11-Dehydrocorticosterone (BioDeep_00000005849)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2R,10S,11S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-ene-5,17-dione

化学式: C21H28O4 (344.19874880000003)
中文名称: 11-去氢皮质甾酮
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.27%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2C(=O)CC2(C)C(C(=O)CO)CCC12
InChI: InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3

描述信息

11-Dehydrocorticosterone is a mineral corticosteroid. The conversion of inactive 11-ketoglucocorticoids such as 11-dehydrocorticosterone) into active 11b-hydroxyglucocorticoids (such as corticosterone) is catalyzed by 11beta-hydroxysteroid dehydrogenase (11b-HSD1, EC 1.1.1.146), which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue, skeletal muscles and possibly kidney. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity rather than elevated systemic glucocorticoid levels has been associated with metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that compounds inhibiting 11beta-HSD1 activity ameliorate the adverse effects of excessive glucocorticoid concentrations on metabolic processes, providing promising opportunities for the development of therapeutic interventions. 11-dehydrocorticosterone and corticosterone display antinatriuretic activity, although 11-dehydrocorticosterone is generally a more potent sodium retainer than corticosterone. (PMID: 17584152, Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40.) [HMDB]
11-Dehydrocorticosterone is a mineral corticosteroid. The conversion of inactive 11-ketoglucocorticoids such as 11-dehydrocorticosterone) into active 11b-hydroxyglucocorticoids (such as corticosterone) is catalyzed by 11beta-hydroxysteroid dehydrogenase (11b-HSD1, EC 1.1.1.146), which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue, skeletal muscles and possibly kidney. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity rather than elevated systemic glucocorticoid levels has been associated with metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that compounds inhibiting 11beta-HSD1 activity ameliorate the adverse effects of excessive glucocorticoid concentrations on metabolic processes, providing promising opportunities for the development of therapeutic interventions. 11-dehydrocorticosterone and corticosterone display antinatriuretic activity, although 11-dehydrocorticosterone is generally a more potent sodium retainer than corticosterone. (PMID: 17584152, Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40.).

同义名列表

18 个代谢物同义名

(1S,2R,10S,11S,15S)-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-ene-5,17-dione; 17-(1-Keto-2-hydroxyethyl)-D4-androsten-3,11-dione; 11-Dehydrocorticosterone, 4-(14)C labeled; 21-hydroxy-pregn-4-ene-3,11,20-trione; 21-Hydroxypregn-4-ene-3,11,20-trione; 21-Hydroxypregn-4-ene-3,11-20-trione; D4-Pregnene-21-ol-3,11,20-trione; D4-Pregnen-21-ol-3,11,20-trione; 4-Pregnen-21-ol-3,11,20-trione; 11-oxo-11-Deoxycorticosterone; 11-Dehydro-corticosterone; 11-DEHYDROCORTICOSTERONE; Dehydrocortocicosterone; 11-Dehydrocorticosteron; Dehydrocorticosterone; 11-Oxocorticosterone; Kendalls compound A; 17-Deoxycortisone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

34 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(34)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Vadim Tseilikman, Maria Komelkova, Marina V Kondashevskaya, Eugenia Manukhina, H Fred Downey, Valerii Chereshnev, Margarita Chereshneva, Pavel Platkovskii, Anna Goryacheva, Anton Pashkov, Julia Fedotova, Olga Tseilikman, Natalya Maltseva, Olga Cherkasova, Charlotte Steenblock, Stefan R Bornstein, Barbara Ettrich, George P Chrousos, Enrico Ullmann. A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413235. [PMID: 34948031]
