Mezlocillin (BioDeep_00000006443)

 

Secondary id: BioDeep_00001867845

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulphonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C21H25N5O8S2 (539.1144)
中文名称: 美洛西林
谱图信息: 最多检出来源 Homo sapiens(blood) 91.67%

分子结构信息

SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)NC(=O)N4CCN(C4=O)S(=O)(=O)C)C(=O)O)C
InChI: InChI=1S/C21H25N5O8S2/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30)/t12-,13-,14+,17-/m1/s1

描述信息

Mezlocillin is only found in individuals that have used or taken this drug. It is a semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. [PubChem]By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that mezlocillin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

33 个代谢物同义名

(2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulphonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulphonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-6-[(2R)-2-[(3-methanesulfonyl-2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6beta-{(2R)-2-[3-(methanesulphonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid; 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid; 6Β-{(2R)-2-[3-(methanesulphonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid; 6b-{(2R)-2-[3-(methanesulphonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid; 6beta-{(2R)-2-[3-(methanesulphonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate; 6b-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid; 6Β-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic acid; 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate; 6Β-{(2R)-2-[3-(methanesulphonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate; 6b-{(2R)-2-[3-(methanesulphonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate; 6Β-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate; 6b-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate; Curasan brand OF mezlocillin sodium (sterile); Bayer brand OF mezlocillin sodium (sterile); Sodium, mezlocillin; Mezlocillin Sodium; Mezlocillinum; Mezlocilline; Meslocillin; Mezlocilina; Mezlocillin; Bay F 1353; Bay-f 1353; Bayf 1353; Melocin; Baypen; Mezlin; Mezlin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALB, MME, ODC1
Peripheral membrane protein 1 CYP27A1
Endoplasmic reticulum membrane 2 MOXD1, REEP6
Mitochondrion membrane 1 CYP27A1
Nucleus 2 ALB, REEP6
cytosol 5 ALB, GPT, IFITM5, LIPE, ODC1
dendrite 2 EPHA5, MME
trans-Golgi network 1 MME
centrosome 1 ALB
Cell membrane 5 CTNS, EPHA5, IFITM5, LIPE, MME
Cell projection, axon 1 EPHA5
Multi-pass membrane protein 3 CTNS, IFITM5, REEP6
Synapse 1 MME
cell surface 1 MME
Golgi apparatus 1 ALB
Golgi membrane 1 INS
lysosomal membrane 1 CTNS
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 2 EPHA5, MME
synaptic vesicle 1 MME
Cytoplasm, cytosol 1 LIPE
Lysosome 1 CTNS
Presynapse 1 MME
plasma membrane 7 CSF2, CTNS, EPHA5, F2, IFITM5, LCT, MME
Membrane 5 CTNS, EPHA5, LIPE, MME, REEP6
axon 2 EPHA5, MME
brush border 1 MME
caveola 1 LIPE
extracellular exosome 6 ALB, CTNS, F2, GPT, LYZ, MME
endoplasmic reticulum 2 ALB, REEP6
extracellular space 9 ALB, CPZ, CRP, CSF2, CSF3, F2, INS, LYZ, MOXD1
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 1 EPHA5
mitochondrion 1 CYP27A1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 CSF2, CTNS, IFITM5
Single-pass type I membrane protein 3 EPHA5, LCT, MOXD1
Secreted 6 ALB, CRP, CSF2, CSF3, F2, INS
extracellular region 7 ALB, CRP, CSF2, CSF3, F2, INS, LYZ
mitochondrial matrix 1 CYP27A1
anchoring junction 1 ALB
photoreceptor inner segment 1 REEP6
external side of plasma membrane 1 EPHA5
Secreted, extracellular space, extracellular matrix 1 CPZ
