12-Hete (BioDeep_00000607970)
Main id: BioDeep_00000003296
Secondary id: BioDeep_00000015329
代谢物信息卡片
(5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
化学式: C20H32O3 (320.2351)
中文名称: 12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
谱图信息:
最多检出来源 Homo sapiens(otcml) 21.5%
分子结构信息
SMILES: C(/CCCC(=O)O)=C/C/C=C\C=C\C(O)C/C=C\CCCCC
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)
描述信息
A HETE that is icosa-5,8,10,14-tetraenoic acid substituted by a hydroxy group at position 12. It is a metabolite of arachidonic acid.
A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.
同义名列表
21 个代谢物同义名
12-Hete; (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid; (5Z,8Z,10E,14Z)-(12S)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid; 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid; 12(S)-HETE; FA 20:4;O; 12S-HETE; 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid; 5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, [S-(E,Z,Z,Z)]-; 12S-hydroxy-5E,8Z,10Z,14Z-eicosatetraenoic acid; 12(S)-5,8,10,14-Hydroxyeicosatetraenoic acid; 12-L-Hydroxy-5,8,10,14-eicosatetraenoic acid; 12-Hydroxy-5,8,10,14-eicosatetraenoic acid; 12-Hydroxyeicosatetraenoic acid; 12S-; 5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (E,Z,Z,Z)-; 12-hydroxy-5E,8Z,10Z,14Z-eicosatetraenoic acid; 12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid; 12R-HETE; 12S; 12(S)-HETE
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:19138
- ChEBI: CHEBI:34146
- ChEBI: CHEBI:175105
- ChEBI: CHEBI:34144
- KEGG: C14777
- KEGG: C14822
- PubChem: 5283155
- PubChem: 5312984
- PubChem: 5312983
- PubChem: 5283156
- Metlin: METLIN75018
- Metlin: METLIN75012
- Metlin: METLIN75011
- ChEMBL: CHEMBL1526258
- ChEMBL: CHEMBL1435825
- LipidMAPS: LMFA03060007
- LipidMAPS: LMFA03060088
- LipidMAPS: LMFA03060064
- LipidMAPS: LMFA03060063
- LipidMAPS: LMFA03060008
- MeSH: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
- CAS: 54397-83-0
- CAS: 82337-46-0
- MetaboLights: MTBLC19138
- MetaboLights: MTBLC34146
- PubChem: 17395775
- NIKKAJI: J356.353G
- PubChem: 17395820
- KNApSAcK: C00000424
- NIKKAJI: J260.110I
- RefMet: 12-HETE
- KNApSAcK: 34146
分类词条
相关代谢途径
Reactome(10)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed Moustafa, Abraham Khalil, Noureldien H E Darwish, Dao-Qi Zhang, Amany Tawfik, Mohamed Al-Shabrawey. 12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29.
Prostaglandins & other lipid mediators.
2023 Dec; 171(?):106805. doi:
10.1016/j.prostaglandins.2023.106805. [PMID: 38141777] - Riyaz Mohamed, Jennifer C Sullivan. Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females.
Molecular medicine (Cambridge, Mass.).
2023 Dec; 29(1):163. doi:
10.1186/s10020-023-00762-y. [PMID: 38049738] - Naixin Zhang, Brian Harsch, Michael J Zhang, Dylan J Gyberg, Jackie A Stevens, Brandon M Wagner, Jenna Mendelson, Michael T Patterson, Devin A Orchard, Chastity L Healy, Jesse W Williams, DeWayne Townsend, Gregory C Shearer, Katherine A Murphy, Timothy D O'Connell. FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome.
Journal of lipid research.
2023 Apr; ?(?):100374. doi:
10.1016/j.jlr.2023.100374. [PMID: 37075982] - Annalisa Contursi, Stefania Tacconelli, Ulrika Hofling, Annalisa Bruno, Melania Dovizio, Patrizia Ballerini, Paola Patrignani. Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk.
Biochemical pharmacology.
2022 11; 205(?):115252. doi:
10.1016/j.bcp.2022.115252. [PMID: 36130648] - Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu, Tong Zhu. Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation.
Particle and fibre toxicology.
2022 10; 19(1):65. doi:
10.1186/s12989-022-00503-9. [PMID: 36280873] - Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice.
Scientific reports.
2022 07; 12(1):11385. doi:
10.1038/s41598-022-15461-7. [PMID: 35790870] - Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S Kanwar. Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway.