  • David J Morris, Andrew S Brem, Alex Odermatt. Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis. The Journal of steroid biochemistry and molecular biology. 2021 11; 214(?):105988. doi: 10.1016/j.jsbmb.2021.105988. [PMID: 34464733]
  • Manu Verma, Karen Sooy, George Just, Mark Nixon, Ruth Morgan, Ruth Andrew, Karen E Chapman, Natalie Z M Homer. Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry. Rapid communications in mass spectrometry : RCM. 2020 Sep; 34 Suppl 4(?):e8610. doi: 10.1002/rcm.8610. [PMID: 31677354]
  • Catharine J Wheaton, Natalie D Mylniczenko, John M Rimoldi, Rama S V S Gadepalli, R Hart, Bobbi R O'Hara, Andrew N Evans. Challenges, pitfalls and surprises: development and validation of a monoclonal antibody for enzyme immunoassay of the steroid 1α-hydroxycorticosterone in elasmobranch species. General and comparative endocrinology. 2018 09; 265(?):83-89. doi: 10.1016/j.ygcen.2018.01.028. [PMID: 29409969]
  • Rachael C Crew, Peter J Mark, Michael W Clarke, Brendan J Waddell. Obesity Disrupts the Rhythmic Profiles of Maternal and Fetal Progesterone in Rat Pregnancy. Biology of reproduction. 2016 09; 95(3):55. doi: 10.1095/biolreprod.116.139451. [PMID: 27465137]
  • P Strajhar, Y Schmid, E Liakoni, P C Dolder, K M Rentsch, D V Kratschmar, A Odermatt, M E Liechti. Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects. Journal of neuroendocrinology. 2016 Mar; 28(3):12374. doi: 10.1111/jne.12374. [PMID: 26849997]
  • Michaela D Wharfe, Peter J Mark, Caitlin S Wyrwoll, Jeremy T Smith, Cassandra Yap, Michael W Clarke, Brendan J Waddell. Pregnancy-induced adaptations of the central circadian clock and maternal glucocorticoids. The Journal of endocrinology. 2016 Mar; 228(3):135-47. doi: 10.1530/joe-15-0405. [PMID: 26883207]
  • Yegor V Antonov, Yuriy V Alexandrovich, Olga E Redina, Michael A Gilinsky, Arcady L Markel. Stress and hypertensive disease: adrenals as a link. Experimental study on hypertensive ISIAH rat strain. Clinical and experimental hypertension (New York, N.Y. : 1993). 2016 ; 38(5):415-23. doi: 10.3109/10641963.2015.1116546. [PMID: 27362777]
  • Linda J Mullins, Christopher J Kenyon, Matthew A Bailey, Bryan R Conway, Mary E Diaz, John J Mullins. Mineralocorticoid Excess or Glucocorticoid Insufficiency: Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model. Hypertension (Dallas, Tex. : 1979). 2015 Sep; 66(3):667-73. doi: 10.1161/hypertensionaha.115.05262. [PMID: 26077568]
  • Andrew S Brem, David J Morris, Xiangpo Li, Yan Ge, Sunil Shaw, Rujun Gong. Adrenalectomy amplifies aldosterone induced injury in cardiovascular tissue: an effect attenuated by adrenally derived steroids. Steroids. 2013 Mar; 78(3):347-55. doi: 10.1016/j.steroids.2012.12.007. [PMID: 23287650]
  • Yue-Jing Wang, Su-Ling Huang, Ying Feng, Meng-Meng Ning, Ying Leng. Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice. Acta pharmacologica Sinica. 2012 Sep; 33(9):1195-203. doi: 10.1038/aps.2012.87. [PMID: 22922341]
  • Bhowmik Salil Kumar, Bong Chul Chung, Oh-Seung Kwon, Byung Hwa Jung. Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics. Journal of applied toxicology : JAT. 2012 Jul; 32(7):505-20. doi: 10.1002/jat.1746. [PMID: 22131085]
  • Laetitia Martinerie, Eric Pussard, Geri Meduri, Anne-Lise Delezoide, Pascal Boileau, Marc Lombès. Lack of renal 11 beta-hydroxysteroid dehydrogenase type 2 at birth, a targeted temporal window for neonatal glucocorticoid action in human and mice. PloS one. 2012; 7(2):e31949. doi: 10.1371/journal.pone.0031949. [PMID: 22359645]
  • Agnes E Coutinho, Mohini Gray, David G Brownstein, Donald M Salter, Deborah A Sawatzky, Spike Clay, James S Gilmour, Jonathan R Seckl, John S Savill, Karen E Chapman. 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. Endocrinology. 2012 Jan; 153(1):234-40. doi: 10.1210/en.2011-1398. [PMID: 22067318]
