Sevoflurane (BioDeep_00000006523)

 

Secondary id: BioDeep_00001867804

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether

化学式: C4H3F7O (200.0072112)
中文名称: 氟甲基-1,1,1,3,3,3-六氟异丙基醚
谱图信息: 最多检出来源 Bos taurus(endogenous) 33.33%

分子结构信息

SMILES: C(F)OC(C(F)(F)F)C(F)(F)F
InChI: InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2

描述信息

Sevoflurane is only found in individuals that have used or taken this drug. Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. [Wikipedia]Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AB - Halogenated hydrocarbons
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

9 个代谢物同义名

Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane; Fluoromethyl hexafluoroisopropyl ether; Sevofluranum; sevoflurane; Sevoflurano; Sevofluran; Sevorane; Ultane



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weiwei Ni, Zhiwei Zou, Ping Jiang, Shuo Wang. Sevoflurane alleviates inflammation, apoptosis and permeability damage of human umbilical vein endothelial cells induced by lipopolysaccharide by inhibiting endoplasmic reticulum stress via upregulating RORα. Prostaglandins & other lipid mediators. 2024 Jun; 172(?):106821. doi: 10.1016/j.prostaglandins.2024.106821. [PMID: 38373554]
  • Yanqiu You, Xudong Zhou, Qiuqin Tang, Tianshou Zhao, Juan Wang, Hanqin Huang, Jibing Chen, Zhongquan Qi, Fujun Li. Echinatin mitigates sevoflurane-induced neurotoxicity through regulation of ferroptosis and iron homeostasis. Aging. 2024 Mar; 16(5):4670-4683. doi: 10.18632/aging.205622. [PMID: 38446592]
  • Ling Zhou, Yang Jianying. Letter to the article by Yunoki et al. Journal of anesthesia. 2024 Feb; 38(1):148. doi: 10.1007/s00540-023-03280-7. [PMID: 37930421]
  • Wenting Li, Xiaowen Meng, Ke Peng, Yaobao Han, Hanghang Liu, Weiming Zhao, Gang Wang, Li Deng, Hong Liu, Zhen Li, Fuhai Ji. Boosting Microglial Lipid Metabolism via TREM2 Signaling by Biomimetic Nanoparticles to Attenuate the Sevoflurane-Induced Developmental Neurotoxicity. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Dec; ?(?):e2305989. doi: 10.1002/advs.202305989. [PMID: 38145349]
  • Liheng Kang, Meihua Piao, Nan Liu, Wanping Gu, Chunsheng Feng. Sevoflurane Exposure Induces Neuronal Cell Ferroptosis Initiated by Increase of Intracellular Hydrogen Peroxide in the Developing Brain via ER Stress ATF3 Activation. Molecular neurobiology. 2023 Oct; ?(?):. doi: 10.1007/s12035-023-03695-z. [PMID: 37874483]
  • Heying Zhong, Xiaojuan Ran, Bin Chen, Yiqiang Xiong, Xiangdi Yu. Apamin, an SK2 Inhibitor, Attenuated Neonatal Sevoflurane Exposures Caused Cognitive Deficits in Mice through the Regulation of Hippocampal Neuroinflammation. ACS chemical neuroscience. 2023 Aug; ?(?):. doi: 10.1021/acschemneuro.3c00310. [PMID: 37647501]
  • Ying Xu, Xueting Wang, Ziyang Xu, Fengwei Sun, Yue Tian. Tbx2 Knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis. Toxicological sciences : an official journal of the Society of Toxicology. 2023 Jul; ?(?):. doi: 10.1093/toxsci/kfad071. [PMID: 37494465]
  • Yong Yang, Lin Feng, Chengcheng Ji, Kaizhi Lu, Yang Chen, Bing Chen. Inhalational Versus Propofol-based Intravenous Maintenance of Anesthesia for Emergence Delirium in Adults: A Meta-analysis and Trial Sequential Analysis. Journal of neurosurgical anesthesiology. 2023 Apr; 35(2):177-186. doi: 10.1097/ana.0000000000000830. [PMID: 35026799]
  • Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Dhavalkumar Patel, Laurence Wood, Juyang Huang, Muhammad Bilal Siddique, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel. Effects of Volatile Anesthetics Versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes. The Journal of pharmacology and experimental therapeutics. 2023 Feb; ?(?):. doi: 10.1124/jpet.122.001281. [PMID: 36828631]
  • Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen. Neonatal exposure to sevoflurane induces adolescent neurobehavioral dysfunction by interfering with hippocampal glycerophoslipid metabolism in rats. Cerebral cortex (New York, N.Y. : 1991). 2023 02; 33(5):1955-1971. doi: 10.1093/cercor/bhac185. [PMID: 35584785]