cytoplasmic vesicle 1 MME
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 REEP6
clathrin-coated vesicle membrane 1 REEP6
Melanosome membrane 1 CTNS
Early endosome 1 MME
Single-pass type II membrane protein 1 MME
Apical cell membrane 1 LCT
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 MME
focal adhesion 1 MME
collagen-containing extracellular matrix 1 F2
Late endosome 1 CTNS
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, F2
Endomembrane system 1 CTNS
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cell projection, dendrite 1 EPHA5
Melanosome 1 CTNS
secretory granule lumen 1 INS
secretory granule membrane 2 MME, MOXD1
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 ALB, F2, INS
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
external side of apical plasma membrane 1 LCT
Rough endoplasmic reticulum 1 EPHA5
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
[Isoform 1]: Lysosome membrane 1 CTNS
[Isoform 2]: Lysosome membrane 1 CTNS
endocytic vesicle lumen 1 CSF3
neuron projection terminus 1 MME
ciliary transition fiber 1 ALB


文献列表

  • Milan Sencanski, Vladimir Perovic, Snezana B Pajovic, Miroslav Adzic, Slobodan Paessler, Sanja Glisic. Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method. Molecules (Basel, Switzerland). 2020 Aug; 25(17):. doi: 10.3390/molecules25173830. [PMID: 32842509]
  • Huan Xia, Jinying Gao, Ming Xiu, Dan Li. Community-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus in a Chinese adult: A case report. Medicine. 2020 Jun; 99(26):e20914. doi: 10.1097/md.0000000000020914. [PMID: 32590802]
  • Aurijit Sarkar, Kelcey C Anderson, Glen E Kellogg. Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. European journal of medicinal chemistry. 2012 Jun; 52(?):98-110. doi: 10.1016/j.ejmech.2012.03.008. [PMID: 22483632]
  • Eric Gomez, Martha Sanchez, Zonaira Gul, Carl Urban, Noriel Mariano, Robert H K Eng, David B Huang, Tom Chiang. Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases. Case reports in medicine. 2011; 2011(?):659769. doi: 10.1155/2011/659769. [PMID: 22162703]
  • Nuh N Rahbari, Johannes B Zimmermann, Moritz Koch, Thomas Bruckner, Thomas Schmidt, Heike Elbers, Christoph Reissfelder, Markus A Weigand, Markus W Büchler, Jürgen Weitz. IVC CLAMP: infrahepatic inferior vena cava clamping during hepatectomy--a randomised controlled trial in an interdisciplinary setting. Trials. 2009 Oct; 10(?):94. doi: 10.1186/1745-6215-10-94. [PMID: 19825186]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Ignas Bunikis, Katrin Denker, Yngve Ostberg, Christian Andersen, Roland Benz, Sven Bergström. An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds. PLoS pathogens. 2008 Feb; 4(2):e1000009. doi: 10.1371/journal.ppat.1000009. [PMID: 18389081]
  • Boris P Ehrenstein, Lea Salamon, Hans-Jörg Linde, Helmut Messmann, Jürgen Schölmerich, Thomas Glück. Clinical determinants for the recovery of fungal and mezlocillin-resistant pathogens from bile specimens. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2002 Apr; 34(7):902-8. doi: 10.1086/339209. [PMID: 11880954]
  • M Schwarz, R Isenmann, E Weikert, P Ebeling, J Thomsen, H G Beger. Pharmacokinetic basis for oral perioperative prophylaxis with ofloxacin in general surgery. Infection. 2001 Aug; 29(4):222-7. doi: 10.1007/s15010-001-1151-5. [PMID: 11545485]
  • H Bernhardt, K Schulz, K Zimmermann, M Knoke. Influence of ciprofloxacin and other antimicrobial drugs on different Escherichia coli strains in continuous-flow cultures under aerobic and anaerobic conditions. The Journal of antimicrobial chemotherapy. 1998 Aug; 42(2):147-52. doi: 10.1093/jac/42.2.147. [PMID: 9738831]
