Vanylglycol (BioDeep_00000005879)

 

Secondary id: BioDeep_00000405447

human metabolite Endogenous blood metabolite natural product BioNovoGene_Lab2019


代谢物信息卡片


1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol

化学式: C9H12O4 (184.0735552)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.03%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C(CO)O)O
InChI: InChI=1S/C9H12O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,10-12H,5H2,1H3

描述信息

Vanylglycol, also known as 3-Methoxy-4-hydroxyphenylethyleneglycol (MHPG), belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. It is synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover. Catecholamines play an important role in platelet activation and aggregation, epinephrine being the most potent one. Vanylglycol and pyrocatechol can be biosynthesized from 3,4-dihydroxyphenylglycol and guaiacol; which is catalyzed by the enzyme catechol O-methyltransferase. Vanylglycol is a O-methylated metabolite of normetanephrine. In humans, vanylglycol is involved in the metabolic disorder called tyrosinemia in newborns. Alcohol consumption increases the level of vanylglycol in urine and CSF. Vanylglycol is found normally in urine, in plasma and cerebrospinal fluid. Outside of the human body, vanylglycol has been detected, but not quantified in several different foods, such as blackcurrants, chinese bayberries, elderberries, oriental wheats, and poppies.

同义名列表

23 个代谢物同义名

1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol; 1-(4-Hydroxy-3-methoxyphenyl)-1,2-ethanediol; 3-Methoxy-4-hydroxyphenylethylene glycol; 4-Hydroxy-3-methoxyphenylethylene glycol; 4 Hydroxy 3 methoxyphenylethylene glycol; 4-Hydroxy-3-methoxyphenylethyleneglycol; Methoxyhydroxyphenylglycol, (+-)-isomer; 4 Hydroxy 3 methoxyphenylethyleneglycol; Methoxyhydroxyphenylglycol, (+)-isomer; Methoxyhydroxyphenylglycol, (-)-isomer; 3-Methoxy-4-hydroxyphenethylene glycol; 4-Hydroxy-3-methoxy-beta-phenylglycol; 4-Hydroxy-3-methoxy-b-phenylglycol; 4-Hydroxy-3-methoxyphenyl glycol; 3-Methoxy-4-hydroxyphenyl glycol; 4-Hydroxy-3-methoxyphenylglycol; 4 Hydroxy 3 methoxyphenylglycol; Methoxyhydroxyphenylglycol; Hydroxymethoxyphenylglycol; Vanylglycol; MOPEG; MHPG; HMPG



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

26 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Han. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4691-4697. doi: 10.19540/j.cnki.cjcmm.20220421.401. [PMID: 36164876]
  • Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh, Shinichi Kato. Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice. Scientific reports. 2021 08; 11(1):16276. doi: 10.1038/s41598-021-95916-5. [PMID: 34381165]
  • Nastaran Shakouri, Ali Soleimanzadeh, Alaleh Rakhshanpour, Mustafa Numan Bucak. Antioxidant effects of supplementation of 3,4-dihydroxyphenyl glycol on sperm parameters and oxidative markers following cryopreservation in canine semen. Reproduction in domestic animals = Zuchthygiene. 2021 Jul; 56(7):1004-1014. doi: 10.1111/rda.13944. [PMID: 33908088]
  • Arthur Lo, Lucy Norcliffe-Kaufmann, Ross Vickery, David Bourdet, Jitendra Kanodia. Pharmacokinetics and pharmacodynamics of ampreloxetine, a novel, selective norepinephrine reuptake inhibitor, in symptomatic neurogenic orthostatic hypotension. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2021 06; 31(3):395-403. doi: 10.1007/s10286-021-00800-x. [PMID: 33782836]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Masayuki Takase, Hisoshi Kimura, Nobuhisa Kanahara, Yusuke Nakata, Masaomi Iyo. Plasma monoamines change under dopamine supersensitivity psychosis in patients with schizophrenia: A comparison with first-episode psychosis. Journal of psychopharmacology (Oxford, England). 2020 05; 34(5):540-547. doi: 10.1177/0269881119900982. [PMID: 31961236]
  • Hikaru Hori, Reiji Yoshimura, Asuka Katsuki, Kiyokazu Atake. Plasma levels of 3-methoxy-4-hydroxyphenylglycol levels, number of hospitalization and cognitive function predicts the cognitive effect of atypical antipsychotic monotherapy in patients with acute schizophrenia. International clinical psychopharmacology. 2020 03; 35(2):89-97. doi: 10.1097/yic.0000000000000293. [PMID: 31743230]
  • Frauke Kepura, Eva Braun, Alexander Dietrich, Tim D Plant. TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons. Cells. 2020 02; 9(2):. doi: 10.3390/cells9020459. [PMID: 32085504]