JCI insight.
2022 03; 7(6):. doi:
10.1172/jci.insight.155487. [PMID: 35315361] - Shuli Chen, Haidong Zou. Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.
Current eye research.
2022 03; 47(3):329-335. doi:
10.1080/02713683.2021.1995003. [PMID: 35129022] - Mariya Misheva, Konstantinos Kotzamanis, Luke C Davies, Victoria J Tyrrell, Patricia R S Rodrigues, Gloria A Benavides, Christine Hinz, Robert C Murphy, Paul Kennedy, Philip R Taylor, Marcela Rosas, Simon A Jones, James E McLaren, Sumukh Deshpande, Robert Andrews, Nils Helge Schebb, Magdalena A Czubala, Mark Gurney, Maceler Aldrovandi, Sven W Meckelmann, Peter Ghazal, Victor Darley-Usmar, Daniel A White, Valerie B O'Donnell. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.
Nature communications.
2022 01; 13(1):139. doi:
10.1038/s41467-021-27766-8. [PMID: 35013270] - Mélissa Simard, Geneviève Rioux, Sophie Morin, Cyril Martin, Sylvain L Guérin, Nicolas Flamand, Pierre Julien, Julie Fradette, Roxane Pouliot. Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.
The Journal of investigative dermatology.
2021 10; 141(10):2391-2401.e13. doi:
10.1016/j.jid.2021.02.755. [PMID: 33857488] - K M Bermingham, L Brennan, R Segurado, I J Gray, R E Barron, E R Gibney, M F Ryan, M J Gibney, J W Newman, Dr A M O'Sullivan. Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 10; 173(?):102338. doi:
10.1016/j.plefa.2021.102338. [PMID: 34500309] - Ying-Chun Han, Ji-Chao Zhang, Cong-Cong Zhang, Jie DU. [Arachidonic acid Alox15/12-HETE signaling inhibits vascular calcification].
Sheng li xue bao : [Acta physiologica Sinica].
2021 Aug; 73(4):571-576. doi:
NULL. [PMID: 34405213] - Jonathan V Pascale, Pamela A Lucchesi, Victor Garcia. Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches.
Journal of cardiovascular pharmacology.
2021 06; 77(6):707-717. doi:
10.1097/fjc.0000000000001013. [PMID: 34016841] - Anne Abot, Eve Wemelle, Claire Laurens, Adrien Paquot, Nicolas Pomie, Deborah Carper, Arnaud Bessac, Xavier Mas Orea, Christophe Fremez, Maxime Fontanie, Alexandre Lucas, Jean Lesage, Amandine Everard, Etienne Meunier, Gilles Dietrich, Giulio G Muccioli, Cedric Moro, Patrice D Cani, Claude Knauf. Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice.
Gut.
2021 06; 70(6):1078-1087. doi:
10.1136/gutjnl-2019-320230. [PMID: 33020209] - Samantha D Pauls, Youjia Du, Luc Clair, Tanja Winter, Harold M Aukema, Carla G Taylor, Peter Zahradka. Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health.
Arteriosclerosis, thrombosis, and vascular biology.
2021 02; 41(2):883-897. doi:
10.1161/atvbaha.120.315133. [PMID: 33380172] - Annalisa Contursi, Simone Schiavone, Melania Dovizio, Christine Hinz, Rosa Fullone, Stefania Tacconelli, Victoria J Tyrrell, Rosalia Grande, Paola Lanuti, Marco Marchisio, Mirco Zucchelli, Patrizia Ballerini, Angel Lanas, Valerie B O'Donnell, Paola Patrignani. Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Journal of lipid research.
2021; 62(?):100109. doi:
10.1016/j.jlr.2021.100109. [PMID: 34428433] - Layla Van Doren, Nga Nguyen, Christopher Garzia, Elizabeth K Fletcher, Ryan Stevenson, David Jaramillo, Athan Kuliopulos, Lidija Covic. Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis.
Arteriosclerosis, thrombosis, and vascular biology.
2021 01; 41(1):e33-e45. doi:
10.1161/atvbaha.120.315154. [PMID: 33267659] - Miriam C Wolters, Julia Schmetzer, Christine V Möser, Lisa Hahnefeld, Carlo Angioni, Dominique Thomas, Nerea Ferreirós, Gerd Geisslinger, Ellen Niederberger. Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers.
Cells.
