Ginsenoside Rh2 (BioDeep_00000622797)

Main id: BioDeep_00000000011

 

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


(2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethylhex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-tri

化学式: C36H62O8 (622.4444452)
中文名称: 20(R)-人参皂甙Rh2, (S型)人参皂苷Rh2, 人参皂甙 Rh2
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)O)C)O)C
InChI: InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1

描述信息

20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3]. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68[4].
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3]. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68[4].
Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.
Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.

同义名列表

14 个代谢物同义名

(2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethylhex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-tri; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-tr; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-methylol-tetrahydropyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methyl-hept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; beta-D-Glucopyranoside, (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl; 20(S)-Ginsenoside Rh2; 20(R)-Ginsenoside Rh2; Ginsenoside Rh2; 78214-33-2; 2-{[16-hydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (20R)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hui Ao, Huizhu Song, Jing Li, Xiangtao Wang. Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2. Drug delivery. 2024 Dec; 31(1):2324716. doi: 10.1080/10717544.2024.2324716. [PMID: 38555735]
  • Xiyu Liu, Jingjing Li, Qingqing Huang, Mingming Jin, Gang Huang. Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer. Molecular medicine (Cambridge, Mass.). 2024 Apr; 30(1):56. doi: 10.1186/s10020-024-00813-y. [PMID: 38671369]
  • Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jiang. Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2. The American journal of Chinese medicine. 2024 Jan; ?(?):1-14. doi: 10.1142/s0192415x24500095. [PMID: 38291582]
  • Jieyu Long, Wanshan Hu, Tao Ren, Xuewen Wang, Chao Lu, Xin Pan, Chuanbin Wu, Tingting Peng. Combating multidrug resistance of breast cancer with ginsenoside Rh2-irrigated nano-in-thermogel. International journal of pharmaceutics. 2024 Jan; 650(?):123718. doi: 10.1016/j.ijpharm.2023.123718. [PMID: 38104849]
  • Chunmei Yang, Cheng Qian, Weiwei Zheng, Guanglu Dong, Shan Zhang, Feihui Wang, Zhonghong Wei, Yuhua Xu, Aiyun Wang, Yang Zhao, Yin Lu. Ginsenoside Rh2 enhances immune surveillance of natural killer (NK) cells via inhibition of ERp5 in breast cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155180. doi: 10.1016/j.phymed.2023.155180. [PMID: 38043385]
  • Chao Hong, Anni Wang, Jiaxuan Xia, Jianming Liang, Ying Zhu, Dan Wang, Huaxing Zhan, Chunbo Feng, Xinnan Jiang, Junjie Pan, Jianxin Wang. Ginsenoside Rh2-Based Multifunctional Liposomes for Advanced Breast Cancer Therapy. International journal of nanomedicine. 2024; 19(?):2879-2888. doi: 10.2147/ijn.s437733. [PMID: 38525007]
  • Mu-Yang Huang, Yu-Chi Chen, Wen-Yu Lyu, Xin-Yu He, Zi-Han Ye, Can-Yu Huang, Xin-Ling He, Xiuping Chen, Xiaobing Chen, Baoxian Zhang, Guoyin Kai, Xiaolei Zhang, Ting Li, Mingqing Huang, Jin-Jian Lu. Ginsenoside Rh2 augmented anti-PD-L1 immunotherapy by reinvigorating CD8+ T cells via increasing intratumoral CXCL10. Pharmacological research. 2023 Dec; 198(?):106988. doi: 10.1016/j.phrs.2023.106988. [PMID: 37984507]
  • Tianyang Zhao. Suppression or Inhibition of VEGFs on Splenic Angiosarcoma Cell with Traditional Chinese Medicine Zhi Gan Cao. Studies in health technology and informatics. 2023 Nov; 308(?):396-403. doi: 10.3233/shti230865. [PMID: 38007765]