  • Quin E Denfeld, Christopher S Lee, William R Woodward, Shirin O Hiatt, James O Mudd, Beth A Habecker. Sympathetic Markers are Different Between Clinical Responders and Nonresponders After Left Ventricular Assist Device Implantation. The Journal of cardiovascular nursing. 2019 Jul; 34(4):E1-E10. doi: 10.1097/jcn.0000000000000580. [PMID: 31094762]
  • Naga Surya Prakash Padala, Devender Reddy Ajjala, Rajesh Kumar Boggavarapu, Hanumanth Rao Pantangi, Jagadeesh Babu Thentu, Abdul Rasheed Mohammed, Ramakrishna Nirogi. LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regions. Bioanalysis. 2019 May; 11(10):971-986. doi: 10.4155/bio-2019-0023. [PMID: 31218903]
  • Dihua Li, Yuzhen Zhuo, Qi Zhang, Lanqiu Zhang, Shukun Zhang, Yuanshan Lv, Caixia Li, Lihua Cui, Xin Guan, Lei Yang, Ximo Wang. Purification of 3, 4-dihydroxyphenylethyl alcohol glycoside from Sargentodoxa cuneata (Oliv.) Rehd. et Wils. and its protective effects against DSS-induced colitis. Scientific reports. 2019 03; 9(1):3222. doi: 10.1038/s41598-019-38926-8. [PMID: 30824734]
  • Alejandra Bermúdez-Oria, Guillermo Rodríguez-Gutiérrez, Fátima Rubio-Senent, África Fernández-Prior, Juan Fernández-Bolaños. Effect of edible pectin-fish gelatin films containing the olive antioxidants hydroxytyrosol and 3,4-dihydroxyphenylglycol on beef meat during refrigerated storage. Meat science. 2019 Feb; 148(?):213-218. doi: 10.1016/j.meatsci.2018.07.003. [PMID: 30025964]
  • A Arando, J V Delgado, A Fernández-Prior, J M León, A Bermúdez-Oria, S Nogales, C C Pérez-Marín. Effect of different olive oil-derived antioxidants (hydroxytyrosol and 3,4-dihydroxyphenylglycol) on the quality of frozen-thawed ram sperm. Cryobiology. 2019 02; 86(?):33-39. doi: 10.1016/j.cryobiol.2019.01.002. [PMID: 30611732]
  • Ismael Galván, Francisco Solano, Mohammed Zougagh, Fernando de Andrés, Khaled Murtada, Ángel Ríos, Eva de la Peña, Juan Carranza. Unprecedented high catecholamine production causing hair pigmentation after urinary excretion in red deer. Cellular and molecular life sciences : CMLS. 2019 Jan; 76(2):397-404. doi: 10.1007/s00018-018-2962-1. [PMID: 30413834]
  • Kazuaki Ohara, Akane Misaizu, Yuji Kaneko, Takafumi Fukuda, Mika Miyake, Yutaka Miura, Hisayoshi Okamura, Jumpei Yajima, Akira Tsuda. β-Eudesmol, an Oxygenized Sesquiterpene, Reduces the Increase in Saliva 3-Methoxy-4-Hydroxyphenylglycol After the "Trier Social Stress Test" in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Study. Nutrients. 2018 Dec; 11(1):. doi: 10.3390/nu11010009. [PMID: 30577513]
  • Nina Eikelis, Francine Z Marques, Dagmara Hering, Petra Marusic, Geoffrey A Head, Antony S Walton, Elisabeth A Lambert, Murray D Esler, Carolina I Sari, Markus P Schlaich, Gavin W Lambert. A polymorphism in the noradrenaline transporter gene is associated with increased blood pressure in patients with resistant hypertension. Journal of hypertension. 2018 07; 36(7):1571-1577. doi: 10.1097/hjh.0000000000001736. [PMID: 29677047]
  • Quin E Denfeld, Beth A Habecker, William R Woodward. Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method development for a translational research study. BMC research notes. 2018 Apr; 11(1):248. doi: 10.1186/s13104-018-3352-3. [PMID: 29673396]
  • Sygrid van der Zee, Yannick Vermeiren, Erik Fransen, Debby Van Dam, Tony Aerts, Marleen J Gerritsen, Jacoba M Spikman, Teus van Laar, Peter P De Deyn. Monoaminergic Markers Across the Cognitive Spectrum of Lewy Body Disease. Journal of Parkinson's disease. 2018; 8(1):71-84. doi: 10.3233/jpd-171228. [PMID: 29480224]
  • Yukako Hino, Ayumi Koyanagi, Motohiro Maebuchi, Takashi Ichinose, Shigeki Furuya. Comparison of the Effect of Soy and Casein-Derived Peptide Administration on Tyrosine and Catecholamine Metabolism in the Mouse Brain. Journal of nutritional science and vitaminology. 2018; 64(5):329-334. doi: 10.3177/jnsv.64.329. [PMID: 30381622]
  • Sladjana Dronjak, Bojana Stefanovic, Predrag Jovanovic, Natasa Spasojevic, Milica Jankovic, Ivica Jeremic, Markus Hoffmann. Altered cardiac gene expression of noradrenaline enzymes, transporter and β-adrenoceptors in rat model of rheumatoid arthritis. Autonomic neuroscience : basic & clinical. 2017 12; 208(?):165-169. doi: 10.1016/j.autneu.2017.10.003. [PMID: 29029974]
  • Matthew R Zahner, Chang-Ning Liu, Vincent Bernardo, Carrie Northcott, Cheryl Tyszkiewicz, Carlin Okerberg, Magalie Boucher, Ingrid Pardo, Chris J Somps. Physiological approaches to assess diminished sympathetic activity in the conscious rat. Journal of pharmacological and toxicological methods. 2017 Nov; 88(Pt 1):64-71. doi: 10.1016/j.vascn.2017.06.002. [PMID: 28658603]
