FA 7:2;O5 (BioDeep_00000629073)
Main id: BioDeep_00000005584
代谢物信息卡片
(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylic acid;3-C-carboxy-2,4-dideoxy-2-methyl-D-threo-pentaric acid
化学式: C7H10O7 (206.0427)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(O)=O)[C@H](C(O)=O)[C@@](O)(C(O)=O)C
InChI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t3-,7-/m1/s1
描述信息
同义名列表
5 个代谢物同义名
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid; FA 7:2;O5; (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylic acid;3-C-carboxy-2,4-dideoxy-2-methyl-D-threo-pentaric acid; (2R, 3S)-2-Hydroxybutane-1,2,3-tricarboxylate;2-Hydroxybutane-1,2,3-tricarboxylate;2-Methylcitrate; (2R,3S)-2-methylcitric acid
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:15607
- ChEBI: CHEBI:30836
- KEGG: C04593
- PubChem: 5459784
- PubChem: 439681
- DrugBank: DB04072
- LipidMAPS: LMFA01050444
- LipidMAPS: LMFA01050442
- CAS: 64815-79-8
- PubChem: 7191
- PDB-CCD: MIC
- 3DMET: B01764
- NIKKAJI: J1.534.785F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiaqi Sun, Jun Ding, Qingsong Shen, Xiyang Wang, Min Wang, Yongping Huang, Xuechun Zhang, Huan Zhu, Feng Zhang, Dongde Wu, Min Peng, Zhonglin Zhang, Yufeng Yuan, Wenhua Li, Zhi-Gang She, Xiao-Jing Zhang, Hongliang Li, Peng Zhang, Zan Huang. Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma.
Journal of hepatology.
2023 Mar; 78(3):627-642. doi:
10.1016/j.jhep.2022.11.017. [PMID: 36462680] - Toshiaki Komatsu, Hinako Morita, Yoko Takayama, Yui Natsume, Yoshinori Tomoda, Hirohisa Miura, Takeo Sato, Takatoshi Nakamura, Masaya Toda, Hirotsugu Okamoto, Hideaki Hanaki, Koichiro Atsuda. Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Aug; 28(8):1105-1111. doi:
10.1016/j.jiac.2022.03.024. [PMID: 35400549] - Yoko Takayama, Toshiaki Komatsu, Takatoshi Nakamura, Yoshinori Tomoda, Masaya Toda, Hirohisa Miura, Takeo Sato, Koichiro Atsuda, Hirotsugu Okamoto, Hideaki Hanaki. Association of serum and fat tissue antibiotic concentrations with surgical site infections in lower gastrointestinal surgery.
Surgery.
2022 04; 171(4):1000-1005. doi:
10.1016/j.surg.2021.10.013. [PMID: 34772516] - Michelle R Denburg, Yunwen Xu, Alison G Abraham, Josef Coresh, Jingsha Chen, Morgan E Grams, Harold I Feldman, Paul L Kimmel, Casey M Rebholz, Eugene P Rhee, Ramachandran S Vasan, Bradley A Warady, Susan L Furth. Metabolite Biomarkers of CKD Progression in Children.
Clinical journal of the American Society of Nephrology : CJASN.
2021 08; 16(8):1178-1189. doi:
10.2215/cjn.00220121. [PMID: 34362785] - Toshiki Etani, Minami Asaoka, Shuhei Kondo, Chiharu Wachino, Kaoru Hori, Nobuhiko Shimizu, Yusuke Noda, Takashi Nagai, Satoshi Nozaki, Keitaro Iida, Taku Naiki, Ryosuke Ando, Noriyasu Kawai, Takeshi Yanagita, Atsushi Nakamura, Takahiro Yasui. Efficacy of fosfomycin in the prevention of postoperative infection following transurethral resection of bladder tumor during periods of limited cefazolin, cefotiam, and cefmetazole supply.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2021 Apr; 27(4):625-631. doi:
10.1016/j.jiac.2020.11.025. [PMID: 33309628] - Evelina Maines, Giulio Catesini, Sara Boenzi, Antonella Mosca, Manila Candusso, Luca Dello Strologo, Diego Martinelli, Arianna Maiorana, Alessandra Liguori, Giorgia Olivieri, Roberta Taurisano, Fiorella Piemonte, Cristiano Rizzo, Marco Spada, Carlo Dionisi-Vici. Plasma methylcitric acid and its correlations with other disease biomarkers: The impact in the follow up of patients with propionic and methylmalonic acidemia.