  • Yahui Hu, Shasha He, Xiaolong Xu, Xuran Cui, Yiming Wei, Chunxia Zhao, Haoran Ye, Jingxia Zhao, Qingquan Liu. Shenhuangdan decoction alleviates sepsis-induced lung injury through inhibition of GSDMD-mediated pyroptosis. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117047. doi: 10.1016/j.jep.2023.117047. [PMID: 37586442]
  • Wei Guan, Wang Qi. Ginsenoside Rh2: A shining and potential natural product in the treatment of human nonmalignant and malignant diseases in the near future. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jun; 118(?):154938. doi: 10.1016/j.phymed.2023.154938. [PMID: 37406390]
  • Dong Zhang, Siwei Duan, Zhangyou He, Zeming Zhu, Zhiping Li, Qincheng Yi, Tiantian Cai, Juanjuan Li, Nan Chen, Shaoju Guo. Sijunzi Decoction Targets IL1B and TNF to Reduce Neutrophil Extracellular Traps (NETs) in Ulcerative Colitis: Evidence from Silicon Prediction and Experiment Validation. Drug design, development and therapy. 2023; 17(?):3103-3128. doi: 10.2147/dddt.s428814. [PMID: 37868820]
  • Ji-Hyeon Jeon, Jin-Hyang Park, So Yeon Jeon, Minyeong Pang, Min-Koo Choi, Im-Sook Song. Concomitant Administration of Red Ginseng Extract with Lactic Acid Bacteria Increases the Plasma Concentration of Deglycosylated Ginsenosides in Healthy Human Subjects. Biomolecules. 2022 12; 12(12):. doi: 10.3390/biom12121896. [PMID: 36551324]
  • Ying Liu, Xinran Wang, Juhui Qiao, Jiawen Wang, Leilei Jiang, Chenxi Wang, Shiting Yu, Peiguang Zhang, Daqing Zhao, Meiling Fan, Meichen Liu. Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227865. [PMID: 36431966]
  • Darcy Lacanilao Garza, Shinya Hanashima, Yuichi Umegawa, Michio Murata, Masanao Kinoshita, Nobuaki Matsumori, Peter Greimel. Behavior of Triterpenoid Saponin Ginsenoside Rh2 in Ordered and Disordered Phases in Model Membranes Consisting of Sphingomyelin, Phosphatidylcholine, and Cholesterol. Langmuir : the ACS journal of surfaces and colloids. 2022 08; 38(34):10478-10491. doi: 10.1021/acs.langmuir.2c01261. [PMID: 35984899]
  • Siyu Chen, Ziwei He, Wei Xie, Xuan Chen, Zhuofeng Lin, Jisheng Ma, Zhi Liu, Shihai Yang, Yanfang Wang. Ginsenoside Rh2 attenuates CDAHFD-induced liver fibrosis in mice by improving intestinal microbial composition and regulating LPS-mediated autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 101(?):154121. doi: 10.1016/j.phymed.2022.154121. [PMID: 35489327]
  • Zhongwen Qi, Zhipeng Yan, Yueyao Wang, Nan Ji, Xiaoya Yang, Ao Zhang, Meng Li, Fengqin Xu, Junping Zhang. Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury. Frontiers in immunology. 2022; 13(?):883946. doi: 10.3389/fimmu.2022.883946. [PMID: 35865525]
  • Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen, Jin-Jian Lu. Anticancer Effects of Ginsenoside Rh2: A Systematic Review. Current molecular pharmacology. 2022; 15(1):179-189. doi: 10.2174/1874467214666210309115105. [PMID: 33687905]
  • B Shen, F Wang, Y Zhou, T Li, C He, W Zhao. [Ginsenoside Rh2 inhibits renal fibrosis and renal cell apoptosis in rats with diabetic nephropathy by downregulating discoid domain receptor 1]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2021 Jul; 41(7):1107-1113. doi: 10.12122/j.issn.1673-4254.2021.07.21. [PMID: 34308864]
  • Zhenlei Wang, Rui Liu, Li Chen, Huanhuan Wang, Mi Zhou, Yongsheng Wang, Yongping Qin. Pharmacokinetics of Ginsenoside Rh2, the Major Anticancer Ingredient of Ginsenoside H Dripping Pills, in Healthy Subjects. Clinical pharmacology in drug development. 2021 06; 10(6):669-674. doi: 10.1002/cpdd.877. [PMID: 33021081]
  • Jingwei Lv, Cong Lu, Ning Jiang, Haixia Wang, Hong Huang, Ying Chen, Yujiao Li, Xinmin Liu. Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway. Phytotherapy research : PTR. 2021 Jan; 35(1):337-345. doi: 10.1002/ptr.6804. [PMID: 32754961]