2020 09; 9(9):. doi:
10.3390/cells9092111. [PMID: 32948055] - Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska. Effect of renal replacement therapy on selected arachidonic acid derivatives concentration.
BMC nephrology.
2020 09; 21(1):394. doi:
10.1186/s12882-020-02053-8. [PMID: 32917166] - Changqing Dong, Shengmao Liu, Yingchun Cui, Qiaoyan Guo. 12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy.
European journal of pharmacology.
2020 Jul; 879(?):173122. doi:
10.1016/j.ejphar.2020.173122. [PMID: 32333927] - Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv, Hua-Ping Liang. Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.
Cell communication and signaling : CCS.
2020 05; 18(1):70. doi:
10.1186/s12964-020-0523-3. [PMID: 32366266] - Vanessa Moreira, José María Gutiérrez, Bruno Lomonte, Marco Aurélio Ramirez Vinolo, Rui Curi, Gérard Lambeau, Catarina Teixeira. 12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages.
Chemico-biological interactions.
2020 Feb; 317(?):108903. doi:
10.1016/j.cbi.2019.108903. [PMID: 31811862] - Vasundhara Kain, Ganesh V Halade. Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment.
Journal of cellular physiology.
2019 04; 234(4):3910-3920. doi:
10.1002/jcp.27165. [PMID: 30191990] - Saskia Kroschwald, Cheng-Ying Chiu, Dagmar Heydeck, Nadine Rohwer, Tatjana Gehring, Ulrike Seifert, Anke Lux, Michael Rothe, Karsten-Henrich Weylandt, Hartmut Kuhn. Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2018 08; 1863(8):866-880. doi:
10.1016/j.bbalip.2018.04.019. [PMID: 29702245] - Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Rui Wang, Chantal Cossette, Sylvie Gravel, Irina Slobodchikova, Dajana Vuckovic, Joshua Rokach, William S Powell. Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).
Journal of medicinal chemistry.
2018 Jul; 61(14):5934-5948. doi:
10.1021/acs.jmedchem.8b00154. [PMID: 29972644] - Bibo Ke, Jerzy W Kupiec-Weglinski. Lipid Metabolites: The Alarm Signal to Trigger Liver Ischemia-reperfusion Injury.
Transplantation.
2018 06; 102(6):887-889. doi:
10.1097/tp.0000000000002206. [PMID: 29782474] - Chen Zhang, Cui Ma, Hongmin Yao, Lixin Zhang, Xiufeng Yu, Yumei Liu, Tingting Shen, Linlin Zhang, Fengying Zhang, Xinxin Chen, Daling Zhu. 12-Lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway.
American journal of physiology. Lung cellular and molecular physiology.
2018 04; 314(4):L606-L616. doi:
10.1152/ajplung.00049.2017. [PMID: 29074487] - Tamas Kriska, Michael J Thomas, John R Falck, William B Campbell. Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.
Journal of lipid research.
2018 04; 59(4):615-624. doi:
10.1194/jlr.m081448. [PMID: 29472381] - Yonghai Lu, Jinling Fang, Li Zou, Liang Cui, Xu Liang, Seng Gee Lim, Yock-Young Dan, Choon Nam Ong. Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases.
Metabolomics : Official journal of the Metabolomic Society.
2018 01; 14(3):26. doi:
10.1007/s11306-018-1326-z. [PMID: 30830341] - Xiao-Jing Zhang, Xu Cheng, Zhen-Zhen Yan, Jing Fang, Xiaozhan Wang, Weijun Wang, Zhen-Yu Liu, Li-Jun Shen, Peng Zhang, Pi-Xiao Wang, Rufang Liao, Yan-Xiao Ji, Jun-Yong Wang, Song Tian, Xue-Yong Zhu, Yan Zhang, Rui-Feng Tian, Lin Wang, Xin-Liang Ma, Zan Huang, Zhi-Gang She, Hongliang Li. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.
Nature medicine.
2018 01; 24(1):73-83. doi:
10.1038/nm.4451. [PMID: 29227475] - Qi Zhang, Xiang Wang, Guifang Yan, Juan Lei, Yu Zhou, Lei Wu, Ting Wang, Xiao Zhang, Duyun Ye, Yongsheng Li. Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(4):1377-1389. doi:
10.1159/000487563. [PMID: 29462800] - Jan Philipp Schuchardt, Annika I Ostermann, Lisa Stork, Sabrina Fritzsch, Heike Kohrs, Theresa Greupner, Andreas Hahn, Nils Helge Schebb. Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood.