Journal of inherited metabolic disease.
2020 11; 43(6):1173-1185. doi:
10.1002/jimd.12287. [PMID: 32681732] - Osama Y Al-Dirbashi, Charu Sharma, Nahid Al Dahouri, Anas Al Aidaros, Shamma Al-Muhairi, Rami Beiram, Salah Gariballa, Juma Al Kaabi. Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study.
Medicina (Kaunas, Lithuania).
2020 Mar; 56(3):. doi:
10.3390/medicina56030142. [PMID: 32245061] - Joanne F Dorgan, Seungyoun Jung, Cher M Dallal, Min Zhan, Christina A Stennett, Yuji Zhang, Richard L Eckert, Linda G Snetselaar, Linda Van Horn. Alcohol consumption and serum metabolite concentrations in young women.
Cancer causes & control : CCC.
2020 Feb; 31(2):113-126. doi:
10.1007/s10552-019-01256-1. [PMID: 31828464] - Akiyoshi Horie, Akiyoshi Nariai, Fumihide Katou, Yasuhiro Abe, Yuya Saito, Daisuke Koike, Tomohiro Hirade, Tomoko Ito, Miho Wakuri, Aiko Fukuma. Increased community-acquired upper urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in children and the efficacy of flomoxef and cefmetazole.
Clinical and experimental nephrology.
2019 Nov; 23(11):1306-1314. doi:
10.1007/s10157-019-01775-w. [PMID: 31428892] - Agnese Serafini, Lendl Tan, Stuart Horswell, Steven Howell, Daniel J Greenwood, Deborah M Hunt, Minh-Duy Phan, Mark Schembri, Mercedes Monteleone, Christine R Montague, Warwick Britton, Acely Garza-Garcia, Ambrosius P Snijders, Brian VanderVen, Maximiliano G Gutierrez, Nicholas P West, Luiz Pedro S de Carvalho. Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism.
Molecular microbiology.
2019 10; 112(4):1284-1307. doi:
10.1111/mmi.14362. [PMID: 31389636] - Nahid Al Dhahouri, Claus-Dieter Langhans, Zalikha Al Hammadi, Jürgen G Okun, Georg F Hoffmann, Fatma Al-Jasmi, Osama Y Al-Dirbashi. Quantification of methylcitrate in dried urine spots by liquid chromatography tandem mass spectrometry for the diagnosis of propionic and methylmalonic acidemias.
Clinica chimica acta; international journal of clinical chemistry.
2018 Dec; 487(?):41-45. doi:
10.1016/j.cca.2018.09.017. [PMID: 30217751] - Hafsa Majid, Lena Jafri, Aysha Habib Khan, Zeba Zulfiqar Ali, Azeema Jamil, Nasir Yusufzai, Midhat Fatimah, Bushra Afroze. Diagnostic dilemma of patients with methylmalonic aciduria: Experience from a tertiary care centre in Pakistan.
JPMA. The Journal of the Pakistan Medical Association.
2018 Apr; 68(4):510-514. doi:
NULL. [PMID: 29808036] - Natsuki Shioji, Minoru Mizutani, Mariko Okayama, Haruna Katayama, Eiko Ooya, Takao Sekine, Masahiro Masuya. [Drug-induced immune hemolytic anemia caused by cefmetazole].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2018 ; 59(7):884-888. doi:
10.11406/rinketsu.59.884. [PMID: 30078798] - Toshitaka Sugawara, Junichi Shindoh, Yujiro Nishioka, Masaji Hashimoto. Total bilirubin amount in drainage fluid can be an early predictor for severe biliary fistula after hepatobiliary surgery.
Bioscience trends.
2017 Nov; 11(5):588-594. doi:
10.5582/bst.2017.01208. [PMID: 29070759] - Nicola Longo, Leisa B Price, Eduard Gappmaier, Nancy L Cantor, Sharon L Ernst, Carrie Bailey, Marzia Pasquali. Anaplerotic therapy in propionic acidemia.
Molecular genetics and metabolism.
2017 09; 122(1-2):51-59. doi:
10.1016/j.ymgme.2017.07.003. [PMID: 28712602] - Lianshu Han, Shengnan Wu, Jun Ye, Wenjuan Qiu, Huiwen Zhang, Xiaolan Gao, Yu Wang, Zhuwen Gong, Jing Jin, Xuefan Gu. Biochemical, molecular and outcome analysis of eight chinese asymptomatic individuals with methyl malonic acidemia detected through newborn screening.
