition.
2003 May; 24(4):153-7. doi:
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Annales pharmaceutiques francaises.
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Chemical & pharmaceutical bulletin.
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Clinical pharmacology and therapeutics.
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Presse medicale (Paris, France : 1983).
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Cardiovascular research.
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Journal of pharmaceutical sciences.
2002 Aug; 91(8):1817-26. doi:
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The Journal of pharmacy and pharmacology.
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The American journal of tropical medicine and hygiene.
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The American journal of tropical medicine and hygiene.
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Biopharmaceutics & drug disposition.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2001 Dec; 14(4):331-7. doi:
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Journal of pharmaceutical sciences.
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