  • J C García-Gonzalez, R Méndez, J Martín-Villacorta. Determination of piperacillin and mezlocillin in human serum and urine by high-performance liquid chromatography after derivatisation with 1,2,4-triazole. Journal of chromatography. A. 1998 Jul; 812(1-2):213-20. doi: 10.1016/s0021-9673(98)00389-6. [PMID: 9691320]
  • P A McCormick, L Greenslade, C C Kibbler, J K Chin, A K Burroughs, N McIntyre. A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients. Hepatology (Baltimore, Md.). 1997 Apr; 25(4):833-6. doi: 10.1002/hep.510250408. [PMID: 9096584]
  • B Rohde, U Werner, H Hickstein, H Ehmcke, B Drewelow. Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure. European journal of clinical pharmacology. 1997; 53(2):111-5. doi: 10.1007/s002280050347. [PMID: 9403281]
  • R Hildebrandt, U Gundert-Remy, R Raedsch, A Sieg, A Stiehl. Biliary excretion of mezlocillin in patients with hepatic disease. International journal of clinical pharmacology and therapeutics. 1995 Jul; 33(7):384-7. doi: NULL. [PMID: 7582392]
  • G Hotz, J Novotny-Lenhard, M Kinzig, F Soergel. Single-dose antibiotic prophylaxis in maxillofacial surgery. Chemotherapy. 1994 Jan; 40(1):65-9. doi: 10.1159/000239173. [PMID: 8306818]
  • M C Sullivan, C H Nightingale, R Quintiliani, K Sweeney. Comparison of the pharmacokinetic and pharmacodynamic activity of piperacillin and mezlocillin. Pharmacotherapy. 1993 Nov; 13(6):607-12. doi: NULL. [PMID: 8302686]
  • R J Rosenthal, S D Steigerwald, H Bockhorn. [Bile composition and antibiotic excretion. Observations with T-drainage]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1993 Jan; 48(1):18-22. doi: . [PMID: 8095119]
  • A E Yellin, T V Berne, M D Appleman, P N Heseltine, M A Gill, M P Okamoto, F J Baker, C Holcomb. A randomized study of cefepime versus the combination of gentamicin and mezlocillin as an adjunct to surgical treatment in patients with acute cholecystitis. Surgery, gynecology & obstetrics. 1993; 177 Suppl(?):23-9; discussion 35. doi: 10.1016/0020-7292(94)90427-8. [PMID: 8256188]
  • A Luttkus, K Windel, J W Dudenhausen. [Prospective study of the clinical value of C-reactive protein in amniotic infection syndrome]. Zeitschrift fur Geburtshilfe und Perinatologie. 1993 Jan; 197(1):31-7. doi: NULL. [PMID: 8484276]
  • Y Tokat, A Coker, A Basci, C Hoscoskun, H Kaplan, O Yararbas. Is mezlocilline prophylaxis effective in clinical renal transplantation?. Transplantation proceedings. 1992 Oct; 24(5):1757. doi: NULL. [PMID: 1412827]
  • N Atabey, M Gökoğlu. [The effect of some antibiotics on primary antibody response]. Mikrobiyoloji bulteni. 1991 Jul; 25(3):265-71. doi: NULL. [PMID: 1762594]
  • G C Oliva, A Fratoni, L Papadia, A Pieroni, P L Paparella, S Mancuso. Antibiotic prophylaxis in gynecological surgery. Journal of chemotherapy (Florence, Italy). 1990 Oct; 2(5):306-9. doi: 10.1080/1120009x.1990.11739034. [PMID: 2090769]
  • F De Lalla, W Bonini, T Broffoni, G Ferrari, G Alegente. Prophylactic mezlocillin-netilmicin combination in permanent transvenous cardiac pacemaker implantation: a single-center, prospective, randomized study. Journal of chemotherapy (Florence, Italy). 1990 Aug; 2(4):252-6. doi: 10.1080/1120009x.1990.11739026. [PMID: 2230910]
  • A C van Lindert, A R Giltaij, M D Derksen, G P Alsbach, M Rozenberg-Arska, J Verhoef. Single-dose prophylaxis with broad-spectrum penicillins (piperacillin and mezlocillin) in gynecologic oncological surgery, with observation on serum and tissue concentrations. European journal of obstetrics, gynecology, and reproductive biology. 1990 Jul; 36(1-2):137-45. doi: 10.1016/0028-2243(90)90059-a. [PMID: 2365119]