  • Minghao Sun, Chune Zhu, Jieyu Long, Chao Lu, Xin Pan, Chuanbin Wu. PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections. Drug delivery. 2020 Dec; 27(1):632-641. doi: 10.1080/10717544.2020.1756985. [PMID: 32329376]
  • Xun Li, Shifeng Chu, Meiyu Lin, Yan Gao, Yingjiao Liu, Songwei Yang, Xin Zhou, Yani Zhang, Yaomei Hu, Huiqin Wang, Naihong Chen. Anticancer property of ginsenoside Rh2 from ginseng. European journal of medicinal chemistry. 2020 Oct; 203(?):112627. doi: 10.1016/j.ejmech.2020.112627. [PMID: 32702586]
  • Hongping Lu, Xiaoxue Yuan, Yu Zhang, Ming Han, Shunai Liu, Kai Han, Pu Liang, Jun Cheng. HCBP6 deficiency exacerbates glucose and lipid metabolism disorders in non-alcoholic fatty liver mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110347. doi: 10.1016/j.biopha.2020.110347. [PMID: 32535386]
  • Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127364. doi: 10.1016/j.bmcl.2020.127364. [PMID: 32738969]
  • Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro. Experimental parasitology. 2020 May; 212(?):107873. doi: 10.1016/j.exppara.2020.107873. [PMID: 32165146]
  • Dong Yang, Xin Li, Xiaoyan Zhang. Ginsenoside Rh2 induces DNA damage and autophagy in vestibular schwannoma is dependent of LAMP2 transcriptional suppression. Biochemical and biophysical research communications. 2020 02; 522(2):300-307. doi: 10.1016/j.bbrc.2019.11.026. [PMID: 31771882]
  • Xin Jin, Qing Yang, Ning Cai, Zhenhai Zhang. A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment. Nanomedicine (London, England). 2020 01; 15(1):41-54. doi: 10.2217/nnm-2018-0479. [PMID: 31868113]
  • Yingying Chen, Yuqiang Zhang, Wei Song, Ying Zhang, Xiu Dong, Mingqi Tan. Ginsenoside Rh2 Improves the Cisplatin Anti-tumor Effect in Lung Adenocarcinoma A549 Cells via Superoxide and PD-L1. Anti-cancer agents in medicinal chemistry. 2020; 20(4):495-503. doi: 10.2174/1871520619666191209091230. [PMID: 31814556]
  • Hadi Zare-Zardini, Ashraf Alemi, Asghar Taheri-Kafrani, Seyed Ahmad Hosseini, Hossein Soltaninejad, Amir Ali Hamidieh, Mojtaba Haghi Karamallah, Majid Farrokhifar, Mohammad Farrokhifar. Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study. Drug design, development and therapy. 2020; 14(?):3315-3324. doi: 10.2147/dddt.s261027. [PMID: 32884236]
  • Huayu Yan, Huding Jin, Yu Fu, Zhenxing Yin, Chengri Yin. Production of Rare Ginsenosides Rg3 and Rh2 by Endophytic Bacteria from Panax ginseng. Journal of agricultural and food chemistry. 2019 Aug; 67(31):8493-8499. doi: 10.1021/acs.jafc.9b03159. [PMID: 31310523]
  • Zeng Qi, Wei Li, Jing Tan, Cuizhu Wang, Hongqiang Lin, Baisong Zhou, Jinping Liu, Pingya Li. Effect of ginsenoside Rh2 on renal apoptosis in cisplatin-induced nephrotoxicity in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Aug; 61(?):152862. doi: 10.1016/j.phymed.2019.152862. [PMID: 31048124]
  • Sandrine L Verstraeten, Magali Deleu, Maria Janikowska-Sagan, Emily J S Claereboudt, Laurence Lins, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq. The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol. Scientific reports. 2019 05; 9(1):7285. doi: 10.1038/s41598-019-43674-w. [PMID: 31086211]
  • Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Min Jiang, Zhihong Jiang, Yuanyuan Hou, Gang Bai. Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects. Journal of proteome research. 2019 05; 18(5):2100-2108. doi: 10.1021/acs.jproteome.8b00972. [PMID: 30860844]
  • Yin-Ping Guo, Man-Yun Chen, Li Shao, Wei Zhang, Tai Rao, Hong-Hao Zhou, Wei-Hua Huang. Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS. Chinese journal of natural medicines. 2019 Mar; 17(3):231-240. doi: 10.1016/s1875-5364(19)30026-3. [PMID: 30910060]
  • Li-Xue Chen, Zeng Qi, Zi-Jun Shao, Shan-Shan Li, Yu-Li Qi, Kun Gao, Song-Xin Liu, Zhuo Li, Yin-Shi Sun, Ping-Ya Li. Study on Antidepressant Activity of Pseudo-Ginsenoside HQ on Depression-Like Behavior in Mice. Molecules (Basel, Switzerland). 2019 Mar; 24(5):. doi: 10.3390/molecules24050870. [PMID: 30823679]