  • Hikaru Hori, Reiji Yoshimura, Asuka Katsuki, Kiyokazu Atake, Ryohei Igata, Yuki Konishi, Jun Nakamura. Relationships between serum brain-derived neurotrophic factor, plasma catecholamine metabolites, cytokines, cognitive function and clinical symptoms in Japanese patients with chronic schizophrenia treated with atypical antipsychotic monotherapy. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2017 08; 18(5):401-408. doi: 10.1080/15622975.2016.1212172. [PMID: 27409727]
  • Seiji Hama, Taro Murakami, Hidehisa Yamashita, Keiichi Onoda, Shigeto Yamawaki, Kaoru Kurisu. Neuroanatomic pathways associated with monoaminergic dysregulation after stroke. International journal of geriatric psychiatry. 2017 06; 32(6):633-642. doi: 10.1002/gps.4503. [PMID: 27251297]
  • Hikaru Hori, Reiji Yoshimura, Asuka Katsuki, Kiyokazu Atake, Ryohei Igata, Yuki Konishi, Hiroki Beppu, Hirotaka Tominaga. Blood Biomarkers Predict the Cognitive Effects of Aripiprazole in Patients with Acute Schizophrenia. International journal of molecular sciences. 2017 Mar; 18(3):. doi: 10.3390/ijms18030568. [PMID: 28272307]
  • Peter R Bieck, Mark Leibowitz, D Richard Lachno, Edouard Ledent, Robert Padich, Stan Jhee. Dihydroxyphenylglycol as a Biomarker of Norepinephrine Transporter Inhibition by Atomoxetine: Human Model to Assess Central and Peripheral Effects of Dosing. Journal of clinical psychopharmacology. 2016 Dec; 36(6):675-683. doi: 10.1097/jcp.0000000000000611. [PMID: 27755221]
  • John J Sramek, Larry W Hardy, Peter Bieck, Cynthia Zamora, Mark Versavel, Jahnavi Kharidia, Todd Grinnell, Yu-Luan Chen, Michael Sullivan, Hong Ding, Neal R Cutler. Exploratory Biomarker Study of the Triple Reuptake Inhibitor SEP-432 Compared to the Dual Reuptake Inhibitor Duloxetine in Healthy Normal Subjects. CNS neuroscience & therapeutics. 2016 May; 22(5):404-12. doi: 10.1111/cns.12513. [PMID: 26849844]
  • Patrik Wennberg, Carl-Johan Boraxbekk, Michael Wheeler, Bethany Howard, Paddy C Dempsey, Gavin Lambert, Nina Eikelis, Robyn Larsen, Parneet Sethi, Jessica Occleston, Jenny Hernestål-Boman, Kathryn A Ellis, Neville Owen, David W Dunstan. Acute effects of breaking up prolonged sitting on fatigue and cognition: a pilot study. BMJ open. 2016 Feb; 6(2):e009630. doi: 10.1136/bmjopen-2015-009630. [PMID: 26920441]
  • Chiung-Chun Huang, Dylan Chou, Che-Ming Yeh, Kuei-Sen Hsu. Acute food deprivation enhances fear extinction but inhibits long-term depression in the lateral amygdala via ghrelin signaling. Neuropharmacology. 2016 Feb; 101(?):36-45. doi: 10.1016/j.neuropharm.2015.09.018. [PMID: 26384653]
  • Seth C Hopkins, Soujanya Sunkaraneni, Estela Skende, Jeremy Hing, Julie A Passarell, Antony Loebel, Kenneth S Koblan. Pharmacokinetics and Exposure-Response Relationships of Dasotraline in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults. Clinical drug investigation. 2016 Feb; 36(2):137-46. doi: 10.1007/s40261-015-0358-7. [PMID: 26597180]
  • Kenya Watanabe, Itaru Miura, Keiko Kanno-Nozaki, Sho Horikoshi, Hirobumi Mashiko, Shin-Ichi Niwa, Hirooki Yabe. Associations between five-factor model of the Positive and Negative Syndrome Scale and plasma levels of monoamine metabolite in patients with schizophrenia. Psychiatry research. 2015 Dec; 230(2):419-23. doi: 10.1016/j.psychres.2015.09.030. [PMID: 26416588]
  • William Kielbasa, Evelyn Lobo. Pharmacodynamics of norepinephrine reuptake inhibition: Modeling the peripheral and central effects of atomoxetine, duloxetine, and edivoxetine on the biomarker 3,4-dihydroxyphenylglycol in humans. Journal of clinical pharmacology. 2015 Dec; 55(12):1422-31. doi: 10.1002/jcph.551. [PMID: 26011686]
  • Fátima Rubio-Senent, Baukje de Roos, Garry Duthie, Juan Fernández-Bolaños, Guillermo Rodríguez-Gutiérrez. Inhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats. European journal of nutrition. 2015 Dec; 54(8):1287-95. doi: 10.1007/s00394-014-0807-8. [PMID: 25504445]
  • Xiao-Qian Fang, Haifa Qiao, Bradley R Groveman, Shuang Feng, Melissa Pflueger, Wen-Kuan Xin, Mohammad K Ali, Shuang-Xiu Lin, Jindong Xu, Florian Duclot, Mohamed Kabbaj, Wei Wang, Xin-Sheng Ding, Teresa Santiago-Sim, Xing-Hong Jiang, Michael W Salter, Xian-Min Yu. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Molecular brain. 2015 Nov; 8(1):75. doi: 10.1186/s13041-015-0167-1. [PMID: 26584860]