  • S L Barriere, D H Catlin, P L Orlando, A Noe, R W Frost. Alteration in the pharmacokinetic disposition of ciprofloxacin by simultaneous administration of azlocillin. Antimicrobial agents and chemotherapy. 1990 May; 34(5):823-6. doi: 10.1128/aac.34.5.823. [PMID: 2360821]
  • W Elies, H Hermes. [Early complications following stapedectomy--surgical or conservative treatment?]. HNO. 1990 Feb; 38(2):67-70. doi: NULL. [PMID: 1690691]
  • K Amendt, R Hild. Pharmacokinetics of mezlocillin after intraarterial or intravenous injection in patients with peripheral arterial occlusive disease (PAOD). VASA. Zeitschrift fur Gefasskrankheiten. 1990; 19(2):161-6. doi: NULL. [PMID: 2371791]
  • J T DiPiro, J B Davis, F D Boudinot, R P Cheung, J F Sisley. Investigation of mezlocillin disposition with a porcine model. Biopharmaceutics & drug disposition. 1989 Nov; 10(6):563-72. doi: 10.1002/bdd.2510100605. [PMID: 2611357]
  • M Mayer, U Simon, H Strosche, W Schonfeld. Pharmacokinetics of mezlocillin in pleural fluid. The British journal of clinical practice. 1989 Jul; 43(7):246-8. doi: NULL. [PMID: 2597608]
  • P Chastagner, O Hartmann, C Tancrede, C Kalifa, C Patte, F Flamant, J Lemerle. Role of parenteral antibiotherapy in gastrointestinal tract flora suppression. A study in children treated with high-dose chemotherapy and autologous bone marrow transplantation. Bone marrow transplantation. 1989 Jul; 4(4):393-8. doi: NULL. [PMID: 2673459]
  • W B Gerecht, N K Henry, W W Hoffman, S M Muller, N F LaRusso, J E Rosenblatt, W R Wilson. Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis. Archives of internal medicine. 1989 Jun; 149(6):1279-84. doi: . [PMID: 2658897]
  • G L Jungbluth, W J Jusko. Dose-dependent pharmacokinetics of mezlocillin in rats. Antimicrobial agents and chemotherapy. 1989 Jun; 33(6):839-43. doi: 10.1128/aac.33.6.839. [PMID: 2764534]
  • L C Rodondi, J F Flaherty, P Schoenfeld, S L Barriere, J G Gambertoglio. Influence of coadministration on the pharmacokinetics of mezlocillin and cefotaxime in healthy volunteers and in patients with renal failure. Clinical pharmacology and therapeutics. 1989 May; 45(5):527-34. doi: 10.1038/clpt.1989.68. [PMID: 2721108]
  • K Roszkowski, H L Ko, J Beuth, Y Ohshima, W Roszkowski, J Jeljaszewicz, G Pulverer. Intestinal microflora of BALB/c-mice and function of local immune cells. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. 1988 Nov; 270(1-2):270-9. doi: 10.1016/s0176-6724(88)80163-9. [PMID: 3223141]
  • C W Jones, H Chmel. Solid-phase ion-pair extraction and liquid chromatography of mezlocillin in serum. Clinical chemistry. 1988 Oct; 34(10):2155-6. doi: NULL. [PMID: 3168240]
  • R Sage, I Hann, H G Prentice, S Devereux, R Corringham, A V Hoffbrand, H Blacklock, L Stirling, M Guimaraes, E Trikka. A randomized trial of empirical antibiotic therapy with one of four beta-lactam antibiotics in combination with netilmicin in febrile neutropenic patients. The Journal of antimicrobial chemotherapy. 1988 Aug; 22(2):237-47. doi: 10.1093/jac/22.2.237. [PMID: 3053555]
  • P Jones, G P Bodey, K Rolston, V Fainstein, S Riccardi. Cefoperazone plus mezlocillin for empiric therapy of febrile cancer patients. The American journal of medicine. 1988 Jul; 85(1A):3-8. doi: 10.1016/0002-9343(88)90168-4. [PMID: 3400680]
  • J Knöller, W Schönfeld, M Mayer, W König. Mezlocillin in pleural effusions--analysis by HPLC. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. 1988 May; 268(3):370-5. doi: 10.1016/s0176-6724(88)80022-1. [PMID: 3407362]
  • J Boldt, F Salomon, W Krumholz, G Hempelmann. [Effect of continuous mechanical hemofiltration on the pharmacokinetics of antibiotics exemplified by mezlocillin]. Anasthesie, Intensivtherapie, Notfallmedizin. 1988 Apr; 23(2):91-4. doi: NULL. [PMID: 3394906]
