Mezlocillin (BioDeep_00001867845)
Main id: BioDeep_00000006443
代谢物信息卡片
Mezlocillin
化学式: C21H25N5O8S2 (539.114449)
中文名称: 美洛西林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)NC(=O)N4CCN(C4=O)S(=O)(=O)C)C(=O)O)C
InChI: InChI=1S/C21H25N5O8S2/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30)/t12-,13-,14+,17-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:6919
- KEGG: C07221
- KEGGdrug: D05021
- PubChem: 656511
- DrugBank: DB00948
- ChEMBL: CHEMBL1731
- MeSH: Mezlocillin
- CAS: 51481-65-3
- MetaboLights: MTBLC6919
- PubChem: 9430
- NIKKAJI: J11.231C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Milan Sencanski, Vladimir Perovic, Snezana B Pajovic, Miroslav Adzic, Slobodan Paessler, Sanja Glisic. Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method.
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Medicine.
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PLoS pathogens.
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Surgery, gynecology & obstetrics.
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HNO.
1990 Feb; 38(2):67-70. doi:
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VASA. Zeitschrift fur Gefasskrankheiten.
1990; 19(2):161-6. doi:
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1989 Nov; 10(6):563-72. doi:
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The British journal of clinical practice.
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Archives of internal medicine.
1989 Jun; 149(6):1279-84. doi:
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Clinical pharmacology and therapeutics.
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1988 Aug; 22(2):237-47. doi:
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The American journal of medicine.
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1988 May; 268(3):370-5. doi:
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1988 Apr; 23(2):91-4. doi:
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1988 Jan; 21(1):49-55. doi:
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Antimicrobial agents and chemotherapy.
1984 Nov; 26(5):686-8. doi:
10.1128/aac.26.5.686. [PMID: 6517555] - E M Rankin, D M Jones, F G Lawston, R J Kane, J H Scarffe. Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia.
The Journal of antimicrobial chemotherapy.
1984 Oct; 14(4):411-21. doi:
10.1093/jac/14.4.411. [PMID: 6238929] - P Kujath, H P Bruch, E Schmidt, W Döll. [Perioperative prophylaxis in elective colorectal surgery].
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen.
1984 Aug; 55(8):519-22. doi:
NULL. [PMID: 6092012] - M E Levison, W D Kobasa. Mezlocillin and ticarcillin alone and combined with gentamicin in the treatment of experimental Enterobacter aerogenes endocarditis.
Antimicrobial agents and chemotherapy.
1984 Jun; 25(6):683-6. doi:
10.1128/aac.25.6.683. [PMID: 6742813] - P Cristiano, M R Iovene, R Cioffi, R A Salerno, A Sicolo, G Cristinzio, F Paradisi. Antibiotic therapy in biliary tract infections: clinical experiences with mezlocillin.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
1984 Jun; 3(3):178-82. doi:
NULL. [PMID: 6529774] - C Odio, N Threlkeld, M L Thomas, G H McCraken. Pharmacokinetic properties of mezlocillin in newborn infants.
Antimicrobial agents and chemotherapy.
1984 May; 25(5):556-9. doi:
10.1128/aac.25.5.556. [PMID: 6563875] - H Lagast, J Klastersky, H Standiford, A Viollier. Comparative study of the serum bactericidal activity of cefoperazone alone and in combination with amikacin or mezlocillin against gram-negative bacilli and Staphylococcus aureus.
Infection.
1984 May; 12(3):190-3. doi:
10.1007/bf01640897. [PMID: 6432702] - D M Janicke, T T Rubio, F H Wirth, E H Karotkin, W J Jusko. Developmental pharmacokinetics of mezlocillin in newborn infants.
The Journal of pediatrics.
1984 May; 104(5):773-81. doi:
10.1016/s0022-3476(84)80966-x. [PMID: 6716226] - S B Calderwood, C C Tung, E Jackson. Measurement of levels of aminoglycosides and vancomycin in serum in the presence of new beta-lactam antibiotics.
Journal of clinical microbiology.
1984 May; 19(5):707-9. doi:
10.1128/jcm.19.5.707-709.1984. [PMID: 6330168] - C Odio, M L Thomas, G H McCracken. Pharmacokinetics and bacteriological efficacy of mezlocillin in experimental Escherichia coli and Listeria monocytogenes meningitis.
Antimicrobial agents and chemotherapy.
1984 Apr; 25(4):427-32. doi:
10.1128/aac.25.4.427. [PMID: 6375552] - N Kobayashi, H Tanimura, W F Huang, T Sekiya, H Takahashi, T Sato, K Yoshida, Y Hikasa. [Chemotherapy of biliary tract infections (XXIV). Biliary excretion and gallbladder tissue levels of mezlocillin].