Prostaglandins, leukotrienes, and essential fatty acids.
2017 Jun; 121(?):76-87. doi:
10.1016/j.plefa.2017.06.007. [PMID: 28651702] - Ashok-Kumar Dilly, Keqin Tang, Yande Guo, Sangeeta Joshi, Prasanna Ekambaram, Krishna Rao Maddipati, Yinlong Cai, Stephanie C Tucker, Kenneth V Honn. Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.
Experimental cell research.
2017 02; 351(1):1-10. doi:
10.1016/j.yexcr.2016.12.011. [PMID: 28011194] - Oscar D Rangel-Huerta, Concepcion M Aguilera, Antonio Perez-de-la-Cruz, Fernando Vallejo, Francisco Tomas-Barberan, Angel Gil, Maria D Mesa. A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study.
Molecular nutrition & food research.
2017 02; 61(2):. doi:
10.1002/mnfr.201600120. [PMID: 27689343] - A L Peters, M A T Vervaart, R van Bruggen, D de Korte, R Nieuwland, W Kulik, A P J Vlaar. Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury.
Vox sanguinis.
2017 Jan; 112(1):25-32. doi:
10.1111/vox.12453. [PMID: 28097705] - Hong-Zhao Xu, Wan-Ning Wang, Yuan-Yuan Zhang, Yan-Li Cheng, Zhong-Gao Xu. Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Journal of nephrology.
2016 Dec; 29(6):775-782. doi:
10.1007/s40620-016-0296-3. [PMID: 27021232] - Qiaoxia Bian, Weihui Wang, Nannan Wang, Yan Peng, Wen Ma, Ronghua Dai. Arachidonic acid metabolomic study of BPH in rats and the interventional effects of Zishen pill, a traditional Chinese medicine.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):149-157. doi:
10.1016/j.jpba.2016.05.027. [PMID: 27262108] - L Malan, J Baumgartner, P C Calder, C M Smuts. Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy.
Prostaglandins, leukotrienes, and essential fatty acids.
2016 07; 110(?):35-41. doi:
10.1016/j.plefa.2016.05.006. [PMID: 27255641] - C Schmöcker, U Kassner, S Kiesler, M Bismarck, M Rothe, E Steinhagen-Thiessen, K H Weylandt. A lipidomic analysis approach in patients undergoing lipoprotein apheresis.
Atherosclerosis.
2016 06; 249(?):30-5. doi:
10.1016/j.atherosclerosis.2016.03.019. [PMID: 27062407] - Hong-Zhao Xu, Yan-Li Cheng, Wan-Ning Wang, Hao Wu, Yuan-Yuan Zhang, Chong-Sen Zang, Zhong-Gao Xu. 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
International journal of molecular sciences.
2016 May; 17(5):. doi:
10.3390/ijms17050684. [PMID: 27164093] - Jelena Klawitter, Kim McFann, Alexander T Pennington, Wei Wang, Jost Klawitter, Uwe Christians, Robert W Schrier, Berenice Gitomer, Melissa A Cadnapaphornchai. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease.
Clinical journal of the American Society of Nephrology : CJASN.
2015 Sep; 10(9):1534-41. doi:
10.2215/cjn.11331114. [PMID: 26224879] - Mark D Farrar, Anna Nicolaou, Kayleigh A Clarke, Sarah Mason, Karen A Massey, Tristan P Dew, Rachel E B Watson, Gary Williamson, Lesley E Rhodes. A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation.
The American journal of clinical nutrition.
2015 Sep; 102(3):608-15. doi:
10.3945/ajcn.115.107995. [PMID: 26178731] - Mária Pekárová, Hartmut Kuhn, Lýdia Bezáková, Christoph Ufer, Dagmar Heydeck. Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation.
Archives of biochemistry and biophysics.
2015 Apr; 571(?):50-7. doi:
10.1016/j.abb.2015.02.029. [PMID: 25731857] - William S Powell, Joshua Rokach. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Biochimica et biophysica acta.
2015 Apr; 1851(4):340-55. doi:
10.1016/j.bbalip.2014.10.008. [PMID: 25449650] - David A Taylor-Fishwick, Jessica Weaver, Lindsey Glenn, Norine Kuhn, Ganesha Rai, Ajit Jadhav, Anton Simeonov, Angela Dudda, Dieter Schmoll, Theodore R Holman, David J Maloney, Jerry L Nadler. Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.