  • R P Smith, H J Wilbur, C Bassey, A L Baltch. Azlocillin and mezlocillin concentration in human prostatic tissue. Chemotherapy. 1988; 34(4):267-71. doi: 10.1159/000238579. [PMID: 3208544]
  • G L Jungbluth, F H Wirth, T T Rubio, D M Janicke, W J Jusko. Developmental pharmacokinetics of mezlocillin in 4 newborn infants. Developmental pharmacology and therapeutics. 1988; 11(6):317-21. doi: 10.1159/000457710. [PMID: 3229277]
  • P Van der Auwera, M Husson, J Klastersky. Bactericidal activity and killing rate of serum in volunteers receiving pefloxacin alone or in combination with ceftazidime, piperacillin or mezlocillin against Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy. 1988 Jan; 21(1):49-55. doi: 10.1093/jac/21.1.49. [PMID: 3128521]
  • R D Adelman, F Wirth, T Rubio. A controlled study of the nephrotoxicity of mezlocillin and gentamicin plus ampicillin in the neonate. The Journal of pediatrics. 1987 Dec; 111(6 Pt 1):888-93. doi: 10.1016/s0022-3476(87)80212-3. [PMID: 3316564]
  • M G Martens, S Faro, S Feldman, D B Cotton, K Dorman, G D Riddle. Pharmacokinetics of the acyclureidopenicillins piperacillin and mezlocillin in the postpartum patient. Antimicrobial agents and chemotherapy. 1987 Dec; 31(12):2015-7. doi: 10.1128/aac.31.12.2015. [PMID: 3439808]
  • R D Adelman, F Wirth, T Rubio. A controlled study of the nephrotoxicity of mezlocillin and amikacin in the neonate. American journal of diseases of children (1960). 1987 Nov; 141(11):1175-8. doi: 10.1001/archpedi.1987.04460110045019. [PMID: 3314475]
  • B R Meyers, M H Mendelson, E Srulevitch-Chin, K Bradbury, L McMurdo, S Z Hirschman. Pharmacokinetic properties of mezlocillin in ambulatory elderly subjects. Journal of clinical pharmacology. 1987 Sep; 27(9):678-81. doi: 10.1002/j.1552-4604.1987.tb03087.x. [PMID: 3680597]
  • J F Flaherty, S L Barriere, J Mordenti, J G Gambertoglio. Effect of dose on pharmacokinetics and serum bactericidal activity of mezlocillin. Antimicrobial agents and chemotherapy. 1987 Jun; 31(6):895-8. doi: 10.1128/aac.31.6.895. [PMID: 3619421]
  • M Mounier, G Lachatre, B Antoine, R Desroches, J Michel, F Denis, G Nicot. Pharmacokinetics of intravenous mezlocillin in elderly patients. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1987 Jun; 6(2 Suppl):254-5. doi: NULL. [PMID: 3509401]
  • K Amendt, W Rexroth, U Römmele, U Stein, E Wagner, R Hild. [Intra-arterial injection of mezlocillin in stage IV arterial occlusive disease. A comparison of serum and tissue concentrations following intra-arterial and intravenous injection]. VASA. Zeitschrift fur Gefasskrankheiten. 1987; 16(2):193-200. doi: NULL. [PMID: 3604409]
  • J P Marie, D Thevenin, R Zittoun. [In vitro inhibition of granulopoiesis by beta-lactam antibiotics. Comparison of piperacillin, mezlocillin, ceftriaxone and ceftazidime]. Presse medicale (Paris, France : 1983). 1986 Dec; 15(46):2358-61. doi: . [PMID: 2949287]
  • B R Meyers, E S Srulevitch, H S Sacks, S Z Hirschman, T M Worner, G P Wormser, J Jacobson. Pharmacokinetics of mezlocillin in patients with hepatobiliary dysfunction. The Journal of antimicrobial chemotherapy. 1986 Dec; 18(6):709-13. doi: 10.1093/jac/18.6.709. [PMID: 3818496]
  • P Martinetto, M Gariglio, G P Cavallo, A Malcangi, M Vitale. In vitro antimicrobial activity in comparison with tonsillar tissue penetration of mezlocillin. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1986 Dec; 5(6):385-7. doi: NULL. [PMID: 3802299]
  • P A Colaizzi, A A Coniglio, W J Poynor, N Vishniavsky, H T Karnes, R E Polk. Comparative pharmacokinetics of two multiple-dose mezlocillin regimens in normal volunteers. Antimicrobial agents and chemotherapy. 1986 Nov; 30(5):675-8. doi: 10.1128/aac.30.5.675. [PMID: 3800343]