  • Bo Zhang, Qi Hou, Xiaoli Zhang, Yiming Ma, Junhu Yuan, Shuai Li, Xinhua Zhao, Li Sun, Hongying Wang, Hui Zheng. Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation. Free radical biology & medicine. 2023 02; 195(?):298-308. doi: 10.1016/j.freeradbiomed.2022.12.092. [PMID: 36586453]
  • Yi Jin, Xiaoxue Hu, Fanhua Meng, Qing Luo, Henry Liu, Zeyong Yang. Sevoflurane Exposure of Clinical Doses in Pregnant Rats Induces Vcan Changes without Significant Neural Apoptosis in the Offspring. Medicina (Kaunas, Lithuania). 2023 Jan; 59(2):. doi: 10.3390/medicina59020190. [PMID: 36837392]
  • Xudong Xu, Rongrong Deng, Lu Zou, Xiaoyan Pan, Zhifeng Sheng, Da Xu, Tingting Gan. Sevoflurane participates in the protection of rat renal ischemia-reperfusion injury by down-regulating the expression of TRPM7. Immunity, inflammation and disease. 2023 01; 11(1):e753. doi: 10.1002/iid3.753. [PMID: 36705408]
  • Pedro Alves Machado-Junior, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Luiza Oliveira Perucci, André Talvani, Silvia Dantas Cangussú, Frank Silva Bezerra. The deleterious impact of exposure to different inhaled anesthetics is time dependent. Life sciences. 2022 Nov; 309(?):121004. doi: 10.1016/j.lfs.2022.121004. [PMID: 36170891]
  • Xiao-Bo Bi, Xia Zhang, Ji-Peng Wen, Wei Ding, Jin Li. [Effects of repeated sevoflurane exposure on hippocampal cell apoptosis and long-term learning and memory ability in neonatal rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2022 Nov; 38(6):807-813. doi: 10.12047/j.cjap.6353.2022.147. [PMID: 37308440]
  • Ruyu Yan, Tieying Song, Wenli Wang, Jun Tian, Xiaojing Ma. Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer. Immunopharmacology and immunotoxicology. 2022 Sep; ?(?):1-7. doi: 10.1080/08923973.2022.2122501. [PMID: 36073191]
  • Chen Chen, Jianwei Zuo, Huimei Zhang. Sevoflurane post-treatment mitigates oxygen-glucose deprivation-induced pyroptosis of hippocampal neurons by regulating the Mafb/DUSP14 axis. Current neurovascular research. 2022 Aug; ?(?):. doi: 10.2174/1567202619666220802104426. [PMID: 35927915]
  • J Robert Sneyd. Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead. British journal of anaesthesia. 2022 07; 129(1):7-10. doi: 10.1016/j.bja.2022.02.031. [PMID: 35331541]
  • Aleksi J Nummela, Lauri T Laaksonen, Timo T Laitio, Roosa E Kallionpää, Jaakko W Långsjö, Joonas M Scheinin, Tero J Vahlberg, Harri T Koskela, Viljami Aittomäki, Katja J Valli, Antti Revonsuo, Mikko Niemi, Markus Perola, Harry Scheinin. Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy. European journal of anaesthesiology. 2022 06; 39(6):521-532. doi: 10.1097/eja.0000000000001591. [PMID: 34534172]
  • Kotaro Hori, Tadashi Matsuura, Shogo Tsujikawa, Hideki Hino, Miyuki Kuno, Yutaka Oda, Kiyonobu Nishikawa, Takashi Mori. Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model. Clinical toxicology (Philadelphia, Pa.). 2022 06; 60(6):716-724. doi: 10.1080/15563650.2021.2020280. [PMID: 34985393]
  • Jiawei Xie, Hongmei Li, Shuai Li, Jianling Li, Yalan Li. Molecular Mechanism of Sevoflurane Preconditioning Based on Whole-transcriptome Sequencing of Lipopolysaccharide-induced Cardiac Dysfunction in Mice. Journal of cardiovascular pharmacology. 2022 06; 79(6):846-857. doi: 10.1097/fjc.0000000000001259. [PMID: 35266915]
  • Junli Luo, Dongdong Li, Song Chen, Hong Zhang, Huijun Cai. Sevoflurane Postconditioning Inhibits Pulmonary Apoptosis via PI3K/AKT in Dog Cardiopulmonary Bypass Model. The heart surgery forum. 2022 May; 25(3):E374-E380. doi: 10.1532/hsf.4721. [PMID: 35787749]
  • Daniel Kiefer, Lukas M Müller-Wirtz, Felix Maurer, Tobias Hüppe, Alexander M Mathes, Thomas Volk, Sascha Kreuer, Tobias Fink. Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats. Experimental animals. 2022 May; 71(2):231-239. doi: 10.1538/expanim.21-0147. [PMID: 34880161]