Diabetologia.
2015 Mar; 58(3):549-57. doi:
10.1007/s00125-014-3452-0. [PMID: 25417214] - Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain.
Journal of lipid research.
2015 Mar; 56(3):502-514. doi:
10.1194/jlr.m053058. [PMID: 25605873] - Elizabeth F Lopez, Janusz H Kabarowski, Kevin A Ingle, Vasundhara Kain, Stephen Barnes, David K Crossman, Merry L Lindsey, Ganesh V Halade. Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction.
American journal of physiology. Heart and circulatory physiology.
2015 Feb; 308(4):H269-80. doi:
10.1152/ajpheart.00604.2014. [PMID: 25485899] - M Setkowicz, L Mastalerz, A Gielicz, A Wojas-Pelc, M Sanak. Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid.
The British journal of dermatology.
2015 Feb; 172(2):337-44. doi:
10.1111/bjd.13225. [PMID: 24975552] - Yuan-yuan Zhang, Qiao-yan Guo, Mei-yan Wu, Chong-sen Zang, Fu-zhe Ma, Tao Sun, Wan-ning Wang, Li-ning Miao, Zhong-gao Xu. p16ink4a Expression Is Increased through 12-Lipoxygenase in High Glucose-Stimulated Glomerular Mesangial Cells and Type 2 Diabetic Glomeruli.
Nephron.
2015; 130(2):141-50. doi:
10.1159/000431106. [PMID: 26022507] - Alwena H Morgan, Victoria J Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B O'Donnell. A novel role for 12/15-lipoxygenase in regulating autophagy.
Redox biology.
2015; 4(?):40-7. doi:
10.1016/j.redox.2014.11.005. [PMID: 25498966] - Asem I Fitian, David R Nelson, Chen Liu, Yiling Xu, Miguel Ararat, Roniel Cabrera. Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS.
Liver international : official journal of the International Association for the Study of the Liver.
2014 Oct; 34(9):1428-44. doi:
10.1111/liv.12541. [PMID: 24661807] - Isabella Squellerio, Benedetta Porro, Paola Songia, Fabrizio Veglia, Donatella Caruso, Elena Tremoli, Viviana Cavalca. Liquid chromatography-tandem mass spectrometry for simultaneous measurement of thromboxane B2 and 12(S)-hydroxyeicosatetraenoic acid in serum.
Journal of pharmaceutical and biomedical analysis.
2014 Aug; 96(?):256-62. doi:
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Talanta.
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Molecular nutrition & food research.
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Archives of toxicology.
2014 Mar; 88(3):691-9. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Oct; 84(?):53-8. doi:
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The British journal of nutrition.
2013 Sep; 110(5):891-900. doi:
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The international journal of biochemistry & cell biology.
2013 Aug; 45(8):1620-8. doi:
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European journal of cancer (Oxford, England : 1990).
2013 Aug; 49(12):2747-59. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2013 Jul; 89(1):19-29. doi:
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Journal of endocrinological investigation.
2013 Jun; 36(6):385-9. doi:
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Thrombosis and haemostasis.
2013 Jun; 109(6):1099-107. doi:
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Cell death & disease.
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Lipids.
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Prostaglandins & other lipid mediators.
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PloS one.
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PloS one.
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Journal of vascular research.
2013; 50(5):372-82. doi:
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The Journal of trauma.
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The Journal of biological chemistry.
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Biochimica et biophysica acta.
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PloS one.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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American journal of physiology. Heart and circulatory physiology.
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The Journal of steroid biochemistry and molecular biology.
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Diabetes.
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The Journal of biological chemistry.
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Arteriosclerosis, thrombosis, and vascular biology.
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Journal of applied physiology (Bethesda, Md. : 1985).
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Integrative cancer therapies.
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Biochemistry.
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Platelets.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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Arteriosclerosis, thrombosis, and vascular biology.
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American journal of physiology. Regulatory, integrative and comparative physiology.
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Biochemical pharmacology.
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The Journal of experimental medicine.
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American journal of physiology. Heart and circulatory physiology.
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American journal of physiology. Gastrointestinal and liver physiology.
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Journal of the American Society of Nephrology : JASN.
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American journal of hypertension.
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British journal of pharmacology.
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Prostaglandins, leukotrienes, and essential fatty acids.
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Annals of surgical oncology.
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Prostaglandins, leukotrienes, and essential fatty acids.
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Endocrinology.
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Planta medica.
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