The Japanese journal of antibiotics.
1984 Apr; 37(4):597-604. doi:
NULL. [PMID: 6471380] - R J Fass, C A Wright. Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits.
Antimicrobial agents and chemotherapy.
1984 Apr; 25(4):408-10. doi:
10.1128/aac.25.4.408. [PMID: 6428306] - M Charton, B Dosne, P Escovar, A Kopf, J M Brisset. [Single-dose preventive treatment of urinary tract infections after endoscopic resection of the prostate].
Presse medicale (Paris, France : 1983).
1984 Mar; 13(9):545-8. doi:
NULL. [PMID: 6230648] - W G Kramer, L K Pickering, S Culbert, L S Frankel. Mezlocillin pharmacokinetics in pediatric oncology patients.
Antimicrobial agents and chemotherapy.
1984 Jan; 25(1):62-4. doi:
10.1128/aac.25.1.62. [PMID: 6703685] - T Chiu, F Fakhreddine, E Ayoub. Clinical evaluation of mezlocillin in neonates.
Clinical therapeutics.
1984; 6(5):625-35. doi:
NULL. [PMID: 6478469] - P C Braga, E Marchi, F Scaglione, G Scarpazza, M Faravelli, F Fraschini. Kinetics of penetration and clearance of mezlocillin in the bronchopulmonary tract.
International journal of clinical pharmacology research.
1984; 4(5):361-5. doi:
NULL. [PMID: 6519850] - U Seppelt, H Bertermann. [Mezlocillin in serum, renal and prostatic tissue and its clinical efficacy].
Die Medizinische Welt.
1983 Nov; 34(46):1309-11. doi:
NULL. [PMID: 6685811] - K Naber, D Adam. [Tissue concentrations of mezlocillin in prostate adenomas following intravenous bolus injections and continuous infusions].
Fortschritte der Medizin.
1983 Nov; 101(41):1862-8. doi:
NULL. [PMID: 6197351] - J D McCue, P Gal, R C Pearson. Interference of new penicillins and cephalosporins with urine glucose monitoring tests.
Diabetes care.
1983 Sep; 6(5):504-5. doi:
10.2337/diacare.6.5.504. [PMID: 6400711] - F P Maesen, B I Davies, J Brouwers, T Salemans. Is treatment of acute exacerbations of chronic bronchitis with intramuscular mezlocillin justifiable?.
The Journal of antimicrobial chemotherapy.
1983 Aug; 12(2):169-73. doi:
10.1093/jac/12.2.169. [PMID: 6604723] - J S Dooley, A Gooding, J M Hamilton-Miller, W Brumfitt, S Sherlock. The biliary excretion and pharmacokinetics of mezlocillin in jaundiced patients with external bile drainage.
Liver.
1983 Aug; 3(4):201-6. doi:
10.1111/j.1600-0676.1983.tb00868.x. [PMID: 6672502] - V Prát, M Hatala, M Horcicková, K Matousovic. [Mezlocillin and carbenicillin in urinary tract infections in patients after kidney transplantation].
Casopis lekaru ceskych.
1983 Jun; 122(22):679-81. doi:
NULL. [PMID: 6223701] - R Alt, J Irazuzta, P Erny, J Messer, H Monteil, R Minck, D Willard. C-reactive protein measurement: a reliable method of diagnosing and monitoring the infected newborn for the assessment of a mezlocillin therapeutic trial.
The Journal of antimicrobial chemotherapy.
1983 May; 11 Suppl C(?):51-5. doi:
10.1093/jac/11.suppl_c.51. [PMID: 6619042] - U Gundert-Remy, R Hildebrandt, A Stiehl, E Weber. Nonlinear mezlocillin kinetics due to dose-dependent metabolism.
Clinical pharmacology and therapeutics.
1983 May; 33(5):656-62. doi:
10.1038/clpt.1983.89. [PMID: 6220858] - P Somani, M R Smith, A Gohara, K Kapila. The effects of mezlocillin, ticarcillin and placebo on blood coagulation and bleeding time in normal volunteers.
The Journal of antimicrobial chemotherapy.
1983 May; 11 Suppl C(?):33-41. doi:
10.1093/jac/11.suppl_c.33. [PMID: 6619040] - K G Naber, D Adam. Tissue concentrations of mezlocillin in benign hypertrophy of the prostate following intravenous bolus injection versus infusion.
The Journal of antimicrobial chemotherapy.
1983 May; 11 Suppl C(?):17-23. doi:
10.1093/jac/11.suppl_c.17. [PMID: 6194144]