  • Lidan Liu, Xin Zhang, Cong Wang, Xiuying Wu, Bo Long. Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis. Journal of biochemical and molecular toxicology. 2022 May; 36(5):e23009. doi: 10.1002/jbt.23009. [PMID: 35174938]
  • Stephanie Franzén, Egidijus Semenas, Micael Taavo, Johan Mårtensson, Anders Larsson, Robert Frithiof. Renal function during sevoflurane or total intravenous propofol anaesthesia: a single-centre parallel randomised controlled study. British journal of anaesthesia. 2022 05; 128(5):838-848. doi: 10.1016/j.bja.2022.02.030. [PMID: 35279277]
  • Jiajia Ma, Wei Xiong, Dongze Guo, Anxin Wang, Hui Qiao, Ruquan Han. Effects of Sevoflurane-Propofol-Balanced Anesthesia on Flash Visual Evoked Potential Monitoring in Spine Surgery: A Randomized Noninferiority Trial. Anesthesia and analgesia. 2022 05; 134(5):1054-1061. doi: 10.1213/ane.0000000000005742. [PMID: 34543246]
  • Vesna Benković, Nada Oršolić, Anica Horvat Knežević, Nikola Borojević, Gordana Brozović, Mirta Milić. Kidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo. Arhiv za higijenu rada i toksikologiju. 2022 Apr; 73(1):62-70. doi: 10.2478/aiht-2022-73-3600. [PMID: 35390237]
  • Youn Joung Cho, Dhong-Eun Jung, Karam Nam, Jinyoung Bae, Seohee Lee, Yunseok Jeon. Effects of transcutaneous electrical nerve stimulation on myocardial protection in patients undergoing aortic valve replacement: a randomized clinical trial. BMC anesthesiology. 2022 03; 22(1):68. doi: 10.1186/s12871-022-01611-x. [PMID: 35264104]
  • Qianfu Wu, Haihui Wang, Fei He, Jiali Zheng, Hongjing Zhang, Chang Cheng, Panwei Hu, Rong Lu, Guoliang Yan. Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia-Reperfusion Injury by Upregulating KLF4. Cardiovascular drugs and therapy. 2022 Feb; ?(?):. doi: 10.1007/s10557-021-07303-x. [PMID: 35171385]
  • Dan Zhao, Minli Zhang, Lingling Yang, Mingquan Zeng. GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF. ACS chemical neuroscience. 2022 02; 13(3):423-431. doi: 10.1021/acschemneuro.1c00830. [PMID: 35025202]
  • Kevin Chang, Michele Barletta, Kristen M Messenger, Daniel M Sakai, Rachel A Reed, Jane E Quandt. The effect of a ketamine constant rate infusion on cardiovascular variables in sheep anesthetized at the minimum alveolar concentration of sevoflurane that blunts adrenergic responses. American journal of veterinary research. 2022 Jan; 83(3):205-211. doi: 10.2460/ajvr.21.08.0129. [PMID: 34986114]
  • Guowei Fu, Junlan Huang, Zhouquan Wu, Lin Zhao. Sevoflurane Suppresses the Growth, Metastasis, and Invasion of Endometrial Carcinoma Cells via miR-195-5p/JAK2 Axis. Computational and mathematical methods in medicine. 2022; 2022(?):2398101. doi: 10.1155/2022/2398101. [PMID: 35242202]
  • Joachim Bansbach, Julian Wenz, Kai Kaufmann, Sebastian Heinrich, Johannes Kalbhenn. Sevoflurane in combination with esketamine is an effective sedation regimen in COVID-19 patients enabling assisted spontaneous breathing even during prone positioning. Anaesthesiology intensive therapy. 2022; 54(1):23-29. doi: 10.5114/ait.2022.113950. [PMID: 35359138]
  • Berna Ayanoğlu Taş, Ceren Şanlı Karip, Süheyla Abitağaoğlu, Mehmet Celal Öztürk, Dilek Erdoğan Arı. Comparison of minimal-flow sevoflurane versus desflurane anesthesia: randomized clinical trial. Brazilian journal of anesthesiology (Elsevier). 2022 Jan; 72(1):77-82. doi: 10.1016/j.bjane.2021.05.012. [PMID: 34119569]
  • Youqing Li, Jiangping Yu, Mingmin Zhang, Meng Jia. Clinical Application of Remifentanil Combined with Sevoflurane in Manual Reduction of Humeral Supracondylar Fracture in Children. Computational and mathematical methods in medicine. 2022; 2022(?):2410433. doi: 10.1155/2022/2410433. [PMID: 35844458]
  • Wang Peipei, Wang Ping, Yin Miaomiao, Wang Shuo. Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. Allergologia et immunopathologia. 2022; 50(4):115-123. doi: 10.15586/aei.v50i4.623. [PMID: 35789410]
