Vanylglycol (BioDeep_00000005879)

 

Secondary id: BioDeep_00000405447

human metabolite Endogenous blood metabolite natural product BioNovoGene_Lab2019


代谢物信息卡片


1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol

化学式: C9H12O4 (184.0736)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 10.09%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C(CO)O)O
InChI: InChI=1S/C9H12O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-4,8,10-12H,5H2,1H3

描述信息

Vanylglycol, also known as 3-Methoxy-4-hydroxyphenylethyleneglycol (MHPG), belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. It is synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover. Catecholamines play an important role in platelet activation and aggregation, epinephrine being the most potent one. Vanylglycol and pyrocatechol can be biosynthesized from 3,4-dihydroxyphenylglycol and guaiacol; which is catalyzed by the enzyme catechol O-methyltransferase. Vanylglycol is a O-methylated metabolite of normetanephrine. In humans, vanylglycol is involved in the metabolic disorder called tyrosinemia in newborns. Alcohol consumption increases the level of vanylglycol in urine and CSF. Vanylglycol is found normally in urine, in plasma and cerebrospinal fluid. Outside of the human body, vanylglycol has been detected, but not quantified in several different foods, such as blackcurrants, chinese bayberries, elderberries, oriental wheats, and poppies.

同义名列表

23 个代谢物同义名

1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol; 1-(4-Hydroxy-3-methoxyphenyl)-1,2-ethanediol; 3-Methoxy-4-hydroxyphenylethylene glycol; 4-Hydroxy-3-methoxyphenylethylene glycol; 4 Hydroxy 3 methoxyphenylethylene glycol; 4-Hydroxy-3-methoxyphenylethyleneglycol; Methoxyhydroxyphenylglycol, (+-)-isomer; 4 Hydroxy 3 methoxyphenylethyleneglycol; Methoxyhydroxyphenylglycol, (+)-isomer; Methoxyhydroxyphenylglycol, (-)-isomer; 3-Methoxy-4-hydroxyphenethylene glycol; 4-Hydroxy-3-methoxy-beta-phenylglycol; 4-Hydroxy-3-methoxy-b-phenylglycol; 4-Hydroxy-3-methoxyphenyl glycol; 3-Methoxy-4-hydroxyphenyl glycol; 4-Hydroxy-3-methoxyphenylglycol; 4 Hydroxy 3 methoxyphenylglycol; Methoxyhydroxyphenylglycol; Hydroxymethoxyphenylglycol; Vanylglycol; MOPEG; MHPG; HMPG



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

26 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 BDNF, DBH, DDC, POMC, PRL, TH
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 1 PNMT
Mitochondrion membrane 2 MAOA, PNMT
Nucleus 2 PRL, TH
cytosol 6 COMT, DDC, MAOA, PNMT, SST, TH
dendrite 5 BDNF, COMT, DRD2, HTR1A, TH
mitochondrial membrane 1 PNMT
nucleoplasm 1 PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 5 ADRB3, COMT, DRD2, HTR1A, SLC6A4
Cytoplasmic side 1 MAOA
Cell projection, axon 1 TH
Multi-pass membrane protein 5 ADRB3, DRD2, HTR1A, PNMT, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 6 COMT, CRH, DBH, DRD2, HTR1A, SLC6A4
glutamatergic synapse 1 DRD2
Golgi apparatus 1 NPY
Golgi membrane 2 DRD2, INS
neuronal cell body 1 SST
presynaptic membrane 2 DRD2, SLC6A4
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 BDNF, TH
Presynapse 1 SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 5 ADRB3, COMT, DRD2, HTR1A, SLC6A4
synaptic vesicle membrane 1 DRD2
terminal bouton 1 TH
Membrane 5 BDNF, COMT, DBH, MAOA, SLC6A4
axon 4 BDNF, COMT, DRD2, TH
extracellular exosome 2 COMT, DDC
endoplasmic reticulum 2 DBH, PNMT
extracellular space 10 BDNF, CRH, DBH, GNRH1, IL6, INS, NPY, POMC, PRL, SST
perinuclear region of cytoplasm 2 BDNF, TH
mitochondrion 3 MAOA, PNMT, TH
intracellular membrane-bounded organelle 3 COMT, DBH, PNMT
Secreted 10 BDNF, CRH, DBH, IL6, INS, NPY, POMC, PRL, SST, TRH
extracellular region 11 BDNF, CRH, DBH, GNRH1, IL6, INS, NPY, POMC, PRL, SST, TRH
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 MAOA
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 1 MAOA
Extracellular side 1 COMT
centriolar satellite 1 DBH
ciliary membrane 1 DRD2
varicosity 1 CRH
dendritic spine 1 DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 3 CRH, DRD2, TH
cytoplasmic vesicle 1 TH
Melanosome membrane 1 TH
Single-pass type II membrane protein 2 COMT, DBH
postsynaptic membrane 2 DRD2, SLC6A4
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 3 DRD2, NPY, SST
secretory granule 2 POMC, TRH
lateral plasma membrane 1 DRD2
receptor complex 1 ADRB3
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 SLC6A4, TH
cilium 1 DRD2
chromatin 1 PRL
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
endosome lumen 2 INS, PRL
[Isoform 1]: Endoplasmic reticulum membrane 1 PNMT
Cell projection, dendrite 1 HTR1A
secretory granule lumen 3 DBH, INS, POMC
secretory granule membrane 1 DBH
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, IL6, INS
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 2 NPY, SST
Single-pass type IV membrane protein 1 MAOA
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
[Isoform 2]: Endoplasmic reticulum membrane 1 PNMT
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
transport vesicle membrane 1 DBH
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
G protein-coupled receptor complex 1 DRD2
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
serotonergic synapse 1 SLC6A4


文献列表

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