Chlorphentermine (BioDeep_00000006538)

 

Secondary id: BioDeep_00001867967

human metabolite blood metabolite


代谢物信息卡片


Warner chilcott brand OF chlorphentermine hydrochloride

化学式: C10H14ClN (183.0815)
中文名称: 对氯苯丁胺
谱图信息: 最多检出来源 Homo sapiens(blood) 74.44%

分子结构信息

SMILES: CC(C)(CC1=CC=C(C=C1)Cl)N
InChI: InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

描述信息

D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant

同义名列表

11 个代谢物同义名

Warner chilcott brand OF chlorphentermine hydrochloride; 1-(4-chlorophenyl)-2-methylpropan-2-amine; Hydrochloride, chlorphentermine; Chlorphentermine hydrochloride; chlorоphentermine; CHLORPHENTERMINE; Desopimon; Pre-Sate; Avipron; Chlorphentermine; Chlorphentermine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 NT5C2, PLA2G12A, RER
Peripheral membrane protein 1 COQ10A
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 3 HSP90B1, PLCZ1, RER
cytosol 5 HSP90B1, LIPE, NT5C2, PLCZ1, TPH1
dendrite 1 HTR1B
nucleoplasm 2 PLCZ1, RER
Cell membrane 4 FCER1G, HTR1B, LIPE, SLC6A4
Multi-pass membrane protein 2 HTR1B, SLC6A4
Synapse 1 SLC6A4
cell surface 1 FCER1G
Golgi membrane 1 INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 COQ10A
presynaptic membrane 2 HTR1B, SLC6A4
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 LIPE, NT5C2
Lysosome 1 GAA
Presynapse 1 SLC6A4
plasma membrane 4 FCER1G, GAA, HTR1B, SLC6A4
Membrane 4 GAA, HSP90B1, LIPE, SLC6A4
caveola 1 LIPE
extracellular exosome 3 GAA, HSP90B1, LYZ
Lysosome membrane 1 GAA
endoplasmic reticulum 2 HSP90B1, HTR1B
extracellular space 3 INS, LYZ, PNLIP
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 HSP90B1, PLCZ1
mitochondrion 1 COQ10A
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 1 GAA
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 FCER1G
Secreted 4 GAA, INS, PLA2G12A, PNLIP
extracellular region 6 GAA, HSP90B1, INS, LYZ, PLA2G12A, PNLIP
external side of plasma membrane 1 FCER1G
nucleolus 1 PLCZ1
midbody 1 HSP90B1
postsynaptic membrane 1 SLC6A4
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 1 COQ10A
Matrix side 1 COQ10A
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 2 HSP90B1, SLC6A4
collagen-containing extracellular matrix 1 HSP90B1
nuclear speck 1 RER
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 SLC6A4, TPH1
Chromosome 1 RER
spindle pole 1 RER
Cytoplasm, cytoskeleton, spindle pole 1 RER
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Nucleus, nucleoplasm 1 RER
tertiary granule membrane 2 FCER1G, GAA
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
calyx of Held 1 HTR1B
Sarcoplasmic reticulum lumen 1 HSP90B1
ficolin-1-rich granule membrane 2 FCER1G, GAA
U2-type precatalytic spliceosome 1 RER
endocytic vesicle lumen 1 HSP90B1
sperm head 1 PLCZ1
endoplasmic reticulum chaperone complex 1 HSP90B1
Fc-gamma receptor III complex 1 FCER1G
autolysosome lumen 1 GAA
G protein-coupled serotonin receptor complex 1 HTR1B
serotonergic synapse 2 HTR1B, SLC6A4
Fc-epsilon receptor I complex 1 FCER1G


文献列表

  • Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Baumann. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. 2011 Mar; 6(3):e17735. doi: 10.1371/journal.pone.0017735. [PMID: 21464983]
  • Robert A Ettlin, Junji Kuroda, Stephanie Plassmann, Makoto Hayashi, David E Prentice. Successful drug development despite adverse preclinical findings part 2: examples. Journal of toxicologic pathology. 2010 Dec; 23(4):213-34. doi: 10.1293/tox.23.213. [PMID: 22272032]
  • Daniel Crona, Julie Harral, Serge Adnot, Saadia Eddahibi, James West. Gene expression in lungs of mice lacking the 5-hydroxytryptamine transporter gene. BMC pulmonary medicine. 2009 May; 9(?):19. doi: 10.1186/1471-2466-9-19. [PMID: 19426553]
  • K Deventer, P Van Eenoo, F T Delbeke. Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006; 20(5):877-82. doi: 10.1002/rcm.2372. [PMID: 16470715]
  • Saadia Eddahibi, Serge Adnot. Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis. Respiratory research. 2002; 3(?):9. doi: 10.1186/rr181. [PMID: 11806844]
  • R B Rothman, M A Ayestas, C M Dersch, M H Baumann. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug; 100(8):869-75. doi: 10.1161/01.cir.100.8.869. [PMID: 10458725]
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  • K Opitz, M L Weischer. [The excretion of anorectic phenylalkylamines in the urine]. Arzneimittel-Forschung. 1966 Oct; 16(10):1311-3. doi: NULL. [PMID: 6014915]
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  • L Cucurachi, A Strata, U Zuliani, S Castello, P Cucurachi. [Lipid-mobilizing action of some anorexic drugs]. Bollettino della Societa italiana di biologia sperimentale. 1965 Dec; 41(24):1477-8. doi: ". [PMID: 5878157]
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