  • Wen-wen Qi, Li-yong Zhong, Xiao-rong Li, Guang Li, Zhao-xia Liu, Jin-feng Hu, Nai-hong Chen. Hyperglycemia induces the variations of 11β-hydroxysteroid dehydrogenase type 1 and peroxisome proliferator-activated receptor-γ expression in hippocampus and hypothalamus of diabetic rats. Experimental diabetes research. 2012; 2012(?):107130. doi: 10.1155/2012/107130. [PMID: 22792090]
  • Daniel Lienhard, Meret Lauterburg, Geneviève Escher, Felix J Frey, Brigitte M Frey. High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11β-hydroxysteroid dehydrogenase type 2. PloS one. 2012; 7(5):e37898. doi: 10.1371/journal.pone.0037898. [PMID: 22693583]
  • Peng Jiang, Weixing Dai, Shikai Yan, Zhongliang Chen, Ruilin Xu, Jianmi Ding, Li Xiang, Shuping Wang, Runhui Liu, Weidong Zhang. Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method. Journal of ethnopharmacology. 2011 Nov; 138(2):530-6. doi: 10.1016/j.jep.2011.09.049. [PMID: 22001859]
  • Louiza Belkacemi, Andrea Jelks, Chun-Hung Chen, Michael G Ross, Mina Desai. Altered placental development in undernourished rats: role of maternal glucocorticoids. Reproductive biology and endocrinology : RB&E. 2011 Aug; 9(?):105. doi: 10.1186/1477-7827-9-105. [PMID: 21806804]
  • Leslie A Reperant, Marco W G van de Bildt, Geert van Amerongen, Debbie M Buehler, Albert D M E Osterhaus, Susi Jenni-Eiermann, Theunis Piersma, Thijs Kuiken. Highly pathogenic avian influenza virus H5N1 infection in a long-distance migrant shorebird under migratory and non-migratory states. PloS one. 2011; 6(11):e27814. doi: 10.1371/journal.pone.0027814. [PMID: 22132150]
  • Fairus Ahmad, Ima Nirwana Soelaiman, Elvy Suhana Mohd Ramli, Tan Ming Hooi, Farihah H Suhaimi. Histomorphometric changes in the perirenal adipocytes of adrenalectomized rats treated with dexamethasone. Clinics (Sao Paulo, Brazil). 2011; 66(5):849-53. doi: 10.1590/s1807-59322011000500023. [PMID: 21789391]
  • Dong Yong Kil, Brittany M Vester Boler, Carolyn J Apanavicius, Lawrence B Schook, Kelly S Swanson. Age and diet affect gene expression profiles in canine liver tissue. PloS one. 2010 Oct; 5(10):e13319. doi: 10.1371/journal.pone.0013319. [PMID: 20967283]
  • Sakamuri S S Vara Prasad, Shanmugam S Jeya Kumar, Putcha Uday Kumar, Syed S Y H Qadri, Ayyalasomayajula Vajreswari. Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue. Lipids in health and disease. 2010 Oct; 9(?):111. doi: 10.1186/1476-511x-9-111. [PMID: 20932307]
  • Iris Ostreicher, Jorge Reis Almeida, Valentina Campean, Manfred Rauh, Christian Plank, Kerstin Amann, Jörg Dötsch. Changes in 11beta-hydroxysteroid dehydrogenase type 2 expression in a low-protein rat model of intrauterine growth restriction. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2010 Oct; 25(10):3195-203. doi: 10.1093/ndt/gfq354. [PMID: 20566573]
  • Andrew S Brem, David J Morris, Yan Ge, Lance Dworkin, Evelyn Tolbert, Rujun Gong. Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity. American journal of physiology. Renal physiology. 2010 May; 298(5):F1178-87. doi: 10.1152/ajprenal.00532.2009. [PMID: 20200098]
  • Donald R Dunbar, Hiba Khaled, Louise C Evans, Emad A S Al-Dujaili, Linda J Mullins, John J Mullins, Christopher J Kenyon, Matthew A Bailey. Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney. Physiological genomics. 2010 Feb; 40(3):158-66. doi: 10.1152/physiolgenomics.00088.2009. [PMID: 19920212]
  • Yadong Huang, Xingwang Li, Han Lin, Yanhui Chu, Bingbing Chen, Qingquan Lian, Ren-Shan Ge. Regulation of 11beta-hydroxysteroid dehydrogenase 1 and 2 by IGF-1 in mice. Biochemical and biophysical research communications. 2010 Jan; 391(4):1752-6. doi: 10.1016/j.bbrc.2009.12.148. [PMID: 20045394]
  • R N Carter, J M Paterson, U Tworowska, D J Stenvers, J J Mullins, J R Seckl, M C Holmes. Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent. Journal of neuroendocrinology. 2009 Nov; 21(11):879-87. doi: 10.1111/j.1365-2826.2009.01899.x. [PMID: 19602102]
