Amyl Nitrite (BioDeep_00000006503)
Secondary id: BioDeep_00000019545, BioDeep_00001868064
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
Isopentyl nitrite
化学式: C5H11NO2 (117.0789746)
中文名称: 亚硝酸异戊酯, 亚硝酸戊酯
谱图信息:
最多检出来源 Homo sapiens(blood) 0.6%
分子结构信息
SMILES: CC(C)CCON=O
InChI: InChI=1S/C5H11NO2/c1-2-3-4-5-8-6-7/h2-5H2,1H3
描述信息
Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use.
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:55344
- ChEBI: CHEBI:2691
- KEGG: C07457
- KEGGdrug: D00517
- PubChem: 10026
- PubChem: 8053
- HMDB: HMDB0015550
- Metlin: METLIN6762
- DrugBank: DB01612
- ChEMBL: CHEMBL3188202
- ChEMBL: CHEMBL1535371
- Wikipedia: Amyl nitrite
- MeSH: Amyl Nitrite
- chemspider: 9632
- CAS: 463-04-7
- CAS: 110-46-3
- PubChem: 9660
- NIKKAJI: J5.092J
- KNApSAcK: 2691
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ruri Kikura-Hanajiri, Nahoko Uchiyama, Maiko Kawamura, Jun Ogata, Yukihiro Goda. [Prevalence of new designer drugs and their legal status in Japan].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2013; 133(1):31-40. doi:
10.1248/yakushi.12-00247-6. [PMID: 23292017] - Ioannis S Minas, Georgia Tanou, Maya Belghazi, Dominique Job, George A Manganaris, Athanassios Molassiotis, Miltiadis Vasilakakis. Physiological and proteomic approaches to address the active role of ozone in kiwifruit post-harvest ripening.
Journal of experimental botany.
2012 Apr; 63(7):2449-64. doi:
10.1093/jxb/err418. [PMID: 22268155] - Christoph Sauer, Kerstin Hoffmann, Ulrich Schimmel, Frank T Peters. Acute poisoning involving the pyrrolidinophenone-type designer drug 4'-methyl-alpha-pyrrolidinohexanophenone (MPHP).
Forensic science international.
2011 May; 208(1-3):e20-5. doi:
10.1016/j.forsciint.2011.02.026. [PMID: 21444164] - Kukhuon Jeong, Yong-Cheol Shin, Sunju Park, Jeong-Su Park, Namil Kim, Jae-Young Um, Hoyeon Go, Seungho Sun, Sundong Lee, Wansu Park, Youkyung Choi, Yunkyung Song, Gyungjun Kim, Chanyong Jeon, Jonghyeong Park, Keysang Lee, Oksun Bang, Seong-Gyu Ko. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice.
Journal of biomedical science.
2011 Feb; 18(?):14. doi:
10.1186/1423-0127-18-14. [PMID: 21299906] - Ming J Wu, Patrick J O'Doherty, Patricia A Murphy, Victoria Lyons, Melinda Christophersen, Peter J Rogers, Trevor D Bailey, Vincent J Higgins. Different reactive oxygen species lead to distinct changes of cellular metal ions in the eukaryotic model organism Saccharomyces cerevisiae.
International journal of molecular sciences.
2011; 12(11):8119-32. doi:
10.3390/ijms12118119. [PMID: 22174654] - Jong Geun Baek, Hoar Lim Jeong, Ji Sook Park, Ji Hyun Seo, Eun Sil Park, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn, Jung Sook Yeom. Successful treatment by exchange transfusion of a young infant with sodium nitroprusside poisoning.
Korean journal of pediatrics.
2010 Aug; 53(8):805-8. doi:
10.3345/kjp.2010.53.8.805. [PMID: 21189979] - F Giuliano, G Jackson, F Montorsi, A Martin-Morales, P Raillard. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database.
International journal of clinical practice.
