Maleic imide (BioDeep_00000006450)
Secondary id: BioDeep_00001867994
human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
Maleimide, potassium, silver (+1) (2:1:1) salt
化学式: C4H3NO2 (97.0163778)
中文名称: 马来酰亚胺
谱图信息:
最多检出来源 Homo sapiens(blood) 0.22%
分子结构信息
SMILES: C1=CC(=O)NC1=O
InChI: InChI=1S/C4H3NO2/c6-3-1-2-4(7)5-3/h1-2H,(H,5,6,7)
描述信息
Maleimide can be used for production of antibody-drug conjugate (ADC) which is used in cancer research. Maleimide also be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes[1][2].
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:16072
- KEGG: C07272
- PubChem: 10935
- HMDB: HMDB0254312
- Metlin: METLIN66614
- ChEMBL: CHEMBL387762
- Wikipedia: Maleimide
- MetaCyc: MALEIMIDE
- KNApSAcK: C00027734
- chemspider: 10471
- CAS: 541-59-3
- PMhub: MS000019493
- PubChem: 9481
- PDB-CCD: SZB
- 3DMET: B01084
- NIKKAJI: J6.395I
- medchemexpress: HY-W007324
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-118
- KNApSAcK: 16072
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michelle D Farrelly, Jiali Zhai, Alice Y J Tiong, Leonie van 't Hag, Heidi H Yu, Jian Li, Lisandra L Martin, San H Thang. Membrane interaction and selectivity of novel alternating cationic lipid-nanodisc assembling polymers.
Biomaterials science.
2023 Jul; ?(?):. doi:
10.1039/d3bm00477e. [PMID: 37477383] - Hideki Kashiwagi, Shinji Kawabata, Kohei Yoshimura, Yusuke Fukuo, Takuya Kanemitsu, Koji Takeuchi, Ryo Hiramatsu, Kai Nishimura, Kazuki Kawai, Takushi Takata, Hiroki Tanaka, Tsubasa Watanabe, Minoru Suzuki, Shin-Ichi Miyatake, Hiroyuki Nakamura, Masahiko Wanibuchi. Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model.
Investigational new drugs.
2022 04; 40(2):255-264. doi:
10.1007/s10637-021-01201-7. [PMID: 34816337] - Javier Giglio, Soledad Fernandez, Ana Martinez, Maia Zeni, Laura Reyes, Ana Rey, Hugo Cerecetto. Glycogen Synthase Kinase-3 Maleimide Inhibitors As Potential PET-Tracers for Imaging Alzheimer's Disease: 11C-Synthesis and In Vivo Proof of Concept.
Journal of medicinal chemistry.
2022 01; 65(2):1342-1351. doi:
10.1021/acs.jmedchem.1c00769. [PMID: 34464131] - Yu Ishima, Nio Yamazaki, Victor T G Chuang, Taro Shimizu, Hidenori Ando, Tatsuhiro Ishida. A Maleimide-Terminally Modified PEGylated Liposome Induced the Accelerated Blood Clearance Independent of the Production of Anti-PEG IgM Antibodies.
Biological & pharmaceutical bulletin.
2022; 45(10):1518-1524. doi:
10.1248/bpb.b22-00389. [PMID: 36184510] - Nobuko Kuroishi, Sayaka Nagata, Emiko Akashi, Shinya Ashizuka, Johji Kato, Motoo Yamasaki, Kazuo Kitamura. Development of a novel human adrenomedullin derivative: human serum albumin-conjugated adrenomedullin.
Journal of biochemistry.
2021 Dec; 170(4):445-451. doi:
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Molecules (Basel, Switzerland).
2021 May; 26(9):. doi:
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Bioconjugate chemistry.
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Bioconjugate chemistry.
2020 08; 31(8):1995-2007. doi:
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Bioconjugate chemistry.
2019 12; 30(12):3107-3118. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2019 Oct; 143(?):24-34. doi:
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Bioconjugate chemistry.
2019 09; 30(9):2340-2348. doi:
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Bioconjugate chemistry.
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Acta biomaterialia.
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Biomacromolecules.
2019 02; 20(2):653-661. doi:
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Bioconjugate chemistry.
2018 02; 29(2):473-485. doi:
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2018 Jan; 111(?):83-90. doi:
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2017 Dec; 18(12):4141-4153. doi:
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Organic & biomolecular chemistry.
2017 Nov; 15(44):9305-9310. doi:
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Bioconjugate chemistry.
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Bioconjugate chemistry.
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Bioconjugate chemistry.
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