  • John Brannian, Kathleen Eyster, Mandi Greenway, Cody Henriksen, Kim Teslaa, Maureen Diggins. Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. Journal of ovarian research. 2009 Aug; 2(?):10. doi: 10.1186/1757-2215-2-10. [PMID: 19650929]
  • Noriko Tagawa, Ryosuke Yuda, Sayaka Kubota, Midori Wakabayashi, Yuko Yamaguchi, Daisuke Kiyonaga, Natsuko Mori, Erika Minamitani, Hiroaki Masuzaki, Yoshiharu Kobayashi. 17Beta-estradiol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes. The Journal of endocrinology. 2009 Jul; 202(1):131-9. doi: 10.1677/joe-09-0021. [PMID: 19380458]
  • Masakatsu Sone, Hirotaka Shibata, Keiko Homma, Naohisa Tamura, Jun-Ichi Akahira, Satoshi Hamada, Mitsuhiko Yahata, Nobuyuki Fukui, Hiroshi Itoh, Hironobu Sasano, Kazuwa Nakao. Close examination of steroidogenesis disorders in a DOC- and progesterone-producing adrenocortical carcinoma. Endocrine. 2009 Feb; 35(1):25-33. doi: 10.1007/s12020-008-9123-5. [PMID: 18985457]
  • P J Lucassen, O J Bosch, E Jousma, S A Krömer, R Andrew, J R Seckl, I D Neumann. Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta-hydroxysteroid dehydrogenase type 2. The European journal of neuroscience. 2009 Jan; 29(1):97-103. doi: 10.1111/j.1460-9568.2008.06543.x. [PMID: 19032587]
  • Yong Liu, Ravinder J Singh, Kristie Usa, Brian C Netzel, Mingyu Liang. Renal medullary 11 beta-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension. Physiological genomics. 2008 Dec; 36(1):52-8. doi: 10.1152/physiolgenomics.90283.2008. [PMID: 18826995]
  • V G Selyatitskaya, O P Cherkasova, T V Pankina, N A Palchikova. Functional state of adrenocortical system in rats with manifest alloxan-induced diabetes mellitus. Bulletin of experimental biology and medicine. 2008 Dec; 146(6):708-10. doi: 10.1007/s10517-009-0393-6. [PMID: 19513361]
  • I J Bujalska, L L Gathercole, J W Tomlinson, C Darimont, J Ermolieff, A N Fanjul, P A Rejto, P M Stewart. A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. The Journal of endocrinology. 2008 May; 197(2):297-307. doi: 10.1677/joe-08-0050. [PMID: 18434359]
  • Yong Liu, Frank Park, Jennifer L Pietrusz, Guangfu Jia, Ravinder J Singh, Brian C Netzel, Mingyu Liang. Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis. Physiological genomics. 2008 Feb; 32(3):343-51. doi: 10.1152/physiolgenomics.00067.2007. [PMID: 18073273]
  • Maj Sundbom, Christina Kaiser, Eva Björkstrand, Victor M Castro, Catarina Larsson, Göran Selén, Charlotte Söderberg Nyhem, Stephen R James. Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice. BMC pharmacology. 2008 Feb; 8(?):3. doi: 10.1186/1471-2210-8-3. [PMID: 18269730]
  • A Katz, R Heiblum, R Meidan, B Robinzon. Corticosterone oxidative neutralization by 11-beta hydroxysteroid dehydrogenases in kidney and colon of the domestic fowl. General and comparative endocrinology. 2008 Feb; 155(3):814-20. doi: 10.1016/j.ygcen.2007.10.002. [PMID: 18022174]
  • Elise P Gomez-Sanchez, Damian G Romero, Angela F de Rodriguez, Mary P Warden, Zygmunt Krozowski, Celso E Gomez-Sanchez. Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat. Endocrinology. 2008 Feb; 149(2):525-33. doi: 10.1210/en.2007-0328. [PMID: 18039793]
  • Zoltan Balazs, Roberto A S Schweizer, Felix J Frey, Françoise Rohner-Jeanrenaud, Alex Odermatt. DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins. Journal of the American Society of Nephrology : JASN. 2008 Jan; 19(1):92-101. doi: 10.1681/asn.2007030263. [PMID: 18032797]
  • Kristie Usa, Ravinder J Singh, Brian C Netzel, Yong Liu, Hershel Raff, Mingyu Liang. Renal interstitial corticosterone and 11-dehydrocorticosterone in conscious rats. American journal of physiology. Renal physiology. 2007 Jul; 293(1):F186-92. doi: 10.1152/ajprenal.00484.2006. [PMID: 17389675]