2010 Jan; 64(2):240-55. doi:
10.1111/j.1742-1241.2009.02254.x. [PMID: 19900167] - Yu Ishima, Takaaki Akaike, Ulrich Kragh-Hansen, Shuichi Hiroyama, Tomohiro Sawa, Ayaka Suenaga, Toru Maruyama, Toshiya Kai, Masaki Otagiri. S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding.
The Journal of biological chemistry.
2008 Dec; 283(50):34966-75. doi:
10.1074/jbc.m807009200. [PMID: 18940810] - John E Mendelson, Dana McGlothlin, Debra S Harris, Elyse Foster, Tom Everhart, Peyton Jacob, Reese T Jones. The clinical pharmacology of intranasal l-methamphetamine.
BMC clinical pharmacology.
2008 Jul; 8(?):4. doi:
10.1186/1472-6904-8-4. [PMID: 18644153] - Naohisa Katayama, Keisuke Nakajou, Hisakazu Komori, Kunitoshi Uchida, Jun-Ichi Yokoe, Norikiyo Yasui, Hisashi Yamamoto, Toshiya Kai, Makoto Sato, Takenobu Nakagawa, Motohiro Takeya, Toru Maruyama, Masaki Otagiri. Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):69-76. doi:
10.1124/jpet.107.132100. [PMID: 18218831] - Valerie J Rose, H Fisher Raymond, Timothy A Kellogg, Willi McFarland. Assessing the feasibility of harm reduction services for MSM: the late night breakfast buffet study.
Harm reduction journal.
2006 Oct; 3(?):29. doi:
10.1186/1477-7517-3-29. [PMID: 17018154] - Maryam Akhyani, Mohammad-Reza Ganji, Nasrin Samadi, Behnaz Khamesan, Maryam Daneshpazhooh. Pruritus in hemodialysis patients.
BMC dermatology.
2005 Jun; 5(?):7. doi:
10.1186/1471-5945-5-7. [PMID: 15975150] - Adrian C Nicolescu, James N Reynolds, L Ross C Barclay, Gregory R J Thatcher. Organic nitrites and NO: inhibition of lipid peroxidation and radical reactions.
Chemical research in toxicology.
2004 Feb; 17(2):185-96. doi:
10.1021/tx034097p. [PMID: 14967006] - Adrian C Nicolescu, Sergei I Zavorin, Nicholas J Turro, James N Reynolds, Gregory R J Thatcher. Inhibition of lipid peroxidation in synaptosomes and liposomes by nitrates and nitrites.
Chemical research in toxicology.
2002 Jul; 15(7):985-98. doi:
10.1021/tx025529j. [PMID: 12119011] - V M Ramanathan, T G Reigle, S Muralidhara, C E Dallas. Effects of acute inhalation exposure to isoamyl nitrite on the hypothalamo-pituitary-adrenal axis in male Sprague-Dawley rats.
Journal of toxicology and environmental health. Part A.
1998 Nov; 55(5):345-58. doi:
10.1080/009841098158395. [PMID: 9829558] - H Wurzburg. Treatment of cyanide poisoning in an industrial setting.
Veterinary and human toxicology.
1996 Feb; 38(1):44-7. doi:
. [PMID: 8825751] - E A Kowaluk, H L Fung. Vascular nitric oxide-generating activities for organic nitrites and organic nitrates are distinct.
The Journal of pharmacology and experimental therapeutics.
1991 Nov; 259(2):519-25. doi:
. [PMID: 1682477] - R Klimmek, C Krettek, H W Werner. Ferrihaemoglobin formation by amyl nitrite and sodium nitrite in different species in vivo and in vitro.
Archives of toxicology.
1988; 62(2-3):152-60. doi:
10.1007/bf00570133. [PMID: 2904249] - S S Mirvish, M D Ramm, D M Babcook. Indications from animal and chemical experiments of a carcinogenic role for isobutyl nitrite.
NIDA research monograph.
1988; 83(?):39-49. doi:
". [PMID: 2902514] - S S Mirvish, M D Ramm, D M Babcook, J P Sams, M Panigot. Lipidic nitrosating agents produced from atmospheric nitrogen dioxide and a nitrosamine produced in vivo from amyl nitrite.