  • Itaru Miura, Keiko Kanno-Nozaki, Mizuki Hino, Sho Horikoshi, Takafumi Ota, Hirobumi Mashiko, Shin-Ichi Niwa, Hirooki Yabe. Influence of -141C Ins/Del Polymorphism in DRD2 Gene on Clinical Symptoms and Plasma Homovanillic Acid Levels in the Treatment of Schizophrenia With Aripiprazole. Journal of clinical psychopharmacology. 2015 Jun; 35(3):333-4. doi: 10.1097/jcp.0000000000000330. [PMID: 25871573]
  • Yoshiomi Imamura, Yoshito Mizoguchi, Hiromi Nabeta, Jun Matsushima, Itaru Watanabe, Naoki Kojima, Toshiro Kawashima, Shigeto Yamada, Akira Monji. Belief in life after death, salivary 3-methoxy-4-hydroxyphenylglycol, and well-being among older people without cognitive impairment dwelling in rural Japan. International journal of geriatric psychiatry. 2015 Mar; 30(3):256-64. doi: 10.1002/gps.4135. [PMID: 24760761]
  • William Kielbasa, Alan Pan, Alvaro Pereira. A pharmacokinetic/pharmacodynamic investigation: assessment of edivoxetine and atomoxetine on systemic and central 3,4-dihydroxyphenylglycol, a biochemical marker for norepinephrine transporter inhibition. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2015 Mar; 25(3):377-85. doi: 10.1016/j.euroneuro.2014.12.009. [PMID: 25637266]
  • David S Goldstein, Irwin J Kopin, Yehonatan Sharabi, Courtney Holmes. Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2015 Feb; 25(1):61-7. doi: 10.1007/s10286-015-0268-z. [PMID: 25638582]
  • Alain D Dekker, Antonia M W Coppus, Yannick Vermeiren, Tony Aerts, Cornelia M van Duijn, Berry P Kremer, Pieter J W Naudé, Debby Van Dam, Peter P De Deyn. Serum MHPG strongly predicts conversion to Alzheimer's disease in behaviorally characterized subjects with Down syndrome. Journal of Alzheimer's disease : JAD. 2015; 43(3):871-91. doi: 10.3233/jad-140783. [PMID: 25125467]
  • Francesca Brambilla, Federico Amianto, Riccardo Dalle Grave, Secondo Fassino. Lack of efficacy of psychological and pharmacological treatments of disorders of eating behavior: neurobiological background. BMC psychiatry. 2014 Dec; 14(?):376. doi: 10.1186/s12888-014-0376-7. [PMID: 25539757]
  • Emi Soda, Itaru Miura, Hiroshi Hoshino, Keiko Kanno-Nozaki, Takafumi Ota, Haruka Oguchi, Kenya Watanabe, Qiaohui Yang, Hirobumi Mashiko, Shin-Ichi Niwa. Impacts of age on plasma monoamine metabolite concentrations in a large cohort of healthy individuals. Psychiatry research. 2014 Dec; 220(1-2):639-45. doi: 10.1016/j.psychres.2014.08.031. [PMID: 25200191]
  • Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Youn-Gil Kwak, Yeo Sung Yoon, In Koo Hwang. Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC complementary and alternative medicine. 2014 Dec; 14(?):476. doi: 10.1186/1472-6882-14-476. [PMID: 25495725]
  • Nora E Straznicky, Mariee T Grima, Carolina I Sari, Nina Eikelis, Gavin W Lambert, Paul J Nestel, Sofie Karapanagiotidis, Chiew Wong, Katrina Richards, Petra Marusic, John B Dixon, Markus P Schlaich, Elisabeth A Lambert. A randomized controlled trial of the effects of pioglitazone treatment on sympathetic nervous system activity and cardiovascular function in obese subjects with metabolic syndrome. The Journal of clinical endocrinology and metabolism. 2014 Sep; 99(9):E1701-7. doi: 10.1210/jc.2014-1976. [PMID: 24937541]
  • Milo Careaga, Tamanna Noyon, Kirin Basuta, Judy Van de Water, Flora Tassone, Randi J Hagerman, Paul Ashwood. Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. Journal of neuroinflammation. 2014 Jun; 11(?):110. doi: 10.1186/1742-2094-11-110. [PMID: 24942544]
  • Tu H Mai, Jing Wu, André Diedrich, Emily M Garland, David Robertson. Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure. Journal of the American Society of Hypertension : JASH. 2014 May; 8(5):286-96. doi: 10.1016/j.jash.2014.03.001. [PMID: 24746612]
  • Yukiko Kutsuzawa, Yasuto Kunii, Itaru Miura, Keiko Kanno-Nozaki, Hirobumi Mashiko, Hirooki Yabe, Shin-Ichi Niwa. High plasma monoamine metabolite levels in Cotard's syndrome. Psychiatry and clinical neurosciences. 2014 May; 68(5):388. doi: 10.1111/pcn.12129. [PMID: 24372956]
  • Maria Varela, George A Alexiou, Magda Liakopoulou, Evaggelos Papakonstantinou, Dimitra Pitsouni, Giorgos A Alevizopoulos. Monoamine metabolites in ventricular CSF of children with posterior fossa tumors: correlation with tumor histology and cognitive functioning. Journal of neurosurgery. Pediatrics. 2014 Apr; 13(4):375-9. doi: 10.3171/2014.1.peds13425. [PMID: 24559277]