  • Zeng Qi, Lixue Chen, Zhuo Li, Zijun Shao, Yuli Qi, Kun Gao, Songxin Liu, Yinshi Sun, Pingya Li, Jinping Liu. Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study. International journal of molecular sciences. 2019 Feb; 20(4):. doi: 10.3390/ijms20040836. [PMID: 30769948]
  • Yingying Chen, Yuqiang Zhang, Wei Song, Ying Zhang, Xiu Dong, Mingqi Tan. Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells under Hypoxia via mir-491. Anti-cancer agents in medicinal chemistry. 2019; 19(13):1633-1641. doi: 10.2174/1871520619666190704165205. [PMID: 31272362]
  • Delgerzul Baatar, Muhammad Zubair Siddiqi, Wan Taek Im, Nisar Ul Khaliq, Seong Gu Hwang. Anti-Inflammatory Effect of Ginsenoside Rh2-Mix on Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophage Cells. Journal of medicinal food. 2018 Oct; 21(10):951-960. doi: 10.1089/jmf.2018.4180. [PMID: 30239266]
  • Cong Lu, Yan Wang, Jingwei Lv, Ning Jiang, Bei Fan, Lina Qu, Yinghui Li, Shanguang Chen, Fengzhong Wang, Xinmin Liu. Ginsenoside Rh2 reverses sleep deprivation-induced cognitive deficit in mice. Behavioural brain research. 2018 09; 349(?):109-115. doi: 10.1016/j.bbr.2018.03.005. [PMID: 29544964]
  • Ni Li, Zhican Lin, Wei Chen, Yi Zheng, Yanlin Ming, Zhizhong Zheng, Wen Huang, Lianghua Chen, Jianbo Xiao, Hetong Lin. Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Sep; 119(?):133-140. doi: 10.1016/j.fct.2018.05.018. [PMID: 29751073]
  • Sandrine L Verstraeten, Marie Albert, Adrien Paquot, Giulio G Muccioli, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq. Membrane cholesterol delays cellular apoptosis induced by ginsenoside Rh2, a steroid saponin. Toxicology and applied pharmacology. 2018 08; 352(?):59-67. doi: 10.1016/j.taap.2018.05.014. [PMID: 29782965]
  • Honglin Li, Nan Huang, Weikang Zhu, Jianchun Wu, Xiaohui Yang, Wenjing Teng, Jianhui Tian, Zhihong Fang, Yingbin Luo, Min Chen, Yan Li. Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2. BMC cancer. 2018 May; 18(1):579. doi: 10.1186/s12885-018-4299-4. [PMID: 29783929]
  • Zhao-Hui Jin, Wen Qiu, Hui Liu, Xue-Hua Jiang, Ling Wang. Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine. Chinese journal of natural medicines. 2018 Feb; 16(2):143-149. doi: 10.1016/s1875-5364(18)30041-4. [PMID: 29455730]
  • Xiu-Wei Yang, Li-Yuan Ma, Qi-Le Zhou, Wei Xu, You-Bo Zhang. SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng. Bioorganic & medicinal chemistry letters. 2018 02; 28(3):240-243. doi: 10.1016/j.bmcl.2017.12.067. [PMID: 29317167]
  • Qi Li, Bai Li, Chengya Dong, Yajie Wang, Qi Li. 20(S)-Ginsenoside Rh2 suppresses proliferation and migration of hepatocellular carcinoma cells by targeting EZH2 to regulate CDKN2A-2B gene cluster transcription. European journal of pharmacology. 2017 Nov; 815(?):173-180. doi: 10.1016/j.ejphar.2017.09.023. [PMID: 28928088]
  • Peng Li, XiaoYue Zhou, Ding Qu, Mengfei Guo, Chenyi Fan, Tong Zhou, Yang Ling. Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol-polyethylene glycol-ginsenoside Rh2. Drug delivery. 2017 Nov; 24(1):834-845. doi: 10.1080/10717544.2017.1326540. [PMID: 28532223]
  • Feifei Yang, Jing Zhou, Xiao Hu, Stephanie Kyoungchun Yu, Chunyu Liu, Ruile Pan, Qi Chang, Xinmin Liu, Yonghong Liao. Preparation and evaluation of self-microemulsions for improved bioavailability of ginsenoside-Rh1 and Rh2. Drug delivery and translational research. 2017 10; 7(5):731-737. doi: 10.1007/s13346-017-0402-7. [PMID: 28677033]
  • Yu Zhuang, Guang-Yu Yang, Xiaohui Chen, Qian Liu, Xueli Zhang, Zixin Deng, Yan Feng. Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme. Metabolic engineering. 2017 07; 42(?):25-32. doi: 10.1016/j.ymben.2017.04.009. [PMID: 28479190]
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