  • B E Cooper, T J Nester, D K Armstrong, J F Dasta. High serum concentrations of mezlocillin in a critically ill patient with renal and hepatic dysfunction. Clinical pharmacy. 1986 Sep; 5(9):764-6. doi: NULL. [PMID: 3757449]
  • A Lewandowski, W Kozaczek, T Orlowski, H Weuta. Kidney function of pyelonephritis patients with impaired renal function treated with mezlocillin. Arzneimittel-Forschung. 1986 Jul; 36(7):1148-50. doi: . [PMID: 3768087]
  • P G Jones, S V Strother, K V Rolston, V Fainstein, G P Bodey. Hypoprothrombinemia in patients with cancer receiving cefoperazone and mezlocillin. Archives of internal medicine. 1986 Jul; 146(7):1397-9. doi: NULL. [PMID: 3521526]
  • M D Lyon, K R Smith, M S Saag, G A Cloud, C G Cobbs. In vitro activity of piperacillin, ticarcillin, and mezlocillin alone and in combination with aminoglycosides against Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy. 1986 Jul; 30(1):25-30. doi: 10.1128/aac.30.1.25. [PMID: 3092731]
  • R Palla, V Panichi, A Bionda, R Cominotto, C Di Stratis, P Galigani, M Neri. Acute renal failure after mezlocilline. Clinical nephrology. 1986 Jun; 25(6):315-6. doi: NULL. [PMID: 3731548]
  • E Rubinstein, Z Mark, Y Samra, M Alkan, S Berger. In vitro activity of ciprofloxacin compared with other agents against recent hospital isolates. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1986 Apr; 5(2):75-82. doi: . [PMID: 2939966]
  • J R Wallace, R D Cushing, R E Bawdon, C Sugawa, C E Lucas, A M Ledgerwood. Assessment of antimicrobial penetrance into the pancreatic juice in humans. Surgery, gynecology & obstetrics. 1986 Apr; 162(4):313-6. doi: NULL. [PMID: 3485828]
  • J Knöller, K D Bremm, W Schönfeld, W König. Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures. Antimicrobial agents and chemotherapy. 1986 Mar; 29(3):527-9. doi: 10.1128/aac.29.3.527. [PMID: 3013089]
  • Y Van Laethem, J Klastersky. Serum bactericidal activity of mezlocillin, ceftazidime, mezlocillin/ceftazidime and mezlocillin/amikacin against Klebsiella pneumoniae and Pseudomonas aeruginosa. European journal of clinical microbiology. 1986 Feb; 5(1):110-4. doi: 10.1007/bf02013479. [PMID: 3084239]
  • F Di Nola, M L Soranzo, E Capra, M Eandi, B Salassa, R Arione, T Cimino, M Grosa, M Chiavarino, C Bramato. [Cefoperazone: microbiological, kinetic and clinical studies]. Minerva medica. 1985 Oct; 76(39):1795-801. doi: NULL. [PMID: 4047462]
  • F Daschner, H M Just, I Kappstein, H Spillner, V Schlosser. Concentrations of mezlocillin in the serum, heart valves, muscle and subcutaneous tissue of patients undergoing open-heart surgery. Infection. 1985 Jul; 13(4):182-3. doi: 10.1007/bf01642809. [PMID: 4044045]
  • C B Wilson, J R Koup. Clinical pharmacology of extended-spectrum penicillins in infants and children. The Journal of pediatrics. 1985 Jun; 106(6):1049-56. doi: 10.1016/s0022-3476(85)80267-5. [PMID: 3889255]
  • A F Viollier, H C Standiford, G L Drusano, B A Tatem, M R Moody, S C Schimpff. Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin. The Journal of antimicrobial chemotherapy. 1985 May; 15(5):597-606. doi: 10.1093/jac/15.5.597. [PMID: 4008387]
  • W R Allan, A Kumar. Prophylactic mezlocillin for transurethral prostatectomy. British journal of urology. 1985 Feb; 57(1):46-9. doi: 10.1111/j.1464-410x.1985.tb08983.x. [PMID: 3971104]
  • F Kees, K G Naber, B Bartoschik-Wich, P Stockmann, G P Meyer, H Grobecker. High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers. Arzneimittel-Forschung. 1985; 35(7):1099-104. doi: NULL. [PMID: 4052146]