  • Itaru Miura, Tetsuya Shiga, Akihiko Katsumi, Keiko Kanno-Nozaki, Hirobumi Mashiko, Shin-Ichi Niwa, Hirooki Yabe. Switching antipsychotics to aripiprazole or blonanserin and plasma monoamine metabolites levels in patients with schizophrenia. Human psychopharmacology. 2014 Mar; 29(2):199-202. doi: 10.1002/hup.2386. [PMID: 24590545]
  • Nora E Straznicky, Elisabeth A Lambert, Mariee T Grima, Nina Eikelis, Katrina Richards, Paul J Nestel, Tye Dawood, Kazuko Masuo, Carolina I Sari, John B Dixon, Murray D Esler, Eldho Paul, Markus P Schlaich, Gavin W Lambert. The effects of dietary weight loss on indices of norepinephrine turnover: modulatory influence of hyperinsulinemia. Obesity (Silver Spring, Md.). 2014 Mar; 22(3):652-62. doi: 10.1002/oby.20614. [PMID: 23997009]
  • Jill C Chappell, Graeme Eisenhofer, Michael J Owens, Harry Haber, D Richard Lachno, Robert A Dean, Mary Pat Knadler, Charles B Nemeroff, Malcolm I Mitchell, Michael J Detke, Smriti Iyengar, Beth Pangallo, Evelyn D Lobo. Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects. Journal of clinical psychopharmacology. 2014 Feb; 34(1):9-16. doi: 10.1097/jcp.0000000000000061. [PMID: 24346757]
  • Masatake Kurita, Satoshi Nishino, Yukio Numata, Yoshiro Okubo, Tadahiro Sato. The noradrenaline metabolite MHPG is a candidate biomarker from the manic to the remission state in bipolar disorder I: a clinical naturalistic study. PloS one. 2014; 9(6):e100634. doi: 10.1371/journal.pone.0100634. [PMID: 24971450]
  • Arnaldo Pinelli, Silvio Trivulzio, Giuseppe Rossoni. Activated partial thromboplastin time correlates with methoxyhydroxyphenylglycol in acute myocardial infarction patients: therapeutic implications for patients at cardiovascular risk. In vivo (Athens, Greece). 2014 Jan; 28(1):99-104. doi: . [PMID: 24425842]
  • Antonio Lama-Muñoz, Guillermo Rodríguez-Gutiérrez, Fátima Rubio-Senent, Rafael Palacios-Díaz, Juan Fernández-Bolaños. A study of the precursors of the natural antioxidant phenol 3,4-dihydroxyphenylglycol in olive oil waste. Food chemistry. 2013 Sep; 140(1-2):154-60. doi: 10.1016/j.foodchem.2013.02.063. [PMID: 23578627]
  • Jana K Shirey-Rice, Rebecca Klar, Hugh M Fentress, Sarah N Redmon, Tiffany R Sabb, Jessica J Krueger, Nathan M Wallace, Martin Appalsamy, Charlene Finney, Suzanna Lonce, André Diedrich, Maureen K Hahn. Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome. Disease models & mechanisms. 2013 Jul; 6(4):1001-11. doi: 10.1242/dmm.012203. [PMID: 23580201]
  • Tomomi Sekiduka-Kumano, Tomotaka Kawayama, Kosuke Ito, Yoshihisa Shoji, Kazuko Matsunaga, Masaki Okamoto, Nobutaka Edakuni, Haruki Imaoka, Naohisa Uchimura, Tomoaki Hoshino. Positive association between the plasma levels of 5-hydroxyindoleacetic acid and the severity of depression in patients with chronic obstructive pulmonary disease. BMC psychiatry. 2013 May; 13(?):159. doi: 10.1186/1471-244x-13-159. [PMID: 23721166]
  • Mark Hamer, Leone Malan. Sympathetic nervous activity, depressive symptoms, and metabolic syndrome in black Africans: the sympathetic activity and ambulatory blood pressure in Africans study. Stress (Amsterdam, Netherlands). 2012 Sep; 15(5):562-8. doi: 10.3109/10253890.2011.648247. [PMID: 22150400]
  • Jinyao Liu, Izumi Takase, Ayako Hakucho, Nanako Okamura, Tatsuya Fujimiya. Carvedilol attenuates the progression of alcohol fatty liver disease in rats. Alcoholism, clinical and experimental research. 2012 Sep; 36(9):1587-99. doi: 10.1111/j.1530-0277.2012.01773.x. [PMID: 22413959]
  • Itaru Miura, Satoshi Takeuchi, Akihiko Katsumi, Keiko Kanno, Kenya Watanabe, Hirobumi Mashiko, Shin-Ichi Niwa. Effect of switching to risperidone after unsuccessful treatment with aripiprazole on plasma monoamine metabolites level in the treatment of acute schizophrenia. Human psychopharmacology. 2012 Sep; 27(5):517-20. doi: 10.1002/hup.2251. [PMID: 22927115]
  • Chiung-Chun Huang, Jia-Peng Chen, Che-Ming Yeh, Kuei-Sen Hsu. Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty. Hippocampus. 2012 Jul; 22(7):1622-34. doi: 10.1002/hipo.21003. [PMID: 22231803]
  • Guillermo Rodríguez-Gutiérrez, Garry G Duthie, Sharon Wood, Phil Morrice, Fergus Nicol, Martin Reid, Louise L Cantlay, Thomas Kelder, Graham W Horgan, Juan Fernández-Bolaños Guzmán, Baukje de Roos. Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats--a proteomics and network analysis approach. Molecular nutrition & food research. 2012 Jul; 56(7):1137-47. doi: 10.1002/mnfr.201100808. [PMID: 22648667]