American journal of medical genetics. Part A.
2015 Oct; 167A(10):2300-5. doi:
10.1002/ajmg.a.37147. [PMID: 25982642] - Yinghui Fang, Yulong Guan, Caihong Wan, Zhida Fu, Juanjuan Jiang, Chunfu Wu, Ju Zhao, Peng Sun, Cun Long. The dynamic observation of plasma concentration of antimicrobial agents during balanced ultrafiltration in vitro.
Artificial organs.
2014 Jan; 38(1):48-55. doi:
10.1111/aor.12113. [PMID: 23865445] - Mukesh K Dubey, Anders Broberg, Dan Funck Jensen, Magnus Karlsson. Role of the methylcitrate cycle in growth, antagonism and induction of systemic defence responses in the fungal biocontrol agent Trichoderma atroviride.
Microbiology (Reading, England).
2013 Dec; 159(Pt 12):2492-2500. doi:
10.1099/mic.0.070466-0. [PMID: 24100269] - Takatoshi Nakamura, Atsushi Tomizawa, Hiroshi Inano, Takeo Sato, Kazuo Yago, Masahiko Watanabe. Tissue concentrations of antibiotics given prophylactically during colorectal cancer surgery.
Hepato-gastroenterology.
2013 Sep; 60(126):1371-5. doi:
10.5754/hge13070. [PMID: 23933929] - Asako Doi, Toshihiko Shimada, Sohei Harada, Kentaro Iwata, Toru Kamiya. The efficacy of cefmetazole against pyelonephritis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2013 Mar; 17(3):e159-63. doi:
10.1016/j.ijid.2012.09.010. [PMID: 23140947] - Paris Jafari, Olivier Braissant, Petra Zavadakova, Hugues Henry, Luisa Bonafé, Diana Ballhausen. Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures.
Orphanet journal of rare diseases.
2013 Jan; 8(?):4. doi:
10.1186/1750-1172-8-4. [PMID: 23298464] - Tetsuhiro Owaki, Hiroshi Okumura, Yasuto Uchikado, Ken Sasaki, Masataka Matsumoto, Itaru Omoto, Tetsuro Setoyama, Yoshiaki Kita, Toshihide Sakurai, Daisuke Matsushita, Sumiya Ishigami, Shinichi Ueno, Shoji Natsugoe. Serum concentrations of antibiotics during severe invasive surgery such as esophagectomy for esophageal cancer.
International surgery.
2013 Jan; 98(1):1-5. doi:
10.9738/cc164.1. [PMID: 23438269] - Swarnalee Dutta, T Swaroopa Rani, Appa Rao Podile. Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion.
PloS one.
2013; 8(10):e78369. doi:
10.1371/journal.pone.0078369. [PMID: 24205213] - Mureo Kasahara, Seisuke Sakamoto, Hiroyuki Kanazawa, Chiaki Karaki, Toshihiko Kakiuchi, Takanobu Shigeta, Akinari Fukuda, Rika Kosaki, Atsuko Nakazawa, Mika Ishige, Masayoshi Nagao, Yosuke Shigematsu, Tohru Yorifuji, Yasuhiro Naiki, Reiko Horikawa. Living-donor liver transplantation for propionic acidemia.
Pediatric transplantation.
2012 May; 16(3):230-4. doi:
10.1111/j.1399-3046.2011.01607.x. [PMID: 22151065] - Sara R Zwart, C Robert Gibson, Thomas H Mader, Karen Ericson, Robert Ploutz-Snyder, Martina Heer, Scott M Smith. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism.
The Journal of nutrition.
2012 Mar; 142(3):427-31. doi:
10.3945/jn.111.154245. [PMID: 22298570] - Y S Lin, R Radzi, M Morimoto, H Saimoto, Y Okamoto, S Minami. Characterization of chitosan-carboxymethyl dextran nanoparticles as a drug carrier and as a stimulator of mouse splenocytes.
Journal of biomaterials science. Polymer edition.
2012; 23(11):1401-20. doi:
10.1163/092050611x582849. [PMID: 21740648] - Randy J Chandler, Suma Chandrasekaran, Nuria Carrillo-Carrasco, Julien S Senac, Sean E Hofherr, Michael A Barry, Charles P Venditti. Adeno-associated virus serotype 8 gene transfer rescues a neonatal lethal murine model of propionic acidemia.
Human gene therapy.