  • Manuela L'Erario, Rosa Maria Roperto, Anna Rosati. Sevoflurane as bridge therapy for plasma exchange and Anakinra in febrile infection-related epilepsy syndrome. Epilepsia open. 2021 12; 6(4):788-792. doi: 10.1002/epi4.12545. [PMID: 34596364]
  • Ping-Ping Jiang, Yan-Xia Guo, Xiao-Lin Yang, Juan Xu, Dan Wang. Effects of different remifentanil target concentrations on MACBAR of sevoflurane in patients with liver dysfunction under carbon dioxide pneumoperitoneum stimulus: A randomized controlled trial. Journal of clinical pharmacy and therapeutics. 2021 Dec; 46(6):1776-1783. doi: 10.1111/jcpt.13524. [PMID: 34514614]
  • Jinting Yang, Lihui Tang, Fengjiang Zhang, Tingting Yang, Ting Lu, Kai Sun, Na Sun, Jinxuan Ren, Min Yan. Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis. Stem cell research & therapy. 2021 11; 12(1):584. doi: 10.1186/s13287-021-02649-3. [PMID: 34809715]
  • Tianyuan Li, Qing-Shi Zeng, Shou-Zhang She. Limb Remote Ischemic Preconditioning Applied During Sevoflurane Anesthesia Does Not Protect the Lungs in Patients Undergoing Adult Heart Valve Surgery. The heart surgery forum. 2021 Oct; 24(5):E916-E924. doi: 10.1532/hsf.4139. [PMID: 34730488]
  • Ying Gao, Tianyun Zhao, Yanxin Chen, Zhixiang Sun, Junming Lu, Ziwen Shi, Xingrong Song. Prenatal sevoflurane exposure causes abnormal development of the entorhinal cortex in rat offspring. Journal of integrative neuroscience. 2021 Sep; 20(3):613-622. doi: 10.31083/j.jin2003065. [PMID: 34645094]
  • Dan Wang, Juan Xu, Xiao-Lin Yang, Yan-Xia Guo, Ping-Ping Jiang, Guo-Yuan Zhang. Effects of different plasma target concentrations of remifentanil on the MACBAR of sevoflurane in children with laparoscopic surgery. BMC anesthesiology. 2021 09; 21(1):231. doi: 10.1186/s12871-021-01453-z. [PMID: 34560835]
  • Ling Ai, Yan Fang. General anesthesia with cisatracurium and sevoflurane for a patient with primary carnitine deficiency receiving L-carnitine therapy: A case report. Medicine. 2021 Sep; 100(38):e27333. doi: 10.1097/md.0000000000027333. [PMID: 34559155]
  • Lu Li, Rongsheng Zhou, Haigang Lv, Lei Song, Xiaohong Xue, Li Wu. Inhibitive Effect of Luteolin on Sevoflurane-Induced Neurotoxicity through Activation of the Autophagy Pathway by HMOX1. ACS chemical neuroscience. 2021 09; 12(18):3314-3322. doi: 10.1021/acschemneuro.1c00157. [PMID: 34445868]
  • Kaiwei Wang, Hongqi Lin, Guosong Zhu, Haoran Zhang, Erju Jia. Effect of anesthesia on the expression of clock gene Clock and Bmal1 in New Zealand rabbits. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2021 Aug; 46(8):809-813. doi: 10.11817/j.issn.1672-7347.2021.200755. [PMID: 34565723]
  • Lukas Martin Müller-Wirtz, Daniel Kiefer, Felix Maurer, Maximilian Alexander Floss, Jonas Doneit, Tobias Hüppe, Theodora Shopova, Beate Wolf, Daniel I Sessler, Thomas Volk, Sascha Kreuer, Tobias Fink. Volutrauma Increases Exhaled Pentanal in Rats: A Potential Breath Biomarker for Ventilator-Induced Lung Injury. Anesthesia and analgesia. 2021 07; 133(1):263-273. doi: 10.1213/ane.0000000000005576. [PMID: 33929393]
  • Eric M Desjardins, Brennan K Smith, Gregory R Steinberg, Russell E Brown. Sevoflurane-induced hyperglycemia is attenuated by salsalate in obese insulin-resistant mice. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2021 07; 68(7):972-979. doi: 10.1007/s12630-021-01935-1. [PMID: 33580878]
  • Fang Ding, Xiuli Wang, Li Zhang, Jinru Li, Feifei Liu, Liang Wang. Effect of propofol-based total intravenous anaesthesia on postoperative cognitive function and sleep quality in elderly patients. International journal of clinical practice. 2021 Jul; 75(7):e14266. doi: 10.1111/ijcp.14266. [PMID: 33893705]
  • Xiang-Kun Zhao, Yi Tian. [Research Progress of Pharmacological Intervention of Sevoflurane-induced Nerve Injury in the Developing Brain]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2021 Jun; 43(3):462-468. doi: 10.3881/j.issn.1000-503x.12732. [PMID: 34238424]