  • Robyn J McQuaid, Marie-Claude Audet, Hymie Anisman. Environmental enrichment in male CD-1 mice promotes aggressive behaviors and elevated corticosterone and brain norepinephrine activity in response to a mild stressor. Stress (Amsterdam, Netherlands). 2012 May; 15(3):354-60. doi: 10.3109/10253890.2011.623249. [PMID: 21995501]
  • Lanyun Fang, Yan Lv, Xuefei Sheng, Shanshan Yao. Sensitive, rapid and easy analysis of three catecholamine metabolites in human urine and serum by liquid chromatography tandem mass spectrometry. Journal of chromatographic science. 2012 May; 50(5):450-6. doi: 10.1093/chromsci/bms068. [PMID: 22511488]
  • Wakako Umene-Nakano, Reiji Yoshimura, Chiharu Yoshii, Kenji Hayashi, Atsuko Ikenouchi-Sugita, Asuka Katsuki, Hikaru Hori, Jun Nakamura. Plasma levels of metabolites of catecholamine in nicotine-dependent patients treated with varenicline. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2012 Apr; 14(4):486-9. doi: 10.1093/ntr/ntr149. [PMID: 22006914]
  • Yuki Tokutsu, Wakako Umene-Nakano, Reiji Yoshimura, Asuka Katsuki, Kiyokazu Atake, Jun Nakamura. The case of a depressed man who exhibited hyperprolactinemia and galactopoiesis after electroconvulsive therapy. The journal of ECT. 2012 Mar; 28(1):56. doi: 10.1097/yct.0b013e31820b846f. [PMID: 21778911]
  • Marcelo Alves de Souza, Raphael Escorsim Szawka, Lígia Aline Centenaro, Luisa Amália Diehl, Aldo Bolten Lucion. Prenatal stress produces sex differences in nest odor preference. Physiology & behavior. 2012 Feb; 105(3):850-5. doi: 10.1016/j.physbeh.2011.10.012. [PMID: 22037198]
  • Itaru Miura, Satoshi Takeuchi, Akihiko Katsumi, Azuma Mori, Keiko Kanno, Qiaohui Yang, Hirobumi Mashiko, Yoshihiko Numata, Shin-Ichi Niwa. Effects of aripiprazole and the Taq1A polymorphism in the dopamine D2 receptor gene on the clinical response and plasma monoamine metabolites level during the acute phase of schizophrenia. Journal of clinical psychopharmacology. 2012 Feb; 32(1):106-9. doi: 10.1097/jcp.0b013e31823f87ac. [PMID: 22198450]
  • Maiko Machida, Shigeru Takechi, Tetsuya Fujimoto, Shigeo Kakinoki, Akikazu Nomura. Carvedilol improves uptake-1 in patients with systolic congestive heart failure. Journal of cardiovascular pharmacology. 2012 Feb; 59(2):175-81. doi: 10.1097/fjc.0b013e31823a94a2. [PMID: 21997260]
  • Reiji Yoshimura, Hikaru Hori, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Asuka Katsuki, Kenji Hayashi, Kiyokazu Atake, Masaru Tomita, Jun Nakamura. Aripiprazole altered plasma levels of brain-derived neurotrophic factor and catecholamine metabolites in first-episode untreated Japanese schizophrenia patients. Human psychopharmacology. 2012 Jan; 27(1):33-8. doi: 10.1002/hup.1257. [PMID: 22213405]
  • Ernesto Trejo, Adolfo Borges, Betty Nañez, Itala Lippo de Becemberg, Ramona González de Alfonzo, Marcelo J Alfonzo. Tityus zulianus venom induces massive catecholamine release from PC12 cells and in a mouse envenomation model. Toxicon : official journal of the International Society on Toxinology. 2012 Jan; 59(1):117-23. doi: 10.1016/j.toxicon.2011.10.013. [PMID: 22085992]
  • Hejun Duan, Na Guan, Yongning Wu, Jing Zhang, Jie Ding, Bing Shao. Identification of biomarkers for melamine-induced nephrolithiasis in young children based on ultra high performance liquid chromatography coupled to time-of-flight mass spectrometry (U-HPLC-Q-TOF/MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3544-50. doi: 10.1016/j.jchromb.2011.09.039. [PMID: 21982507]
  • Maura Castelli, Mauro Federici, Silvia Rossi, Valentina De Chiara, Francesco Napolitano, Valeria Studer, Caterina Motta, Lucia Sacchetti, Rosaria Romano, Alessandra Musella, Giorgio Bernardi, Alberto Siracusano, Howard H Gu, Nicola B Mercuri, Alessandro Usiello, Diego Centonze. Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter. The European journal of neuroscience. 2011 Nov; 34(9):1369-77. doi: 10.1111/j.1460-9568.2011.07876.x. [PMID: 22034972]
  • Baukje de Roos, Xuguang Zhang, Guillermo Rodriguez Gutierrez, Sharon Wood, Garry J Rucklidge, Martin D Reid, Gary J Duncan, Louise L Cantlay, Garry G Duthie, Niamh O'Kennedy. Anti-platelet effects of olive oil extract: in vitro functional and proteomic studies. European journal of nutrition. 2011 Oct; 50(7):553-62. doi: 10.1007/s00394-010-0162-3. [PMID: 21197537]