2011 Apr; 22(4):477-81. doi:
10.1089/hum.2010.164. [PMID: 20950151] - Seung-Ho Lee, You-Kyoung Han, Sung-Hwan Yun, Yin-Won Lee. Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae.
Eukaryotic cell.
2009 Aug; 8(8):1155-64. doi:
10.1128/ec.00335-08. [PMID: 19525419] - Chang-I Ho, Yao-Ko Wen, Mei-Ling Chen. Xanthogranulomatous pyelonephritis successfully treated with antibiotics only.
Journal of the Chinese Medical Association : JCMA.
2008 Dec; 71(12):643-5. doi:
10.1016/s1726-4901(09)70008-5. [PMID: 19114330] - Miki Katoh, Chise Tateno, Katsutoshi Yoshizato, Tsuyoshi Yokoi. Chimeric mice with humanized liver.
Toxicology.
2008 Apr; 246(1):9-17. doi:
10.1016/j.tox.2007.11.012. [PMID: 18248870] - Yao Zhang, Yan-ling Yang, Yuki Hasegawa, Seiji Yamaguchi, Chun-yan Shi, Jin-qing Song, Sujan Sayami, Ping Liu, Rong Yan, Jin-hua Dong, Jiong Qin. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid.
Chinese medical journal.
2008 Feb; 121(3):216-9. doi:
. [PMID: 18298912] - Hirotoshi Okumura, Miki Katoh, Keiichi Minami, Miki Nakajima, Tsuyoshi Yokoi. Change of drug excretory pathway by CCl4-induced liver dysfunction in rat.
Biochemical pharmacology.
2007 Aug; 74(3):488-95. doi:
10.1016/j.bcp.2007.04.025. [PMID: 17544377] - Hanna Krawczyk, Tomasz Martyniuk. Characterisation of the 1H and 13C NMR spectra of methylcitric acid.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2007 Jun; 67(2):298-305. doi:
10.1016/j.saa.2006.07.017. [PMID: 16997619] - Hirotoshi Okumura, Miki Katoh, Toshiro Sawada, Miki Nakajima, Yoshinori Soeno, Hikaru Yabuuchi, Toshihiko Ikeda, Chise Tateno, Katsutoshi Yoshizato, Tsuyoshi Yokoi. Humanization of excretory pathway in chimeric mice with humanized liver.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Jun; 97(2):533-8. doi:
10.1093/toxsci/kfm041. [PMID: 17341479] - H Krawczyk, W Gradowska. 1H NMR spectra of methylcitric acid in urine.
Journal of inherited metabolic disease.
2007 Apr; 30(2):263. doi:
10.1007/s10545-007-0420-6. [PMID: 17295121] - Masato Tomita, Satoru Motokawa. Effects of air tourniquet on the antibiotics concentration, in bone marrow, injected just before the start of operation.
Modern rheumatology.
2007; 17(5):409-12. doi:
10.1007/s10165-007-0609-4. [PMID: 17929134] - C D Campbell, J Ganesh, C Ficicioglu. Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.
Haematologica.
2005 Dec; 90(12 Suppl):ECR45. doi:
. [PMID: 16464760] - Shin-ichi Otani, S Endo, Y Sato, T Hasegawa, N Saito, Y Sohara. [Feasibility of short-term antibiotic prophylaxis after pulmonary resection].
Kyobu geka. The Japanese journal of thoracic surgery.
2004 Dec; 57(13):1171-4; discussion 1175. doi:
NULL. [PMID: 15609652] - Stefan Kölker, Marina Schwab, Friederike Hörster, Sven Sauer, Angela Hinz, Nicole I Wolf, Ertan Mayatepek, Georg F Hoffmann, Jan A M Smeitink, Jürgen G Okun. Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain.
The Journal of biological chemistry.
2003 Nov; 278(48):47388-93. doi:
10.1074/jbc.m308861200. [PMID: 12972416] - Martin Busch, Günter Stein, Wolfgang Poppitz, Gert Hein, Andreas Müller. Validated capillary gas chromatographic-mass spectrometric assay to determine 2-methylcitric acid I and II levels in human serum by using a pulsed splitless injection procedure.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Aug; 775(2):215-23. doi:
10.1016/s1570-0232(02)00293-3. [PMID: 12113988] - Jürgen G Okun, Friederike Hörster, Lilla M Farkas, Patrik Feyh, Angela Hinz, Sven Sauer, Georg F Hoffmann, Klaus Unsicker, Ertan Mayatepek, Stefan Kölker. Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity.
The Journal of biological chemistry.