  • Meiyu Liu, Shaoyong Song, Qingcai Chen, Jianhong Sun, Wei Chu, Yunzeng Zhang, Fuhai Ji. Gut microbiota mediates cognitive impairment in young mice after multiple neonatal exposures to sevoflurane. Aging. 2021 06; 13(12):16733-16748. doi: 10.18632/aging.203193. [PMID: 34182544]
  • Li Xie, Qianjin Fang, Xin Wei, Ling Zhou, Sheng Wang. Exogenous insulin-like growth factor 1 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged rats. Journal of neurophysiology. 2021 06; 125(6):2117-2124. doi: 10.1152/jn.00124.2021. [PMID: 33949883]
  • Rachel C Hector, Marlis L Rezende, Khursheed R Mama, Eugene P Steffey, Marja R Raekallio, Outi M Vainio. Combined effects of dexmedetomidine and vatinoxan infusions on minimum alveolar concentration and cardiopulmonary function in sevoflurane-anesthetized dogs. Veterinary anaesthesia and analgesia. 2021 May; 48(3):314-323. doi: 10.1016/j.vaa.2020.12.007. [PMID: 33678575]
  • Fu-Quan Fang, Jie-Hao Sun, Qiao-Lin Wu, Lin-Ya Feng, Yu-Xiu Fan, Jun-Xin Ye, Wei Gao, Guo-Liang He, Wei-Jian Wang. Protective effect of sevoflurane on vascular endothelial glycocalyx in patients undergoing heart valve surgery: A randomised controlled trial. European journal of anaesthesiology. 2021 05; 38(5):477-486. doi: 10.1097/eja.0000000000001429. [PMID: 33399382]
  • Yue Yang, Lei Yang, Yu Wu, Jun Yuan. [Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2021 Apr; 43(2):235-246. doi: 10.3881/j.issn.1000-503x.12913. [PMID: 33966704]
  • Lingling Ding, Jiaqi Ning, Qi Wang, Bin Lu, Hai Ke. Sevoflurane improves nerve regeneration and repair of neurological deficit in brain damage rats via microRNA-490-5p/CDK1 axis. Life sciences. 2021 Apr; 271(?):119111. doi: 10.1016/j.lfs.2021.119111. [PMID: 33513398]
  • Silvia Coppola, Stefano Cenci, Mario Cozzolino, Davide Chiumello. Sevoflurane sedation and nephrogenic diabetes insipidus in patients affected with severe acute respiratory syndrome coronavirus 2. European journal of anaesthesiology. 2021 04; 38(4):438-441. doi: 10.1097/eja.0000000000001318. [PMID: 33661827]
  • Mukilan Balasubramanian, Aswini Kuberan, Amit Rawat, Sivashanmugam Dhandapani, Nidhi Panda, Ajay Kumar, Asish K Sahoo, Munish Kumar, Tanavi Sharma, Paul S Garcia, Hemant Bhagat. Effect of General Anesthetics on Caspase-3 Levels in Patients With Aneurysmal Subarachnoid Hemorrhage: A Preliminary Study. Journal of neurosurgical anesthesiology. 2021 Apr; 33(2):172-176. doi: 10.1097/ana.0000000000000648. [PMID: 31599811]
  • Quan Wang, Jingcong Luo, Ruiqiang Sun, Jia Liu. MicroRNA-1297 suppressed the Akt/GSK3β signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model. The Journal of international medical research. 2021 Apr; 49(4):300060520982104. doi: 10.1177/0300060520982104. [PMID: 33843359]
  • Hirotsugu Miyoshi, Takahiro Kato, Ryuji Nakamura, Noboru Saeki, Yuko Noda, Satoshi Kamiya, Atsushi Morio, Yasuo M Tsutsumi. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats. Journal of anesthesia. 2021 04; 35(2):168-174. doi: 10.1007/s00540-020-02883-8. [PMID: 33386432]
  • Reshmi L Jose, Deepa Damayanathi, Koniaparambil P Unnikrishnan, Puthuvassery R Suneel. A comparison of sevoflurane versus sevoflurane-propofol combination on renal function in patients undergoing valvular heart surgery-A prospective randomized controlled pilot study. Annals of cardiac anaesthesia. 2021 Apr; 24(2):172-177. doi: 10.4103/aca.aca_171_19. [PMID: 33884972]
  • Gertrude J Nieuwenhuijs-Moeke, Dirk J Bosch, Henri G D Leuvenink. Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation. International journal of molecular sciences. 2021 Mar; 22(5):. doi: 10.3390/ijms22052727. [PMID: 33800423]
  • Natsuki Akashi, Yusuke Murahata, Masahumi Hosokawa, Yoshiaki Hikasa, Yoshiharu Okamoto, Tomohiro Imagawa. Cardiovascular and renal effects of constant rate infusions of remifentanil, dexmedetomidine and their combination in dogs anesthetized with sevoflurane. The Journal of veterinary medical science. 2021 Mar; 83(2):285-296. doi: 10.1292/jvms.20-0457. [PMID: 33310997]