IARC scientific publications.
1987; ?(84):315-8. doi:
. [PMID: 2890579] - G W Bisset, H S Chowdrey. A cholinergic link in the reflex release of vasopressin by hypotension in the rat.
The Journal of physiology.
1984 Sep; 354(?):523-45. doi:
10.1113/jphysiol.1984.sp015391. [PMID: 6148413] - A R Olshan, D T O'Connor, I M Cohen, J A Mitas, R A Stone. Baroreflex dysfunction in patients with adult-onset diabetes and hypertension.
The American journal of medicine.
1983 Feb; 74(2):233-42. doi:
10.1016/0002-9343(83)90617-4. [PMID: 6130701] - C J Estler. [Side effects of drugs and their cause].
Tierarztliche Praxis.
1981; 9(3):411-20. doi:
NULL. [PMID: 6129722] - O Tomiyama, T Shiigai, T Ideura, K Tomita, Y Mito, S Shinohara, J Takeuchi. Baroreflex sensitivity in renal failure.
Clinical science (London, England : 1979).
1980 Jan; 58(1):21-7. doi:
10.1042/cs0580021. [PMID: 7353350] - J J Lilley, J Golden, R A Stone. Adrenergic regulation of blood pressure in chronic renal failure.
The Journal of clinical investigation.
1976 May; 57(5):1190-200. doi:
10.1172/jci108387. [PMID: 1262465] - T Sawatzki, G Werner. [Extended cutaneous necroses after self-medication of abrasion wounds with Pectocor-ointment].
Zeitschrift fur arztliche Fortbildung.
1975 Dec; 69(23):1219-21. doi:
". [PMID: 1229161] - R A Miller, N C Flowers, T B Berndt, V H Johnson. Polycystic kidney disease, hypertension, and subaortic stenosis.
Southern medical journal.
1974 Mar; 67(3):354-7. doi:
10.1097/00007611-197403000-00029. [PMID: 4273398] - J M Lazarus, C L Hampers, E G Lowrie, J P Merrill. Baroreceptor activity in normotensive and hypertensive uremic patients.
Circulation.
1973 May; 47(5):1015-21. doi:
10.1161/01.cir.47.5.1015. [PMID: 4350274] - T Ino. Study on the idiopathic cardiomyopathy. Diagnostic value of the apexcardiogram, 131 Cs scintiscanning of the heart and plasma hydroxyproline.
Japanese circulation journal.
1971 Jul; 35(7):731-6. doi:
10.1253/jcj.35.731. [PMID: 5170990] - L L Branchevskiĭ. [Mechanism of changes of natriuresis in experimental acute myocardial ischemia].
Kardiologiia.
1970 Dec; 10(12):37-41. doi:
NULL. [PMID: 5507774] - N Akatsuka. Studies of pulmonary blood volume in man. Effect of amyl nitrite.
Japanese heart journal.
1969 Jul; 10(4):307-17. doi:
10.1536/ihj.10.307. [PMID: 5307393] - A A Lebedev, A S Malachevskaia. [Homeostatic kidney functions in hemorrhage and vasomotor collapse].
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova.
1968 Sep; 54(9):1115-22. doi:
NULL. [PMID: 4977617] - E G Biglieri, M B McIlroy. Abnormalities of renal function and circulatory reflexes in primary aldosteronism.
Circulation.
1966 Jan; 33(1):78-86. doi:
10.1161/01.cir.33.1.78. [PMID: 5901761] - W S KISER, H L TANENBAUM, J M HOLLAND. THE PHONORENOGRAM: TRANSURETERAL PHONOCATHETER RECORDING OF THE RENAL ARTERY PULSE IN THE DIAGNOSIS OF RENAL VASCULAR DISEASE.
The Journal of urology.
1964 Nov; 92(?):391-8. doi:
10.1016/s0022-5347(17)63974-0. [PMID: 14226461]