  • A S Gorina, L S Kolesnichenko, V I Mikhnovich. [Catecholamines and their metabolites in children with Asperger and Kanner syndromes]. Biomeditsinskaia khimiia. 2011 Sep; 57(5):562-70. doi: 10.18097/pbmc20115705562. [PMID: 22629607]
  • Xiaobo Shi, Lingyan Zhang, Shuxin Fu, Na Li. Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome. Archives of gynecology and obstetrics. 2011 Sep; 284(3):773-8. doi: 10.1007/s00404-011-1947-1. [PMID: 21688169]
  • Alexander A Zoerner, Karsten Heusser, Frank M Gutzki, Anja Mitschke, Jens Tank, Dirk O Stichtenoth, Jens Jordan, Dimitrios Tsikas. Unique pentafluorobenzylation and collision-induced dissociation for specific and accurate GC-MS/MS quantification of the catecholamine metabolite 3,4-dihydroxyphenylglycol (DHPG) in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 May; 879(17-18):1444-56. doi: 10.1016/j.jchromb.2010.06.022. [PMID: 20638915]
  • Kanae Okuno, Reiji Yoshimura, Nobuhisa Ueda, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Hikaru Hori, Kenji Hayashi, Asuka Katsuki, Hsin-I Chen, Jun Nakamura. Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan. Psychiatry research. 2011 Apr; 186(2-3):326-32. doi: 10.1016/j.psychres.2010.07.023. [PMID: 20832122]
  • Alonso Montoya, Rodrigo Escobar, María J García-Polavieja, D Richard Lachno, José Ángel Alda, Josep Artigas, Esther Cardo, Marta García, Xavier Gastaminza, Inmaculada Gilaberte. Changes of urine dihydroxyphenylglycol to norepinephrine ratio in children with attention-deficit hyperactivity disorder (ADHD) treated with atomoxetine. Journal of child neurology. 2011 Jan; 26(1):31-6. doi: 10.1177/0883073810371981. [PMID: 20525942]
  • N Goto, R Yoshimura, S Kakeda, J Moriya, K Hayashi, A Ikenouchi-Sugita, W Umene-Nakano, H Hori, N Ueda, Y Korogi, J Nakamura. Comparison of brain N-acetylaspartate levels and serum brain-derived neurotrophic factor (BDNF) levels between patients with first-episode schizophrenia psychosis and healthy controls. European psychiatry : the journal of the Association of European Psychiatrists. 2011 Jan; 26(1):57-63. doi: 10.1016/j.eurpsy.2009.10.001. [PMID: 20434315]
  • Tamar Goren, Liat Adar, Nissim Sasson, Yoni M Weiss. Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline. Journal of clinical pharmacology. 2010 Dec; 50(12):1420-8. doi: 10.1177/0091270010369674. [PMID: 20445015]
  • Wakako Umene-Nakano, Reiji Yoshimura, Nobuhisa Ueda, Akihito Suzuki, Atsuko Ikenouchi-Sugita, Hikaru Hori, Koichi Otani, Jun Nakamura. Predictive factors for responding to sertraline treatment: views from plasma catecholamine metabolites and serotonin transporter polymorphism. Journal of psychopharmacology (Oxford, England). 2010 Dec; 24(12):1764-71. doi: 10.1177/0269881109106899. [PMID: 19825907]
  • Boubacar Pasto Wann, Marie-Claude Audet, Hymie Anisman. Impact of acute and chronic stressor experiences on heart atrial and brain natriuretic peptides in response to a subsequent stressor. Hormones and behavior. 2010 Nov; 58(5):907-16. doi: 10.1016/j.yhbeh.2010.09.001. [PMID: 20832411]
  • Jussi Jokinen, John Ouda, Peter Nordström. Noradrenergic function and HPA axis dysregulation in suicidal behaviour. Psychoneuroendocrinology. 2010 Nov; 35(10):1536-42. doi: 10.1016/j.psyneuen.2010.05.008. [PMID: 20576361]
  • Chen Yue-Jian, Tao Juan, Xiong Fei, Zhu Jia-Bi, Gu Ning, Zhang Yi-Hua, Ding Ye, Ge Liang. Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent. Drug development and industrial pharmacy. 2010 Oct; 36(10):1235-44. doi: 10.3109/03639041003710151. [PMID: 20818962]
  • Jakob Nyhlén, Radu Constantinescu, Henrik Zetterberg. Problems associated with fluid biomarkers for Parkinson's disease. Biomarkers in medicine. 2010 Oct; 4(5):671-81. doi: 10.2217/bmm.10.84. [PMID: 20945980]
  • Georg Nikisch, Pierre Baumann, Georg Wiedemann, Bernhard Kiessling, Heike Weisser, Andreas Hertel, Takashi Yoshitake, Jan Kehr, Aleksander A Mathé. Quetiapine and norquetiapine in plasma and cerebrospinal fluid of schizophrenic patients treated with quetiapine: correlations to clinical outcome and HVA, 5-HIAA, and MHPG in CSF. Journal of clinical psychopharmacology. 2010 Oct; 30(5):496-503. doi: 10.1097/jcp.0b013e3181f2288e. [PMID: 20814316]
  • Anthony Donsante, Paul Johnson, Laura A Jansen, Stephen G Kaler. Somatic mosaicism in Menkes disease suggests choroid plexus-mediated copper transport to the developing brain. American journal of medical genetics. Part A. 2010 Oct; 152A(10):2529-34. doi: 10.1002/ajmg.a.33632. [PMID: 20799318]