  • Lyubomir G Nashev, Charlie Chandsawangbhuwana, Zoltan Balazs, Atanas G Atanasov, Bernhard Dick, Felix J Frey, Michael E Baker, Alex Odermatt. Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PloS one. 2007 Jun; 2(6):e561. doi: 10.1371/journal.pone.0000561. [PMID: 17593962]
  • Mariana Baserga, Merica A Hale, Zheng Ming Wang, Xing Yu, Christopher W Callaway, Robert A McKnight, Robert H Lane. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 May; 292(5):R1943-55. doi: 10.1152/ajpregu.00558.2006. [PMID: 17272666]
  • Noriko Tagawa, Nao Ikariko, Keiko Fukumura, Yoshiharu Kobayashi. Development of an enzyme-linked immunosorbent assay for serum 11-dehydrocorticosterone in rat and mouse. Biological & pharmaceutical bulletin. 2007 Mar; 30(3):403-9. doi: 10.1248/bpb.30.403. [PMID: 17329828]
  • O P Cherkasova. [The activity of 11beta-hydroxysteroid dehydrogenase of rat kidney and liver at inherited stress-induced arterial hypertension]. Biomeditsinskaia khimiia. 2006 Nov; 52(6):568-75. doi: NULL. [PMID: 17288248]
  • M Kucka, K Vagnerová, P Klusonová, I Miksík, J Pácha. Corticosterone metabolism in chicken tissues: evidence for tissue-specific distribution of steroid dehydrogenases. General and comparative endocrinology. 2006 Jul; 147(3):377-83. doi: 10.1016/j.ygcen.2006.02.007. [PMID: 16574115]
  • Megan C Holmes, Jonathan R Seckl. The role of 11beta-hydroxysteroid dehydrogenases in the brain. Molecular and cellular endocrinology. 2006 Mar; 248(1-2):9-14. doi: 10.1016/j.mce.2005.12.002. [PMID: 16413106]
  • P Alberts, Y Rönquist-Nii, C Larsson, G Klingström, L Engblom, N Edling, V Lidell, I Berg, P-O Edlund, M Ashkzari, N Sahaf, S Norling, V Berggren, K Bergdahl, M Forsgren, L Abrahmsén. Effect of high-fat diet on KKAy and ob/ob mouse liver and adipose tissue corticosterone and 11-dehydrocorticosterone concentrations. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2005 Jul; 37(7):402-7. doi: 10.1055/s-2005-870228. [PMID: 16034710]
  • Jiandong Zhang, Timothy D Osslund, Matthew H Plant, Christi L Clogston, Rebecca E Nybo, Fei Xiong, John M Delaney, Steven R Jordan. Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes. Biochemistry. 2005 May; 44(18):6948-57. doi: 10.1021/bi047599q. [PMID: 15865440]
  • Karla Mazancová, Marek Kucka, Ivan Miksík, Jirí Pácha. Glucocorticoid metabolism and Na+ transport in chicken intestine. Journal of experimental zoology. Part A, Comparative experimental biology. 2005 Feb; 303(2):113-22. doi: 10.1002/jez.a.132. [PMID: 15662663]
  • Keiko Homma, Tomonobu Hasegawa, Masami Masumoto, Eiko Takeshita, Kiyoaki Watanabe, Hitoshi Chiba, Takao Kurosawa, Takao Takahashi, Nobutake Matsuo. Reference values for urinary steroids in Japanese newborn infants: gas chromatography/mass spectrometry in selected ion monitoring. Endocrine journal. 2003 Dec; 50(6):783-92. doi: 10.1507/endocrj.50.783. [PMID: 14709852]
  • Clare Christy, Patrick W F Hadoke, Janice M Paterson, John J Mullins, Jonathan R Seckl, Brian R Walker. 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids. Hypertension (Dallas, Tex. : 1979). 2003 Oct; 42(4):580-7. doi: 10.1161/01.hyp.0000088855.06598.5b. [PMID: 12925564]
  • Elise P Gomez-Sanchez, Venkataseshu Ganjam, Yuan Jian Chen, Ying Liu, Ming Yi Zhou, Cigdem Toroslu, Damian G Romero, Michael D Hughson, Angela de Rodriguez, Celso E Gomez-Sanchez. Regulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol. American journal of physiology. Endocrinology and metabolism. 2003 Aug; 285(2):E272-9. doi: 10.1152/ajpendo.00409.2002. [PMID: 12700160]
  • Makoto Kusakabe, Ikumi Nakamura, Graham Young. 11beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid in rainbow trout: cloning, sites of expression, and seasonal changes in gonads. Endocrinology. 2003 Jun; 144(6):2534-45. doi: 10.1210/en.2002-220446. [PMID: 12746316]
  • Jirí Pácha, Radka Vagnerová, Jana Bryndová. Carbenoxolone accelerates maturation of rat intestine. Pediatric research. 2003 May; 53(5):808-13. doi: 10.1203/01.pdr.0000058923.08017.6f. [PMID: 12621120]