2002 Apr; 277(17):14674-80. doi:
10.1074/jbc.m200997200. [PMID: 11847233] - M Takeuchi, M Harada, M Nagata, A Watanabe, K Nakamura. [Immunological properties of S-1090, cefmatilen hydrochloride hydrate].
The Journal of toxicological sciences.
2001 May; 26 Suppl 1(?):231-42. doi:
NULL. [PMID: 11400315] - B F Henning, M Tepel, R Riezler, H J Naurath. Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations.
Gerontology.
2001 Jan; 47(1):30-5. doi:
10.1159/000052767. [PMID: 11244289] - B F Henning, R Riezler, M Tepel, K Langer, H Raidt, U Graefe, W Zidek. Evidence of altered homocysteine metabolism in chronic renal failure.
Nephron.
1999; 83(4):314-22. doi:
10.1159/000045423. [PMID: 10575293] - K Goto, M Oda, H Saitoh, M Nishida, M Takada. Effect of side chains including the N-methyl-tetrazole-thiol group of beta-lactam antibiotics on transport in cultured kidney epithelial cells LLC-PK1.
Biological & pharmaceutical bulletin.
1998 Oct; 21(10):1113-6. doi:
10.1248/bpb.21.1113. [PMID: 9821822] - R H Allen, S P Stabler, J Lindenbaum. Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders.
European journal of pediatrics.
1998 Apr; 157 Suppl 2(?):S122-6. doi:
10.1007/pl00014295. [PMID: 9587039] - G Scalabrino, F R Buccellato, G Tredici, A Morabito, E C Lorenzini, R H Allen, J Lindenbaum. Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord.
Experimental neurology.
1997 Apr; 144(2):258-65. doi:
10.1006/exnr.1996.6376. [PMID: 9168827] - G A Breen, W L St Peter. Hypoprothrombinemia associated with cefmetazole.
The Annals of pharmacotherapy.
1997 Feb; 31(2):180-4. doi:
10.1177/106002809703100210. [PMID: 9034420] - C Si, G Tian. [The evaluation of cefmetazole in clinical use. The study group of cefmetazole in clinical use].
Zhonghua nei ke za zhi.
1996 Oct; 35(10):668-72. doi:
NULL. [PMID: 9592326] - H J Naurath, E Joosten, R Riezler, S P Stabler, R H Allen, J Lindenbaum. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.
Lancet (London, England).
1995 Jul; 346(8967):85-9. doi:
10.1016/s0140-6736(95)92113-3. [PMID: 7603218] - R H Allen, S P Stabler, D G Savage, J Lindenbaum. Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency.
Metabolism: clinical and experimental.
1993 Aug; 42(8):978-88. doi:
10.1016/0026-0495(93)90010-l. [PMID: 8345822] - M T Fields, B L Herndon, D M Bamberger. beta-Lactamase-mediated inactivation and efficacy of cefazolin and cefmetazole in Staphylococcus aureus abscesses.
Antimicrobial agents and chemotherapy.
1993 Feb; 37(2):203-6. doi:
10.1128/aac.37.2.203. [PMID: 8452349] - M J García-Agundez, C Fernández-Lastra, R Jiménez, J González, E L Mariño. Pharmacokinetic parameters from data relating to the plasma and biliary excretion kinetics of cefmetazole in rats.
European journal of drug metabolism and pharmacokinetics.
1992 Jul; 17(3):167-73. doi:
10.1007/bf03190141. [PMID: 1490484] - T Hirano, T Manabe, G Ohshio, Y Nio. Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole.
Nihon geka hokan. Archiv fur japanische Chirurgie.
1992 May; 61(3):213-23. doi:
NULL. [PMID: 1444701] - J E Schweinle, M Nishiyasu. Sub-minimal inhibitory concentrations of cefmetazole enhance serum bactericidal activity in vitro by amplifying poly-C9 deposition.
The Journal of clinical investigation.
1992 Apr; 89(4):1198-207. doi:
10.1172/jci115703. [PMID: 1556181] - F Cava, J Gonzalez, J M Gonzalez-Buitrago, C Muriel, R Jimenez. Inhibition of biliary cholesterol and phospholipid secretion by cefmetazole. The role of vesicular transport and of canalicular events.
The Biochemical journal.
1991 May; 275 ( Pt 3)(?):591-5. doi:
10.1042/bj2750591. [PMID: 1674860] - A B Rodriguez, C Barriga, M de la Fuente. Stimulation of phagocytic processes and antibody-dependent cellular cytotoxicity of human neutrophils by cefmetazole.