  • Kátina Meneghetti Souza, Immaculata De Vivo, Chung-Yen Chen, Flávia Ribeiro Nogueira, Aline Garcia Aun, Nayara Micarelli Arruda, Juliana Rodrigues Lara, Mariane Aparecida P Silva, Drielle Baptista S Figueiredo, Camila Renata Corrêa, Lídia Raquel de Carvalho, José Reinaldo C Braz, Leandro Gobbo Braz, Mariana Gobbo Braz. Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anesthesia providers. Environmental and molecular mutagenesis. 2021 02; 62(2):155-164. doi: 10.1002/em.22420. [PMID: 33341964]
  • Toru Morohashi, Sayako Itakura, Ken-Ichi Shimokawa, Fumiyoshi Ishii, Yoshimitsu Sanjo, Tomiei Kazama. Anesthetic Potency of Intravenous Infusion of 20\% Emulsified Sevoflurane and Effect on the Blood-Gas Partition Coefficient in Dogs. Anesthesia and analgesia. 2021 02; 132(2):575-583. doi: 10.1213/ane.0000000000005232. [PMID: 33105277]
  • G H Maarten Honing, Christian H Martini, Erik Olofsen, Rob F M Bevers, Volkert A L Huurman, Ian P J Alwayn, Monique van Velzen, Marieke Niesters, Leon P H J Aarts, Albert Dahan, Martijn Boon. Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anaesthesia for laparoscopic renal surgery. British journal of anaesthesia. 2021 02; 126(2):377-385. doi: 10.1016/j.bja.2020.09.024. [PMID: 33092803]
  • Thiago Augusto Azevedo Maranhão Cardoso, Gudrun Kunst, Caetano Nigro Neto, José de Ribamar Costa Júnior, Carlos Gustavo Santos Silva, Gisele Medeiros Bastos, Jéssica Bassani Borges, Mario Hiroyuki Hirata. Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial. Trials. 2021 Jan; 22(1):25. doi: 10.1186/s13063-020-04809-x. [PMID: 33407763]
  • Ci Han, Zhaodi Zhang, Nana Guo, Xueting Li, Mengyuan Yang, Yahui Peng, Xiaohui Ma, Kaijiang Yu, Changsong Wang. Effects of Sevoflurane Inhalation Anesthesia on the Intestinal Microbiome in Mice. Frontiers in cellular and infection microbiology. 2021; 11(?):633527. doi: 10.3389/fcimb.2021.633527. [PMID: 33816336]
  • F Wang, F Shu, X-Q Wang, L-L Zheng, H-L Wang, L Li, H-G Lv. Sevoflurane ameliorates adriamycin-induced myocardial injury in rats through the PI3K/Akt/GSK-3β pathway. European review for medical and pharmacological sciences. 2021 01; 25(2):968-975. doi: 10.26355/eurrev_202101_24666. [PMID: 33577052]
  • Hai-Xin Hua, Hai-Bo Deng, Xiu-Ling Huang, Chang-Qing Ma, Ping Xu, Ye-Hua Cai, Hai-Tang Wang. Effects of Occupational Exposure to Waste Anesthetic Gas on Oxidative Stress and DNA Damage. Oxidative medicine and cellular longevity. 2021; 2021(?):8831535. doi: 10.1155/2021/8831535. [PMID: 33542785]
  • Ning Wang, Jing Zhang, Ruiling Zhao, Bin Zhao, Yongzhang Li, Xiaoqing Zhang, Peng Liu. Effects of Sevoflurane versus Propofol on Endogenous Nitric Oxide Metabolism during Laparoscopic Surgery. Journal of healthcare engineering. 2021; 2021(?):6691943. doi: 10.1155/2021/6691943. [PMID: 33613928]
  • Xing Lan, Dong Yang, Shengnan Xie, Zhenghua Zhao. Effects of Full Inhalation of Sevoflurane and Total Intravenous Anesthesia on Hemodynamics, Serum Myocardial Enzymes, and Myocardial Markers in Elderly Patients Undergoing Hysterectomy. BioMed research international. 2021; 2021(?):9983988. doi: 10.1155/2021/9983988. [PMID: 34258289]
  • Vesna Benković, Nikola Borojević, Dunja Šikić, Anica Horvat Knežević, Mirta Milić. DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo. International journal of radiation biology. 2021; 97(10):1425-1435. doi: 10.1080/09553002.2021.1962565. [PMID: 34328801]
  • Yavuz Orak, Fatma İnanç Tolun, Murat Bakacak, Aslı Yaylalı, Hakan Kıran, Hafize Öksüz, Adem Doğaner, Işıl Yağmur, Ahmet Altun. Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients. Pain research & management. 2021; 2021(?):5517150. doi: 10.1155/2021/5517150. [PMID: 33936350]