  • Marie-Edith Rafestin-Oblin, Anny Souque, Brigitte Bocchi, Gregory Pinon, Jerome Fagart, Alain Vandewalle. The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related. Endocrinology. 2003 Feb; 144(2):528-33. doi: 10.1210/en.2002-220708. [PMID: 12538613]
  • Brigitte Bocchi, Jerome Fagart, Francoise Cluzeaud, Michel Fay, Marie-Edith Rafestin-Oblin, Nicolette Farman. Glucocorticoid metabolism by 11-beta hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity. The Journal of steroid biochemistry and molecular biology. 2003 Feb; 84(2-3):239-44. doi: 10.1016/s0960-0760(03)00036-0. [PMID: 12711009]
  • Sophie Combet, Nancy Geffroy, Véronique Berthonaud, Bernhard Dick, Laurent Teillet, Jean-Marc Verbavatz, Bruno Corman, Marie-Marcelle Trinh-Trang-Tan. Correction of age-related polyuria by dDAVP: molecular analysis of aquaporins and urea transporters. American journal of physiology. Renal physiology. 2003 Jan; 284(1):F199-208. doi: 10.1152/ajprenal.00167.2002. [PMID: 12388383]
  • S Hundertmark, A Dill, H Bühler, P Stevens, K Looman, V Ragosch, J R Seckl, C Lipka. 11beta-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2002 Oct; 34(10):537-44. doi: 10.1055/s-2002-35424. [PMID: 12439780]
  • S Hundertmark, A Dill, A Ebert, B Zimmermann, Y V Kotelevtsev, J J Mullins, J R Seckl. Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2002 Oct; 34(10):545-9. doi: 10.1055/s-2002-35425. [PMID: 12439781]
  • Bruno Vogt, Bernhard Dick, Hans-Peter Marti, Felix J Frey, Brigitte M Frey. Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2002 May; 17(5):753-8. doi: 10.1093/ndt/17.5.753. [PMID: 11981059]
  • O P Cherkasova, V I Fedorov. [Influence of diet without added bran on the contents of corticosteroid hormones in adrenal gland and blood plasma of rats]. Voprosy pitaniia. 2002; 71(4):6-8. doi: NULL. [PMID: 12462946]
  • Karen E Sheppard, Dominic J Autelitano. 11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Endocrinology. 2002 Jan; 143(1):198-204. doi: 10.1210/endo.143.1.8583. [PMID: 11751610]
  • N M Morton, M C Holmes, C Fiévet, B Staels, A Tailleux, J J Mullins, J R Seckl. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. The Journal of biological chemistry. 2001 Nov; 276(44):41293-300. doi: 10.1074/jbc.m103676200. [PMID: 11546766]
  • B Yao, Y D Zhang, J P Shen. Correlation between decrease of 11beta-hydroxysteroid dehydrogenase activity and hypokalemia induced by furosemide in rats. Acta pharmacologica Sinica. 2001 Nov; 22(11):991-6. doi: NULL. [PMID: 11749789]
  • E P Gomez-Sanchez, V Ganjam, Y J Chen, Y Liu, S A Clark, C E Gomez-Sanchez. The 11beta hydroxysteroid dehydrogenase 2 exists as an inactive dimer. Steroids. 2001 Nov; 66(11):845-8. doi: 10.1016/s0039-128x(01)00119-2. [PMID: 11576624]
  • K Aoki, M Homma, T Hirano, K Oka, S Satoh, K Mukasa, S Ito, H Sekihara. MRNA and enzyme activity of hepatic 11beta-hydroxysteroid dehydrogenase type 1 are elevated in C57BL/KsJ-db/db mice. Life sciences. 2001 Oct; 69(21):2543-9. doi: 10.1016/s0024-3205(01)01328-5. [PMID: 11693261]
  • H Horigome, T Hirano, K Oka. Therapeutic effect of glycyrrhetinic acid in MRL lpr/lpr mice: implications of alteration of corticosteroid metabolism. Life sciences. 2001 Oct; 69(20):2429-38. doi: 10.1016/s0024-3205(01)01317-0. [PMID: 11681629]
  • P S Brereton, R R van Driel, Suhaimi Fb, K Koyama, R Dilley, Z Krozowski. Light and electron microscopy localization of the 11beta-hydroxysteroid dehydrogenase type I enzyme in the rat. Endocrinology. 2001 Apr; 142(4):1644-51. doi: 10.1210/endo.142.4.8088. [PMID: 11250946]
  • H Woitge, J Harrison, A Ivkosic, Z Krozowski, B Kream. Cloning and in vitro characterization of alpha 1(I)-collagen 11 beta-hydroxysteroid dehydrogenase type 2 transgenes as models for osteoblast-selective inactivation of natural glucocorticoids. Endocrinology. 2001 Mar; 142(3):1341-8. doi: 10.1210/endo.142.3.8044. [PMID: 11181553]
