FAPy-adenine (BioDeep_00000006181)

 

Secondary id: BioDeep_00000405594

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


N-(4,6-diamino-5-Pyrimidinyl)-formamide

化学式: C5H7N5O (153.0650572)
中文名称: 4,6-二氨基-5-(甲酰氨基)嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 1.42%

分子结构信息

SMILES: C1=NC(=C(C(=N1)N)NC=O)N
InChI: InChI=1S/C5H7N5O/c6-4-3(10-2-11)5(7)9-1-8-4/h1-2H,(H,10,11)(H4,6,7,8,9)

描述信息

Fapy-adenine is an oxidized DNA base. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases (PMID 15116424). Oxidative stress damage to DNA bases may contribute to neuronal loss in Alzheimers disease (AD). Increased levels were observed in parietal, temporal, occipital, and frontal lobe, superior temporal gyrus, and hippocampus areas of the brain in patients with AD. (PMID 9109533).
Fapy-adenine is an oxidized DNA base. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases. (PMID 15116424)
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

同义名列表

10 个代谢物同义名

N-(4,6-diamino-5-Pyrimidinyl)-formamide; N-(4,6-diaminopyrimidin-5-yl)formamide; N-(4,6-diamino-5-Pyrimidinyl)formamide; 4,6-Diamino-5-(formylamino)pyrimidine; 4,6-Diamino-5-N-formamidopyrimidine; 4,6-Diamino-5-pyrimidinylformamide; 4,6-diamino-5-Formamidopyrimidine; FAPy-adenine; Fapyade; FAPY



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

85 个相关的代谢反应过程信息。

Reactome(85)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Donald H Atha, Huanhua Wang, Elijah J Petersen, Danielle Cleveland, R David Holbrook, Pawel Jaruga, Miral Dizdaroglu, Baoshan Xing, Bryant C Nelson. Copper oxide nanoparticle mediated DNA damage in terrestrial plant models. Environmental science & technology. 2012 Feb; 46(3):1819-27. doi: 10.1021/es202660k. [PMID: 22201446]
  • Michael K Chan, Maria T Ocampo-Hafalla, Vladimir Vartanian, Pawel Jaruga, Güldal Kirkali, Karen L Koenig, Stuart Brown, R Stephen Lloyd, Miral Dizdaroglu, George W Teebor. Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA repair. 2009 Jul; 8(7):786-94. doi: 10.1016/j.dnarep.2009.03.001. [PMID: 19346169]
  • Meltem Muftuoglu, Nadja C de Souza-Pinto, Arin Dogan, Maria Aamann, Tinna Stevnsner, Ivana Rybanska, Güldal Kirkali, Miral Dizdaroglu, Vilhelm A Bohr. Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. The Journal of biological chemistry. 2009 Apr; 284(14):9270-9. doi: 10.1074/jbc.m807006200. [PMID: 19179336]