FAPy-adenine (BioDeep_00000006181)

 

Secondary id: BioDeep_00000405594

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


N-(4,6-diamino-5-Pyrimidinyl)-formamide

化学式: C5H7N5O (153.0651)
中文名称: 4,6-二氨基-5-(甲酰氨基)嘧啶, 4,6-二氨基-5-甲酰胺嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 41.8%

分子结构信息

SMILES: C1=NC(=C(C(=N1)N)NC=O)N
InChI: InChI=1S/C5H7N5O/c6-4-3(10-2-11)5(7)9-1-8-4/h1-2H,(H,10,11)(H4,6,7,8,9)

描述信息

Fapy-adenine is an oxidized DNA base. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases (PMID 15116424). Oxidative stress damage to DNA bases may contribute to neuronal loss in Alzheimers disease (AD). Increased levels were observed in parietal, temporal, occipital, and frontal lobe, superior temporal gyrus, and hippocampus areas of the brain in patients with AD. (PMID 9109533).
Fapy-adenine is an oxidized DNA base. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases. (PMID 15116424)
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

同义名列表

12 个代谢物同义名

N-(4,6-diamino-5-Pyrimidinyl)-formamide; N-(4,6-diaminopyrimidin-5-yl)formamide; N-(4,6-diamino-5-Pyrimidinyl)formamide; 4,6-Diamino-5-(formylamino)pyrimidine; 4,6-Diamino-5-N-formamidopyrimidine; 4,6-Diamino-5-pyrimidinylformamide; 4,6-diamino-5-Formamidopyrimidine; FAPy-adenine; Fapyade; FAPY; 4,6-Diamino-5-formamidopyrimidine; 4,6-Diamino-5-formamidopyrimidine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

85 个相关的代谢反应过程信息。

Reactome(85)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADA, ADAR, ALB, CAT, ENDOV, MYD88, NEIL1, NEIL2, POLB, TLR2, TP53, XDH, ZMYND8
Peripheral membrane protein 2 ADA, CYP1B1
Endosome membrane 1 MYD88
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 13 ADAR, ALB, ERCC5, LIG4, MYD88, NEIL1, NEIL2, NEIL3, OGG1, POLB, POLL, TP53, ZMYND8
cytosol 10 ADA, ADAR, ALB, CAT, HCCS, MYD88, NEIL1, OGG1, TP53, XDH
centrosome 3 ALB, NEIL1, TP53
nucleoplasm 11 ADAR, ERCC5, LIG4, NEIL1, NEIL2, NEIL3, OGG1, POLB, POLL, TP53, ZMYND8
Cell membrane 1 ADA
Lipid-anchor 1 HCCS
cell junction 1 ADA
cell surface 3 ADA, MYD88, TLR2
dendritic shaft 1 ZMYND8
Golgi apparatus 2 ALB, TLR2
mitochondrial inner membrane 1 HCCS
Lysosome 1 ADA
plasma membrane 3 ADA, MYD88, TLR2
Membrane 8 ADA, ADAR, CAT, CYP1B1, ERCC5, HCCS, TLR2, TP53
extracellular exosome 2 ALB, CAT
endoplasmic reticulum 2 ALB, TP53
extracellular space 2 ALB, XDH
mitochondrion 6 ADAR, CAT, CYP1B1, HCCS, OGG1, TP53
protein-containing complex 7 ALB, CAT, ERCC5, MYD88, OGG1, POLB, TP53
intracellular membrane-bounded organelle 4 CAT, CYP1B1, LIG4, NEIL2
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 TLR2
Secreted 1 ALB
extracellular region 2 ALB, CAT
Mitochondrion matrix 1 TP53
mitochondrial matrix 3 CAT, OGG1, TP53
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 2 ADA, ALB
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 NEIL1, TP53
external side of plasma membrane 1 ADA
dendritic spine 1 ZMYND8
nucleolus 4 ADAR, ENDOV, TP53, ZMYND8
Mitochondrion inner membrane 1 HCCS
Membrane raft 1 TLR2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
microtubule 1 POLB
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
nuclear speck 1 OGG1
receptor complex 1 TLR2
ciliary basal body 1 ALB
chromatin 2 TP53, ZMYND8
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic vesicle membrane 1 TLR2
mitotic spindle 1 NEIL2
Chromosome 5 ERCC5, NEIL1, NEIL3, POLL, ZMYND8
centriole 1 ALB
[Isoform 5]: Cytoplasm 1 ADAR
Nucleus, nucleolus 2 ADAR, ENDOV
spindle pole 1 ALB
chromosome, telomeric region 1 LIG4
blood microparticle 1 ALB
site of double-strand break 2 POLL, TP53
Nucleus, nucleoplasm 1 OGG1
Cytoplasm, Stress granule 1 ENDOV
cytoplasmic stress granule 1 ENDOV
Nucleus speckle 1 OGG1
cell body 1 TLR2
germ cell nucleus 1 TP53
replication fork 1 TP53
[Isoform 1]: Cytoplasm 2 ADAR, ENDOV
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 TLR2
endoplasmic reticulum lumen 1 ALB
nuclear matrix 2 OGG1, TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
Nucleus matrix 1 OGG1
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
spindle microtubule 1 POLB
condensed chromosome 1 LIG4
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 MYD88
site of DNA damage 1 ZMYND8
[Isoform 7]: Cytoplasm 1 ENDOV
catalase complex 1 CAT
nucleotide-excision repair complex 1 ERCC5
[Isoform 6]: Cytoplasm 1 ENDOV
DNA-dependent protein kinase-DNA ligase 4 complex 1 LIG4
nonhomologous end joining complex 1 LIG4
supraspliceosomal complex 1 ADAR
ciliary transition fiber 1 ALB
DNA ligase IV complex 1 LIG4


文献列表

  • Donald H Atha, Huanhua Wang, Elijah J Petersen, Danielle Cleveland, R David Holbrook, Pawel Jaruga, Miral Dizdaroglu, Baoshan Xing, Bryant C Nelson. Copper oxide nanoparticle mediated DNA damage in terrestrial plant models. Environmental science & technology. 2012 Feb; 46(3):1819-27. doi: 10.1021/es202660k. [PMID: 22201446]
  • Michael K Chan, Maria T Ocampo-Hafalla, Vladimir Vartanian, Pawel Jaruga, Güldal Kirkali, Karen L Koenig, Stuart Brown, R Stephen Lloyd, Miral Dizdaroglu, George W Teebor. Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA repair. 2009 Jul; 8(7):786-94. doi: 10.1016/j.dnarep.2009.03.001. [PMID: 19346169]
  • Meltem Muftuoglu, Nadja C de Souza-Pinto, Arin Dogan, Maria Aamann, Tinna Stevnsner, Ivana Rybanska, Güldal Kirkali, Miral Dizdaroglu, Vilhelm A Bohr. Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. The Journal of biological chemistry. 2009 Apr; 284(14):9270-9. doi: 10.1074/jbc.m807006200. [PMID: 19179336]