  • H Horigome, M Homma, T Hiran, K Oka, T Niitsuma, T Hayashi. Magnolol from Magnolia officinalis inhibits 11beta-hydroxysteroid dehydrogenase without increases of corticosterone and thymocyte apoptosis in mice. Planta medica. 2001 Feb; 67(1):33-7. doi: 10.1055/s-2001-10626. [PMID: 11270719]
  • M C Holmes, Y Kotelevtsev, J J Mullins, J R Seckl. Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes. Molecular and cellular endocrinology. 2001 Jan; 171(1-2):15-20. doi: 10.1016/s0303-7207(00)00386-5. [PMID: 11165006]
  • H J Harris, Y Kotelevtsev, J J Mullins, J R Seckl, M C Holmes. Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice. Endocrinology. 2001 Jan; 142(1):114-20. doi: 10.1210/endo.142.1.7887. [PMID: 11145573]
  • L J Eyre, E H Rabbitt, R Bland, S V Hughes, M S Cooper, M C Sheppard, P M Stewart, M Hewison. Expression of 11 beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone. Journal of cellular biochemistry. 2001; 81(3):453-62. doi: 10.1002/1097-4644(20010601)81:3<453::aid-jcb1059>3.0.co;2-z. [PMID: 11255228]
  • P M Jamieson, B R Walker, K E Chapman, R Andrew, S Rossiter, J R Seckl. 11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver. The Journal of endocrinology. 2000 Jun; 165(3):685-92. doi: 10.1677/joe.0.1650685. [PMID: 10828853]
  • D E Livingstone, G C Jones, K Smith, P M Jamieson, R Andrew, C J Kenyon, B R Walker. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2000 Feb; 141(2):560-3. doi: 10.1210/endo.141.2.7297. [PMID: 10650936]
  • K Kuhlmann, H Bühler, V Ragosch, G Halis, H K Weitzel, S Hundertmark. Kinetic studies on rabbit liver glucocorticoid 5alpha-reductase. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2000 Jan; 32(1):20-5. doi: 10.1055/s-2007-978580. [PMID: 10727009]
  • Z Krozowski, K X Li, K Koyama, R E Smith, V R Obeyesekere, A Stein-Oakley, H Sasano, C Coulter, T Cole, K E Sheppard. The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes. The Journal of steroid biochemistry and molecular biology. 1999 Apr; 69(1-6):391-401. doi: 10.1016/s0960-0760(99)00074-6. [PMID: 10419017]
  • O A Ajilore, R M Sapolsky. In vivo characterization of 11beta-hydroxysteroid dehydrogenase in rat hippocampus using glucocorticoid neuroendangerment as an endpoint. Neuroendocrinology. 1999 Feb; 69(2):138-44. doi: 10.1159/000054412. [PMID: 9986927]
  • C M Leckie, L A Welberg, J R Seckl. 11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells. The Journal of endocrinology. 1998 Nov; 159(2):233-8. doi: 10.1677/joe.0.1590233. [PMID: 9795363]
  • S Muto, J Nemoto, S Ebata, K Kawakami, Y Asano. Corticosterone and 11-dehydrocorticosterone stimulate Na,K-ATPase gene expression in vascular smooth muscle cells. Kidney international. 1998 Aug; 54(2):492-508. doi: 10.1046/j.1523-1755.1998.00033.x. [PMID: 9690216]
  • M Vylitová, I Miksík, J Pácha. Metabolism of corticosterone in mammalian and avian intestine. General and comparative endocrinology. 1998 Mar; 109(3):315-24. doi: 10.1006/gcen.1997.7035. [PMID: 9480739]
  • R B Bina, N Hill, A S Brem. Effect of serum on vascular smooth muscle function. Life sciences. 1998; 62(13):1195-201. doi: 10.1016/s0024-3205(98)00046-0. [PMID: 9519801]
  • A S Brem, R B Bina, T C King, D J Morris. Localization of 2 11beta-OH steroid dehydrogenase isoforms in aortic endothelial cells. Hypertension (Dallas, Tex. : 1979). 1998 Jan; 31(1 Pt 2):459-62. doi: 10.1161/01.hyp.31.1.459. [PMID: 9453345]
  • M Hay, P Mormède. Improved determination of urinary cortisol and cortisone, or corticosterone and 11-dehydrocorticosterone by high-performance liquid chromatography with ultraviolet absorbance detection. Journal of chromatography. B, Biomedical sciences and applications. 1997 Nov; 702(1-2):33-9. doi: 10.1016/s0378-4347(97)00361-7. [PMID: 9449553]