Microbiology and immunology.
1991; 35(7):545-56. doi:
10.1111/j.1348-0421.1991.tb01585.x. [PMID: 1784256] - H Yanagi, N Ishikura, H Kenmotsu, N Yagi, K Goto, S Kato, S Sumiya, M Takada. [Effect of inclusion complexation of decanoic acid with alpha-cyclodextrin on rectal absorption of cefmetazole sodium suppository in rabbits].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1991 Jan; 111(1):65-9. doi:
10.1248/yakushi1947.111.1_65. [PMID: 2056446] - L S Welage, M T Borin, J H Wilton, L G Hejmanowski, P B Wels, J J Schentag. Comparative evaluation of the pharmacokinetics of N-methylthiotetrazole following administration of cefoperazone, cefotetan, and cefmetazole.
Antimicrobial agents and chemotherapy.
1990 Dec; 34(12):2369-74. doi:
10.1128/aac.34.12.2369. [PMID: 2088192] - N Wada, K Fukunaga, M Kubo. [Two cases of Yersinia pseudotuberculosis infection in children].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
1990 Nov; 64(11):1462-7. doi:
10.11150/kansenshogakuzasshi1970.64.1462. [PMID: 2286788] - M T Borin, G R Peters, T C Smith. Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers.
Antimicrobial agents and chemotherapy.
1990 Oct; 34(10):1944-8. doi:
10.1128/aac.34.10.1944. [PMID: 2291659] - J Igari, M Shitara, M Shitara, K Yoshimoto, Y Hayashi. [Susceptibilities of uropathogenic bacteria to ampicillin, cefazolin, cefmetazole and gentamicin. Nine-year survey of changing patterns of susceptibilities].
The Japanese journal of antibiotics.
1990 Sep; 43(9):1530-7. doi:
. [PMID: 2262960] - C E Halstenson, D R Guay, J A Opsahl, C A Hirata, L S Olanoff, E Novak, H Ko, K S Cathcart, G R Matzke. Disposition of cefmetazole in healthy volunteers and patients with impaired renal function.
Antimicrobial agents and chemotherapy.
1990 Apr; 34(4):519-23. doi:
10.1128/aac.34.4.519. [PMID: 2344159] - J Igari, M Shitara, M Shitara, K Yoshimoto, Y Hayashi. [In vitro susceptibility of Escherichia coli and Klebsiella sp. to antibiotics].
The Japanese journal of antibiotics.
1990 Apr; 43(4):659-69. doi:
NULL. [PMID: 2199690] - J Morisaki, N Morisaki, T Chimura. [A study of tissue transfer of cefmetazole in the blood and uterus in pregnant rabbits].
The Japanese journal of antibiotics.
1990 Feb; 43(2):318-20. doi:
NULL. [PMID: 2362353] - R N Jones. Cefmetazole (CS-1170), a "new" cephamycin with a decade of clinical experience.
Diagnostic microbiology and infectious disease.
1989 Sep; 12(5):367-79. doi:
10.1016/0732-8893(89)90106-5. [PMID: 2692950] - J S Tan, S J Salstrom, S A Signs, H E Hoffman, T M File. Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels.
Antimicrobial agents and chemotherapy.
1989 Jun; 33(6):924-7. doi:
10.1128/aac.33.6.924. [PMID: 2764542] - M Sugimoto, K Saito, M Hashimoto, S Horie, Y Wakabayashi, S Hirose, Y Murata, M Kobayashi. [Antibiotics-induced agranulocytosis. Patient's IgG inhibits a GM colony formation].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
1989 May; 30(5):768-73. doi:
NULL. [PMID: 2795889] - H Takeuchi, Y Okada, O Yoshida, T Konishi, T Tomoyoshi, S Nakahara. [Urinary tract infection associated with urinary calculi. 2. Effects of antibiotics on bacteria within infected stones].
Hinyokika kiyo. Acta urologica Japonica.
1989 May; 35(5):755-61. doi:
NULL. [PMID: 2801373] - J B Moe, R C Piper, H Tanase, K Sotani, J Manabe. Preclinical safety studies of cefmetazole.
The Journal of antimicrobial chemotherapy.
1989 Apr; 23 Suppl D(?):125-9. doi:
10.1093/jac/23.suppl_d.125. [PMID: 2722719] - H Ko, E Novak, G R Peters, W M Bothwell, J D Hosley, S K Closson, W J Adams. Pharmacokinetics of single-dose cefmetazole following intramuscular administration of cefmetazole sodium to healthy male volunteers.
