Vanylglycol (BioDeep_00000005879)

 

Secondary id: BioDeep_00000405447

human metabolite Endogenous blood metabolite


代谢物信息卡片


1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol

化学式: C9H12O4 (184.0735552)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.42%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C(CO)O)O
InChI: InChI=1S/C9H12O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,10-12H,5H2,1H3

描述信息

Vanylglycol, also known as 3-Methoxy-4-hydroxyphenylethyleneglycol (MHPG), belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. It is synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover. Catecholamines play an important role in platelet activation and aggregation, epinephrine being the most potent one. Vanylglycol and pyrocatechol can be biosynthesized from 3,4-dihydroxyphenylglycol and guaiacol; which is catalyzed by the enzyme catechol O-methyltransferase. Vanylglycol is a O-methylated metabolite of normetanephrine. In humans, vanylglycol is involved in the metabolic disorder called tyrosinemia in newborns. Alcohol consumption increases the level of vanylglycol in urine and CSF. Vanylglycol is found normally in urine, in plasma and cerebrospinal fluid. Outside of the human body, vanylglycol has been detected, but not quantified in several different foods, such as blackcurrants, chinese bayberries, elderberries, oriental wheats, and poppies.

同义名列表

23 个代谢物同义名

1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol; 1-(4-Hydroxy-3-methoxyphenyl)-1,2-ethanediol; 3-Methoxy-4-hydroxyphenylethylene glycol; 4-Hydroxy-3-methoxyphenylethylene glycol; 4 Hydroxy 3 methoxyphenylethylene glycol; 4-Hydroxy-3-methoxyphenylethyleneglycol; Methoxyhydroxyphenylglycol, (+-)-isomer; 4 Hydroxy 3 methoxyphenylethyleneglycol; Methoxyhydroxyphenylglycol, (+)-isomer; Methoxyhydroxyphenylglycol, (-)-isomer; 3-Methoxy-4-hydroxyphenethylene glycol; 4-Hydroxy-3-methoxy-beta-phenylglycol; 4-Hydroxy-3-methoxy-b-phenylglycol; 4-Hydroxy-3-methoxyphenyl glycol; 3-Methoxy-4-hydroxyphenyl glycol; 4-Hydroxy-3-methoxyphenylglycol; 4 Hydroxy 3 methoxyphenylglycol; Methoxyhydroxyphenylglycol; Hydroxymethoxyphenylglycol; Vanylglycol; MOPEG; MHPG; HMPG



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

26 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Han. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4691-4697. doi: 10.19540/j.cnki.cjcmm.20220421.401. [PMID: 36164876]
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