  • V L Nacharaju, O Muneyyirci-Delale, N Khan. Presence of 11 beta-hydroxysteroid dehydrogenase in human semen: evidence of correlation with semen characteristics. Steroids. 1997 Mar; 62(3):311-4. doi: 10.1016/s0039-128x(96)00225-5. [PMID: 9071740]
  • H Morita, M Zhou, M F Foecking, E P Gomez-Sanchez, E N Cozza, C E Gomez-Sanchez. 11 beta-Hydroxysteroid dehydrogenase type 2 complementary deoxyribonucleic acid stably transfected into Chinese hamster ovary cells: specific inhibition by 11 alpha-hydroxyprogesterone. Endocrinology. 1996 Jun; 137(6):2308-14. doi: 10.1210/endo.137.6.8641180. [PMID: 8641180]
  • E P Gomez-Sanchez, D Cox, M Foecking, V Ganjam, C E Gomez-Sanchez. 11 beta-hydroxysteroid dehydrogenases of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances. Steroids. 1996 Mar; 61(3):110-5. doi: 10.1016/0039-128x(95)00201-z. [PMID: 8852827]
  • J J Hermans, B Steckel, H H Thijssen, B J Janssen, K J Netter, E Maser. Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats. Steroids. 1995 Nov; 60(11):773-9. doi: 10.1016/0039-128x(95)00118-a. [PMID: 8585102]
  • N Alfaidy, M Blot-Chabaud, D Robic, S Kenouch, R Bourbouze, J P Bonvalet, N Farman. Characteristics and regulation of 11 beta-hydroxysteroid dehydrogenase of proximal and distal nephron. Biochimica et biophysica acta. 1995 Apr; 1243(3):461-8. doi: 10.1016/0304-4165(94)00173-u. [PMID: 7727521]
  • G Escher, K V Meyer, B S Vishwanath, B M Frey, F J Frey. Furosemide inhibits 11 beta-hydroxysteroid dehydrogenase in vitro and in vivo. Endocrinology. 1995 Apr; 136(4):1759-65. doi: 10.1210/endo.136.4.7895688. [PMID: 7895688]
  • S C Low, K E Chapman, C R Edwards, J R Seckl. 'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells. Journal of molecular endocrinology. 1994 Oct; 13(2):167-74. doi: 10.1677/jme.0.0130167. [PMID: 7848528]
  • A S Brem, B Bina, K L Matheson, J L Barnes, D J Morris. Developmental changes in rat renal 11 beta-hydroxysteroid dehydrogenase. Kidney international. 1994 Mar; 45(3):679-83. doi: 10.1038/ki.1994.91. [PMID: 8196270]
  • G W Souness, K Myles, D J Morris. Other physiological considerations of protective mechanisms of mineralocorticoid action. Steroids. 1994 Feb; 59(2):142-7. doi: 10.1016/0039-128x(94)90092-2. [PMID: 8191544]
  • B R Walker, K S Sang, B C Williams, C R Edwards. Direct and indirect effects of carbenoxolone on responses to glucocorticoids and noradrenaline in rat aorta. Journal of hypertension. 1994 Jan; 12(1):33-9. doi: NULL. [PMID: 8157942]
  • A S Brem, K L Matheson, S Latif, D J Morris. Activity of 11 beta-hydroxysteroid dehydrogenase in toad bladder: effects of 11-dehydrocorticosterone. The American journal of physiology. 1993 May; 264(5 Pt 2):F854-8. doi: 10.1152/ajprenal.1993.264.5.f854. [PMID: 8498539]
  • H Duperrex, S Kenouch, H P Gaeggeler, J R Seckl, C R Edwards, N Farman, B C Rossier. Rat liver 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid encodes oxoreductase activity in a mineralocorticoid-responsive toad bladder cell line. Endocrinology. 1993 Feb; 132(2):612-9. doi: 10.1210/endo.132.2.8425481. [PMID: 8425481]
  • S Sabatini, A Hartsell, M Meyer, N A Kurtzman, K Hierholzer. Corticosterone metabolism and membrane transport. Mineral and electrolyte metabolism. 1993; 19(6):343-50. doi: NULL. [PMID: 8164615]
  • G W Souness, D J Morris. 11-Dehydrocorticosterone in the presence of carbenoxolone is a more potent sodium retainer than corticosterone. Steroids. 1993 Jan; 58(1):24-8. doi: 10.1016/0039-128x(93)90013-d. [PMID: 8430442]
  • A S Brem, K L Matheson, D J Morris. Effect of carbenoxolone sodium on steroid-induced sodium transport in the toad bladder: further studies. The Journal of steroid biochemistry and molecular biology. 1992 Sep; 42(8):911-4. doi: 10.1016/0960-0760(92)90100-w. [PMID: 1525050]