  • Yonghao Hou, Xiaowen Lin, Zhen Lei, Meng Zhao, Shengqiang Li, Meng Zhang, Cheng Zhang, Jingui Yu, Tao Meng. Sevoflurane prevents vulnerable plaque disruption in apolipoprotein E-knockout mice by increasing collagen deposition and inhibiting inflammation. British journal of anaesthesia. 2020 12; 125(6):1034-1044. doi: 10.1016/j.bja.2020.07.054. [PMID: 32943192]
  • A M Emara, K A Alrasheedi, M A Aldubayan, A H Alhowail, R M Elgarabawy. Effect of inhaled waste anaesthetic gas on blood and liver parameters among hospital staff. Human & experimental toxicology. 2020 Dec; 39(12):1585-1595. doi: 10.1177/0960327120938840. [PMID: 32662669]
  • Xiang Fei, Jin-Xin Wang, Yao Wu, Ning Dong, Zhi-Yong Sheng. Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. Brain research bulletin. 2020 12; 165(?):23-29. doi: 10.1016/j.brainresbull.2020.08.030. [PMID: 32910992]
  • Vikas Kaura, Philip M Hopkins. Sevoflurane may not be a complete sigh of relief in COVID-19. British journal of anaesthesia. 2020 12; 125(6):e487-e488. doi: 10.1016/j.bja.2020.09.012. [PMID: 33012516]
  • L Wang, X Z Li, W G Yu, R Dong, M S Wang, Y L Bi, H C Chu, S D Wang, J Z Li. [The effect on bleeding volume and postoperative recovery of regional cerebral oxygen saturation guides controlled hypotension in elderly patients with hypertension undergoing spinal surgery]. Zhonghua yi xue za zhi. 2020 Nov; 100(41):3230-3234. doi: 10.3760/cma.j.cn112137-20200515-01554. [PMID: 33167109]
  • H Chen, X-M Zhu, Z-L Luo, Y-J Hu, X-C Cai, Q-H Gu. Sevoflurane induction alleviates the progression of gastric cancer by upregulating the miR-34a/TGIF2 axis. European review for medical and pharmacological sciences. 2020 11; 24(22):11883-11890. doi: 10.26355/eurrev_202011_23846. [PMID: 33275259]
  • Rakesh V Sondekoppam, Karim H Narsingani, Trent A Schimmel, Brie M McConnell, Karen Buro, Timur J-P Özelsel. The impact of sevoflurane anesthesia on postoperative renal function: a systematic review and meta-analysis of randomized-controlled trials. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2020 Nov; 67(11):1595-1623. doi: 10.1007/s12630-020-01791-5. [PMID: 32812189]
  • Sangbin Han, Jaesik Park, Sang Hyun Hong, Soojin Lim, Yong Hyun Park, Min Suk Chae. Comparison of the impact of propofol versus sevoflurane on early postoperative recovery in living donors after laparoscopic donor nephrectomy: a prospective randomized controlled study. BMC anesthesiology. 2020 10; 20(1):273. doi: 10.1186/s12871-020-01190-9. [PMID: 33115408]
  • Asensio Gonzalez, Tinen L Iles, Paul A Iaizzo, Oliver Bandschapp. Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study. BMC anesthesiology. 2020 10; 20(1):270. doi: 10.1186/s12871-020-01186-5. [PMID: 33096987]
  • Dian-Xiang Tan, Xiao-Xi Chen, Tai-Zhu Bai, Juan Zhang, Zhen-Fa Li. Sevoflurane up-regulates microRNA-204 to ameliorate myocardial ischemia/reperfusion injury in mice by suppressing Cotl1. Life sciences. 2020 Oct; 259(?):118162. doi: 10.1016/j.lfs.2020.118162. [PMID: 32730836]
  • Yu Fan, Hao Wang, Qi Ma. Effects of sevoflurane and propofol anesthesia on intraoperative endothelial cell function in patients undergoing laparoscopic cholecystectomy. The Journal of international medical research. 2020 Oct; 48(10):300060520918407. doi: 10.1177/0300060520918407. [PMID: 33050753]
  • Yunxia Dong, Wei Hong, Zhiyin Tang, Yan Gao, Xiuying Wu, Hongtao Liu. Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1. Neurochemistry international. 2020 10; 139(?):104789. doi: 10.1016/j.neuint.2020.104789. [PMID: 32650025]
  • Yanxia Guo, Dan Wang, Xiaolin Yang, Pingping Jiang, Juan Xu, Guoyuan Zhang. Effects of different sufentanil target concentrations on the MACBAR of sevoflurane in patients with carbon dioxide pneumoperitoneum stimulus. BMC anesthesiology. 2020 09; 20(1):239. doi: 10.1186/s12871-020-01160-1. [PMID: 32957929]
  • Arpa Chutipongtanate, Sasichol Prukviwat, Nutkridta Pongsakul, Supanart Srisala, Nakarin Kamanee, Nuttapon Arpornsujaritkun, Goragoch Gesprasert, Nopporn Apiwattanakul, Suradej Hongeng, Wichai Ittichaikulthol, Vasant Sumethkul, Somchai Chutipongtanate. Effects of Desflurane and Sevoflurane anesthesia on regulatory T cells in patients undergoing living donor kidney transplantation: a randomized intervention trial. BMC anesthesiology. 2020 08; 20(1):215. doi: 10.1186/s12871-020-01130-7. [PMID: 32854613]