Antimicrobial agents and chemotherapy.
1989 Apr; 33(4):508-12. doi:
10.1128/aac.33.4.508. [PMID: 2729944] - J T DiPiro, J E Connors, T A Bowden, J A Stanfield, B M Lampert, J T Stewart. Comparative intraoperative concentrations of two cephalosporins with activity against anaerobic bacteria.
The Journal of antimicrobial chemotherapy.
1989 Apr; 23 Suppl D(?):89-95. doi:
10.1093/jac/23.suppl_d.89. [PMID: 2722728] - H Ko, K S Cathcart, D L Griffith, G R Peters, W J Adams. Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.
Antimicrobial agents and chemotherapy.
1989 Mar; 33(3):356-61. doi:
10.1128/aac.33.3.356. [PMID: 2729930] - W M Bothwell, K S Cathcart, P A Bombardt. An on-line, column-switching high-performance liquid chromatographic procedure for the removal of probenecid from human plasma, serum, or urine in the quantitative determination of cefmetazole or cefoxitin.
Journal of pharmaceutical and biomedical analysis.
1989; 7(8):987-95. doi:
10.1016/0731-7085(89)80024-x. [PMID: 2490108] - T Hayashi, A Maruden, K Irimura, M Kuwata, K Morita. [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
The Journal of toxicological sciences.
1988 Jun; 13 Suppl 1(?):285-327. doi:
10.2131/jts.13.supplementi_285. [PMID: 3172294] - F Soriano, M Santamaría, C Ponte, C Castilla, R Fernández-Roblas. In vivo significance of the inoculum effect of antibiotics on Escherichia coli.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
1988 Jun; 7(3):410-2. doi:
10.1007/bf01962350. [PMID: 3137046] - M K Ito, M A Gill, F C Chenella, T V Berne, A E Yellin, P N Heseltine, M D Appleman. Intraoperative serum, bile, and gallbladder-wall concentrations of cefmetazole in patients undergoing cholecystectomy.
Clinical pharmacy.
1988 Jun; 7(6):467-8. doi:
NULL. [PMID: 3165314] - K Yoshino, K Fujita, M Takemoto, M Suga. [Penetration of cefmetazole and netilmicin into the cerebrospinal fluid].
The Japanese journal of antibiotics.
1988 May; 41(5):563-6. doi:
NULL. [PMID: 3216478] - R E Kretschmer, C Bachmann. Methylcitric acid determination in amniotic fluid by electron-impact mass fragmentography.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1988 May; 26(5):345-8. doi:
10.1515/cclm.1988.26.5.345. [PMID: 3404093] - J A Stanfield, J T DiPiro. Interference of cefmetazole sodium and cefotetan disodium with urine-glucose testing systems.
American journal of hospital pharmacy.
1988 Mar; 45(3):625-6. doi:
10.1093/ajhp/45.3.625. [PMID: 3163470] - T Miura, I Hashimoto, Y Sawada, T Nakamura, M Nakahara. [Pharmacokinetics of cefmetazole during and after surgical operations].
The Japanese journal of antibiotics.
1987 Nov; 40(11):1923-36. doi:
NULL. [PMID: 3481836] - S Asari, M Horikawa, H Tsukamoto, K Kouda, C Hayashi, K Miyai. [Susceptibility of clinical isolates to aztreonam].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1317-31. doi:
. [PMID: 3479624] - H Nakahata, Y Hirai, Y Kumasaka, T Miyazawa, T Nakamura, K Imamura, I Makino, K Takebe, H Kudo. [Free methyltetrazolethiol concentrations in men subjected to intravenous administration of cephems with methyltetrazolethiol].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1294-8. doi:
NULL. [PMID: 3479623] - M Shiga, M Hayashi, T Horie, S Awazu. Differences in the promotion mechanism of the colonic absorption of antipyrine, phenol red and cefmetazole.
The Journal of pharmacy and pharmacology.
1987 Feb; 39(2):118-23. doi:
10.1111/j.2042-7158.1987.tb06956.x. [PMID: 2881996] - J Igari, M Shitara, M Morimoto, N Shiga, N Kosakai. [A nationwide study of the antimicrobial susceptibility of clinical isolates of Klebsiella sp. in Japan].
The Japanese journal of antibiotics.