  • Georg Nikisch, Pierre Baumann, Bernhard Kiessling, Michael Reinert, Georg Wiedemann, Jan Kehr, Aleksander A Mathé, Markus Piel, Frank Roesch, Heike Weisser, Peter Schneider, Andreas Hertel. Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine. Journal of psychiatric research. 2010 Sep; 44(12):754-9. doi: 10.1016/j.jpsychires.2010.02.004. [PMID: 20176367]
  • F Brambilla, R Dalle Grave, S Calugi, G Marchesini, S Baroni, D Marazziti. Effects of cognitive-behavioral therapy on Eating Disorders: neurotransmitter secretory response to treatment. Psychoneuroendocrinology. 2010 Jun; 35(5):729-37. doi: 10.1016/j.psyneuen.2009.10.014. [PMID: 19962832]
  • Javier Navarro-Zaragoza, Cristina Núñez, M Luisa Laorden, M Victoria Milanés. Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. Molecular pharmacology. 2010 May; 77(5):864-73. doi: 10.1124/mol.109.062463. [PMID: 20159948]
  • Mercedes Zumárraga, Ricardo Dávila, Nieves Basterreche, Aurora Arrue, Biotza Goienetxea, María I Zamalloa, Leire Erkoreka, Sonia Bustamante, Lucía Inchausti, Miguel A González-Torres, José Guimón. Catechol O-methyltransferase and monoamine oxidase A genotypes, and plasma catecholamine metabolites in bipolar and schizophrenic patients. Neurochemistry international. 2010 May; 56(6-7):774-9. doi: 10.1016/j.neuint.2010.02.015. [PMID: 20206656]
  • Reiji Yoshimura, Nobuhisa Ueda, Hikaru Hori, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Jun Nakamura. Different patterns of longitudinal changes in plasma levels of catecholamine metabolites and brain-derived neurotrophic factor after administration of atypical antipsychotics in first episode untreated schizophrenic patients. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2010 Mar; 11(2 Pt 2):256-61. doi: 10.3109/15622970802309617. [PMID: 20218790]
  • Francisco A Moreno, Damian Parkinson, Craig Palmer, Wm Lesley Castro, John Misiaszek, Aram El Khoury, Aleksander A Mathé, Ron Wright, Pedro L Delgado. CSF neurochemicals during tryptophan depletion in individuals with remitted depression and healthy controls. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2010 Jan; 20(1):18-24. doi: 10.1016/j.euroneuro.2009.10.003. [PMID: 19896342]
  • Naoki Goto, Reiji Yoshimura, Shingo Kakeda, Junji Moriya, Kenji Hayashi, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Hikaru Hori, Nobuhisa Ueda, Yukunori Korogi, Jun Nakamura. Associations between plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and negative symptoms or cognitive impairments in early-stage schizophrenia. Human psychopharmacology. 2009 Dec; 24(8):639-45. doi: 10.1002/hup.1070. [PMID: 19946939]
  • Graeme Eisenhofer, David Goldstein, Irwin Kopin. Simultaneous liquid-chromatographic determination of plasma catecholamines and metabolites. Clinical chemistry. 2009 Dec; 55(12):2223-4. doi: 10.1373/clinchem.2009.134478. [PMID: 19833834]
  • Ivan Berlin, Claire Heilbronner, Sabine Georgieu, Cathy Meier, Jean-Marie Launay, Odile Spreux-Varoquaux. Reduced monoamine oxidase A activity in pregnant smokers and in their newborns. Biological psychiatry. 2009 Oct; 66(8):728-33. doi: 10.1016/j.biopsych.2009.05.029. [PMID: 19615672]
  • David S Goldstein, Courtney S Holmes, Stephen G Kaler. Relative efficiencies of plasma catechol levels and ratios for neonatal diagnosis of menkes disease. Neurochemical research. 2009 Aug; 34(8):1464-8. doi: 10.1007/s11064-009-9933-8. [PMID: 19234788]
  • Daniel Lindqvist, Shorena Janelidze, Peter Hagell, Sophie Erhardt, Martin Samuelsson, Lennart Minthon, Oskar Hansson, Maria Björkqvist, Lil Träskman-Bendz, Lena Brundin. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biological psychiatry. 2009 Aug; 66(3):287-92. doi: 10.1016/j.biopsych.2009.01.030. [PMID: 19268915]
  • Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC clinical pharmacology. 2009 Aug; 9(?):13. doi: 10.1186/1472-6904-9-13. [PMID: 19646280]
  • David A Mitchell, Gavin Lambert, Niels H Secher, Peter B Raven, Johannes van Lieshout, Murray D Esler. Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. The Journal of physiology. 2009 Jun; 587(Pt 11):2589-97. doi: 10.1113/jphysiol.2008.167999. [PMID: 19403604]
  • Jyoti C Patel, Paul Witkovsky, Marat V Avshalumov, Margaret E Rice. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 May; 29(20):6568-79. doi: 10.1523/jneurosci.0181-09.2009. [PMID: 19458227]