  • Katerina Tomsič, Alenka Nemec Svete, Ana Nemec, Aleksandra Domanjko Petrič, Tatjana Pirman, Vida Rezar, Tomaž Vovk, Alenka Seliškar. Antioxidant capacity of lipid- and water-soluble antioxidants in dogs with subclinical myxomatous mitral valve degeneration anaesthetised with propofol or sevoflurane. BMC veterinary research. 2020 Aug; 16(1):305. doi: 10.1186/s12917-020-02529-7. [PMID: 32831105]
  • Gertrude J Nieuwenhuijs-Moeke, Jayant S Jainandunsing, Michel M R F Struys. Sevoflurane, a sigh of relief in COVID-19?. British journal of anaesthesia. 2020 08; 125(2):118-121. doi: 10.1016/j.bja.2020.04.076. [PMID: 32416995]
  • Jennifer Herzog-Niescery, Hans-Martin Seipp, Martin Bellgardt, Torsten Herzog, Orlin Belyaev, Waldemar Uhl, Philipp Gude, Thomas P Weber, Heike Vogelsang. Comparison of 3 Methods to Assess Occupational Sevoflurane Exposure in Abdominal Surgeons: A Single-Center Observational Pilot Study. Anesthesia and analgesia. 2020 08; 131(2):537-543. doi: 10.1213/ane.0000000000004301. [PMID: 31295179]
  • Angela Jerath, Niall D Ferguson, Brian Cuthbertson. Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS. Intensive care medicine. 2020 Aug; 46(8):1563-1566. doi: 10.1007/s00134-020-06154-8. [PMID: 32588067]
  • Anmin Shao, Jianping Fei, Shuquan Feng, Jiandong Weng. Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway. Pharmacological reports : PR. 2020 Aug; 72(4):833-845. doi: 10.1007/s43440-020-00078-2. [PMID: 32124392]
  • Xinyu Chen, Minjie Li, Rujie Zheng, Qinfeng Huang, Yanzhen Li, Yu Zhu, Zhiwei Chen, Jianqing Lin. Effects of sevoflurane inhalation anesthesia on IL-6, TNF-α and MMP-9 expression and hemodynamics in elderly patients undergoing lobectomy for lung cancer. Cellular and molecular biology (Noisy-le-Grand, France). 2020 Jul; 66(5):49-53. doi: 10.14715/cmb/2020.66.5.10. [PMID: 33040813]
  • Felipe Maldonado, Diego Morales, Rodrigo Gutiérrez, Maximiliano Barahona, Oscar Cerda, Mónica Cáceres. Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery. BMC anesthesiology. 2020 05; 20(1):121. doi: 10.1186/s12871-020-01030-w. [PMID: 32434495]
  • Mu-Huo Ji, Li-Li Qiu, Ming-Jie Mao, Lin Zhang, Jian-Jun Yang. Hippocampal complement C3 might contribute to cognitive impairment induced by anesthesia and surgery. Neuroreport. 2020 05; 31(7):507-514. doi: 10.1097/wnr.0000000000001422. [PMID: 32168099]
  • Beverley A Orser, Dian-Shi Wang, Wei-Yang Lu. Sedating ventilated COVID-19 patients with inhalational anesthetic drugs. EBioMedicine. 2020 05; 55(?):102770. doi: 10.1016/j.ebiom.2020.102770. [PMID: 32344199]
  • Emmanuel Besnier, Anne Perdrix, André Gillibert, Jean Selim, Benoit Froëmer, Antoine Ghemired, Benoit Berby, Nathalie Rives, Bertrand Dureuil, Thomas Clavier, Vincent Compère. Postoperative hunger after outpatient surgery in patients anesthetized with propofol vs sevoflurane: a randomized-controlled trial. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2020 05; 67(5):550-559. doi: 10.1007/s12630-020-01584-w. [PMID: 31997087]
  • F Yu, L-J Tong, D-S Cai. Sevoflurane inhibits neuronal apoptosis and expressions of HIF-1 and HSP70 in brain tissues of rats with cerebral ischemia/reperfusion injury. European review for medical and pharmacological sciences. 2020 05; 24(9):5082-5090. doi: 10.26355/eurrev_202005_21201. [PMID: 32432772]
  • Arnulfo Calixto-Flores, Monserrat Román-Sánchez, Edgar Jiménez-Sánchez, José Cruz-Santiago, Guillermo Meza-Jiménez, Germán Bernáldez-Gómez. Evaluation of Renal Function at 24, 48, and 72 Hours and 3 Months After Transplant: Comparison of 3 Anesthetic Techniques. Transplantation proceedings. 2020 May; 52(4):1094-1101. doi: 10.1016/j.transproceed.2020.02.011. [PMID: 32178928]