  • E Haen, J Remien, E Richter, U Frank, D Adam. [The effect of infusion rate on pharmacokinetic parameters of azlocillin and mezlocillin]. Arzneimittel-Forschung. 1985; 35(5):864-8. doi: NULL. [PMID: 4026911]
  • A Dalhoff, G Stübner. Comparative analysis of the antimicrobial action of polymorphonuclear leucocytes in vitro, ex vivo and in vivo. The Journal of antimicrobial chemotherapy. 1985 Jan; 15 Suppl A(?):283-91. doi: 10.1093/jac/15.suppl_a.283. [PMID: 3980331]
  • R Grundmann, R Kraume. [Perioperative antibiotic prophylaxis and the risk of wound infection in kidney transplantation]. Fortschritte der Medizin. 1984 Dec; 102(47-48):1199-202. doi: NULL. [PMID: 6394459]
  • D Fiore, F A Auger, G L Drusano, V R Dandu, L J Lesko. Improved micromethod for mezlocillin quantitation in serum and urine by high-pressure liquid chromatography. Antimicrobial agents and chemotherapy. 1984 Nov; 26(5):775-7. doi: 10.1128/aac.26.5.775. [PMID: 6517560]
  • G L Drusano, A Forrest, D Fiore, F Auger, E S Caplan. Effect of saturable clearance during high-dose mezlocillin therapy. Antimicrobial agents and chemotherapy. 1984 Nov; 26(5):686-8. doi: 10.1128/aac.26.5.686. [PMID: 6517555]
  • E M Rankin, D M Jones, F G Lawston, R J Kane, J H Scarffe. Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia. The Journal of antimicrobial chemotherapy. 1984 Oct; 14(4):411-21. doi: 10.1093/jac/14.4.411. [PMID: 6238929]
  • P Kujath, H P Bruch, E Schmidt, W Döll. [Perioperative prophylaxis in elective colorectal surgery]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen. 1984 Aug; 55(8):519-22. doi: NULL. [PMID: 6092012]
  • M E Levison, W D Kobasa. Mezlocillin and ticarcillin alone and combined with gentamicin in the treatment of experimental Enterobacter aerogenes endocarditis. Antimicrobial agents and chemotherapy. 1984 Jun; 25(6):683-6. doi: 10.1128/aac.25.6.683. [PMID: 6742813]
  • P Cristiano, M R Iovene, R Cioffi, R A Salerno, A Sicolo, G Cristinzio, F Paradisi. Antibiotic therapy in biliary tract infections: clinical experiences with mezlocillin. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1984 Jun; 3(3):178-82. doi: NULL. [PMID: 6529774]
  • C Odio, N Threlkeld, M L Thomas, G H McCraken. Pharmacokinetic properties of mezlocillin in newborn infants. Antimicrobial agents and chemotherapy. 1984 May; 25(5):556-9. doi: 10.1128/aac.25.5.556. [PMID: 6563875]
  • H Lagast, J Klastersky, H Standiford, A Viollier. Comparative study of the serum bactericidal activity of cefoperazone alone and in combination with amikacin or mezlocillin against gram-negative bacilli and Staphylococcus aureus. Infection. 1984 May; 12(3):190-3. doi: 10.1007/bf01640897. [PMID: 6432702]
  • D M Janicke, T T Rubio, F H Wirth, E H Karotkin, W J Jusko. Developmental pharmacokinetics of mezlocillin in newborn infants. The Journal of pediatrics. 1984 May; 104(5):773-81. doi: 10.1016/s0022-3476(84)80966-x. [PMID: 6716226]
  • S B Calderwood, C C Tung, E Jackson. Measurement of levels of aminoglycosides and vancomycin in serum in the presence of new beta-lactam antibiotics. Journal of clinical microbiology. 1984 May; 19(5):707-9. doi: 10.1128/jcm.19.5.707-709.1984. [PMID: 6330168]
  • C Odio, M L Thomas, G H McCracken. Pharmacokinetics and bacteriological efficacy of mezlocillin in experimental Escherichia coli and Listeria monocytogenes meningitis. Antimicrobial agents and chemotherapy. 1984 Apr; 25(4):427-32. doi: 10.1128/aac.25.4.427. [PMID: 6375552]
  • N Kobayashi, H Tanimura, W F Huang, T Sekiya, H Takahashi, T Sato, K Yoshida, Y Hikasa. [Chemotherapy of biliary tract infections (XXIV). Biliary excretion and gallbladder tissue levels of mezlocillin]. The Japanese journal of antibiotics. 1984 Apr; 37(4):597-604. doi: NULL. [PMID: 6471380]