1986 Nov; 39(11):3110-24. doi:
NULL. [PMID: 3469423] - J Igari, M Shitara, M Morimoto, N Shiga, N Kosakai. [A nationwide study of the antimicrobial susceptibility of clinical isolates of Escherichia coli in Japan].
The Japanese journal of antibiotics.
1986 Nov; 39(11):3094-109. doi:
NULL. [PMID: 3546776] - H Takahagi, K Inoue, M Horiguchi. Drug monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma.
Journal of chromatography.
1986 Feb; 352(?):369-79. doi:
10.1016/s0021-9673(01)83394-x. [PMID: 3457796] - Y Kumasaka, H Nakahata, Y Hirai, K Imamura, K Takebe, I Suzuki, H Senda. [In vivo antibacterial activity of cefbuperazone. Synergy of cefbuperazone for bactericidal effect with human polymorphonuclear leukocytes].
The Japanese journal of antibiotics.
1986 Jan; 39(1):154-8. doi:
NULL. [PMID: 3517405] - J Rodriguez-Barbero, E L Mariño, A Dominguez-Gil. Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults.
Antimicrobial agents and chemotherapy.
1985 Oct; 28(4):544-7. doi:
10.1128/aac.28.4.544. [PMID: 3865631] - D M Mock, D L Baswell, H Baker, R T Holman, L Sweetman. Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment.
The Journal of pediatrics.
1985 May; 106(5):762-9. doi:
10.1016/s0022-3476(85)80350-4. [PMID: 3923177] - J Rodriquez Barbero, E L Mariño, A Dominquez-Gil, J Garcia Garcia, J M Rodriquez Rodriquez, A Gomez Alonso. Cefmetazole plasma levels after intraincisional administration.
Drug intelligence & clinical pharmacy.
1985 May; 19(5):394-6. doi:
10.1177/106002808501900516. [PMID: 3859398] - M Sekine, H Terashima, K Sasahara, K Nishimura, R Okada, S Awazu. Improvement of bioavailability of poorly absorbed drugs. II. Effect of medium chain glyceride base on the intestinal absorption of cefmetazole sodium in rats and dogs.
Journal of pharmacobio-dynamics.
1985 Apr; 8(4):286-95. doi:
10.1248/bpb1978.8.286. [PMID: 3861846] - J Shimada, Y Hayashi, K Nakamura. Cefmetazole: clinical evaluation of efficacy and safety in Japan.
Drugs under experimental and clinical research.
1985; 11(3):181-94. doi:
. [PMID: 3869805] - T Ueda, K Sakai, M Fujimoto. Studies of cefotaxime serum concentrations during surgery under general anaesthesia and its passage to the wound fluid after surgery for breast cancer.
Infection.
1985; 13 Suppl 1(?):S43-5. doi:
10.1007/bf01644217. [PMID: 3863795] - J R Rodríguez, E L Mariño, M J Otero, J R Commes, J Garcia, J M Rodriguez, F Lozano, A Dominguez-Gil, A G Alonso. Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy.
Antimicrobial agents and chemotherapy.
1984 Nov; 26(5):787-8. doi:
10.1128/aac.26.5.787. [PMID: 6595964] - K Fujita, M Sugimoto, T Hara, T Murayama. [Concentration of antibiotics in the prostate: cefmetazole].
The Japanese journal of antibiotics.
1984 Sep; 37(9):1694-6. doi:
NULL. [PMID: 6210377] - T Watanabe, T Hara, T Kasai, T Ishii, K Miyauchi, H Date, M Jinzaki, H Shindo, A Matsugami, H Goi. [Antibacterial activity of MT-141 against anaerobic bacteria].
The Japanese journal of antibiotics.
1984 Jun; 37(6):1058-69. doi:
. [PMID: 6092738] - T Miyano, T Arai, H Shimomura, T Ogawa, K Sasaki, E Deguchi, K Suruga, H Nittono. [The correlation between the biliary excretion of cefmetazole and the bile acid metabolism in postoperative patients with biliary atresia].
The Japanese journal of antibiotics.
1984 Feb; 37(2):243-6. doi:
NULL. [PMID: 6588213] - T Miyano, H Shimomura, T Arai, K Sasaki, T Ogawa, E Deguchi, K Suruga. [Postoperative evaluation of renal function from the aspect of urinary concentration of cefmetazole in infants and children with vesicoureteral reflux and hydronephrosis. I].
The Japanese journal of antibiotics.
1984 Feb; 37(2):237-42. doi:
NULL. [PMID: 6588212]