  • R J Fass, C A Wright. Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits. Antimicrobial agents and chemotherapy. 1984 Apr; 25(4):408-10. doi: 10.1128/aac.25.4.408. [PMID: 6428306]
  • M Charton, B Dosne, P Escovar, A Kopf, J M Brisset. [Single-dose preventive treatment of urinary tract infections after endoscopic resection of the prostate]. Presse medicale (Paris, France : 1983). 1984 Mar; 13(9):545-8. doi: NULL. [PMID: 6230648]
  • W G Kramer, L K Pickering, S Culbert, L S Frankel. Mezlocillin pharmacokinetics in pediatric oncology patients. Antimicrobial agents and chemotherapy. 1984 Jan; 25(1):62-4. doi: 10.1128/aac.25.1.62. [PMID: 6703685]
  • T Chiu, F Fakhreddine, E Ayoub. Clinical evaluation of mezlocillin in neonates. Clinical therapeutics. 1984; 6(5):625-35. doi: NULL. [PMID: 6478469]
  • P C Braga, E Marchi, F Scaglione, G Scarpazza, M Faravelli, F Fraschini. Kinetics of penetration and clearance of mezlocillin in the bronchopulmonary tract. International journal of clinical pharmacology research. 1984; 4(5):361-5. doi: NULL. [PMID: 6519850]
  • U Seppelt, H Bertermann. [Mezlocillin in serum, renal and prostatic tissue and its clinical efficacy]. Die Medizinische Welt. 1983 Nov; 34(46):1309-11. doi: NULL. [PMID: 6685811]
  • K Naber, D Adam. [Tissue concentrations of mezlocillin in prostate adenomas following intravenous bolus injections and continuous infusions]. Fortschritte der Medizin. 1983 Nov; 101(41):1862-8. doi: NULL. [PMID: 6197351]
  • J D McCue, P Gal, R C Pearson. Interference of new penicillins and cephalosporins with urine glucose monitoring tests. Diabetes care. 1983 Sep; 6(5):504-5. doi: 10.2337/diacare.6.5.504. [PMID: 6400711]
  • F P Maesen, B I Davies, J Brouwers, T Salemans. Is treatment of acute exacerbations of chronic bronchitis with intramuscular mezlocillin justifiable?. The Journal of antimicrobial chemotherapy. 1983 Aug; 12(2):169-73. doi: 10.1093/jac/12.2.169. [PMID: 6604723]
  • J S Dooley, A Gooding, J M Hamilton-Miller, W Brumfitt, S Sherlock. The biliary excretion and pharmacokinetics of mezlocillin in jaundiced patients with external bile drainage. Liver. 1983 Aug; 3(4):201-6. doi: 10.1111/j.1600-0676.1983.tb00868.x. [PMID: 6672502]
  • V Prát, M Hatala, M Horcicková, K Matousovic. [Mezlocillin and carbenicillin in urinary tract infections in patients after kidney transplantation]. Casopis lekaru ceskych. 1983 Jun; 122(22):679-81. doi: NULL. [PMID: 6223701]
  • R Alt, J Irazuzta, P Erny, J Messer, H Monteil, R Minck, D Willard. C-reactive protein measurement: a reliable method of diagnosing and monitoring the infected newborn for the assessment of a mezlocillin therapeutic trial. The Journal of antimicrobial chemotherapy. 1983 May; 11 Suppl C(?):51-5. doi: 10.1093/jac/11.suppl_c.51. [PMID: 6619042]
  • U Gundert-Remy, R Hildebrandt, A Stiehl, E Weber. Nonlinear mezlocillin kinetics due to dose-dependent metabolism. Clinical pharmacology and therapeutics. 1983 May; 33(5):656-62. doi: 10.1038/clpt.1983.89. [PMID: 6220858]
  • P Somani, M R Smith, A Gohara, K Kapila. The effects of mezlocillin, ticarcillin and placebo on blood coagulation and bleeding time in normal volunteers. The Journal of antimicrobial chemotherapy. 1983 May; 11 Suppl C(?):33-41. doi: 10.1093/jac/11.suppl_c.33. [PMID: 6619040]
  • K G Naber, D Adam. Tissue concentrations of mezlocillin in benign hypertrophy of the prostate following intravenous bolus injection versus infusion. The Journal of antimicrobial chemotherapy. 1983 May; 11 Suppl C(?):17-23. doi: 10.1093/jac/11.suppl_c.17. [PMID: 6194144]